Covid‐19 and thymoquinone: Connecting the dots
Ajaz Ahmad, Muneeb U Rehman, Parvaiz Ahmad, PharmD Khalid M Alkharfy
Phytotherapy Research, doi:10.1002/ptr.6793
At present, the medical approaches to cope with Covid-19 infection caused by the respiratory syndrome coronavirus 2 (SARS-CoV-2) are
CONFLICT OF INTEREST None.
AUTHOR CONTRIBUTIONS
Ajaz
References
Ahmad, Alkharfy, Jan, Ahad, Ansari et al., Thymoquinone treatment modulates the Nrf2/HO-1 signaling pathway and abrogates the inflammatory response in an animal model of lung fibrosis, Experimental Lung Research,
doi:10.1080/01902148.2020.1726529Akhondian, Kianifar, Raoofziaee, Moayedpour, Toosi et al., The effect of thymoquinone on intractable pediatric seizures (pilot study), Epilepsy Research,
doi:10.1016/j.eplepsyres.2010.10.010Alkharfy, Ahmad, Jan, Raish, Thymoquinone reduces mortality and suppresses early acute inflammatory markers of sepsis in a mouse model, Biomedicine & Pharmacotherapy,
doi:10.1016/j.biopha.2018.01.028Alkharfy, Ahmad, Raish, Vanhoutte, Thymoquinone modulates nitric oxide production and improves organ dysfunction of sepsis, Life Sciences,
doi:10.1016/j.lfs.2015.08.007Alkharfy, Al-Daghri, Al-Attas, Alokail, The protective effect of thymoquinone against sepsis syndrome morbidity and mortality in mice, International Immunopharmacology,
doi:10.1016/j.intimp.2010.11.032Banerjee, Kaseb, Wang, Kong, Mohammad et al., Antitumor activity of gemcitabine and oxaliplatin is augmented by thymoquinone in pancreatic cancer, Cancer Research,
doi:10.1158/0008-5472.CAN-08-4235Bouchentouf, Missoum, Identification of compounds from Nigella sativa as new potential inhibitors of 2019 novel corona virus (Covid-19): Molecular docking study,
doi:10.26434/chemrxiv.12055716.v1Chaieb, Kouidhi, Jrah, Mahdouani, Bakhrouf, Antibacterial activity of Thymoquinone, an active principle of Nigella sativa and its potency to prevent bacterial biofilm formation, BMC Complementary and Alternative Medicine,
doi:10.1186/1472-6882-11-29Coldewey, Rogazzo, Collino, Patel, Thiemermann, Inhibition of IκB kinase reduces the multiple organ dysfunction caused by sepsis in the mouse, Disease Models & Mechanisms,
doi:10.1242/dmm.012435Galley, Oxidative stress and mitochondrial dysfunction in sepsis, British Journal of Anaesthesia,
doi:10.1093/bja/aer093Green, Scheller, Marletta, Seguin, Klotz et al., Nitric oxide: Cytokine-regulation of nitric oxide in host resistance to intracellular pathogens, Immunology Letters,
doi:10.1016/0165-2478(94)00158-8Heinrich, Appendino, Efferth, Furst, Izzo et al., Best practice in research -Overcoming common challenges in phytopharmacological research, Journal of Ethnopharmacology,
doi:10.1016/j.jep.2019.112230Ichinose, Buys, Neilan, Furutani, Morgan et al., Cardiomyocyte-specific overexpression of nitric oxide synthase 3 prevents myocardial dysfunction in murine models of septic shock, Circulation Research,
doi:10.1161/01.RES.0000253888.09574.7aJin, Cai, Cheng, Cheng, Deng et al., A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version), Military Medical Research,
doi:10.1186/s40779-020-0233-6Liu, Malik, NF-kappa B activation as a pathological mechanism of septic shock and inflammation, American Journal of Physiology. Lung Cellular and Molecular Physiology,
doi:10.1152/ajplung.00477.2005Munzel, Gori, Bruno, Taddei, Is oxidative stress a therapeutic target in cardiovascular disease?, European Heart Journal,
doi:10.1093/eurheartj/ehq396Rabuel, Samuel, Lortat-Jacob, Marotte, Lanone et al., Activation of the ubiquitin proteolytic pathway in human septic heart and diaphragm, Cardiovascular Pathology,
doi:10.1016/j.carpath.2009.01.002Salem, Hossain, Protective effect of black seed oil from Nigella sativa against murine cytomegalovirus infection, International Journal of Immunopharmacology,
doi:10.1016/s0192-0561(00)00036-9Schneider-Stock, Fakhoury, Zaki, El-Baba, Gali-Muhtasib, Thymoquinone: Fifty years of success in the battle against cancer models, Drug Discovery Today,
doi:10.1016/j.drudis.2013.08.021Sekiou, Ismail, Zihad, Abdelhak, In-silico identification of potent inhibitors of COVID-19 main protease (M pro ) and Angiotensin converting enzyme 2 (ACE2) from natural products: Quercetin, Hispidulin, and Cirsimaritin exhibited better potential inhibition than Hydroxy-Chloroquine against COVID-19 main protease active site and ACE2, Chem-Rxiv,
doi:10.26434/-chemrxiv.12181404.v1Tsolaki, Makris, Mantzarlis, Zakynthinos, Sepsisinduced cardiomyopathy: Oxidative implications in the initiation and resolution of the damage, Oxidative Medicine and Cellular Longevity,
doi:10.1155/2017/7393525Ulasli, Gurses, Bayraktar, Yumrutas, Oztuzcu et al., The effects of Nigella sativa (Ns), Anthemis hyalina (Ah) and Citrus sinensis (Cs) extracts on the replication of coronavirus and the expression of TRP genes family, Molecular Biology Reports,
doi:10.1007/s11033-014-3019-7Umar, Munir, Subhan, Azam, Nisa et al., Protective and antiviral activities of Nigella sativa against avian influenza (H9N2) in turkeys, Journal of the Saudi Society of Agricultural Sciences,
doi:10.1016/j.jssas.2016.09.004
