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Effect of polyphenols against complications of COVID-19: current evidence and potential efficacy

Vajdi et al., Pharmacological Reports, doi:10.1007/s43440-024-00585-6

Mar 2024

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Quercetin for COVID-19

24th treatment shown to reduce risk in July 2021, now with p = 0.0031 from 11 studies.

Lower risk for ICU admission, hospitalization, recovery, cases, and viral clearance.

No treatment is 100% effective. Protocols combine treatments.

5,100+ studies for 109 treatments. c19early.org

Review of polyphenols for COVID-19. Authors note that polyphenols can inhibit key SARS-CoV-2 enzymes involved in viral replication and infection, and that many polyphenols have well-established safety profiles. Authors recommend additional research and randomized controlled trials.

Reviews covering quercetin for COVID-19 include1-18.

Important missing comments or errors? Let us know.

Review covers quercetin and curcumin.

1. Beşler et al., Investigation of potential effects of quercetin on COVID-19 treatment: a systematic review of randomized controlled trials, Clinical Science of Nutrition, doi:10.62210/ClinSciNutr.2024.86.clinscinutr.org, doi.org.

2. Ho et al., Therapeutic Implications of Quercetin and its Derived-products in COVID-19 Protection and Prophylactic, Heliyon, doi:10.1016/j.heliyon.2024.e30080.sciencedirect.com, doi.org.

3. Vajdi et al., Effect of polyphenols against complications of COVID-19: current evidence and potential efficacy, Pharmacological Reports, doi:10.1007/s43440-024-00585-6.springer.com, doi.org.

4. Chen et al., Effect and mechanism of quercetin or quercetin‐containing formulas against COVID‐19: From bench to bedside, Phytotherapy Research, doi:10.1002/ptr.8175.wiley.com, doi.org.

5. Yong et al., Natural Products-Based Inhaled Formulations for Treating Pulmonary Diseases, International Journal of Nanomedicine, doi:10.2147/ijn.s451206.dovepress.com, doi.org.

6. Agrawal et al., Antiviral Significance of Isoquercetin (Quercetin-3-O-Glucoside) With Special Reference to its Anti-Coronaviral Potential, Natural Product Communications, doi:10.1177/1934578X231219560.sagepub.com, doi.org.

7. Matías-Pérez et al., Relationship of quercetin intake and oxidative stress in persistent Covid, Frontiers in Nutrition, doi:10.3389/fnut.2023.1278039.frontiersin.org, doi.org.

8. Georgiou et al., Quercetin: A Potential Polydynamic Drug, Molecules, doi:10.3390/molecules28248141.mdpi.com, doi.org.

9. Donzelli, A., Neglected Effective Early Therapies against COVID-19: Focus on Functional Foods and Related Active Substances. A Review, MDPI AG, doi:10.20944/preprints202312.1178.v1.preprints.org, doi.org.

10. Dinda et al., Anti-SARS-CoV-2, antioxidant and immunomodulatory potential of dietary flavonol quercetin: Focus on molecular targets and clinical efficacy, European Journal of Medicinal Chemistry Reports, doi:10.1016/j.ejmcr.2023.100125.sciencedirect.com, doi.org.

11. Mirza et al., Quercetin as a Therapeutic Product: Evaluation of Its Pharmacological Action and Clinical Applications—A Review, Pharmaceuticals, doi:10.3390/ph16111631.mdpi.com, doi.org.

12. Massimo Magro et al., Use of Quercetin for Therapeutic Purposes in COVID-19 Infections: The Opinion of the Geriatrician Doctor, Journal of Modern Biology and Drug Discovery, doi:10.53964/jmbdd.2023004.innovationforever.com, doi.org.

13. Shorobi et al., Quercetin: A Functional Food-Flavonoid Incredibly Attenuates Emerging and Re-Emerging Viral Infections through Immunomodulatory Actions, Molecules, doi:10.3390/molecules28030938.mdpi.com, doi.org.

14. Gasmi et al., Quercetin in the Prevention and Treatment of Coronavirus Infections: A Focus on SARS-CoV-2, Pharmaceuticals, doi:10.3390/ph15091049.mdpi.com, doi.org.

15. Rizky et al., The pharmacological mechanism of quercetin as adjuvant therapy of COVID-19, Life Research, doi:10.53388/life2022-0205-302.tmrjournals.com, doi.org.

16. Imran et al., The Therapeutic and Prophylactic Potential of Quercetin against COVID-19: An Outlook on the Clinical Studies, Inventive Compositions, and Patent Literature, Antioxidants, doi:10.3390/antiox11050876.mdpi.com, doi.org.

17. Derosa et al., A role for quercetin in coronavirus disease 2019 (COVID-19), Phytotherapy Research, doi:10.1002/ptr.6887.wiley.com, doi.org.

18. Biancatelli et al., Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19), Frontiers in Immunology, doi:10.3389/fimmu.2020.01451.frontiersin.org, doi.org.

Vajdi et al., 18 Mar 2024, peer-reviewed, 9 authors.

This Paper Quercetin All

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' '2007;224:265–73.', 'journal-title': 'Toxicol Appl Pharmacol'}], 'container-title': 'Pharmacological Reports', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://link.springer.com/content/pdf/10.1007/s43440-024-00585-6.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/article/10.1007/s43440-024-00585-6/fulltext.html', 'content-type': 'text/html', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/content/pdf/10.1007/s43440-024-00585-6.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2024, 3, 18]], 'date-time': '2024-03-18T07:27:59Z', 'timestamp': 1710746879000}, 'score': 1, 'resource': {'primary': {'URL': 'https://link.springer.com/10.1007/s43440-024-00585-6'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2024, 3, 18]]}, 'references-count': 250, 'alternative-id': ['585'], 'URL': 'http://dx.doi.org/10.1007/s43440-024-00585-6', 'relation': {}, 'ISSN': ['1734-1140', '2299-5684'], 'subject': ['Pharmacology', 'General Medicine'], 'container-title-short': 'Pharmacol. 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