Potential influence of Nagella sativa (Black cumin) in reinforcing immune system: A hope to decelerate the COVID-19 pandemic

DOI record: { "DOI": "10.1016/j.phymed.2020.153277", "ISSN": [ "0944-7113" ], "URL": "http://dx.doi.org/10.1016/j.phymed.2020.153277", "alternative-id": [ "S0944711320301082" ], "article-number": "153277", "assertion": [ { "label": "This article is maintained by", "name": "publisher", "value": "Elsevier" }, { "label": "Article Title", "name": "articletitle", "value": "Potential influence of Nagella sativa (Black cumin) in reinforcing immune system: A hope to decelerate the COVID-19 pandemic" }, { "label": "Journal Title", "name": "journaltitle", "value": "Phytomedicine" }, { "label": "CrossRef DOI link to publisher maintained version", "name": "articlelink", "value": "https://doi.org/10.1016/j.phymed.2020.153277" }, { "label": "Content Type", "name": "content_type", "value": "article" }, { "label": "Copyright", "name": "copyright", "value": "© 2020 Elsevier GmbH. All rights reserved." } ], "author": [ { "affiliation": [], "family": "Kulyar", "given": "Muhammad Fakhar-e-Alam", "sequence": "first" }, { "affiliation": [], "family": "Li", "given": "Rongrong", "sequence": "additional" }, { "affiliation": [], "family": "Mehmood", "given": "Khalid", "sequence": "additional" }, { "affiliation": [], "family": "Waqas", "given": "Muhammad", "sequence": "additional" }, { "affiliation": [], "family": "Li", "given": "Kun", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0002-6065-6648", "affiliation": [], "authenticated-orcid": false, "family": "Li", "given": "Jiakui", "sequence": "additional" } ], "container-title": "Phytomedicine", "container-title-short": "Phytomedicine", "content-domain": { "crossmark-restriction": true, "domain": [ "elsevier.com", "sciencedirect.com" ] }, "created": { "date-parts": [ [ 2020, 7, 10 ] ], "date-time": "2020-07-10T03:29:16Z", "timestamp": 1594351756000 }, "deposited": { "date-parts": [ [ 2022, 11, 2 ] ], "date-time": "2022-11-02T05:12:27Z", "timestamp": 1667365947000 }, "indexed": { "date-parts": [ [ 2024, 3, 2 ] ], "date-time": "2024-03-02T09:15:24Z", "timestamp": 1709370924641 }, "is-referenced-by-count": 50, "issued": { "date-parts": [ [ 2021, 5 ] ] }, "language": "en", "license": [ { "URL": "https://www.elsevier.com/tdm/userlicense/1.0/", "content-version": "tdm", "delay-in-days": 0, "start": { "date-parts": [ [ 2021, 5, 1 ] ], "date-time": "2021-05-01T00:00:00Z", "timestamp": 1619827200000 } } ], "link": [ { "URL": "https://api.elsevier.com/content/article/PII:S0944711320301082?httpAccept=text/xml", "content-type": "text/xml", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://api.elsevier.com/content/article/PII:S0944711320301082?httpAccept=text/plain", "content-type": "text/plain", "content-version": "vor", "intended-application": "text-mining" } ], "member": "78", "original-title": [], "page": "153277", "prefix": "10.1016", "published": { "date-parts": [ [ 2021, 5 ] ] }, "published-print": { "date-parts": [ [ 2021, 5 ] ] }, "publisher": "Elsevier BV", "reference": [ { "DOI": "10.1016/j.biopha.2017.04.009", "article-title": "Nigella sativa, a traditional Tunisian herbal medicine, attenuates bleomycin-induced pulmonary fibrosis in a rat model", "author": "Abidi", "doi-asserted-by": "crossref", "first-page": "626", "journal-title": "Biomed. Pharmacother.", "key": "10.1016/j.phymed.2020.153277_bib0001", "volume": "90", "year": "2017" }, { "DOI": "10.1016/S2221-1691(13)60075-1", "article-title": "A review on therapeutic potential of Nigella sativa: a miracle herb", "author": "Ahmad", "doi-asserted-by": "crossref", "first-page": "337", "journal-title": "Asian Pac. J. Trop. Biomed.", "key": "10.1016/j.phymed.2020.153277_bib0002", "volume": "3", "year": "2013" }, { "DOI": "10.1016/j.jsps.2019.09.008", "article-title": "Thymoquinone (2-Isoprpyl-5-methyl-1, 4-benzoquinone) as a chemopreventive/anticancer agent: chemistry and biological effects", "author": "Ahmad", "doi-asserted-by": "crossref", "journal-title": "Saudi Pharm. J.", "key": "10.1016/j.phymed.2020.153277_bib0003", "year": "2019" }, { "DOI": "10.1016/j.micpath.2019.103767", "article-title": "Anti-inflammatory effects of Hederacoside-C on Staphylococcus aureus induced inflammation via TLRs and their downstream signal pathway in vivo and in vitro", "author": "Akhtar", "doi-asserted-by": "crossref", "journal-title": "Microb. Pathog.", "key": "10.1016/j.phymed.2020.153277_bib0004", "volume": "137", "year": "2019" }, { "DOI": "10.1016/j.sjbs.2016.02.019", "article-title": "Challenges presented by MERS corona virus, and SARS corona virus to global health", "author": "Al-Hazmi", "doi-asserted-by": "crossref", "first-page": "507", "journal-title": "Saudi J. Biol. Sci.", "key": "10.1016/j.phymed.2020.153277_bib0005", "volume": "23", "year": "2016" }, { "article-title": "Broncho-relaxant activity of Nigella sativa versus anthemisnobilis in chronic bronchial asthma; a comparative study of efficacy", "author": "Al-Jawad", "first-page": "81", "journal-title": "IOSR J Pharmac", "key": "10.1016/j.phymed.2020.153277_bib0006", "volume": "2", "year": "2012" }, { "DOI": "10.7314/APJCP.2014.15.2.983", "article-title": "Cytotoxicity of Nigella sativa seed oil and extract against human lung cancer cell line", "author": "Al-Sheddi", "doi-asserted-by": "crossref", "first-page": "983", "journal-title": "Asian Pac J Cancer Prev", "key": "10.1016/j.phymed.2020.153277_bib0007", "volume": "15", "year": "2014" }, { "article-title": "Narrative review of Middle East respiratory syndrome coronavirus (MERS-CoV) infection: updates and implications for practice", "author": "Al Mutair", "journal-title": "J. Int. Med. Res.", "key": "10.1016/j.phymed.2020.153277_bib0008", "year": "2019" }, { "article-title": "Bioavailability enhancement studies of amoxicillin with Nigella", "author": "Ali", "first-page": "555", "journal-title": "Indian J. Med. Res.", "key": "10.1016/j.phymed.2020.153277_bib0009", "volume": "135", "year": "2012" }, { "article-title": "Black cumin (Nigella sativa) and its active constituent, thymoquinone: an overview on the analgesic and anti-inflammatory effects", "author": "Amin", "first-page": "8", "journal-title": "Planta Med", "key": "10.1016/j.phymed.2020.153277_bib0010", "volume": "82", "year": "2016" }, { "DOI": "10.1016/j.intimp.2011.10.013", "article-title": "Comparative evaluation of anti-inflammatory properties of thymoquinone and curcumin using an asthmatic murine model", "author": "Ammar", "doi-asserted-by": "crossref", "first-page": "2232", "journal-title": "Int. Immunopharmacol.", "key": "10.1016/j.phymed.2020.153277_bib0011", "volume": "11", "year": "2011" }, { "article-title": "Role of MicroRNAs in lung disease", "author": "Angulo", "first-page": "325", "journal-title": "Arch. Bronconeumol. (English Ed.", "key": "10.1016/j.phymed.2020.153277_bib0012", "volume": "48", "year": "2012" }, { "DOI": "10.3390/ijms19051355", "article-title": "Thymoquinone suppresses IRF-3-mediated expression of type I interferons via suppression of TBK1", "author": "Aziz", "doi-asserted-by": "crossref", "first-page": "1355", "journal-title": "Int. J. Mol. Sci.", "key": "10.1016/j.phymed.2020.153277_bib0013", "volume": "19", "year": "2018" }, { "DOI": "10.1016/j.chroma.2011.07.028", "article-title": "Direct screening of G-quadruplex ligands from Kalopanax septemlobus (Thunb.) Koidz extract by high performance liquid chromatography", "author": "Bai", "doi-asserted-by": "crossref", "first-page": "6433", "journal-title": "J. Chromatogr. A", "key": "10.1016/j.phymed.2020.153277_bib0014", "volume": "1218", "year": "2011" }, { "article-title": "Nigella sativa as a potential therapy for the treatment of lung injury caused by cecal ligation and puncture-induced sepsis model in rats", "author": "Bayir", "first-page": "860", "journal-title": "Cell Mol Biol", "key": "10.1016/j.phymed.2020.153277_bib0015", "volume": "58", "year": "2012" }, { "DOI": "10.1016/S0140-6736(20)30673-5", "article-title": "COVID-19: towards controlling of a pandemic", "author": "Bedford", "doi-asserted-by": "crossref", "journal-title": "Lancet.", "key": "10.1016/j.phymed.2020.153277_bib0016", "year": "2020" }, { "key": "10.1016/j.phymed.2020.153277_bib0017", "unstructured": "Boskabady, H., Keyhanmanesh, R., Saadatloo, M.A.E., 2008. Relaxant effects of different fractions from Nigella sativa L. on guinea pig tracheal chains and its possible mechanism (s)." }, { "DOI": "10.1111/j.1472-8206.2007.00509.x", "article-title": "The possible prophylactic effect of Nigella sativa seed extract in asthmatic patients", "author": "Boskabady", "doi-asserted-by": "crossref", "first-page": "559", "journal-title": "Fundam. Clin. Pharmacol.", "key": "10.1016/j.phymed.2020.153277_bib0018", "volume": "21", "year": "2007" }, { "DOI": "10.26434/chemrxiv.12055716", "doi-asserted-by": "crossref", "key": "10.1016/j.phymed.2020.153277_bib0019", "unstructured": "Bouchentouf, S., Missoum, N., 2020. Identification of Compounds from Nigella Sativa as New Potential Inhibitors of 2019 Novel Coronasvirus (Covid-19): molecular Docking Study." }, { "DOI": "10.1186/1471-2466-11-29", "article-title": "Altered expression of microRNA in the airway wall in chronic asthma: miR-126 as a potential therapeutic target", "author": "Collison", "doi-asserted-by": "crossref", "first-page": "29", "journal-title": "BMC Pulm. Med.", "key": "10.1016/j.phymed.2020.153277_bib0020", "volume": "11", "year": "2011" }, { "DOI": "10.1038/s41579-018-0118-9", "article-title": "Origin and evolution of pathogenic coronaviruses", "author": "Cui", "doi-asserted-by": "crossref", "first-page": "181", "journal-title": "Nat. Rev. Microbiol.", "key": "10.1016/j.phymed.2020.153277_bib0021", "volume": "17", "year": "2019" }, { "DOI": "10.1248/bpb.26.429", "article-title": "Antiinflammatory activity of $α$-hederin methyl ester from the alkaline hydrolysate of the butanol fraction of Kalopanax pictus bark extract", "author": "Da", "doi-asserted-by": "crossref", "first-page": "429", "journal-title": "Biol. Pharm. Bull.", "key": "10.1016/j.phymed.2020.153277_bib0022", "volume": "26", "year": "2003" }, { "key": "10.1016/j.phymed.2020.153277_bib0023", "unstructured": "Dajani, E.Z., Shahwan, T.G., Dajani, N.E., 2018. Overview of the Human Investigations of Nigella sativa (Black Seeds): a Complementary Drug with Historical and Clinical Significance." }, { "DOI": "10.1093/eurheartj/ehaa254", "article-title": "Acute pulmonary embolism and COVID-19 pneumonia: a random association?", "author": "Danzi", "doi-asserted-by": "crossref", "journal-title": "Eur. Heart J.", "key": "10.1016/j.phymed.2020.153277_bib0024", "year": "2020" }, { "DOI": "10.1016/j.phrs.2015.03.011", "article-title": "Thymoquinone and its therapeutic potentials", "author": "Darakhshan", "doi-asserted-by": "crossref", "first-page": "138", "journal-title": "Pharmacol. Res.", "key": "10.1016/j.phymed.2020.153277_bib0025", "volume": "95", "year": "2015" }, { "DOI": "10.1093/nar/gkm142", "article-title": "Mechanisms of activation of interferon regulator factor 3: the role of C-terminal domain phosphorylation in IRF-3 dimerization and DNA binding", "author": "Dragan", "doi-asserted-by": "crossref", "first-page": "3525", "journal-title": "Nucleic Acids Res", "key": "10.1016/j.phymed.2020.153277_bib0026", "volume": "35", "year": "2007" }, { "article-title": "Nigella (Nigella sativa L.): a high value seed spice with immense medicinal potential", "author": "Dubey", "first-page": "967", "journal-title": "Indian J. Agric. Sci", "key": "10.1016/j.phymed.2020.153277_bib0027", "volume": "86", "year": "2016" }, { "DOI": "10.1002/ddr.21292", "article-title": "Effect of $α$-Hederin on IL-2 and IL-17 mRNA and miRNA-133a Levels in lungs of ovalbumin-sensitized male rats", "author": "Ebrahimi", "doi-asserted-by": "crossref", "first-page": "87", "journal-title": "Drug Dev. Res.", "key": "10.1016/j.phymed.2020.153277_bib0028", "volume": "77", "year": "2016" }, { "DOI": "10.1016/j.tox.2012.09.001", "article-title": "Thymoquinone blocks lung injury and fibrosis by attenuating bleomycin-induced oxidative stress and activation of nuclear factor Kappa-B in rats", "author": "El-Khouly", "doi-asserted-by": "crossref", "first-page": "106", "journal-title": "Toxicology", "key": "10.1016/j.phymed.2020.153277_bib0029", "volume": "302", "year": "2012" }, { "article-title": "The black seed Nigella sativa Linnaeus-A mine for multi cures: a plea for urgent clinical evaluation of its volatile oil", "author": "El-Tahir", "first-page": "1", "journal-title": "J. Taibah Univ. Med. Sci.", "key": "10.1016/j.phymed.2020.153277_bib0030", "volume": "1", "year": "2006" }, { "DOI": "10.1016/j.intimp.2006.02.004", "article-title": "Anti-inflammatory effect of thymoquinone in a mouse model of allergic lung inflammation", "author": "El Gazzar", "doi-asserted-by": "crossref", "first-page": "1135", "journal-title": "Int. Immunopharmacol.", "key": "10.1016/j.phymed.2020.153277_bib0031", "volume": "6", "year": "2006" }, { "DOI": "10.1248/bpb.24.307", "article-title": "Hematological studies on black cumin oil from the seeds of Nigella sativa L", "author": "Enomoto", "doi-asserted-by": "crossref", "first-page": "307", "journal-title": "Biol. Pharm. Bull.", "key": "10.1016/j.phymed.2020.153277_bib0032", "volume": "24", "year": "2001" }, { "DOI": "10.1002/ptr.4944", "article-title": "Blood pressure lowering effect of Nigella sativa L. seed oil in healthy volunteers: a randomized, double-blind, placebo-controlled clinical trial", "author": "Fallah Huseini", "doi-asserted-by": "crossref", "first-page": "1849", "journal-title": "Phyther. Res.", "key": "10.1016/j.phymed.2020.153277_bib0033", "volume": "27", "year": "2013" }, { "article-title": "Effect of Alpha-Hederin, the active constituent of Nigella sativa, on miRNA-126, IL-13 mRNA levels and inflammation of lungs in ovalbumin-sensitized male rats", "author": "Fallahi", "first-page": "77", "journal-title": "Avicenna J. phytomedicine", "key": "10.1016/j.phymed.2020.153277_bib0034", "volume": "6", "year": "2016" }, { "article-title": "Black cumin (Nigella sativa) and its constituent (thymoquinone): a review on antimicrobial effects", "author": "Forouzanfar", "first-page": "929", "journal-title": "Iran. J. Basic Med. Sci.", "key": "10.1016/j.phymed.2020.153277_bib0035", "volume": "17", "year": "2014" }, { "DOI": "10.1016/S1572-557X(05)02008-8", "article-title": "The medicinal potential of black seed (Nigella sativa) and its components", "author": "Gali-Muhtasib", "doi-asserted-by": "crossref", "first-page": "133", "journal-title": "Adv. Phytomedicine", "key": "10.1016/j.phymed.2020.153277_bib0036", "volume": "2", "year": "2006" }, { "DOI": "10.2147/DDDT.S87251", "article-title": "Comparative analysis of essential oil composition of iranian and indian nigella sativa L. Extracted using supercritical fluid extraction and solvent extraction", "author": "Ghahramanloo", "doi-asserted-by": "crossref", "first-page": "2221", "journal-title": "Drug Des. Devel. Ther.", "key": "10.1016/j.phymed.2020.153277_bib0037", "volume": "11", "year": "2017" }, { "DOI": "10.1016/j.jff.2015.06.032", "article-title": "Anti-inflammatory, antioxidant, and immunomodulatory aspects of Nigella sativa for its preventive and bronchodilatory effects on obstructive respiratory diseases: a review of basic and clinical evidence", "author": "Gholamnezhad", "doi-asserted-by": "crossref", "first-page": "910", "journal-title": "J. Funct. Foods", "key": "10.1016/j.phymed.2020.153277_bib0038", "volume": "17", "year": "2015" }, { "DOI": "10.3389/fphar.2017.00656", "article-title": "Therapeutic potential and pharmaceutical development of thymoquinone: a multitargeted molecule of natural origin", "author": "Goyal", "doi-asserted-by": "crossref", "first-page": "656", "journal-title": "Front. Pharmacol.", "key": "10.1016/j.phymed.2020.153277_bib0039", "volume": "8", "year": "2017" }, { "DOI": "10.1097/MCP.0b013e32835a5bc8", "article-title": "microRNAs in asthma: potential therapeutic targets", "author": "Greene", "doi-asserted-by": "crossref", "first-page": "66", "journal-title": "Curr. Opin. Pulm. Med.", "key": "10.1016/j.phymed.2020.153277_bib0040", "volume": "19", "year": "2013" }, { "article-title": "Interleukin 13 and the evolution of asthma therapy", "author": "Grünig", "first-page": "20", "journal-title": "Am. J. Clin. Exp. Immunol.", "key": "10.1016/j.phymed.2020.153277_bib0041", "volume": "1", "year": "2012" }, { "DOI": "10.2353/ajpath.2007.061088", "article-title": "Pathology and pathogenesis of severe acute respiratory syndrome", "author": "Gu", "doi-asserted-by": "crossref", "first-page": "1136", "journal-title": "Am. J. Pathol.", "key": "10.1016/j.phymed.2020.153277_bib0042", "volume": "170", "year": "2007" }, { "DOI": "10.1080/01902140801935082", "article-title": "The protective effect of nigella sativa on lung injury of sulfur mustard–exposed guinea pigs", "author": "Hossein", "doi-asserted-by": "crossref", "first-page": "183", "journal-title": "Exp. Lung Res.", "key": "10.1016/j.phymed.2020.153277_bib0043", "volume": "34", "year": "2008" }, { "DOI": "10.1038/srep42995", "article-title": "Thymoquinone: an IRAK1 inhibitor with in vivo and in vitro anti-inflammatory activities", "author": "Hossen", "doi-asserted-by": "crossref", "first-page": "1", "journal-title": "Sci. Rep.", "key": "10.1016/j.phymed.2020.153277_bib0044", "volume": "7", "year": "2017" }, { "DOI": "10.1016/j.ijid.2020.01.009", "article-title": "The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health The latest 2019 novel coronavirus outbreak in Wuhan, China", "author": "Hui", "doi-asserted-by": "crossref", "first-page": "264", "journal-title": "Int. J. Infect. Dis.", "key": "10.1016/j.phymed.2020.153277_bib0045", "volume": "91", "year": "2020" }, { "article-title": "Nigella sativa (Prophetic Medicine): a Review", "author": "Ijaz", "journal-title": "Pak. J. Pharm. Sci.", "key": "10.1016/j.phymed.2020.153277_bib0046", "volume": "30", "year": "2017" }, { "DOI": "10.1186/s13104-018-3858-8", "article-title": "Nigella sativa as an anti-inflammatory agent in asthma", "author": "Ikhsan", "doi-asserted-by": "crossref", "first-page": "1", "journal-title": "BMC Res. Notes", "key": "10.1016/j.phymed.2020.153277_bib0047", "volume": "11", "year": "2018" }, { "article-title": "An updated literature-based review: phytochemistry, pharmacology and therapeutic promises of Nigella sativa L. Orient", "author": "Islam", "first-page": "1", "journal-title": "Pharm. Exp. Med.", "key": "10.1016/j.phymed.2020.153277_bib0048", "year": "2019" }, { "DOI": "10.5812/ircmj.10421", "article-title": "Nigella sativa pretreatment in guinea pigs exposed to cigarette smoke modulates in vitro tracheal responsiveness", "author": "Keyhanmanesh", "doi-asserted-by": "crossref", "journal-title": "Iran. Red Crescent Med. J.", "key": "10.1016/j.phymed.2020.153277_bib0049", "volume": "16", "year": "2014" }, { "article-title": "Thymoquinone: an emerging natural drug with a wide range of medical applications", "author": "Khader", "first-page": "950", "journal-title": "Iran. J. Basic Med. Sci.", "key": "10.1016/j.phymed.2020.153277_bib0050", "volume": "17", "year": "2014" }, { "DOI": "10.1007/s10787-016-0262-7", "article-title": "Chemical composition of Nigella sativa Linn: part 2 recent advances", "author": "Khan", "doi-asserted-by": "crossref", "first-page": "67", "journal-title": "Inflammopharmacology", "key": "10.1016/j.phymed.2020.153277_bib0051", "volume": "24", "year": "2016" }, { "DOI": "10.4315/0362-028X-71.12.2475", "article-title": "Comparison of chemical composition and antibacterial activity of Nigella sativa seed essential oils obtained by different extraction methods", "author": "Kokoska", "doi-asserted-by": "crossref", "first-page": "2475", "journal-title": "J. Food Prot.", "key": "10.1016/j.phymed.2020.153277_bib0052", "volume": "71", "year": "2008" }, { "article-title": "Phytochemistry, pharmacology, and therapeutic uses of black seed (Nigella sativa)", "author": "Kooti", "first-page": "732", "journal-title": "Chin. J. Nat. Med.", "key": "10.1016/j.phymed.2020.153277_bib0053", "volume": "14", "year": "2016" }, { "DOI": "10.1128/JVI.80.9.4211-4219.2006", "article-title": "Animal origins of the severe acute respiratory syndrome coronavirus: insight from ACE2-S-protein interactions", "author": "Li", "doi-asserted-by": "crossref", "first-page": "4211", "journal-title": "J. Virol.", "key": "10.1016/j.phymed.2020.153277_bib0054", "volume": "80", "year": "2006" }, { "DOI": "10.1016/j.jpha.2020.03.001", "article-title": "Molecular immune pathogenesis and diagnosis of COVID-19", "author": "Li", "doi-asserted-by": "crossref", "journal-title": "J. Pharm. Anal", "key": "10.1016/j.phymed.2020.153277_bib0055", "year": "2020" }, { "DOI": "10.2139/ssrn.3548761", "doi-asserted-by": "crossref", "key": "10.1016/j.phymed.2020.153277_bib0056", "unstructured": "Liu, T., Zhang, Jieying, Yang, Y., Zhang, L., Ma, H., Li, Z., Zhang, Jiaoyue, Cheng, J., Zhang, X., Wu, G., others, 2020. The potential role of IL-6 in monitoring coronavirus disease 2019. Available SSRN 3548761." }, { "DOI": "10.1016/j.intimp.2015.06.023", "article-title": "Immunomodulatory and anti-inflammatory action of Nigella sativa and thymoquinone: a comprehensive review", "author": "Majdalawieh", "doi-asserted-by": "crossref", "first-page": "295", "journal-title": "Int. Immunopharmacol.", "key": "10.1016/j.phymed.2020.153277_bib0057", "volume": "28", "year": "2015" }, { "DOI": "10.1016/j.chnaes.2020.02.001", "article-title": "Nigella sativa L.: uses in traditional and contemporary medicines–An overview", "author": "Majeed", "doi-asserted-by": "crossref", "journal-title": "Acta Ecol. Sin.", "key": "10.1016/j.phymed.2020.153277_bib0058", "year": "2020" }, { "DOI": "10.1002/cbf.968", "article-title": "Effects of thymoquinone on antioxidant enzyme activities, lipid peroxidation and DT-diaphorase in different tissues of mice: a possible mechanism of action", "author": "Mansour", "doi-asserted-by": "crossref", "first-page": "143", "journal-title": "Cell Biochem. Funct.", "key": "10.1016/j.phymed.2020.153277_bib0059", "volume": "20", "year": "2002" }, { "DOI": "10.1016/j.jep.2020.112585", "article-title": "Effects of Nigella sativa on endothelial dysfunction in diabetes mellitus; A review", "author": "Mohebbati", "doi-asserted-by": "crossref", "journal-title": "J. Ethnopharmacol.", "key": "10.1016/j.phymed.2020.153277_bib0060", "year": "2020" }, { "DOI": "10.1155/2019/6491738", "article-title": "Middle east respiratory syndrome coronavirus (MERS-CoV): infection, immunological response, and vaccine development", "author": "Mubarak", "doi-asserted-by": "crossref", "journal-title": "J. Immunol. Res.", "key": "10.1016/j.phymed.2020.153277_bib0061", "volume": "2019", "year": "2019" }, { "article-title": "The Effects of Different Extraction Methods on Antioxidant Properties, Chemical Composition, and Thermal Behavior of", "author": "Muhialdin", "first-page": "7", "journal-title": "Carcinogenesis", "key": "10.1016/j.phymed.2020.153277_bib0062", "volume": "5", "year": "2016" }, { "article-title": "A glance at black cumin (Nigella sativa) and its active constituent, thymoquinone, in ischemia: a review", "author": "Oskouei", "first-page": "1200", "journal-title": "Iran. J. Basic Med. Sci.", "key": "10.1016/j.phymed.2020.153277_bib0063", "volume": "21", "year": "2018" }, { "DOI": "10.1016/j.anl.2013.12.002", "article-title": "Topical Nigella Sativa for nasal symptoms in elderly", "author": "Oysu", "doi-asserted-by": "crossref", "first-page": "269", "journal-title": "Auris Nasus Larynx", "key": "10.1016/j.phymed.2020.153277_bib0064", "volume": "41", "year": "2014" }, { "DOI": "10.1016/j.etap.2016.06.019", "article-title": "Thymoquinone effectively alleviates lung fibrosis induced by paraquat herbicide through down-regulation of pro-fibrotic genes and inhibition of oxidative stress", "author": "Pourgholamhossein", "doi-asserted-by": "crossref", "first-page": "340", "journal-title": "Environ. Toxicol. Pharmacol.", "key": "10.1016/j.phymed.2020.153277_bib0065", "volume": "45", "year": "2016" }, { "article-title": "Black seed, Nigella sativa, deserves more attention", "author": "Randhawa", "first-page": "1", "journal-title": "J Ayub Med Coll Abbottabad", "key": "10.1016/j.phymed.2020.153277_bib0066", "volume": "20", "year": "2008" }, { "article-title": "Potential Treatments for COVID-19; a Narrative Literature Review", "author": "Rismanbaf", "journal-title": "Arch. Acad. Emerg. Med.", "key": "10.1016/j.phymed.2020.153277_bib0067", "volume": "8", "year": "2020" }, { "article-title": "Effects of alpha-hederin and thymoquinone, constituents of Nigella sativa, on human cancer cell lines", "author": "ROONEY", "first-page": "2199", "journal-title": "Anticancer Res", "key": "10.1016/j.phymed.2020.153277_bib0068", "volume": "25", "year": "2005" }, { "DOI": "10.1016/j.jaut.2020.102433", "article-title": "The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak", "author": "Rothan", "doi-asserted-by": "crossref", "journal-title": "J. Autoimmun.", "key": "10.1016/j.phymed.2020.153277_bib0069", "year": "2020" }, { "DOI": "10.1007/s12576-015-0367-6", "article-title": "The protective effect of $α$-hederin, the active constituent of Nigella sativa, on tracheal responsiveness and lung inflammation in ovalbumin-sensitized guinea pigs", "author": "Saadat", "doi-asserted-by": "crossref", "first-page": "285", "journal-title": "J. Physiol. Sci.", "key": "10.1016/j.phymed.2020.153277_bib0070", "volume": "65", "year": "2015" }, { "DOI": "10.5144/0256-4947.2017.64", "article-title": "Effect of Nigella sativa supplementation on lung function and inflammatory mediators in partly controlled asthma: a randomized controlled trial", "author": "Salem", "doi-asserted-by": "crossref", "first-page": "64", "journal-title": "Ann. Saudi Med.", "key": "10.1016/j.phymed.2020.153277_bib0071", "volume": "37", "year": "2017" }, { "DOI": "10.1101/2020.03.21.001586", "doi-asserted-by": "crossref", "key": "10.1016/j.phymed.2020.153277_bib0072", "unstructured": "Sardar, R., Satish, D., Birla, S., Gupta, D., 2020. Comparative analyses of SAR-CoV2 genomes from different geographical locations and other coronavirus family genomes reveals unique features potentially consequential to host-virus interaction and pathogenesis. bioRxiv." }, { "DOI": "10.1159/000486829", "article-title": "An overview on renoprotective effects of Thymoquinone", "author": "Shaterzadeh-Yazdi", "doi-asserted-by": "crossref", "first-page": "74", "journal-title": "Kidney Dis", "key": "10.1016/j.phymed.2020.153277_bib0073", "volume": "4", "year": "2018" }, { "DOI": "10.1016/S2221-1691(12)60236-6", "article-title": "In vitro antimicrobial effects of grape seed extract on peri-implantitis microflora in craniofacial implants", "author": "Shrestha", "doi-asserted-by": "crossref", "first-page": "822", "journal-title": "Asian Pac. J. Trop. Biomed.", "key": "10.1016/j.phymed.2020.153277_bib0074", "volume": "2", "year": "2012" }, { "DOI": "10.1093/fqsafe/fyx031", "article-title": "Cumin (Cuminum cyminum) and black cumin (Nigella sativa) seeds: traditional uses, chemical constituents, and nutraceutical effects", "author": "Srinivasan", "doi-asserted-by": "crossref", "first-page": "1", "journal-title": "Food Qual. Saf.", "key": "10.1016/j.phymed.2020.153277_bib0075", "volume": "2", "year": "2018" }, { "DOI": "10.1101/2020.03.03.972133", "doi-asserted-by": "crossref", "key": "10.1016/j.phymed.2020.153277_bib0076", "unstructured": "Tang, B., He, F., Liu, D., Fang, M., Wu, Z., Xu, D., 2020. AI-aided design of novel targeted covalent inhibitors against SARS-CoV-2. bioRxiv." }, { "DOI": "10.3831/KPI.2017.20.021", "article-title": "Review on clinical trials of black seed (Nigella sativa) and its active constituent, thymoquinone", "author": "Tavakkoli", "doi-asserted-by": "crossref", "first-page": "179", "journal-title": "J. pharmacopuncture", "key": "10.1016/j.phymed.2020.153277_bib0077", "volume": "20", "year": "2017" }, { "DOI": "10.5897/JMPR10.737", "article-title": "A review on therapeutic potential of Nigella sativa (kalonji) seeds", "author": "Tembhurne", "doi-asserted-by": "crossref", "first-page": "167", "journal-title": "J Med Plants Res", "key": "10.1016/j.phymed.2020.153277_bib0078", "volume": "8", "year": "2014" }, { "DOI": "10.3201/eid1807.101638", "article-title": "Retrospective evaluation of control measures for contacts of patient with Marburg hemorrhagic fever", "author": "Timen", "doi-asserted-by": "crossref", "first-page": "1107", "journal-title": "Emerg. Infect. Dis.", "key": "10.1016/j.phymed.2020.153277_bib0079", "volume": "18", "year": "2012" }, { "DOI": "10.1002/minf.202000028", "article-title": "Rapid Identification of Potential Inhibitors of SARS-CoV-2 Main Protease by Deep Docking of 1.3 Billion Compounds", "author": "Ton", "doi-asserted-by": "crossref", "journal-title": "Mol. Inform", "key": "10.1016/j.phymed.2020.153277_bib0080", "year": "2020" }, { "DOI": "10.1038/nm1024", "article-title": "Identification of a new human coronavirus", "author": "van der Hoek", "doi-asserted-by": "crossref", "first-page": "368", "journal-title": "Nat. Med.", "key": "10.1016/j.phymed.2020.153277_bib0081", "volume": "10", "year": "2004" }, { "article-title": "The black seed, Nigella sativa (Ranunculaceae), for prevention and treatment of hypertension", "author": "Vaz", "journal-title": "Hypertens. Ser. “Recent Prog. Med. Plants.", "key": "10.1016/j.phymed.2020.153277_bib0082", "volume": "48", "year": "2018" }, { "DOI": "10.1007/s13197-010-0109-y", "article-title": "Chemical composition of Nigella sativa L. seed extracts obtained by supercritical carbon dioxide", "author": "Venkatachallam", "doi-asserted-by": "crossref", "first-page": "598", "journal-title": "J. Food Sci. Technol", "key": "10.1016/j.phymed.2020.153277_bib0083", "volume": "47", "year": "2010" }, { "DOI": "10.1128/MMBR.69.4.635-664.2005", "article-title": "Coronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome coronavirus", "author": "Weiss", "doi-asserted-by": "crossref", "first-page": "635", "journal-title": "Microbiol. Mol. Biol. Rev.", "key": "10.1016/j.phymed.2020.153277_bib0084", "volume": "69", "year": "2005" }, { "article-title": "Evaluation of bioflavonoids as potential chemotherapeutic agents", "author": "Womack", "first-page": "464", "journal-title": "Biomed. Sci. Instrum.", "key": "10.1016/j.phymed.2020.153277_bib0085", "volume": "42", "year": "2006" }, { "DOI": "10.1016/j.chom.2015.09.013", "article-title": "MERS, SARS, and Ebola: the role of super-spreaders in infectious disease", "author": "Wong", "doi-asserted-by": "crossref", "first-page": "398", "journal-title": "Cell Host Microbe", "key": "10.1016/j.phymed.2020.153277_bib0086", "volume": "18", "year": "2015" }, { "DOI": "10.1101/2020.01.27.921627", "doi-asserted-by": "crossref", "key": "10.1016/j.phymed.2020.153277_bib0087", "unstructured": "Xu, Zhijian, Peng, C., Shi, Y., Zhu, Z., Mu, K., Wang, X., Zhu, W., 2020. Nelfinavir was predicted to be a potential inhibitor of 2019-nCov main protease by an integrative approach combining homology modelling, molecular docking and binding free energy calculation. BioRxiv." }, { "DOI": "10.1016/S2213-2600(20)30076-X", "article-title": "Pathological findings of COVID-19 associated with acute respiratory distress syndrome", "author": "Xu", "doi-asserted-by": "crossref", "first-page": "420", "journal-title": "Lancet Respir. Med.", "key": "10.1016/j.phymed.2020.153277_bib0088", "volume": "8", "year": "2020" }, { "article-title": "Nigella sativa L.(black cumin): a promising natural remedy for wide range of illnesses. Evidence-Based Complement", "author": "Yimer", "journal-title": "Altern. Med.", "key": "10.1016/j.phymed.2020.153277_bib0089", "volume": "2019", "year": "2019" }, { "DOI": "10.14639/0392-100X-1143", "article-title": "The value of Nigella sativa in the treatment of experimentally induced rhinosinusitis", "author": "Yoruk", "doi-asserted-by": "crossref", "first-page": "32", "journal-title": "Acta Otorhinolaryngol. Ital.", "key": "10.1016/j.phymed.2020.153277_bib0090", "volume": "37", "year": "2017" }, { "article-title": "Observations on the biological effects of black cumin seed (Nigella sativa) and green tea (Camellia sinensis)", "author": "Zaher", "first-page": "198", "journal-title": "Glob. Vet.", "key": "10.1016/j.phymed.2020.153277_bib0091", "volume": "2", "year": "2008" }, { "article-title": "A Review of Pharmacological & Clinical Researches on Shoneez (Nigella sativa Linn.)-A Unani Medicine", "author": "Zaidi", "first-page": "2805", "journal-title": "Indo Am. J. Pharm. Res.", "key": "10.1016/j.phymed.2020.153277_bib0092", "volume": "5", "year": "2015" }, { "DOI": "10.1016/j.joim.2020.02.005", "article-title": "In silico screening of Chinese herbal medicines with the potential to directly inhibit 2019 novel coronavirus", "author": "Zhang", "doi-asserted-by": "crossref", "first-page": "152", "journal-title": "J. Integr. Med.", "key": "10.1016/j.phymed.2020.153277_bib0093", "volume": "18", "year": "2020" }, { "DOI": "10.7150/ijbs.45053", "article-title": "SARS-CoV-2: an Emerging Coronavirus that Causes a Global Threat", "author": "Zheng", "doi-asserted-by": "crossref", "first-page": "1678", "journal-title": "Int. J. Biol. Sci.", "key": "10.1016/j.phymed.2020.153277_bib0094", "volume": "16", "year": "2020" }, { "DOI": "10.1056/NEJMoa2001017", "article-title": "A novel coronavirus from patients with pneumonia in China, 2019", "author": "Zhu", "doi-asserted-by": "crossref", "journal-title": "N. Engl. J. Med.", "key": "10.1016/j.phymed.2020.153277_bib0095", "year": "2020" }, { "DOI": "10.1016/j.ijcard.2016.06.192", "article-title": "Thymoquinone attenuates monocrotaline-induced pulmonary artery hypertension via inhibiting pulmonary arterial remodeling in rats", "author": "Zhu", "doi-asserted-by": "crossref", "first-page": "587", "journal-title": "Int. J. Cardiol.", "key": "10.1016/j.phymed.2020.153277_bib0096", "volume": "221", "year": "2016" } ], "reference-count": 96, "references-count": 96, "relation": {}, "resource": { "primary": { "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0944711320301082" } }, "score": 1, "short-title": [], "source": "Crossref", "subject": [], "subtitle": [], "title": "Potential influence of Nagella sativa (Black cumin) in reinforcing immune system: A hope to decelerate the COVID-19 pandemic", "type": "journal-article", "update-policy": "http://dx.doi.org/10.1016/elsevier_cm_policy", "volume": "85" }