Study Understanding Pre-Exposure pRophylaxis of NOvel Anitbodies (SUPERNOVA)

Haidar et al., NCT05648110, SUPERNOVA, NCT05648110, Jun 2026
Mortality -139% improvement lower risk ← → higher risk AZD5156 for COVID-19  SUPERNOVA  PROPHYLAXIS RCT Is prophylaxis with AZD5156 beneficial for COVID-19? Double-blind RCT 57 patients in multiple countries Trial underpowered to detect differences c19early.org Haidar et al., NCT05648110, June 2026 0 0.5 1 1.5 2+ RR
RCT 57 patients showing no significant differences with AZD5156 (sipavibart + cilgavimab).
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Study covers AZD5156 and tixagevimab/cilgavimab.
risk of death, 139.0% higher, RR 2.39, p = 1.00, treatment 1 of 41 (2.4%), control 0 of 16 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm), all-cause mortality, day 451, registry.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Haidar et al., 18 Jun 2026, Double Blind Randomized Controlled Trial, placebo-controlled, multiple countries, preprint, 1 author, trial NCT05648110 (history) (SUPERNOVA). Contact: taylor.cohen@astrazeneca.com.
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