COVID-19: a vascular nightmare unfolding

DOI record: { "DOI": "10.3389/fimmu.2025.1593885", "ISSN": [ "1664-3224" ], "URL": "http://dx.doi.org/10.3389/fimmu.2025.1593885", "abstract": "<jats:p>The emergence of COVID-19 has been associated with an increased risk of arteriovenous thrombosis, with immune inflammation playing a significant role in the pathogenesis of thrombosis. Numerous drug-related clinical trials have been undertaken to prevent thrombosis, and guidelines for its prevention and treatment are continuously evolving as our understanding of the disease progresses. This article provides a comprehensive review of the mechanisms underlying thrombosis in COVID-19 patients, as well as the advancements in clinical trials and guidelines for thrombosis prevention with pharmacological interventions.</jats:p>", "alternative-id": [ "10.3389/fimmu.2025.1593885" ], "article-number": "1593885", "author": [ { "affiliation": [], "family": "Yin", "given": "Qinan", "sequence": "first" }, { "affiliation": [], "family": "Huang", "given": "Youjin", "sequence": "additional" }, { "affiliation": [], "family": "Wang", "given": "Hulin", "sequence": "additional" }, { "affiliation": [], "family": "Wang", "given": "Yin", "sequence": "additional" }, { "affiliation": [], "family": "Huang", "given": "Xuefei", "sequence": "additional" }, { "affiliation": [], "family": "Song", "given": "Yujie", "sequence": "additional" }, { "affiliation": [], "family": "Wang", "given": "Yueyuan", "sequence": "additional" }, { "affiliation": [], "family": "Han", "given": "Lizhu", "sequence": "additional" }, { "affiliation": [], "family": "Yuan", "given": "Bian", "sequence": "additional" } ], "container-title": "Frontiers in Immunology", "container-title-short": "Front. Immunol.", "content-domain": { "crossmark-restriction": true, "domain": [ "frontiersin.org" ] }, "created": { "date-parts": [ [ 2025, 8, 1 ] ], "date-time": "2025-08-01T05:33:27Z", "timestamp": 1754026407000 }, "deposited": { "date-parts": [ [ 2025, 8, 1 ] ], "date-time": "2025-08-01T05:33:31Z", "timestamp": 1754026411000 }, "funder": [ { "DOI": "10.13039/501100012166", "award": [ "2020YFC2005500" ], "doi-asserted-by": "publisher", "id": [ { "asserted-by": "publisher", "id": "10.13039/501100012166", "id-type": "DOI" } ], "name": "National Key Research and Development Program of China" } ], "indexed": { "date-parts": [ [ 2025, 8, 1 ] ], "date-time": "2025-08-01T06:10:05Z", "timestamp": 1754028605520, "version": "3.41.2" }, "is-referenced-by-count": 0, "issued": { "date-parts": [ [ 2025, 8, 1 ] ] }, "license": [ { "URL": "https://creativecommons.org/licenses/by/4.0/", "content-version": "vor", "delay-in-days": 0, "start": { "date-parts": [ [ 2025, 8, 1 ] ], "date-time": "2025-08-01T00:00:00Z", "timestamp": 1754006400000 } } ], "link": [ { "URL": "https://www.frontiersin.org/articles/10.3389/fimmu.2025.1593885/full", "content-type": "unspecified", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "1965", "original-title": [], "prefix": "10.3389", "published": { "date-parts": [ [ 2025, 8, 1 ] ] }, "published-online": { "date-parts": [ [ 2025, 8, 1 ] ] }, "publisher": "Frontiers Media SA", "reference": [ { "DOI": "10.1016/j.tem.2023.03.002", "article-title": "Long COVID: pathophysiological factors and abnormalities of coagulation", "author": "Turner", "doi-asserted-by": "publisher", "journal-title": "Trends Endocrinol Metab", "key": "B1", "volume": "34", "year": "2023" }, { "DOI": "10.1038/s41401-022-00998-0", "article-title": "Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies", "author": "Xu", "doi-asserted-by": "publisher", "first-page": "695", 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