Potential influence of Nagella sativa (Black cumin) in reinforcing immune system: A hope to decelerate the COVID-19 pandemic
Kulyar et al.
, Potential influence of Nagella sativa (Black cumin) in reinforcing immune system: A hope to decelerate the..
, Phytomedicine, doi:10.1016/j.phymed.2020.153277 (Review)
Review of immune-regulating, anti-inflammatory, and antioxidant benefits of nigella sativa, and potential benefits for COVID-19.
Kulyar et al., 10 Jul 2020, peer-reviewed, 6 authors.
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Phytomedicine 85 (2021) 153277
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Potential influence of Nagella sativa (Black cumin) in reinforcing immune
system: A hope to decelerate the COVID-19 pandemic
Muhammad Fakhar-e-Alam Kulyar a, †, Rongrong Li b, †, Khalid Mehmood c,
Muhammad Waqas a, d, Kun Li a, *, Jiakui Li a, **
College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China
Department of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu, China
Faculty of Veterinary and Animal Sciences, The Islamia University of Bahawalpur-63100, Pakistan
Faculty of Veterinary & Animal Sciences, University of the Poonch, Rawalakot, District Poonch 12350, Azad Jammu & Kashmir, Pakistan
A R T I C L E I N F O
A B S T R A C T
The world is witnessing a difficult time. The race of developing a new coronavirus (COVID-19) vaccine is
becoming more urgent. Many preliminary studies on the pathophysiology of COVID-19 patients have provided
some clues to treat this pandemic. However, no suitable treatment has found yet. Various symptoms of patients
infected with COVID-19 indicated the importance of immune regulation in the human body. Severe cases
admitted to the intensive care unit showed high level of pro-inflammatory cytokines which enhanced the disease
severity. Acute Respiratory Distress Syndrome (ARDS) in COVID-19 patients is another critical factor of disease
severity and mortality. So, Immune modulation is the only way of regulating immune system. Nigella sativa has
been used for medicinal purposes for centuries. The components of this plant are known for its intense immuneregulatory, anti-inflammatory, and antioxidant benefits in obstructive respiratory disorders. A molecular docking
study also gave evidences that N. sativa decelerates COVID-19 and might give the same or better results than the
FDA approved drugs. The aim of this review was to investigate the possible immune-regulatory effects of N. sativa
on COVID-19 pandemic. Our review found N. sativa’s Thymoquinone, Nigellidine, and α-hederin can be a po
tential influencer in reinforcing the immune response on molecular grounds.
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