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The potential role of thymoquinone in preventing the cardiovascular complications of COVID-19

Ahmad et al., Vascular Pharmacology, doi:10.1016/j.vph.2021.106899
Jul 2021  
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11th treatment shown to reduce risk in January 2021
 
*, now with p = 0.00016 from 14 studies.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 79 treatments. c19early.org
Review of the potential role of thymoquinone (a component of nigella sativa) in minimizing cardiovascular complications of COVID-19.
Reviews covering nigella sativa for COVID-19 include1-6.
Ahmad et al., 23 Jul 2021, peer-reviewed, 3 authors.
This PaperNigella SativaAll
The potential role of thymoquinone in preventing the cardiovascular complications of COVID-19
Ajaz Ahmad, Mohammad Raish, Khalid M Alkharfy
Vascular Pharmacology, doi:10.1016/j.vph.2021.106899
A new virus strain detected in late 2019 and not previously described in humans is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes corona virus disease . While potential therapeutic approaches for COVID-19 are being investigated, significant initiatives are being made to create protective drugs and study various antiviral agents to cure the infection. However, an effective treatment strategy against COVID-19 is worrisome inadequate. The objective of the present manuscript is to discuss the potential role of thymoquinone (TQ) in preventing the cardiovascular complications of COVID-19, focusing on viral inhibition, antioxidant potential, vascular effect, and cardiac protection. The multifunctional properties of TQ could potentially synergize with the activity of current therapeutic interventions and offer a basis for managing COVID-19 disease more effectively. Even though the experimental evidence is positive, a translational application of TQ in COVID-19 is timely warranted.
Author statement A.A., K.M.A. conceptualization and drafted the manuscript. A.A and M.R. prepared figure. K.M.A and A.A. edited and revised the manuscript. All authors approved the final version of manuscript. Declaration of Competing Interest The authors declare that they have no conflicts of interest.
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