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Therapeutic Potential of Thymoquinone and Its Nanoformulations in Pulmonary Injury: A Comprehensive Review

Al-Gabri et al., International Journal of Nanomedicine, doi:10.2147/IJN.S314321
Jul 2021  
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Review of thymoquinone (a component of nigella sativa) research, antioxidant, anti-inflammatory, and antineoplastic properties, application to lung conditions, and the potential advantages of nanoformulations on drug solubility, cellular absorption, and drug delivery to lung tissue target sites.
Reviews covering nigella sativa for COVID-19 include Ahmad, Ahmad (B), Al-Gabri, Cyril, Kulyar, Shad.
Al-Gabri et al., 27 Jul 2021, peer-reviewed, 11 authors.
This PaperNigella SativaAll
Therapeutic Potential of Thymoquinone and Its Nanoformulations in Pulmonary Injury: A Comprehensive Review
Naif A Al-Gabri, Sultan Am Saghir, Sallah A Al-Hashedi, Ali H El-Far, Asmaa F Khafaga, Ayman A Swelum, Abdullah S Al-Wajeeh, Shaker A Mousa, Mohamed E Abd El-Hack, Mohammed Ae Naiel, Khaled A El-Tarabily
International Journal of Nanomedicine, doi:10.2147/ijn.s314321
As a crucial organ, the lung is exposed to various harmful agents that may induce inflammation and oxidative stress, which may cause chronic or acute lung injury. Nigella sativa, also known as black seed, has been widely used to treat various diseases and is one of the most extensively researched medicinal plants. Thymoquinone (TQ) is the main component of black seed volatile oil and has been proven to have antioxidant, anti-inflammatory, and antineoplastic properties. The potential therapeutic properties of TQ against various pulmonary disorders have been studied in both in vitro and in vivo studies. Furthermore, the application of nanotechnology may increase drug solubility, cellular absorption, drug release (sustained or control), and drug delivery to lung tissue target sites. As a result, fabricating TQ as nanoparticles (NPs) is a potential therapeutic approach against a variety of lung diseases. In this current review, we summarize recent findings on the efficacy of TQ and its nanotypes in lung disorders caused by immunocompromised conditions such as cancer, diabetes, gastric ulcers, and other neurodegenerative diseases. It is concluded that TQ nanoparticles with antiinflammatory, antioxidant, antiasthma, and antitumor activity may be safely applied to treat lung disorders. However, more research is required before TQ nanoparticles can be used as pharmaceutical preparations in human studies.
Author Contributions All authors made substantial contributions to conception and design, acquisition of data, or analysis and interpretation of data; took part in drafting the article or revising it critically for important intellectual content; agreed to submit to the current journal; gave final approval of the version to be published; and agree to be accountable for all aspects of the work. Disclosure The authors declare that they have no conflicts of interest for this work.
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