Conv. Plasma
Nigella Sativa
Nitric Oxide
Peg.. Lambda

Home   COVID-19 treatment studies for Nigella Sativa  COVID-19 treatment studies for Nigella Sativa  C19 studies: Nigella Sativa  Nigella Sativa   Select treatmentSelect treatmentTreatmentsTreatments
Alkalinization Meta Lactoferrin Meta
Melatonin Meta
Bromhexine Meta Metformin Meta
Budesonide Meta Molnupiravir Meta
Cannabidiol Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta Nitric Oxide Meta
Ensovibep Meta Paxlovid Meta
Famotidine Meta Peg.. Lambda Meta
Favipiravir Meta Povidone-Iod.. Meta
Fluvoxamine Meta Quercetin Meta
Hydroxychlor.. Meta Remdesivir Meta
Iota-carragee.. Meta
Ivermectin Meta Zinc Meta

Other Treatments Global Adoption
All Studies   Meta Analysis   Recent:  
Covid-19 and thymoquinone: Connecting the dots
Ahmad et al., Phytotherapy Research, doi:10.1002/ptr.6793 (Review) (Preprint)
Ahmad et al., Covid-19 and thymoquinone: Connecting the dots, Phytotherapy Research, doi:10.1002/ptr.6793 (Review) (Preprint)
Jun 2020   Source   PDF  
  All Studies   Meta
Review of the potential benefits of thymoquinone (a component of nigella sativa) for COVID-19, recommending clinical trials.
Ahmad et al., 26 Jun 2020, preprint, 4 authors.
All Studies   Meta Analysis   Submit Updates or Corrections
This PaperNigella SativaAll
Abstract: Received: 30 May 2020 Revised: 15 June 2020 Accepted: 16 June 2020 DOI: 10.1002/ptr.6793 LETTER TO THE EDITOR Covid-19 and thymoquinone: Connecting the dots At present, the medical approaches to cope with Covid-19 infection systemic inflammation of sepsis including vasodilatation, altered caused by the respiratory syndrome coronavirus 2 (SARS-CoV-2) are vascular permeability and extravasation, leukocyte migration, and mainly supportive. In the absence of specific anti-viral therapies or activation (Ince et al., 2016). Notably, inflammatory cytokines such as vaccines, the medical care is complemented with different combina- TNF-α, IL-1α, IL-2, IL-6, and IL-10 also enhance NO production tions via iNOS (Green et al., 1994). Thymoquinone has been shown to of broad-spectrum antiviral agents, antibiotics, hydro- xychloroquine, and convalescent plasma transfusion (Jin et al., 2020). downregulate inflammatory cytokines, reduce NO levels, and improve Thymoquinone, the main constituent of Nigella sativa, has demon- organ functions and survival of sepsis in an animal model (Alkharfy strated anti-inflammatory, anti-oxidant, anti-tumor, and antimicrobial et al., 2015). This perhaps through a redox mechanism, which activities (Banerjee et al., 2009; Chaieb, Kouidhi, Jrah, Mahdouani, & decreases the systemic oxidative stress and inflammatory response. Bakhrouf, 2011). Thymoquinone was also effective and tolerable in Consequently, thymoquinone decreases the levels of early-stage sep- children with intractable epilepsy in a randomized controlled clinical sis biomarkers (e.g., ESM-1, CRP, and VEGF) by 30–50% (Alkharfy trial at a dose of 1 mg/kg/day orally (Akhondian et al., 2011). Interest- et al., 2018). Interestingly, thymoquinone has also been found to have ingly, thymoquinone and Nigella sativa extract were found to be effec- a protective effect against lung fibrosis and collagen deposition by tive against avian influenza virus (H9N2 AIV) and a murine modulating the nuclear factor Kappa-B (NF-κB) and the antioxidant cytomegalovirus infection model (Salem & Hossain, 2000; Umar enzyme nuclear factor 2 heme oxygenase-1 (Nrf2/HO-1) signaling et al., 2016). Ulasli and co-workers reported that the treatment of pathway (Ahmad et al., 2020). cells with Nigella sativa extract prior to infection with coronavirus Virus-induced phagocyte activation is correlated with oxidative decreases the replication of the virus (Ulasli et al., 2014). Moreover, stress, not just because ROS is produced, but also because activated gene expression analysis of the transient receptor potential proteins phagocytes also produce inflammatory cytokines by the activation of (TRPs) showed a reduction in virus loads upon extract treatments, NF-κB (S. F. Liu & Malik, 2006; Schwarz, 1996). Actually, many genes which can decrease coronavirus survival inside cells. It should be that are regulated by NF-κB, including inflammatory cytokines, noted, however, that these studies on the herbal extracts may not COX-2, and iNOS, contribute to a rise in sepsis inflammatory have been carried out according to the more recent scientific qualita- responses (Ghosh, May, & Kopp, 1998; Schneider-Stock, Fakhoury, tive standards for plant-derived products (Heinrich et al., 2020). Zaki, El-Baba, & Gali-Muhtasib, 2014). Thus, NF-κB inhibition can sup- Therefore, there is the possibility that high concentrations in vitro or press inflammatory genes,..
Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop