All Studies Meta Analysis

Effect of polyphenols against complications of COVID-19: current evidence and potential efficacy

Vajdi et al., Pharmacological Reports, doi:10.1007/s43440-024-00585-6

Mar 2024

Post
Facebook

Source PDF All Studies Meta AnalysisMeta

Quercetin for COVID-19

24th treatment shown to reduce risk in July 2021, now with p = 0.002 from 12 studies.

Lower risk for ICU, hospitalization, recovery, cases, and viral clearance.

No treatment is 100% effective. Protocols combine treatments.

5,300+ studies for 116 treatments. c19early.org

Review of polyphenols for COVID-19. Authors note that polyphenols can inhibit key SARS-CoV-2 enzymes involved in viral replication and infection, and that many polyphenols have well-established safety profiles. Authors recommend additional research and randomized controlled trials.

Reviews covering quercetin for COVID-19 include1-20.

Important missing comments or errors? Let us know.

Review covers quercetin and curcumin.

1. Sanduzzi Zamparelli et al., Immune-Boosting and Antiviral Effects of Antioxidants in COVID-19 Pneumonia: A Therapeutic Perspective, Life, doi:10.3390/life15010113.mdpi.com, doi.org.

2. Duan et al., Bioactive compounds,quercetin, curcumin and β-glucan,regulate innate immunity via the gut-liver-brain axis, Trends in Food Science & Technology, doi:10.1016/j.tifs.2024.104864.sciencedirect.com, doi.org.

3. Beşler et al., Investigation of potential effects of quercetin on COVID-19 treatment: a systematic review of randomized controlled trials, Clinical Science of Nutrition, doi:10.62210/ClinSciNutr.2024.86.clinscinutr.org, doi.org.

4. Ho et al., Therapeutic Implications of Quercetin and its Derived-products in COVID-19 Protection and Prophylactic, Heliyon, doi:10.1016/j.heliyon.2024.e30080.sciencedirect.com, doi.org.

5. Vajdi et al., Effect of polyphenols against complications of COVID-19: current evidence and potential efficacy, Pharmacological Reports, doi:10.1007/s43440-024-00585-6.springer.com, doi.org.

6. Chen et al., Effect and mechanism of quercetin or quercetin‐containing formulas against COVID‐19: From bench to bedside, Phytotherapy Research, doi:10.1002/ptr.8175.wiley.com, doi.org.

7. Yong et al., Natural Products-Based Inhaled Formulations for Treating Pulmonary Diseases, International Journal of Nanomedicine, doi:10.2147/ijn.s451206.dovepress.com, doi.org.

8. Agrawal et al., Antiviral Significance of Isoquercetin (Quercetin-3-O-Glucoside) With Special Reference to its Anti-Coronaviral Potential, Natural Product Communications, doi:10.1177/1934578X231219560.sagepub.com, doi.org.

9. Matías-Pérez et al., Relationship of quercetin intake and oxidative stress in persistent Covid, Frontiers in Nutrition, doi:10.3389/fnut.2023.1278039.frontiersin.org, doi.org.

10. Georgiou et al., Quercetin: A Potential Polydynamic Drug, Molecules, doi:10.3390/molecules28248141.mdpi.com, doi.org.

11. Donzelli, A., Neglected Effective Early Therapies against COVID-19: Focus on Functional Foods and Related Active Substances. A Review, MDPI AG, doi:10.20944/preprints202312.1178.v1.preprints.org, doi.org.

12. Dinda et al., Anti-SARS-CoV-2, antioxidant and immunomodulatory potential of dietary flavonol quercetin: Focus on molecular targets and clinical efficacy, European Journal of Medicinal Chemistry Reports, doi:10.1016/j.ejmcr.2023.100125.sciencedirect.com, doi.org.

13. Mirza et al., Quercetin as a Therapeutic Product: Evaluation of Its Pharmacological Action and Clinical Applications—A Review, Pharmaceuticals, doi:10.3390/ph16111631.mdpi.com, doi.org.

14. Massimo Magro et al., Use of Quercetin for Therapeutic Purposes in COVID-19 Infections: The Opinion of the Geriatrician Doctor, Journal of Modern Biology and Drug Discovery, doi:10.53964/jmbdd.2023004.innovationforever.com, doi.org.

15. Shorobi et al., Quercetin: A Functional Food-Flavonoid Incredibly Attenuates Emerging and Re-Emerging Viral Infections through Immunomodulatory Actions, Molecules, doi:10.3390/molecules28030938.mdpi.com, doi.org.

16. Gasmi et al., Quercetin in the Prevention and Treatment of Coronavirus Infections: A Focus on SARS-CoV-2, Pharmaceuticals, doi:10.3390/ph15091049.mdpi.com, doi.org.

17. Rizky et al., The pharmacological mechanism of quercetin as adjuvant therapy of COVID-19, Life Research, doi:10.53388/life2022-0205-302.tmrjournals.com, doi.org.

18. Imran et al., The Therapeutic and Prophylactic Potential of Quercetin against COVID-19: An Outlook on the Clinical Studies, Inventive Compositions, and Patent Literature, Antioxidants, doi:10.3390/antiox11050876.mdpi.com, doi.org.

19. Derosa et al., A role for quercetin in coronavirus disease 2019 (COVID-19), Phytotherapy Research, doi:10.1002/ptr.6887.wiley.com, doi.org.

20. Biancatelli et al., Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19), Frontiers in Immunology, doi:10.3389/fimmu.2020.01451.frontiersin.org, doi.org.

Vajdi et al., 18 Mar 2024, peer-reviewed, 9 authors.

This Paper Quercetin All

DOI record: { "DOI": "10.1007/s43440-024-00585-6", "ISSN": [ "1734-1140", "2299-5684" ], "URL": "http://dx.doi.org/10.1007/s43440-024-00585-6", "alternative-id": [ "585" ], "assertion": [ { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Received", "name": "received", "order": 1, "value": "23 September 2023" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Revised", "name": "revised", "order": 2, "value": "1 March 2024" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Accepted", "name": "accepted", "order": 3, "value": "3 March 2024" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "First Online", "name": "first_online", "order": 4, "value": "18 March 2024" }, { "group": { "label": "Declarations", "name": "EthicsHeading" }, "name": "Ethics", "order": 1 }, { "group": { "label": "Conflict of interest", "name": "EthicsHeading" }, "name": "Ethics", "order": 2, "value": "The authors declare no conflict of interest." } ], "author": [ { "affiliation": [], "family": "Vajdi", "given": "Mahdi", "sequence": "first" }, { "affiliation": [], "family": "Karimi", "given": "Arash", "sequence": "additional" }, { "affiliation": [], "family": "Hassanizadeh", "given": "Shirin", "sequence": "additional" }, { "affiliation": [], "family": "Farhangi", "given": "Mahdieh Abbasalizad", "sequence": "additional" }, { "affiliation": [], "family": "Bagherniya", "given": "Mohammad", "sequence": "additional" }, { "affiliation": [], "family": "Askari", "given": "Gholamreza", "sequence": "additional" }, { "affiliation": [], "family": "Roufogalis", "given": "Basil D.", "sequence": "additional" }, { "affiliation": [], "family": "Davies", "given": "Neal M.", "sequence": "additional" }, { "affiliation": [], "family": "Sahebkar", "given": "Amirhossein", "sequence": "additional" } ], "container-title": "Pharmacological Reports", "container-title-short": "Pharmacol. Rep", "content-domain": { "crossmark-restriction": false, "domain": [ "link.springer.com" ] }, "created": { "date-parts": [ [ 2024, 3, 18 ] ], "date-time": "2024-03-18T06:01:31Z", "timestamp": 1710741691000 }, "deposited": { "date-parts": [ [ 2024, 3, 18 ] ], "date-time": "2024-03-18T07:27:59Z", "timestamp": 1710746879000 }, "indexed": { "date-parts": [ [ 2024, 3, 19 ] ], "date-time": "2024-03-19T00:32:13Z", "timestamp": 1710808333818 }, "is-referenced-by-count": 0, "issued": { "date-parts": [ [ 2024, 3, 18 ] ] }, "language": "en", "license": [ { "URL": "https://www.springernature.com/gp/researchers/text-and-data-mining", "content-version": "tdm", "delay-in-days": 0, "start": { "date-parts": [ [ 2024, 3, 18 ] ], "date-time": "2024-03-18T00:00:00Z", "timestamp": 1710720000000 } }, { "URL": "https://www.springernature.com/gp/researchers/text-and-data-mining", "content-version": "vor", "delay-in-days": 0, "start": { "date-parts": [ [ 2024, 3, 18 ] ], "date-time": "2024-03-18T00:00:00Z", "timestamp": 1710720000000 } } ], "link": [ { "URL": "https://link.springer.com/content/pdf/10.1007/s43440-024-00585-6.pdf", "content-type": "application/pdf", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://link.springer.com/article/10.1007/s43440-024-00585-6/fulltext.html", "content-type": "text/html", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://link.springer.com/content/pdf/10.1007/s43440-024-00585-6.pdf", "content-type": "application/pdf", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "297", "original-title": [], "prefix": "10.1007", "published": { "date-parts": [ [ 2024, 3, 18 ] ] }, "published-online": { "date-parts": [ [ 2024, 3, 18 ] ] }, "publisher": "Springer Science and Business Media LLC", "reference": [ { "DOI": "10.1111/ijlh.13412", "author": "M Karimi Shahri", "doi-asserted-by": "publisher", "first-page": "160", "journal-title": "Int J Lab Hematol", "key": "585_CR1", "unstructured": "Karimi Shahri M, Niazkar HR, Rad F. COVID-19 and hematology findings based on the current evidences: a puzzle with many missing pieces. Int J Lab Hematol. 2021;43:160–8.", "volume": "43", "year": "2021" }, { "author": "E Salavati", "first-page": "104", "journal-title": "Med J Islam Repub Iran", "key": "585_CR2", "unstructured": "Salavati E, Hajirezaee H, Niazkar HR, Ramezani MS, Sargazi A. COVID-19 patients may present with myocarditis: a case report emphasizing the cardiac involvement of SARS-CoV-2. Med J Islam Repub Iran. 2021;35:104.", "volume": "35", "year": "2021" }, { "key": "585_CR3", "unstructured": "COVID-19 Excess Mortality Collaborators. Estimating excess mortality due to the COVID-19 pandemic: a systematic analysis of COVID-19-related mortality, 2020–21. Lancet. 2022;399:1513–36." }, { "DOI": "10.1002/rmv.2146", "author": "B Gallo Marin", "doi-asserted-by": "publisher", "first-page": "1", "journal-title": "Rev Med Virol", "key": "585_CR4", "unstructured": "Gallo Marin B, Aghagoli G, Lavine K, Yang L, Siff EJ, Chiang SS, et al. Predictors of COVID-19 severity: a literature review. Rev Med Virol. 2021;31:1–10.", "volume": "31", "year": "2021" }, { "DOI": "10.1080/17476348.2020.1820329", "author": "F Montenegro", "doi-asserted-by": "publisher", "first-page": "183", "journal-title": "Expert Rev Respir Med", "key": "585_CR5", "unstructured": "Montenegro F, Unigarro L, Paredes G, Moya T, Romero A, Torres L, et al. Acute respiratory distress syndrome (ARDS) caused by the novel coronavirus disease (COVID-19): a practical comprehensive literature review. Expert Rev Respir Med. 2021;15:183–95.", "volume": "15", "year": "2021" }, { "DOI": "10.1371/journal.pone.0250602", "author": "X Li", "doi-asserted-by": "publisher", "journal-title": "PLoS ONE", "key": "585_CR6", "unstructured": "Li X, Zhong X, Wang Y, Zeng X, Luo T, Liu Q. Clinical determinants of the severity of COVID-19: a systematic review and meta-analysis. PLoS ONE. 2021;16: e0250602.", "volume": "16", "year": "2021" }, { "DOI": "10.1007/s10311-021-01369-7", "author": "C Wang", "doi-asserted-by": "publisher", "first-page": "2215", "journal-title": "Environ Chem Lett", "key": "585_CR7", "unstructured": "Wang C, Han J. Will the COVID-19 pandemic end with the Delta and Omicron variants? Environ Chem Lett. 2022;20:2215–25.", "volume": "20", "year": "2022" }, { "DOI": "10.1038/s41586-020-2313-x", "author": "K Xiao", "doi-asserted-by": "publisher", "first-page": "286", "journal-title": "Nature", "key": "585_CR8", "unstructured": "Xiao K, Zhai J, Feng Y, Zhou N, Zhang X, Zou JJ, et al. Isolation of SARS-CoV-2-related coronavirus from Malayan pangolins. Nature. 2020;583:286–9.", "volume": "583", "year": "2020" }, { "DOI": "10.1001/jamacardio.2020.1286", "author": "M Madjid", "doi-asserted-by": "publisher", "first-page": "831", "journal-title": "JAMA Cardiol", "key": "585_CR9", "unstructured": "Madjid M, Safavi-Naeini P, Solomon SD, Vardeny O. Potential effects of coronaviruses on the cardiovascular system: a review. JAMA Cardiol. 2020;5:831–40.", "volume": "5", "year": "2020" }, { "DOI": "10.1038/s41564-020-0688-y", "author": "M Letko", "doi-asserted-by": "publisher", "first-page": "562", "journal-title": "Nat Microbiol", "key": "585_CR10", "unstructured": "Letko M, Marzi A, Munster V. Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses. Nat Microbiol. 2020;5:562–9.", "volume": "5", "year": "2020" }, { "DOI": "10.1093/jtm/taaa041", "author": "JH Diaz", "doi-asserted-by": "publisher", "first-page": "041", "journal-title": "J Travel Med", "key": "585_CR11", "unstructured": "Diaz JH. Hypothesis: angiotensin-converting enzyme inhibitors and angiotensin receptor blockers may increase the risk of severe COVID-19. J Travel Med. 2020;27:041.", "volume": "27", "year": "2020" }, { "DOI": "10.1016/S2213-2600(21)00218-6", "author": "MF Osuchowski", "doi-asserted-by": "publisher", "first-page": "622", "journal-title": "Lancet Respir Med", "key": "585_CR12", "unstructured": "Osuchowski MF, Winkler MS, Skirecki T, Cajander S, Shankar-Hari M, Lachmann G, et al. The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity. Lancet Respir Med. 2021;9:622–42.", "volume": "9", "year": "2021" }, { "DOI": "10.1111/bjh.17240", "author": "E Calabretta", "doi-asserted-by": "publisher", "first-page": "43", "journal-title": "Br J Haematol", "key": "585_CR13", "unstructured": "Calabretta E, Moraleda JM, Iacobelli M, Jara R, Vlodavsky I, O’Gorman P, et al. COVID-19-induced endotheliitis: emerging evidence and possible therapeutic strategies. Br J Haematol. 2021;193:43–51.", "volume": "193", "year": "2021" }, { "DOI": "10.1111/sji.13097", "author": "S Tomerak", "doi-asserted-by": "publisher", "journal-title": "Scand J Immunol", "key": "585_CR14", "unstructured": "Tomerak S, Khan S, Almasri M, Hussein R, Abdelati A, Aly A, et al. Systemic inflammation in COVID-19 patients may induce various types of venous and arterial thrombosis: a systematic review. Scand J Immunol. 2021;94: e13097.", "volume": "94", "year": "2021" }, { "DOI": "10.7554/eLife.69417", "author": "MA Badawy", "doi-asserted-by": "publisher", "journal-title": "Elife", "key": "585_CR15", "unstructured": "Badawy MA, Yasseen BA, El-Messiery RM, Abdel-Rahman EA, Elkhodiry AA, Kamel AG, et al. Neutrophil-mediated oxidative stress and albumin structural damage predict COVID-19-associated mortality. Elife. 2021;10: e69417.", "volume": "10", "year": "2021" }, { "DOI": "10.3390/ijms21041250", "author": "M Leri", "doi-asserted-by": "publisher", "first-page": "1250", "journal-title": "Int J Mol Sci", "key": "585_CR16", "unstructured": "Leri M, Scuto M, Ontario ML, Calabrese V, Calabrese EJ, Bucciantini M, et al. Healthy effects of plant polyphenols: molecular mechanisms. Int J Mol Sci. 2020;21:1250.", "volume": "21", "year": "2020" }, { "DOI": "10.3390/nu10111618", "author": "N Yahfoufi", "doi-asserted-by": "publisher", "first-page": "1618", "journal-title": "Nutrients", "key": "585_CR17", "unstructured": "Yahfoufi N, Alsadi N, Jambi M, Matar C. The immunomodulatory and anti-inflammatory role of polyphenols. Nutrients. 2018;10:1618.", "volume": "10", "year": "2018" }, { "DOI": "10.1024/0300-9831/a000710", "author": "M Vajdi", "doi-asserted-by": "publisher", "first-page": "252", "journal-title": "Int J Vitam Nutr Res", "key": "585_CR18", "unstructured": "Vajdi M, Farhangi MA. Citrus peel derived’poly-methoxylated flavones (PMF). Int J Vitam Nutr Res. 2021;93:252–67.", "volume": "93", "year": "2021" }, { "DOI": "10.1039/D1FO00275A", "author": "H Zhou", "doi-asserted-by": "publisher", "first-page": "3420", "journal-title": "Food Funct", "key": "585_CR19", "unstructured": "Zhou H, Zheng B, McClements DJ. Encapsulation of lipophilic polyphenols in plant-based nanoemulsions: Impact of carrier oil on lipid digestion and curcumin, resveratrol and quercetin bioaccessibility. Food Funct. 2021;12:3420–32.", "volume": "12", "year": "2021" }, { "DOI": "10.22271/journalofsport.2021.v6.i1e.2236", "author": "S Prabhu", "doi-asserted-by": "publisher", "first-page": "293", "journal-title": "Int J Physiol Nutr Phys Educ", "key": "585_CR20", "unstructured": "Prabhu S, Molath A, Choksi H, Kumar S, Mehra R. Classifications of polyphenols and their potential application in human health and diseases. Int J Physiol Nutr Phys Educ. 2021;6:293–301.", "volume": "6", "year": "2021" }, { "DOI": "10.1080/2162402X.2020.1807836", "author": "C Melenotte", "doi-asserted-by": "publisher", "first-page": "1807836", "journal-title": "Oncoimmunology", "key": "585_CR21", "unstructured": "Melenotte C, Silvin A, Goubet A-G, Lahmar I, Dubuisson A, Zumla A, et al. Immune responses during COVID-19 infection. Oncoimmunology. 2020;9:1807836.", "volume": "9", "year": "2020" }, { "DOI": "10.3390/ph13040055", "author": "G-L Chen", "doi-asserted-by": "publisher", "first-page": "55", "journal-title": "Pharmaceuticals", "key": "585_CR22", "unstructured": "Chen G-L, Munyao Mutie F, Xu Y-B, Saleri FD, Hu G-W, Guo M-Q. Antioxidant, anti-inflammatory activities and polyphenol profile of Rhamnus prinoides. Pharmaceuticals. 2020;13:55.", "volume": "13", "year": "2020" }, { "DOI": "10.1080/14756366.2019.1690480", "author": "S Jo", "doi-asserted-by": "publisher", "first-page": "145", "journal-title": "J Enzyme Inhib Med Chem", "key": "585_CR23", "unstructured": "Jo S, Kim S, Shin DH, Kim M-S. Inhibition of SARS-CoV 3CL protease by flavonoids. J Enzyme Inhib Med Chem. 2020;35:145–51.", "volume": "35", "year": "2020" }, { "author": "R Schettig", "first-page": "45", "journal-title": "Adv Infect Dis", "key": "585_CR24", "unstructured": "Schettig R, Sears T, Klein M, Tan-Lim R, Matthias R Jr, Aussems C, et al. COVID-19 patient with multifocal pneumonia and respiratory difficulty resolved quickly: possible antiviral and anti-inflammatory benefits of quercinex (nebulized quercetin-NAC) as adjuvant. Adv Infect Dis. 2020;10:45–55.", "volume": "10", "year": "2020" }, { "DOI": "10.1016/j.bmc.2010.09.035", "author": "YB Ryu", "doi-asserted-by": "publisher", "first-page": "7940", "journal-title": "Bioorg Med Chem", "key": "585_CR25", "unstructured": "Ryu YB, Jeong HJ, Kim JH, Kim YM, Park J-Y, Kim D, et al. Biflavonoids from Torreya nucifera displaying SARS-CoV 3CLpro inhibition. Bioorg Med Chem. 2010;18:7940–7.", "volume": "18", "year": "2010" }, { "DOI": "10.1016/j.crphar.2021.100038", "author": "D Verma", "doi-asserted-by": "publisher", "journal-title": "Curr Res Pharmacol Drug Discov", "key": "585_CR26", "unstructured": "Verma D, Mitra D, Paul M, Chaudhary P, Kamboj A, Thatoi H, et al. Potential inhibitors of SARS-CoV-2 (COVID 19) proteases PLpro and Mpro/3CLpro: molecular docking and simulation studies of three pertinent medicinal plant natural components. Curr Res Pharmacol Drug Discov. 2021;2: 100038.", "volume": "2", "year": "2021" }, { "DOI": "10.1055/s-0033-1360277", "author": "S Schwarz", "doi-asserted-by": "publisher", "first-page": "177", "journal-title": "Planta Med", "key": "585_CR27", "unstructured": "Schwarz S, Sauter D, Wang K, Zhang R, Sun B, Karioti A, et al. Kaempferol derivatives as antiviral drugs against the 3a channel protein of coronavirus. Planta Med. 2014;80:177–82.", "volume": "80", "year": "2014" }, { "DOI": "10.1093/jn/131.1.27", "author": "Y Miura", "doi-asserted-by": "publisher", "first-page": "27", "journal-title": "J Nutr", "key": "585_CR28", "unstructured": "Miura Y, Chiba T, Tomita I, Koizumi H, Miura S, Umegaki K, et al. Tea catechins prevent the development of atherosclerosis in apoprotein E-deficient mice. J Nutr. 2001;131:27–32.", "volume": "131", "year": "2001" }, { "DOI": "10.1038/sj.onc.1209829", "author": "DN Syed", "doi-asserted-by": "publisher", "first-page": "673", "journal-title": "Oncogene", "key": "585_CR29", "unstructured": "Syed DN, Afaq F, Kweon MH, Hadi N, Bhatia N, Spiegelman VS, et al. Green tea polyphenol EGCG suppresses cigarette smoke condensate-induced NF-κB activation in normal human bronchial epithelial cells. Oncogene. 2007;26:673–82.", "volume": "26", "year": "2007" }, { "author": "J Villagomez", "first-page": "1", "journal-title": "Theses Dissert Culminating Proj", "key": "585_CR30", "unstructured": "Villagomez J. In vitro antiviral activity of black tea polyphenols on sindbis virus in vero cells. Theses Dissert Culminating Proj. 2017;19:1–33.", "volume": "19", "year": "2017" }, { "DOI": "10.1016/j.antiviral.2018.07.012", "author": "M Ge", "doi-asserted-by": "publisher", "first-page": "52", "journal-title": "Antivir Res", "key": "585_CR31", "unstructured": "Ge M, Xiao Y, Chen H, Luo F, Du G, Zeng F. Multiple antiviral approaches of (–)-epigallocatechin-3-gallate (EGCG) against porcine reproductive and respiratory syndrome virus infection in vitro. Antivir Res. 2018;158:52–62.", "volume": "158", "year": "2018" }, { "DOI": "10.1016/j.apjtm.2015.12.002", "author": "KH Chiow", "doi-asserted-by": "publisher", "first-page": "1", "journal-title": "Asian Pac J Trop Med", "key": "585_CR32", "unstructured": "Chiow KH, Phoon MC, Putti T, Tan BK, Chow VT. Evaluation of antiviral activities of Houttuynia cordata Thunb. extract, quercetin, quercetrin and cinanserin on murine coronavirus and dengue virus infection. Asian Pac J Trop Med. 2016;9:1–7.", "volume": "9", "year": "2016" }, { "DOI": "10.1086/429694", "author": "AT Palamara", "doi-asserted-by": "publisher", "first-page": "1719", "journal-title": "J Infect Dis", "key": "585_CR33", "unstructured": "Palamara AT, Nencioni L, Aquilano K, De Chiara G, Hernandez L, Cozzolino F, et al. Inhibition of influenza A virus replication by resveratrol. J Infect Dis. 2005;191:1719–29.", "volume": "191", "year": "2005" }, { "DOI": "10.2147/IJGM.S318720", "author": "F Di Pierro", "doi-asserted-by": "publisher", "first-page": "2359", "journal-title": "Int J Gen Med", "key": "585_CR34", "unstructured": "Di Pierro F, Derosa G, Maffioli P, Bertuccioli A, Togni S, Riva A, et al. Possible therapeutic effects of adjuvant quercetin supplementation against early-stage COVID-19 infection: a prospective, randomized, controlled, and open-label study. Int J Gen Med. 2021;14:2359–66.", "volume": "14", "year": "2021" }, { "DOI": "10.1016/j.phymed.2020.153230", "author": "H Huang", "doi-asserted-by": "publisher", "journal-title": "Phytomedicine", "key": "585_CR35", "unstructured": "Huang H, Liao D, Zhou G, Zhu Z, Cui Y, Pu R. Antiviral activities of resveratrol against rotavirus in vitro and in vivo. Phytomedicine. 2020;77: 153230.", "volume": "77", "year": "2020" }, { "DOI": "10.1016/j.bbagen.2005.02.012", "author": "S Liu", "doi-asserted-by": "publisher", "first-page": "270", "journal-title": "Biochim Biophys Acta Gen Subj", "key": "585_CR36", "unstructured": "Liu S, Lu H, Zhao Q, He Y, Niu J, Debnath AK, et al. Theaflavin derivatives in black tea and catechin derivatives in green tea inhibit HIV-1 entry by targeting gp41. Biochim Biophys Acta Gen Subj. 2005;1723:270–81.", "volume": "1723", "year": "2005" }, { "DOI": "10.1002/hep.24610", "author": "S Ciesek", "doi-asserted-by": "publisher", "first-page": "1947", "journal-title": "Hepatology", "key": "585_CR37", "unstructured": "Ciesek S, von Hahn T, Colpitts CC, Schang LM, Friesland M, Steinmann J, et al. The green tea polyphenol, epigallocatechin-3-gallate, inhibits hepatitis C virus entry. Hepatology. 2011;54:1947–55.", "volume": "54", "year": "2011" }, { "DOI": "10.3390/v13020354", "author": "S Pasquereau", "doi-asserted-by": "publisher", "first-page": "354", "journal-title": "Viruses", "key": "585_CR38", "unstructured": "Pasquereau S, Nehme Z, Haidar Ahmad S, Daouad F, Van Assche J, Wallet C, et al. Resveratrol inhibits HCoV-229E and SARS-CoV-2 coronavirus replication in vitro. Viruses. 2021;13:354.", "volume": "13", "year": "2021" }, { "DOI": "10.1016/S0140-6736(20)30183-5", "author": "C Huang", "doi-asserted-by": "publisher", "first-page": "497", "journal-title": "Lancet", "key": "585_CR39", "unstructured": "Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395:497–506.", "volume": "395", "year": "2020" }, { "DOI": "10.1016/j.dsx.2020.04.020", "author": "I Astuti", "doi-asserted-by": "publisher", "first-page": "407", "journal-title": "Diabetes Metab Syndr Clin Res Rev", "key": "585_CR40", "unstructured": "Astuti I. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): an overview of viral structure and host response. Diabetes Metab Syndr Clin Res Rev. 2020;14:407–12.", "volume": "14", "year": "2020" }, { "DOI": "10.1097/JCMA.0000000000000463", "author": "P-H Tsai", "doi-asserted-by": "publisher", "first-page": "3", "journal-title": "J Chin Med Assoc", "key": "585_CR41", "unstructured": "Tsai P-H, Lai W-Y, Lin Y-Y, Luo Y-H, Lin Y-T, Chen H-K, et al. Clinical manifestation and disease progression in COVID-19 infection. J Chin Med Assoc. 2021;84:3–8.", "volume": "84", "year": "2021" }, { "DOI": "10.1007/s00508-020-01760-4", "doi-asserted-by": "crossref", "key": "585_CR42", "unstructured": "da Rosa Mesquita R, Francelino Silva Junior LC, Santos Santana FM, Farias de Oliveira T, Campos Alcântara R, Monteiro Arnozo G, et al. Clinical manifestations of COVID-19 in the general population: systematic review. Wien Klin Wochenschr. 2021;133:377–82." }, { "DOI": "10.1134/S0006297921030032", "author": "AV Letarov", "doi-asserted-by": "publisher", "first-page": "257", "journal-title": "Biochem (Mosc)", "key": "585_CR43", "unstructured": "Letarov AV, Babenko VV, Kulikov EE. Free SARS-CoV-2 spike protein S1 particles may play a role in the pathogenesis of COVID-19 infection. Biochem (Mosc). 2021;86:257–61.", "volume": "86", "year": "2021" }, { "DOI": "10.1038/s41423-020-0458-z", "author": "C Yi", "doi-asserted-by": "publisher", "first-page": "621", "journal-title": "Cell Mol Immunol", "key": "585_CR44", "unstructured": "Yi C, Sun X, Ye J, Ding L, Liu M, Yang Z, et al. Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies. Cell Mol Immunol. 2020;17:621–30.", "volume": "17", "year": "2020" }, { "DOI": "10.1073/pnas.0306446101", "author": "G Simmons", "doi-asserted-by": "publisher", "first-page": "4240", "journal-title": "Proc Natl Acad Sci USA", "key": "585_CR45", "unstructured": "Simmons G, Reeves JD, Rennekamp AJ, Amberg SM, Piefer AJ, Bates P. Characterization of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spike glycoprotein-mediated viral entry. Proc Natl Acad Sci USA. 2004;101:4240–5.", "volume": "101", "year": "2004" }, { "DOI": "10.1073/pnas.0809524106", "author": "S Belouzard", "doi-asserted-by": "publisher", "first-page": "5871", "journal-title": "Proc Natl Acad Sci USA", "key": "585_CR46", "unstructured": "Belouzard S, Chu VC, Whittaker GR. Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites. Proc Natl Acad Sci USA. 2009;106:5871–6.", "volume": "106", "year": "2009" }, { "DOI": "10.1073/pnas.2117576119", "author": "B Yang", "doi-asserted-by": "publisher", "journal-title": "Proc Natl Acad Sci USA", "key": "585_CR47", "unstructured": "Yang B, Jia Y, Meng Y, Xue Y, Liu K, Li Y, et al. SNX27 suppresses SARS-CoV-2 infection by inhibiting viral lysosome/late endosome entry. Proc Natl Acad Sci USA. 2022;119: e2117576119.", "volume": "119", "year": "2022" }, { "DOI": "10.15252/embj.2021107821", "author": "J Koch", "doi-asserted-by": "publisher", "journal-title": "EMBO J", "key": "585_CR48", "unstructured": "Koch J, Uckeley ZM, Doldan P, Stanifer M, Boulant S, Lozach PY. TMPRSS2 expression dictates the entry route used by SARS-CoV-2 to infect host cells. EMBO J. 2021;40: e107821.", "volume": "40", "year": "2021" }, { "DOI": "10.1038/cr.2008.15", "author": "H Wang", "doi-asserted-by": "publisher", "first-page": "290", "journal-title": "Cell Res", "key": "585_CR49", "unstructured": "Wang H, Yang P, Liu K, Guo F, Zhang Y, Zhang G, et al. SARS coronavirus entry into host cells through a novel clathrin- and caveolae-independent endocytic pathway. Cell Res. 2008;18:290–301.", "volume": "18", "year": "2008" }, { "DOI": "10.1016/j.jbc.2021.100306", "author": "A Bayati", "doi-asserted-by": "publisher", "journal-title": "J Biol Chem", "key": "585_CR50", "unstructured": "Bayati A, Kumar R, Francis V, McPherson PS. SARS-CoV-2 infects cells after viral entry via clathrin-mediated endocytosis. J Biol Chem. 2021;296: 100306.", "volume": "296", "year": "2021" }, { "DOI": "10.1002/jmv.28212", "author": "X Li", "doi-asserted-by": "publisher", "journal-title": "J Med Virol", "key": "585_CR51", "unstructured": "Li X, Yuan H, Li X, Wang H. Spike protein mediated membrane fusion during SARS-CoV-2 infection. J Med Virol. 2023;95: e28212.", "volume": "95", "year": "2023" }, { "DOI": "10.1038/s41579-020-00468-6", "author": "P Vkovski", "doi-asserted-by": "publisher", "first-page": "155", "journal-title": "Nat Rev Microbiol", "key": "585_CR52", "unstructured": "Vkovski P, Kratzel A, Steiner S, Stalder H, Thiel V. Coronavirus biology and replication: implications for SARS-CoV-2. Nat Rev Microbiol. 2021;19:155–70.", "volume": "19", "year": "2021" }, { "DOI": "10.1111/his.14264", "author": "H Hopfer", "doi-asserted-by": "publisher", "first-page": "358", "journal-title": "Histopathology", "key": "585_CR53", "unstructured": "Hopfer H, Herzig MC, Gosert R, Menter T, Hench J, Tzankov A, et al. Hunting coronavirus by transmission electron microscopy–a guide to SARS-CoV-2-associated ultrastructural pathology in COVID-19 tissues. Histopathology. 2021;78:358–70.", "volume": "78", "year": "2021" }, { "DOI": "10.1128/mBio.02602-21", "author": "U Okalang", "doi-asserted-by": "publisher", "first-page": "e02602", "journal-title": "MBio", "key": "585_CR54", "unstructured": "Okalang U, Mualem Bar-Ner B, Rajan KS, Friedman N, Aryal S, Egarmina K, et al. The spliced leader RNA silencing (SLS) pathway in Trypanosoma brucei is induced by perturbations of endoplasmic reticulum, golgi complex, or mitochondrial protein factors: functional analysis of SLS-inducing kinase PK3. MBio. 2021;12:e02602-e2621.", "volume": "12", "year": "2021" }, { "DOI": "10.1080/21645515.2020.1823777", "author": "Y Cun", "doi-asserted-by": "publisher", "first-page": "1097", "journal-title": "Hum Vaccin Immunother", "key": "585_CR55", "unstructured": "Cun Y, Li C, Shi L, Sun M, Dai S, Sun L, et al. COVID-19 coronavirus vaccine T cell epitope prediction analysis based on distributions of HLA class I loci (HLA-A,-B,-C) across global populations. Hum Vaccin Immunother. 2021;17:1097–108.", "volume": "17", "year": "2021" }, { "DOI": "10.1016/j.clim.2022.108990", "doi-asserted-by": "crossref", "key": "585_CR56", "unstructured": "Hernández-Doño S, Sánchez-González RA, Trujillo-Vizuet MG, Zamudio-Castellanos FY, García-Silva R, Bulos-Rodríguez P, et al. Protective HLA alleles against severe COVID-19: HLA-A* 68 as an ancestral protection allele in Tapachula-Chiapas, Mexico. Clin Immunol. 2022:108990." }, { "DOI": "10.1038/s41467-021-26910-8", "author": "J-S Yoo", "doi-asserted-by": "publisher", "first-page": "6602", "journal-title": "Nat Commun", "key": "585_CR57", "unstructured": "Yoo J-S, Sasaki M, Cho SX, Kasuga Y, Zhu B, Ouda R, et al. SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis. Nat Commun. 2021;12:6602.", "volume": "12", "year": "2021" }, { "DOI": "10.3389/fimmu.2020.01949", "author": "VK Shah", "doi-asserted-by": "publisher", "first-page": "1949", "journal-title": "Front Immunol", "key": "585_CR58", "unstructured": "Shah VK, Firmal P, Alam A, Ganguly D, Chattopadhyay S. Overview of immune response during SARS-CoV-2 infection: lessons from the past. Front Immunol. 2020;11:1949.", "volume": "11", "year": "2020" }, { "DOI": "10.1016/j.meegid.2021.104846", "author": "ACM Dos Santos", "doi-asserted-by": "publisher", "journal-title": "Infect Genet Evol", "key": "585_CR59", "unstructured": "Dos Santos ACM, Dos Santos BRC, Dos Santos BB, de Moura EL, Ferreira JM, Dos Santos LKC, et al. Genetic polymorphisms as multi-biomarkers in severe acute respiratory syndrome (SARS) by coronavirus infection: a systematic review of candidate gene association studies. Infect Genet Evol. 2021;93: 104846.", "volume": "93", "year": "2021" }, { "DOI": "10.1093/cid/ciaa489", "author": "J Qu", "doi-asserted-by": "publisher", "first-page": "2255", "journal-title": "Clin Infect Dis", "key": "585_CR60", "unstructured": "Qu J, Wu C, Li X, Zhang G, Jiang Z, Li X, et al. Profile of immunoglobulin G and IgM antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Clin Infect Dis. 2020;71:2255–8.", "volume": "71", "year": "2020" }, { "DOI": "10.1038/s41467-020-17488-8", "author": "H-W Jiang", "doi-asserted-by": "publisher", "first-page": "1", "journal-title": "Nat Commun", "key": "585_CR61", "unstructured": "Jiang H-W, Li Y, Zhang H-N, Wang W, Yang X, Qi H, et al. SARS-CoV-2 proteome microarray for global profiling of COVID-19 specific IgG and IgM responses. Nat Commun. 2020;11:1–11.", "volume": "11", "year": "2020" }, { "DOI": "10.1021/acsinfecdis.0c00646", "author": "Z Shang", "doi-asserted-by": "publisher", "first-page": "1369", "journal-title": "ACS Infect Dis", "key": "585_CR62", "unstructured": "Shang Z, Chan SY, Liu WJ, Li P, Huang W. Recent insights into emerging coronavirus: SARS-CoV-2. ACS Infect Dis. 2020;7:1369–88.", "volume": "7", "year": "2020" }, { "DOI": "10.1038/nrmicro.2016.81", "author": "E De Wit", "doi-asserted-by": "publisher", "first-page": "523", "journal-title": "Nat Rev Microbiol", "key": "585_CR63", "unstructured": "De Wit E, Van Doremalen N, Falzarano D, Munster VJ. SARS and MERS: recent insights into emerging coronaviruses. Nat Rev Microbiol. 2016;14:523–34.", "volume": "14", "year": "2016" }, { "DOI": "10.1016/j.ebiom.2020.102763", "author": "J Liu", "doi-asserted-by": "publisher", "journal-title": "EBioMedicine", "key": "585_CR64", "unstructured": "Liu J, Li S, Liu J, Liang B, Wang X, Wang H, et al. Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients. EBioMedicine. 2020;55: 102763.", "volume": "55", "year": "2020" }, { "DOI": "10.1016/S0140-6736(20)30566-3", "author": "F Zhou", "doi-asserted-by": "publisher", "first-page": "1054", "journal-title": "Lancet", "key": "585_CR65", "unstructured": "Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395:1054–62.", "volume": "395", "year": "2020" }, { "DOI": "10.1111/imm.13262", "author": "SM Toor", "doi-asserted-by": "publisher", "first-page": "30", "journal-title": "Immunology", "key": "585_CR66", "unstructured": "Toor SM, Saleh R, Sasidharan Nair V, Taha RZ, Elkord E. T-cell responses and therapies against SARS-CoV-2 infection. Immunology. 2021;162:30–43.", "volume": "162", "year": "2021" }, { "DOI": "10.1016/j.cell.2021.01.007", "author": "A Sette", "doi-asserted-by": "publisher", "first-page": "861", "journal-title": "Cell", "key": "585_CR67", "unstructured": "Sette A, Crotty S. Adaptive immunity to SARS-CoV-2 and COVID-19. Cell. 2021;184:861–80.", "volume": "184", "year": "2021" }, { "DOI": "10.1056/NEJMoa2015432", "author": "M Ackermann", "doi-asserted-by": "publisher", "first-page": "120", "journal-title": "N Engl J Med", "key": "585_CR68", "unstructured": "Ackermann M, Verleden SE, Kuehnel M, Haverich A, Welte T, Laenger F, et al. Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19. N Engl J Med. 2020;383:120–8.", "volume": "383", "year": "2020" }, { "DOI": "10.1038/ni.1863", "author": "T Kawai", "doi-asserted-by": "publisher", "first-page": "373", "journal-title": "Nat Immunol", "key": "585_CR69", "unstructured": "Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol. 2010;11:373–84.", "volume": "11", "year": "2010" }, { "DOI": "10.1128/CMR.00046-08", "author": "TH Mogensen", "doi-asserted-by": "publisher", "first-page": "240", "journal-title": "Clin Microbiol Rev", "key": "585_CR70", "unstructured": "Mogensen TH. Pathogen recognition and inflammatory signaling in innate immune defenses. Clin Microbiol Rev. 2009;22:240–73.", "volume": "22", "year": "2009" }, { "DOI": "10.1038/s41591-020-1051-9", "author": "DM Del Valle", "doi-asserted-by": "publisher", "first-page": "1636", "journal-title": "Nat Med", "key": "585_CR71", "unstructured": "Del Valle DM, Kim-Schulze S, Huang HH, Beckmann ND, Nirenberg S, Wang B, et al. An inflammatory cytokine signature predicts COVID-19 severity and survival. Nat Med. 2020;26:1636–43.", "volume": "26", "year": "2020" }, { "DOI": "10.1038/s41590-020-00840-x", "author": "IE Galani", "doi-asserted-by": "publisher", "first-page": "32", "journal-title": "Nat Immunol", "key": "585_CR72", "unstructured": "Galani IE, Rovina N, Lampropoulou V, Triantafyllia V, Manioudaki M, Pavlos E, et al. Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison. Nat Immunol. 2021;22:32–40.", "volume": "22", "year": "2021" }, { "DOI": "10.1128/JVI.02501-05", "author": "EJ Snijder", "doi-asserted-by": "publisher", "first-page": "5927", "journal-title": "J Virol", "key": "585_CR73", "unstructured": "Snijder EJ, van der Meer Y, Zevenhoven-Dobbe J, Onderwater JJ, van der Meulen J, Koerten HK, et al. Ultrastructure and origin of membrane vesicles associated with the severe acute respiratory syndrome coronavirus replication complex. J Virol. 2006;80:5927–40.", "volume": "80", "year": "2006" }, { "DOI": "10.1016/j.chom.2016.01.007", "author": "R Channappanavar", "doi-asserted-by": "publisher", "first-page": "181", "journal-title": "Cell Host Microbe", "key": "585_CR74", "unstructured": "Channappanavar R, Fehr AR, Vijay R, Mack M, Zhao J, Meyerholz DK, et al. Dysregulated type I interferon and inflammatory monocyte-macrophage responses cause lethal pneumonia in SARS-CoV-infected mice. Cell Host Microbe. 2016;19:181–93.", "volume": "19", "year": "2016" }, { "DOI": "10.1016/j.bbadis.2023.166671", "author": "T Yao", "doi-asserted-by": "publisher", "journal-title": "Biochim Biophys Acta Mol Basis Dis", "key": "585_CR75", "unstructured": "Yao T, Foo C, Zheng G, Huang R, Li Q, Shen J, et al. Insight into the mechanisms of coronaviruses evading host innate immunity. Biochim Biophys Acta Mol Basis Dis. 2023;1869: 166671.", "volume": "1869", "year": "2023" }, { "author": "JM Minkoff", "first-page": "178", "journal-title": "Nat Rev Microbiol", "key": "585_CR76", "unstructured": "Minkoff JM, tenOever B. Innate immune evasion strategies of SARS-CoV-2. Nat Rev Microbiol. 2023;21:178–94.", "volume": "21", "year": "2023" }, { "DOI": "10.3390/biomedicines10061339", "author": "A Rubio-Casillas", "doi-asserted-by": "publisher", "first-page": "1339", "journal-title": "Biomedicines", "key": "585_CR77", "unstructured": "Rubio-Casillas A, Redwan EM, Uversky VN. SARS-CoV-2: a master of immune evasion. Biomedicines. 2022;10:1339.", "volume": "10", "year": "2022" }, { "DOI": "10.3389/fimmu.2022.801522", "author": "C Chakraborty", "doi-asserted-by": "publisher", "journal-title": "Front immunol", "key": "585_CR78", "unstructured": "Chakraborty C, Sharma AR, Bhattacharya M, Lee S-S. A detailed overview of immune escape, antibody escape, partial vaccine escape of SARS-CoV-2 and their emerging variants with escape mutations. Front immunol. 2022;13: 801522.", "volume": "13", "year": "2022" }, { "DOI": "10.1371/journal.ppat.1010260", "author": "A Mittal", "doi-asserted-by": "publisher", "journal-title": "PLoS Pathog", "key": "585_CR79", "unstructured": "Mittal A, Khattri A, Verma V. Structural and antigenic variations in the spike protein of emerging SARS-CoV-2 variants. PLoS Pathog. 2022;18: e1010260.", "volume": "18", "year": "2022" }, { "DOI": "10.1016/j.ymthe.2022.02.014", "author": "S Zhang", "doi-asserted-by": "publisher", "first-page": "1869", "journal-title": "Mol Ther", "key": "585_CR80", "unstructured": "Zhang S, Wang L, Cheng G. The battle between host and SARS-CoV-2: innate immunity and viral evasion strategies. Mol Ther. 2022;30:1869–84.", "volume": "30", "year": "2022" }, { "DOI": "10.1111/j.1365-2621.2009.02077.x", "author": "H El Gharras", "doi-asserted-by": "publisher", "first-page": "2512", "journal-title": "Food Sci Technol Int", "key": "585_CR81", "unstructured": "El Gharras H. Polyphenols: food sources, properties and applications—a review. Food Sci Technol Int. 2009;44:2512–8.", "volume": "44", "year": "2009" }, { "DOI": "10.5772/intechopen.68862", "doi-asserted-by": "crossref", "key": "585_CR82", "unstructured": "Mrduljaš N, Krešic G, Bilušic T. Polyphenols: food sources and health benefits in functional food-improve health through adequate food. In: Hueda MC, editor. London: IntechOpen; 2017. https://www.intechopen.com/" }, { "DOI": "10.1021/jf970832p", "author": "S Guyot", "doi-asserted-by": "publisher", "first-page": "1698", "journal-title": "J Agric Food Chem", "key": "585_CR83", "unstructured": "Guyot S, Marnet N, Laraba D, Sanoner P, Drilleau J-F. Reversed-phase HPLC following thiolysis for quantitative estimation and characterization of the four main classes of phenolic compounds in different tissue zones of a French cider apple variety (Malus domestica var. Kermerrien). J Agric Food Chem. 1998;46:1698–705.", "volume": "46", "year": "1998" }, { "DOI": "10.1016/j.bcp.2018.07.050", "author": "A Tresserra-Rimbau", "doi-asserted-by": "publisher", "first-page": "186", "journal-title": "Biochem Pharmacol", "key": "585_CR84", "unstructured": "Tresserra-Rimbau A, Lamuela-Raventos RM, Moreno JJ. Polyphenols, food and pharma. Current knowledge and directions for future research. Biochem Pharmacol. 2018;156:186–95.", "volume": "156", "year": "2018" }, { "DOI": "10.1093/jn/130.8.2073S", "author": "A Scalbert", "doi-asserted-by": "publisher", "first-page": "2073S", "journal-title": "J Nutr", "key": "585_CR85", "unstructured": "Scalbert A, Williamson G. Dietary intake and bioavailability of polyphenols. J Nutr. 2000;130:2073S-S2085.", "volume": "130", "year": "2000" }, { "DOI": "10.3390/ijms11041321", "author": "M D’Archivio", "doi-asserted-by": "publisher", "first-page": "1321", "journal-title": "Int J Mol Sci", "key": "585_CR86", "unstructured": "D’Archivio M, Filesi C, Varì R, Scazzocchio B, Masella R. Bioavailability of the polyphenols: status and controversies. Int J Mol Sci. 2010;11:1321–42.", "volume": "11", "year": "2010" }, { "DOI": "10.1016/S0753-3322(02)00178-6", "author": "H Tapiero", "doi-asserted-by": "publisher", "first-page": "200", "journal-title": "Biomed Pharmacother", "key": "585_CR87", "unstructured": "Tapiero H, Tew K, Ba GN, Mathe G. Polyphenols: do they play a role in the prevention of human pathologies? Biomed Pharmacother. 2002;56:200–7.", "volume": "56", "year": "2002" }, { "DOI": "10.1093/jn/133.3.773", "author": "AL Sesink", "doi-asserted-by": "publisher", "first-page": "773", "journal-title": "J Nutr", "key": "585_CR88", "unstructured": "Sesink AL, Arts IC, Faassen-Peters M, Hollman PC. Intestinal uptake of quercetin-3-glucoside in rats involves hydrolysis by lactase phlorizin hydrolase. J Nutr. 2003;133:773–6.", "volume": "133", "year": "2003" }, { "DOI": "10.3390/nu8030167", "author": "Y Li", "doi-asserted-by": "publisher", "first-page": "167", "journal-title": "Nutrients", "key": "585_CR89", "unstructured": "Li Y, Yao J, Han C, Yang J, Chaudhry MT, Wang S, et al. Quercetin, Inflammation and Immunity. Nutrients. 2016;8:167.", "volume": "8", "year": "2016" }, { "DOI": "10.3390/molecules26020450", "author": "K Mitsunari", "doi-asserted-by": "publisher", "first-page": "450", "journal-title": "Molecules", "key": "585_CR90", "unstructured": "Mitsunari K, Miyata Y, Matsuo T, Mukae Y, Otsubo A, Harada J, et al. Pharmacological effects and potential clinical usefulness of polyphenols in benign prostatic hyperplasia. Molecules. 2021;26:450.", "volume": "26", "year": "2021" }, { "DOI": "10.1111/jfbc.14093", "author": "F Naeini", "doi-asserted-by": "publisher", "journal-title": "J Food Biochem", "key": "585_CR91", "unstructured": "Naeini F, Tutunchi H, Razmi H, Mahmoodpoor A, Vajdi M, Sefidmooye Azar P, et al. Does nano-curcumin supplementation improve hematological indices in critically ill patients with sepsis? A randomized controlled clinical trial. J Food Biochem. 2022;46: e14093.", "volume": "46", "year": "2022" }, { "DOI": "10.1002/ptr.7917", "author": "M Vajdi", "doi-asserted-by": "publisher", "first-page": "3780", "journal-title": "Phytother Res", "key": "585_CR92", "unstructured": "Vajdi M, Sefidmooye Azar P, Mahmoodpoor A, Dashti F, Sanaie S, Kiani Chalmardi F, et al. A comprehensive insight into the molecular and cellular mechanisms of action of resveratrol on complications of sepsis a systematic review. Phytother Res. 2023;37:3780–808.", "volume": "37", "year": "2023" }, { "DOI": "10.1016/j.phymed.2023.154734", "doi-asserted-by": "crossref", "key": "585_CR93", "unstructured": "Vajdi M, Karimi A, Karimi M, Farhangi MA, Askari G. Effects of luteolin on sepsis: a comprehensive systematic review. Phytomedicine. 2023:154734." }, { "DOI": "10.1016/j.numecd.2023.07.003", "author": "A Karimi", "doi-asserted-by": "publisher", "first-page": "2089", "issue": "11", "journal-title": "Nutr Metab Cardiovasc Dis", "key": "585_CR94", "unstructured": "Karimi A, Jazani AM, Darzi M, Azgomi RND, Vajdi M. Effects of curcumin on blood pressure: a systematic review and dose-response meta-analysis. Nutr Metab Cardiovasc Dis. 2023;33(11):2089–101.", "volume": "33", "year": "2023" }, { "DOI": "10.1038/nrcardio.2013.140-c1", "author": "A Sahebkar", "doi-asserted-by": "publisher", "first-page": "123", "journal-title": "Nat Rev Cardiol", "key": "585_CR95", "unstructured": "Sahebkar A. Curcuminoids for the management of hypertriglyceridaemia. Nat Rev Cardiol. 2014;11:123.", "volume": "11", "year": "2014" }, { "DOI": "10.1017/S0007114510003910", "author": "J González-Gallego", "doi-asserted-by": "publisher", "first-page": "S15", "issue": "Suppl 3", "journal-title": "Br J Nutr", "key": "585_CR96", "unstructured": "González-Gallego J, García-Mediavilla MV, Sánchez-Campos S, Tuñón MJ. Fruit polyphenols, immunity and inflammation. Br J Nutr. 2010;104 (Suppl 3):S15–27. https://doi.org/10.1017/S0007114510003910.", "volume": "104", "year": "2010" }, { "DOI": "10.1124/pr.111.004994", "author": "P Gazzerro", "doi-asserted-by": "publisher", "first-page": "102", "journal-title": "Pharmacol Rev", "key": "585_CR97", "unstructured": "Gazzerro P, Proto MC, Gangemi G, Malfitano AM, Ciaglia E, Pisanti S, et al. Pharmacological actions of statins: a critical appraisal in the management of cancer. Pharmacol Rev. 2012;64:102–46.", "volume": "64", "year": "2012" }, { "DOI": "10.2337/dc07-s217", "author": "DR Coustan", "doi-asserted-by": "publisher", "first-page": "S206", "journal-title": "Diabetes Care", "key": "585_CR98", "unstructured": "Coustan DR. Pharmacological management of gestational diabetes: an overview. Diabetes Care. 2007;30:S206–8.", "volume": "30", "year": "2007" }, { "DOI": "10.1093/jac/dkq447", "author": "PL Anderson", "doi-asserted-by": "publisher", "first-page": "240", "journal-title": "J Antimicrob Chemother", "key": "585_CR99", "unstructured": "Anderson PL, Kiser JJ, Gardner EM, Rower JE, Meditz A, Grant RM. Pharmacological considerations for tenofovir and emtricitabine to prevent HIV infection. J Antimicrob Chemother. 2011;66:240–50.", "volume": "66", "year": "2011" }, { "DOI": "10.2337/dcS15-3016", "author": "L Van Gaal", "doi-asserted-by": "publisher", "first-page": "S260", "journal-title": "Diabetes Care", "key": "585_CR100", "unstructured": "Van Gaal L, Dirinck E. Pharmacological approaches in the treatment and maintenance of weight loss. Diabetes Care. 2016;39:S260–7.", "volume": "39", "year": "2016" }, { "DOI": "10.1038/82107", "author": "W Palinski", "doi-asserted-by": "publisher", "first-page": "1311", "journal-title": "Nat Med", "key": "585_CR101", "unstructured": "Palinski W. Immunomodulation: a new role for statins? Nat Med. 2000;6:1311–2.", "volume": "6", "year": "2000" }, { "DOI": "10.1016/j.phrs.2022.106414", "author": "A Ahmadi", "doi-asserted-by": "publisher", "journal-title": "Pharmacol Res", "key": "585_CR102", "unstructured": "Ahmadi A, Jamialahmadi T, Sahebkar A. Polyphenols and atherosclerosis: a critical review of clinical effects on LDL oxidation. Pharmacol Res. 2022;184: 106414.", "volume": "184", "year": "2022" }, { "DOI": "10.1007/s00394-019-01916-7", "author": "AFG Cicero", "doi-asserted-by": "publisher", "first-page": "477", "journal-title": "Eur J Nutr", "key": "585_CR103", "unstructured": "Cicero AFG, Sahebkar A, Fogacci F, Bove M, Giovannini M, Borghi C. Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trial. Eur J Nutr. 2020;59:477–83.", "volume": "59", "year": "2020" }, { "DOI": "10.1002/jcp.26249", "author": "F Keihanian", "doi-asserted-by": "publisher", "first-page": "4497", "journal-title": "J Cell Physiol", "key": "585_CR104", "unstructured": "Keihanian F, Saeidinia A, Khameneh Bagheri R, Johnston ThP, Sahebkar A. Curcumin, hemostasis, thrombosis, and coagulation. J Cell Physiol. 2018;233:4497–511.", "volume": "233", "year": "2018" }, { "DOI": "10.1093/nutrit/nuad166", "author": "M Vajdi", "doi-asserted-by": "publisher", "first-page": "nuad166", "journal-title": "Nutr Rev", "key": "585_CR105", "unstructured": "Vajdi M, Hassanizadeh S, Hassanizadeh R, Bagherniya M. Curcumin supplementation effect on liver enzymes in patients with nonalcoholic fatty liver disease: a GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials. Nutr Rev. 2024;12:nuad166.", "volume": "12", "year": "2024" }, { "DOI": "10.1002/jcp.26538", "author": "RM Marjaneh", "doi-asserted-by": "publisher", "first-page": "6785", "journal-title": "J Cell Physiol", "key": "585_CR106", "unstructured": "Marjaneh RM, Rahmani F, Hassanian SM, Rezaei N, Hashemzehi M, Bahrami A, et al. Phytosomal curcumin inhibits tumor growth in colitis-associated colorectal cancer. J Cell Physiol. 2018;233:6785–98.", "volume": "233", "year": "2018" }, { "DOI": "10.1016/j.critrevonc.2017.12.005", "author": "M Mohajeri", "doi-asserted-by": "publisher", "first-page": "30", "journal-title": "Crit Rev Oncol Hematol", "key": "585_CR107", "unstructured": "Mohajeri M, Sahebkar A. Protective effects of curcumin against doxorubicin-induced toxicity and resistance: a review. Crit Rev Oncol Hematol. 2018;122:30–51.", "volume": "122", "year": "2018" }, { "DOI": "10.1002/jcp.26848", "author": "A Mokhtari-Zaer", "doi-asserted-by": "publisher", "first-page": "214", "journal-title": "J Cell Physiol", "key": "585_CR108", "unstructured": "Mokhtari-Zaer A, Marefati N, Atkin SL, Butler AE, Sahebkar A. The protective role of curcumin in myocardial ischemia–reperfusion injury. J Cell Physiol. 2018;234:214–22.", "volume": "234", "year": "2018" }, { "DOI": "10.1002/jcp.27096", "author": "Y Panahi", "doi-asserted-by": "publisher", "first-page": "1165", "journal-title": "J Cell Physiol", "key": "585_CR109", "unstructured": "Panahi Y, Fazlolahzadeh O, Atkin SL, Majeed M, Butler AE, Johnston TP, et al. Evidence of curcumin and curcumin analogue effects in skin diseases: a narrative review. J Cell Physiol. 2019;234:1165–78.", "volume": "234", "year": "2019" }, { "DOI": "10.1111/nure.12081", "author": "A Sahebkar", "doi-asserted-by": "publisher", "first-page": "822", "journal-title": "Nutr Rev", "key": "585_CR110", "unstructured": "Sahebkar A. Effects of resveratrol supplementation on plasma lipids: a systematic review and meta-analysis of randomized controlled trials. Nutr Rev. 2013;71:822–35.", "volume": "71", "year": "2013" }, { "DOI": "10.1016/j.ijcard.2015.04.008", "author": "A Sahebkar", "doi-asserted-by": "publisher", "first-page": "47", "journal-title": "Int J Cardiol", "key": "585_CR111", "unstructured": "Sahebkar A, Serban C, Ursoniu S, Wong ND, Muntner P, Graham IM, et al. Lack of efficacy of resveratrol on C-reactive protein and selected cardiovascular risk factors - Results from a systematic review and meta-analysis of randomized controlled trials. Int J Cardiol. 2015;189:47–55.", "volume": "189", "year": "2015" }, { "DOI": "10.1016/j.clnu.2013.09.012", "author": "A Sahebkar", "doi-asserted-by": "publisher", "first-page": "406", "issue": "3", "journal-title": "Clin Nutr", "key": "585_CR112", "unstructured": "Sahebkar A. A systematic review and meta-analysis of randomized controlled trials investigating the effects of curcumin on blood lipid levels. Clin Nutr. 2014;33(3):406–14.", "volume": "33", "year": "2014" }, { "DOI": "10.1038/s41698-017-0038-6", "author": "AY Berman", "doi-asserted-by": "publisher", "first-page": "35", "journal-title": "NPJ Precis Oncol", "key": "585_CR113", "unstructured": "Berman AY, Motechin RA, Wiesenfeld MY, Holz MK. The therapeutic potential of resveratrol: a review of clinical trials. NPJ Precis Oncol. 2017;1:35.", "volume": "1", "year": "2017" }, { "DOI": "10.1080/87559129.2022.2071936", "author": "K Chojnacka", "doi-asserted-by": "publisher", "first-page": "5459", "journal-title": "Food Rev Int", "key": "585_CR114", "unstructured": "Chojnacka K, Lewandowska U. Inhibition of pro-inflammatory cytokine secretion by polyphenol-rich extracts in macrophages via NF-κB pathway. Food Rev Int. 2023;39:5459–78.", "volume": "39", "year": "2023" }, { "DOI": "10.1128/aem.00237-23", "author": "T Murata", "doi-asserted-by": "publisher", "journal-title": "Appl Environ Microbiol", "key": "585_CR115", "unstructured": "Murata T, Jamsransuren D, Matsuda S, Ogawa H, Takeda Y. Rapid virucidal activity of japanese saxifraga species-derived condensed tannins against SARS-CoV-2, influenza A virus, and human norovirus surrogate viruses. Appl Environ Microbiol. 2023;89: e0023723.", "volume": "89", "year": "2023" }, { "DOI": "10.1016/j.mehy.2020.110102", "author": "R Cecchini", "doi-asserted-by": "publisher", "journal-title": "Med Hypotheses", "key": "585_CR116", "unstructured": "Cecchini R, Cecchini AL. SARS-CoV-2 infection pathogenesis is related to oxidative stress as a response to aggression. Med Hypotheses. 2020;143: 110102.", "volume": "143", "year": "2020" }, { "DOI": "10.3390/antiox9030193", "author": "E Panieri", "doi-asserted-by": "publisher", "first-page": "193", "journal-title": "Antioxidants", "key": "585_CR117", "unstructured": "Panieri E, Buha A, Telkoparan-Akillilar P, Cevik D, Kouretas D, Veskoukis A, et al. Potential applications of NRF2 modulators in cancer therapy. Antioxidants. 2020;9:193.", "volume": "9", "year": "2020" }, { "DOI": "10.1017/S0007114511006544", "author": "Y Panahi", "doi-asserted-by": "publisher", "first-page": "1272", "journal-title": "Br J Nutr", "key": "585_CR118", "unstructured": "Panahi Y, Sahebkar A, Amiri M, Davoudi SM, Beiraghdar F, Hoseininejad SL, et al. Improvement of sulphur mustard-induced chronic pruritus, quality of life and antioxidant status by curcumin: results of a randomised, double-blind, placebo-controlled trial. Br J Nutr. 2012;108:1272–9.", "volume": "108", "year": "2012" }, { "DOI": "10.1111/jfbc.13557", "author": "C Lammi", "doi-asserted-by": "publisher", "journal-title": "J Food Biochem", "key": "585_CR119", "unstructured": "Lammi C, Arnoldi A. Food-derived antioxidants and COVID-19. J Food Biochem. 2021;45: e13557.", "volume": "45", "year": "2021" }, { "DOI": "10.3390/molecules26051200", "author": "M Chourasia", "doi-asserted-by": "publisher", "first-page": "1200", "journal-title": "Molecules", "key": "585_CR120", "unstructured": "Chourasia M, Koppula PR, Battu A, Ouseph MM, Singh AK. EGCG, a green tea catechin, as a potential therapeutic agent for symptomatic and asymptomatic SARS-CoV-2 infection. Molecules. 2021;26:1200.", "volume": "26", "year": "2021" }, { "DOI": "10.2174/1871523015666160915154443", "author": "T Ohishi", "doi-asserted-by": "publisher", "first-page": "74", "journal-title": "Antiinflamm Antiallergy Agents Med Chem", "key": "585_CR121", "unstructured": "Ohishi T, Goto S, Monira P, Isemura M, Nakamura Y. Anti-inflammatory action of green tea. Antiinflamm Antiallergy Agents Med Chem. 2016;15:74–90.", "volume": "15", "year": "2016" }, { "DOI": "10.1371/journal.pone.0059064", "author": "X Li", "doi-asserted-by": "publisher", "journal-title": "PLoS ONE", "key": "585_CR122", "unstructured": "Li X, Yao X, Wang Y, Hu F, Wang F, Jiang L, et al. MLH1 promoter methylation frequency in colorectal cancer patients and related clinicopathological and molecular features. PLoS ONE. 2013;8: e59064.", "volume": "8", "year": "2013" }, { "DOI": "10.1165/rcmb.2008-0119OC", "author": "D Tang", "doi-asserted-by": "publisher", "first-page": "651", "journal-title": "Am J Respir Cell Mol Biol", "key": "585_CR123", "unstructured": "Tang D, Kang R, Xiao W, Zhang H, Lotze MT, Wang H, et al. Quercetin prevents LPS-induced high-mobility group box 1 release and proinflammatory function. Am J Respir Cell Mol Biol. 2009;41:651–60.", "volume": "41", "year": "2009" }, { "DOI": "10.1016/j.phymed.2021.153567", "author": "A Karimi", "doi-asserted-by": "publisher", "journal-title": "Phytomedicine", "key": "585_CR124", "unstructured": "Karimi A, Naeini F, Azar VA, Hasanzadeh M, Ostadrahimi A, Niazkar HR, et al. A comprehensive systematic review of the therapeutic effects and mechanisms of action of quercetin in sepsis. Phytomedicine. 2021;86: 153567.", "volume": "86", "year": "2021" }, { "DOI": "10.1002/mnfr.201000641", "author": "SC Forester", "doi-asserted-by": "publisher", "first-page": "844", "journal-title": "Mol Nutr Food Res", "key": "585_CR125", "unstructured": "Forester SC, Lambert JD. The role of antioxidant versus pro-oxidant effects of green tea polyphenols in cancer prevention. Mol Nutr Food Res. 2011;55:844–54.", "volume": "55", "year": "2011" }, { "DOI": "10.1016/j.fshw.2021.12.008", "author": "V-L Truong", "doi-asserted-by": "publisher", "first-page": "502", "journal-title": "Food Sci Hum Wellness", "key": "585_CR126", "unstructured": "Truong V-L, Jeong W-S. Antioxidant and anti-inflammatory roles of tea polyphenols in inflammatory bowel diseases. Food Sci Hum Wellness. 2022;11:502–11.", "volume": "11", "year": "2022" }, { "DOI": "10.3390/nu10111741", "author": "I-A Jang", "doi-asserted-by": "publisher", "first-page": "1741", "journal-title": "Nutrients", "key": "585_CR127", "unstructured": "Jang I-A, Kim EN, Lim JH, Kim MY, Ban TH, Yoon HE, et al. Effects of resveratrol on the renin-angiotensin system in the aging kidney. Nutrients. 2018;10:1741.", "volume": "10", "year": "2018" }, { "DOI": "10.1111/dth.13989", "author": "H Aksoy", "doi-asserted-by": "publisher", "journal-title": "Dermatol Ther", "key": "585_CR128", "unstructured": "Aksoy H, Karadag AS, Wollina U. Angiotensin II receptors: Impact for COVID-19 severity. Dermatol Ther. 2020;33: e13989.", "volume": "33", "year": "2020" }, { "DOI": "10.1042/CS20201268", "author": "FJ Warner", "doi-asserted-by": "publisher", "first-page": "3137", "journal-title": "Clin Sci", "key": "585_CR129", "unstructured": "Warner FJ, Rajapaksha H, Shackel N, Herath CB. ACE2: from protection of liver disease to propagation of COVID-19. Clin Sci. 2020;134:3137–58.", "volume": "134", "year": "2020" }, { "DOI": "10.4149/av_2020_309", "doi-asserted-by": "crossref", "key": "585_CR130", "unstructured": "Ramdani L, Bachari K. Potential therapeutic effects of resveratrol against SARS-CoV-2. Acta Virol. 2020;64." }, { "DOI": "10.1080/21623945.2021.1965315", "author": "M de Ligt", "doi-asserted-by": "publisher", "first-page": "408", "journal-title": "Adipocyte", "key": "585_CR131", "unstructured": "de Ligt M, Hesselink MK, Jorgensen J, Hoebers N, Blaak EE, Goossens GH. Resveratrol supplementation reduces ACE2 expression in human adipose tissue. Adipocyte. 2021;10:408–11.", "volume": "10", "year": "2021" }, { "DOI": "10.1002/ptr.6916", "author": "M Yang", "doi-asserted-by": "publisher", "first-page": "1127", "journal-title": "Phytother Res", "key": "585_CR132", "unstructured": "Yang M, Wei J, Huang T, Lei L, Shen C, Lai J, et al. Resveratrol inhibits the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in cultured Vero cells. Phytother Res. 2021;35:1127.", "volume": "35", "year": "2021" }, { "DOI": "10.3389/fimmu.2021.670955", "author": "GA Rossi", "doi-asserted-by": "publisher", "journal-title": "Front immunol", "key": "585_CR133", "unstructured": "Rossi GA, Sacco O, Capizzi A, Mastromarino P. Can resveratrol-inhaled formulations be considered potential adjunct treatments for COVID-19? Front immunol. 2021;12: 670955.", "volume": "12", "year": "2021" }, { "DOI": "10.3390/v13071335", "author": "BM Ter Ellen", "doi-asserted-by": "publisher", "first-page": "1335", "journal-title": "Viruses", "key": "585_CR134", "unstructured": "Ter Ellen BM, Dinesh Kumar N, Bouma EM, Troost B, van de Pol DP, Van der Ende-Metselaar HH, et al. Resveratrol and pterostilbene inhibit SARS-CoV-2 replication in air–liquid interface cultured human primary bronchial epithelial cells. Viruses. 2021;13:1335.", "volume": "13", "year": "2021" }, { "DOI": "10.52586/4988", "author": "H Xu", "doi-asserted-by": "publisher", "first-page": "789", "journal-title": "Front Biosci (Landmark Ed)", "key": "585_CR135", "unstructured": "Xu H, Li J, Song S, Xiao Z, Chen X, Huang B, et al. Effective inhibition of coronavirus replication by Polygonum cuspidatum. Front Biosci (Landmark Ed). 2021;26:789–98.", "volume": "26", "year": "2021" }, { "DOI": "10.1111/ijcp.13535", "author": "MA Marinella", "doi-asserted-by": "publisher", "journal-title": "Int J Clin Pract Suppl", "key": "585_CR136", "unstructured": "Marinella MA. Indomethacin and resveratrol as potential treatment adjuncts for SARS-CoV-2/COVID-19. Int J Clin Pract Suppl. 2020;74: e13535.", "volume": "74", "year": "2020" }, { "DOI": "10.1038/s41598-022-13920-9", "author": "MR McCreary", "doi-asserted-by": "publisher", "first-page": "10978", "journal-title": "Sci Rep", "key": "585_CR137", "unstructured": "McCreary MR, Schnell PM, Rhoda DA. Randomized double-blind placebo-controlled proof-of-concept trial of resveratrol for outpatient treatment of mild coronavirus disease (COVID-19). Sci Rep. 2022;12:10978.", "volume": "12", "year": "2022" }, { "DOI": "10.1016/j.pharmthera.2020.107613", "author": "S Filardo", "doi-asserted-by": "publisher", "journal-title": "Pharmacol Ther", "key": "585_CR138", "unstructured": "Filardo S, Di Pietro M, Mastromarino P, Sessa R. Therapeutic potential of resveratrol against emerging respiratory viral infections. Pharmacol Ther. 2020;214: 107613.", "volume": "214", "year": "2020" }, { "DOI": "10.1016/j.obmed.2020.100317", "author": "A AbdelMassih", "doi-asserted-by": "publisher", "journal-title": "Obes Med", "key": "585_CR139", "unstructured": "AbdelMassih A, Yacoub E, Husseiny RJ, Kamel A, Hozaien R, El Shershaby M, et al. Hypoxia-inducible factor (HIF): the link between obesity and COVID-19. Obes Med. 2021;22: 100317.", "volume": "22", "year": "2021" }, { "DOI": "10.1002/ptr.6956", "author": "T Hoang", "doi-asserted-by": "publisher", "first-page": "2269", "journal-title": "Phytother Res", "key": "585_CR140", "unstructured": "Hoang T. An approach of fatty acids and resveratrol in the prevention of COVID-19 severity. Phytother Res. 2021;35:2269.", "volume": "35", "year": "2021" }, { "DOI": "10.1016/j.ejim.2021.04.019", "author": "F Angeli", "doi-asserted-by": "publisher", "first-page": "1", "journal-title": "Eur J Intern Med", "key": "585_CR141", "unstructured": "Angeli F, Spanevello A, Reboldi G, Visca D, Verdecchia P. SARS-CoV-2 vaccines: lights and shadows. Eur J Intern Med. 2021;88:1–8.", "volume": "88", "year": "2021" }, { "DOI": "10.1002/ptr.7294", "author": "M Hassaniazad", "doi-asserted-by": "publisher", "first-page": "6417", "journal-title": "Phytother Res", "key": "585_CR142", "unstructured": "Hassaniazad M, Eftekhar E, Inchehsablagh BR, Kamali H, Tousi A, Jaafari MR, et al. A triple-blind, placebo-controlled, randomized clinical trial to evaluate the effect of curcumin-containing nanomicelles on cellular immune responses subtypes and clinical outcome in COVID-19 patients. Phytother Res. 2021;35:6417–27.", "volume": "35", "year": "2021" }, { "DOI": "10.1089/vim.2006.19.147", "author": "D Bruder", "doi-asserted-by": "publisher", "first-page": "147", "journal-title": "Viral Immunol", "key": "585_CR143", "unstructured": "Bruder D, Srikiatkhachorn A, Enelow RI. Cellular immunity and lung injury in respiratory virus infection. Viral Immunol. 2006;19:147–55.", "volume": "19", "year": "2006" }, { "DOI": "10.1016/j.tmaid.2020.101623", "author": "AJ Rodriguez-Morales", "doi-asserted-by": "publisher", "journal-title": "Travel Med Infect Dis", "key": "585_CR144", "unstructured": "Rodriguez-Morales AJ, Cardona-Ospina JA, Gutiérrez-Ocampo E, Villamizar-Peña R, Holguin-Rivera Y, Escalera-Antezana JP, et al. Clinical, laboratory and imaging features of COVID-19: a systematic review and meta-analysis. Travel Med Infect Dis. 2020;34: 101623.", "volume": "34", "year": "2020" }, { "DOI": "10.1016/j.ctcp.2020.101256", "author": "M Djalali", "doi-asserted-by": "publisher", "journal-title": "Complement Ther Clin Pract", "key": "585_CR145", "unstructured": "Djalali M, Abdolahi M, Hosseini R, Miraghajani M, Mohammadi H, Djalali M. The effects of nano-curcumin supplementation on Th1/Th17 balance in migraine patients: a randomized controlled clinical trial. Complement Ther Clin Pract. 2020;41: 101256.", "volume": "41", "year": "2020" }, { "DOI": "10.1016/j.lfs.2020.119010", "author": "S Meidaninikjeh", "doi-asserted-by": "publisher", "journal-title": "Life Sci", "key": "585_CR146", "unstructured": "Meidaninikjeh S, Sabouni N, Marzouni HZ, Bengar S, Khalili A, Jafari R. Monocytes and macrophages in COVID-19: friends and foes. Life Sci. 2021;269: 119010.", "volume": "269", "year": "2021" }, { "DOI": "10.1172/jci.insight.147413", "author": "L MacDonald", "doi-asserted-by": "publisher", "issue": "13", "journal-title": "JCI Insight", "key": "585_CR147", "unstructured": "MacDonald L, Alivernini S, Tolusso B, Elmesmari A, Somma D, Perniola S, et al. COVID-19 and RA share an SPP1 myeloid pathway that drives PD-L1+ neutrophils and CD14+ monocytes. JCI Insight. 2021;6(13): e147413.", "volume": "6", "year": "2021" }, { "DOI": "10.3390/vaccines9050436", "author": "AA Rabaan", "doi-asserted-by": "publisher", "first-page": "436", "journal-title": "Vaccines", "key": "585_CR148", "unstructured": "Rabaan AA, Al-Ahmed SH, Muhammad J, Khan A, Sule AA, Tirupathi R, et al. Role of inflammatory cytokines in COVID-19 patients: a review on molecular mechanisms, immune functions, immunopathology and immunomodulatory drugs to counter cytokine storm. Vaccines. 2021;9:436.", "volume": "9", "year": "2021" }, { "DOI": "10.1016/j.heliyon.2021.e06350", "author": "RK Thimmulappa", "doi-asserted-by": "publisher", "journal-title": "Heliyon", "key": "585_CR149", "unstructured": "Thimmulappa RK, Mudnakudu-Nagaraju KK, Shivamallu C, Subramaniam KT, Radhakrishnan A, Bhojraj S, et al. Antiviral and immunomodulatory activity of curcumin: a case for prophylactic therapy for COVID-19. Heliyon. 2021;7: e06350.", "volume": "7", "year": "2021" }, { "DOI": "10.1002/ptr.6916", "author": "M Yang", "doi-asserted-by": "publisher", "first-page": "1127", "issue": "3", "journal-title": "Phytother Res", "key": "585_CR150", "unstructured": "Yang M, Wei J, Huang T, Lei L, Shen C, Lai J, et al. Resveratrol inhibits the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in cultured vero cells. Phytother Res. 2021;35(3):1127–9.", "volume": "35", "year": "2021" }, { "DOI": "10.3390/antiox11020294", "author": "R Ungarala", "doi-asserted-by": "publisher", "first-page": "294", "journal-title": "Antioxidants", "key": "585_CR151", "unstructured": "Ungarala R, Munikumar M, Sinha SN, Kumar D, Sunder RS, Challa S. Assessment of antioxidant, immunomodulatory activity of oxidised Epigallocatechin-3-Gallate (green tea polyphenol) and its action on the main protease of SARS-CoV-2—an in vitro and in silico approach. Antioxidants. 2022;11:294.", "volume": "11", "year": "2022" }, { "DOI": "10.1016/j.aimed.2020.07.007", "author": "M Aucoin", "doi-asserted-by": "publisher", "first-page": "247", "journal-title": "Adv Integr Med", "key": "585_CR152", "unstructured": "Aucoin M, Cooley K, Saunders PR, Cardozo V, Remy D, Cramer H, et al. The effect of quercetin on the prevention or treatment of COVID-19 and other respiratory tract infections in humans: a rapid review. Adv Integr Med. 2020;7:247–51.", "volume": "7", "year": "2020" }, { "DOI": "10.1016/j.jnutbio.2018.12.005", "author": "A Mohammadi", "doi-asserted-by": "publisher", "first-page": "1", "journal-title": "J Nutr Biochem", "key": "585_CR153", "unstructured": "Mohammadi A, Blesso ChN, Barreto GE, Banach M, Majeed M, Sahebkar A. Macrophage plasticity, polarization and function in response to curcumin, a diet-derived polyphenol, as an immunomodulatory agent. J Nutr Biochem. 2019;66:1–19.", "volume": "66", "year": "2019" }, { "DOI": "10.1016/j.jpha.2021.09.009", "author": "SH Manjunath", "doi-asserted-by": "publisher", "first-page": "29", "journal-title": "J Pharm Anal", "key": "585_CR154", "unstructured": "Manjunath SH, Thimmulappa RK. Antiviral, immunomodulatory, and anticoagulant effects of quercetin and its derivatives: potential role in prevention and management of COVID-19. J Pharm Anal. 2022;12:29–34.", "volume": "12", "year": "2022" }, { "DOI": "10.1016/j.biopha.2020.109946", "author": "Y-S Chai", "doi-asserted-by": "publisher", "first-page": "109946", "journal-title": "Biomed Pharmacother", "key": "585_CR155", "unstructured": "Chai Y-S, Chen Y-Q, Lin S-H, Xie K, Wang C-J, Yang Y-Z, et al. Curcumin regulates the differentiation of naïve CD4+T cells and activates IL-10 immune modulation against acute lung injury in mice. Biomed Pharmacother. 2020;125:109946.", "volume": "125", "year": "2020" }, { "DOI": "10.18632/oncotarget.24788", "author": "U Saqib", "doi-asserted-by": "publisher", "first-page": "17937", "journal-title": "Oncotarget", "key": "585_CR156", "unstructured": "Saqib U, Sarkar S, Suk K, Mohammad O, Baig MS, Savai R. Phytochemicals as modulators of M1–M2 macrophages in inflammation. Oncotarget. 2018;9:17937.", "volume": "9", "year": "2018" }, { "DOI": "10.1016/j.jnutbio.2019.03.009", "author": "L Zhang", "doi-asserted-by": "publisher", "first-page": "19", "journal-title": "J Nutr Biochem", "key": "585_CR157", "unstructured": "Zhang L, Virgous C, Si H. Synergistic anti-inflammatory effects and mechanisms of combined phytochemicals. J Nutr Biochem. 2019;69:19–30.", "volume": "69", "year": "2019" }, { "DOI": "10.1007/s10741-018-09764-z", "author": "AA Momtazi-Borojeni", "doi-asserted-by": "publisher", "first-page": "399", "journal-title": "Heart Fail Rev", "key": "585_CR158", "unstructured": "Momtazi-Borojeni AA, Abdollahi E, Nikfar B, Chaichian S, Ekhlasi-Hundrieser M. Curcumin as a potential modulator of M1 and M2 macrophages: new insights in atherosclerosis therapy. Heart Fail Rev. 2019;24:399–409.", "volume": "24", "year": "2019" }, { "DOI": "10.1002/jcb.23411", "author": "JM Zingg", "doi-asserted-by": "publisher", "first-page": "833", "journal-title": "J Cell Biochem", "key": "585_CR159", "unstructured": "Zingg JM, Hasan ST, Cowan D, Ricciarelli R, Azzi A, Meydani M. Regulatory effects of curcumin on lipid accumulation in monocytes/macrophages. J Cell Biochem. 2012;113:833–40.", "volume": "113", "year": "2012" }, { "DOI": "10.1016/j.nutres.2012.11.010", "author": "S-M Lee", "doi-asserted-by": "publisher", "first-page": "136", "journal-title": "Nutr Res", "key": "585_CR160", "unstructured": "Lee S-M, Moon J, Cho Y, Chung JH, Shin M-J. Quercetin up-regulates expressions of peroxisome proliferator-activated receptor γ, liver X receptor α, and ATP binding cassette transporter A1 genes and increases cholesterol efflux in human macrophage cell line. Nutr Res. 2013;33:136–43.", "volume": "33", "year": "2013" }, { "DOI": "10.1002/ptr.6467", "author": "A Karimi", "doi-asserted-by": "publisher", "first-page": "2798", "journal-title": "Phytother Res", "key": "585_CR161", "unstructured": "Karimi A, Ghodsi R, Kooshki F, Karimi M, Asghariazar V, Tarighat-Esfanjani A. Therapeutic effects of curcumin on sepsis and mechanisms of action: a systematic review of preclinical studies. Phytother Res. 2019;33:2798–820.", "volume": "33", "year": "2019" }, { "DOI": "10.1016/j.cellimm.2016.08.011", "author": "S Bhaskar", "doi-asserted-by": "publisher", "first-page": "131", "journal-title": "Cell Immunol", "key": "585_CR162", "unstructured": "Bhaskar S, Sudhakaran P, Helen A. Quercetin attenuates atherosclerotic inflammation and adhesion molecule expression by modulating TLR-NF-κB signaling pathway. Cell Immunol. 2016;310:131–40.", "volume": "310", "year": "2016" }, { "author": "Y Zhong", "first-page": "1856", "journal-title": "Exp Ther Med", "key": "585_CR163", "unstructured": "Zhong Y, Liu C, Feng J, Li JF, Fan ZC. Curcumin affects ox-LDL-induced IL-6, TNF-α, MCP-1 secretion and cholesterol efflux in THP-1 cells by suppressing the TLR4/NF-κB/miR33a signaling pathway. Exp Ther Med. 2020;20:1856–70.", "volume": "20", "year": "2020" }, { "DOI": "10.1006/phrs.1998.0404", "author": "Y Abe", "doi-asserted-by": "publisher", "first-page": "41", "journal-title": "Pharmacol Res", "key": "585_CR164", "unstructured": "Abe Y, Hashimoto SHU, Horie T, Abe Y, Hashimoto SH, Horie T. Curcumin inhibition of inflammatory cytokine production by human peripheral blood monocytes and alveolar macrophages. Pharmacol Res. 1999;39:41–7.", "volume": "39", "year": "1999" }, { "DOI": "10.1111/jfbc.14093", "doi-asserted-by": "crossref", "key": "585_CR165", "unstructured": "Naeini F, Tutunchi H, Razmi H, Mahmoodpoor A, Vajdi M, Sefidmooye Azar P, et al. Does nano‐curcumin supplementation improve hematological indices in critically ill patients with sepsis? A randomized controlled clinical trial. J Food Biochem. 2022:e14093." }, { "DOI": "10.3390/molecules27082376", "author": "E Domi", "doi-asserted-by": "publisher", "first-page": "2376", "journal-title": "Molecules", "key": "585_CR166", "unstructured": "Domi E, Hoxha M, Kolovani E, Tricarico D, Zappacosta B. The importance of nutraceuticals in COVID-19: What’s the role of resveratrol? Molecules. 2022;27:2376.", "volume": "27", "year": "2022" }, { "DOI": "10.1002/mnfr.201400819", "author": "L Chen", "doi-asserted-by": "publisher", "first-page": "853", "journal-title": "Mol Nutr Food Res", "key": "585_CR167", "unstructured": "Chen L, Yang S, Zumbrun EE, Guan H, Nagarkatti PS, Nagarkatti M. Resveratrol attenuates lipopolysaccharide-induced acute kidney injury by suppressing inflammation driven by macrophages. Mol Nutr Food Res. 2015;59:853–64.", "volume": "59", "year": "2015" }, { "DOI": "10.1371/journal.pone.0171139", "author": "ES Lovelace", "doi-asserted-by": "publisher", "journal-title": "PLoS ONE", "key": "585_CR168", "unstructured": "Lovelace ES, Maurice NJ, Miller HW, Slichter CK, Harrington R, Magaret A, et al. Silymarin suppresses basal and stimulus-induced activation, exhaustion, differentiation, and inflammatory markers in primary human immune cells. PLoS ONE. 2017;12: e0171139.", "volume": "12", "year": "2017" }, { "DOI": "10.3390/biology10030206", "author": "P Alarcon", "doi-asserted-by": "publisher", "first-page": "206", "journal-title": "Biology", "key": "585_CR169", "unstructured": "Alarcon P, Espinosa G, Millan C, Saravia J, Quinteros V, Enriquez R, et al. Piscirickettsia salmonis-triggered extracellular traps formation as an innate immune response of Atlantic salmon-derived polymorphonuclear neutrophils. Biology. 2021;10:206.", "volume": "10", "year": "2021" }, { "DOI": "10.1097/SHK.0000000000001740", "author": "S-N Cui", "doi-asserted-by": "publisher", "first-page": "345", "journal-title": "Shock (Augusta, GA)", "key": "585_CR170", "unstructured": "Cui S-N, Tan H-Y, Fan G-C. Immunopathological roles of neutrophils in virus infection and COVID-19. Shock (Augusta, GA). 2021;56:345.", "volume": "56", "year": "2021" }, { "DOI": "10.1016/j.thromres.2004.06.020", "author": "NC Kaneider", "doi-asserted-by": "publisher", "first-page": "185", "journal-title": "Thromb Res", "key": "585_CR171", "unstructured": "Kaneider NC, Mosheimer B, Reinisch N, Patsch JR, Wiedermann CJ. Inhibition of thrombin-induced signaling by resveratrol and quercetin: effects on adenosine nucleotide metabolism in endothelial cells and platelet–neutrophil interactions. Thromb Res. 2004;114:185–94.", "volume": "114", "year": "2004" }, { "DOI": "10.1016/j.freeradbiomed.2019.09.021", "author": "YF Tsai", "doi-asserted-by": "publisher", "first-page": "67", "journal-title": "Free Radic Biol Med", "key": "585_CR172", "unstructured": "Tsai YF, Chen CY, Chang WY, Syu YT, Hwang TL. Resveratrol suppresses neutrophil activation via inhibition of Src family kinases to attenuate lung injury. Free Radic Biol Med. 2019;145:67–77.", "volume": "145", "year": "2019" }, { "DOI": "10.1371/journal.pone.0255608", "author": "R Littera", "doi-asserted-by": "publisher", "journal-title": "PLoS ONE", "key": "585_CR173", "unstructured": "Littera R, Chessa L, Deidda S, Angioni G, Campagna M, Lai S, et al. Natural killer-cell immunoglobulin-like receptors trigger differences in immune response to SARS-CoV-2 infection. PLoS ONE. 2021;16: e0255608.", "volume": "16", "year": "2021" }, { "DOI": "10.1016/j.jbior.2020.100737", "author": "E Masselli", "doi-asserted-by": "publisher", "journal-title": "Adv Biol Regul", "key": "585_CR174", "unstructured": "Masselli E, Vaccarezza M, Carubbi C, Pozzi G, Presta V, Mirandola P, et al. NK cells: a double edge sword against SARS-CoV-2. Adv Biol Regul. 2020;77: 100737.", "volume": "77", "year": "2020" }, { "DOI": "10.3390/molecules26195803", "author": "R Bernini", "doi-asserted-by": "publisher", "first-page": "5803", "journal-title": "Molecules", "key": "585_CR175", "unstructured": "Bernini R, Velotti F. Natural polyphenols as immunomodulators to rescue immune response homeostasis: Quercetin as a research model against severe COVID-19. Molecules. 2021;26:5803.", "volume": "26", "year": "2021" }, { "DOI": "10.1158/1535-7163.MCT-09-0377", "author": "MA Bill", "doi-asserted-by": "publisher", "first-page": "2726", "journal-title": "Mol Cancer Ther", "key": "585_CR176", "unstructured": "Bill MA, Bakan C, Benson DM, Fuchs J, Young G, Lesinski GB. Curcumin induces proapoptotic effects against human melanoma cells and modulates the cellular response to immunotherapeutic cytokines. Mol Cancer Ther. 2009;8:2726–35.", "volume": "8", "year": "2009" }, { "DOI": "10.3390/antiox10091440", "doi-asserted-by": "crossref", "key": "585_CR177", "unstructured": "Liao M-T, Wu C-C, Wu S-FV, Lee M-C, Hu W-C, Tsai K-W, et al. Resveratrol as an adjunctive therapy for excessive oxidative stress in aging COVID-19 patients. Antioxidants. 2021;10:1440." }, { "DOI": "10.3746/jkfn.2015.44.3.307", "author": "Y Ha", "doi-asserted-by": "publisher", "first-page": "307", "journal-title": "J Korean Soc Food Sci Nutr", "key": "585_CR178", "unstructured": "Ha Y, Kim O-K, Nam D-E, Kim Y, Kim E, Jun W, et al. Effects of Curcuma longa L. extracts on natural killer cells and T cells. J Korean Soc Food Sci Nutr. 2015;44:307–13.", "volume": "44", "year": "2015" }, { "author": "P Meroni", "first-page": "177", "journal-title": "Int J Tissue React", "key": "585_CR179", "unstructured": "Meroni P, Barcellini W, Borghi M, Vismara A, Ferraro G, Ciani D, et al. Silybin inhibition of human T-lymphocyte activation. Int J Tissue React. 1988;10:177–81.", "volume": "10", "year": "1988" }, { "DOI": "10.15414/jmbfs.2020.9.4.836-843", "author": "V Valková", "doi-asserted-by": "publisher", "first-page": "836", "journal-title": "J Microbiol Biotechnol Food Sci", "key": "585_CR180", "unstructured": "Valková V, Ďúranová H, Bilčíková J. Milk thistle (Silybum marianum): a valuable medicinal plant with several therapeutic purposes. J Microbiol Biotechnol Food Sci. 2020;9:836.", "volume": "9", "year": "2020" }, { "DOI": "10.1016/j.clim.2020.108486", "author": "J Urra", "doi-asserted-by": "publisher", "journal-title": "Clin Immunol", "key": "585_CR181", "unstructured": "Urra J, Cabrera C, Porras L, Ródenas I. Selective CD8 cell reduction by SARS-CoV-2 is associated with a worse prognosis and systemic inflammation in COVID-19 patients. Clin Immunol. 2020;217: 108486.", "volume": "217", "year": "2020" }, { "DOI": "10.1002/cyto.a.22348", "author": "L Cosmi", "doi-asserted-by": "publisher", "first-page": "36", "journal-title": "Cytometry A", "key": "585_CR182", "unstructured": "Cosmi L, Maggi L, Santarlasci V, Liotta F, Annunziato F. T helper cells plasticity in inflammation. Cytometry A. 2014;85:36–42.", "volume": "85", "year": "2014" }, { "DOI": "10.1016/j.intimp.2017.11.013", "author": "Y Yang", "doi-asserted-by": "publisher", "first-page": "153", "journal-title": "Int Immunopharmacol", "key": "585_CR183", "unstructured": "Yang Y, Zhang X, Xu M, Wu X, Zhao F, Zhao C. Quercetin attenuates collagen-induced arthritis by restoration of Th17/Treg balance and activation of Heme Oxygenase 1-mediated anti-inflammatory effect. Int Immunopharmacol. 2018;54:153–62.", "volume": "54", "year": "2018" }, { "DOI": "10.2174/18755666MTEwoMDkm0", "author": "S Bastaminejad", "doi-asserted-by": "publisher", "first-page": "385", "journal-title": "Curr Mol Med", "key": "585_CR184", "unstructured": "Bastaminejad S, Bakhtiyari S. Quercetin and its relative therapeutic potential against COVID-19: a retrospective review and prospective overview. Curr Mol Med. 2021;21:385–91.", "volume": "21", "year": "2021" }, { "DOI": "10.1016/j.intimp.2008.10.015", "author": "TJ Imler Jr", "doi-asserted-by": "publisher", "first-page": "134", "journal-title": "Int Immunopharmacol", "key": "585_CR185", "unstructured": "Imler TJ Jr, Petro TM. Decreased severity of experimental autoimmune encephalomyelitis during resveratrol administration is associated with increased IL-17+ IL-10+ T cells, CD4− IFN-γ+ cells, and decreased macrophage IL-6 expression. Int Immunopharmacol. 2009;9:134–43.", "volume": "9", "year": "2009" }, { "DOI": "10.1016/j.phrs.2019.104353", "author": "R Shafabakhsh", "doi-asserted-by": "publisher", "journal-title": "Pharmacol Res", "key": "585_CR186", "unstructured": "Shafabakhsh R, Pourhanifeh MH, Mirzaei HR, Sahebkar A, Asemi Z, Mirzaei H. Targeting regulatory T cells by curcumin: a potential for cancer immunotherapy. Pharmacol Res. 2019;147: 104353.", "volume": "147", "year": "2019" }, { "DOI": "10.4103/2221-1691.319567", "author": "MR Khazdair", "doi-asserted-by": "publisher", "first-page": "327", "journal-title": "Asian Pac J Trop Biomed", "key": "585_CR187", "unstructured": "Khazdair MR, Anaeigoudari A, Agbor GA. Anti-viral and anti-inflammatory effects of kaempferol and quercetin and COVID-2019: a scoping review. Asian Pac J Trop Biomed. 2021;11:327–34.", "volume": "11", "year": "2021" }, { "DOI": "10.1016/j.ejphar.2017.12.003", "author": "S-H Kim", "doi-asserted-by": "publisher", "first-page": "53", "journal-title": "Eur J Pharmacol", "key": "585_CR188", "unstructured": "Kim S-H, Saba E, Kim B-K, Yang W-K, Park Y-C, Shin HJ, et al. Luteolin attenuates airway inflammation by inducing the transition of CD4+ CD25–to CD4+ CD25+ regulatory T cells. Eur J Pharmacol. 2018;820:53–64.", "volume": "820", "year": "2018" }, { "DOI": "10.18311/jnr/2016/4782", "author": "HR Sodagari", "doi-asserted-by": "publisher", "first-page": "60", "journal-title": "J Nat Remed", "key": "585_CR189", "unstructured": "Sodagari HR, Bahramsoltani R, Farzaei MH, Abdolghaffari AH, Rezaei N, Taylor-Robinson AW. Tea polyphenols as natural products for potential future management of HIV infection-an overview. J Nat Remed. 2016;16:60–72.", "volume": "16", "year": "2016" }, { "DOI": "10.1016/j.jaci.2008.12.024", "author": "CL Nance", "doi-asserted-by": "publisher", "first-page": "459", "journal-title": "J Allergy Clin Immunol", "key": "585_CR190", "unstructured": "Nance CL, Siwak EB, Shearer WT. Preclinical development of the green tea catechin, epigallocatechin gallate, as an HIV-1 therapy. J Allergy Clin Immunol. 2009;123:459–65.", "volume": "123", "year": "2009" }, { "DOI": "10.4049/jimmunol.177.2.896", "author": "AG Jarnicki", "doi-asserted-by": "publisher", "first-page": "896", "journal-title": "J Immunol", "key": "585_CR191", "unstructured": "Jarnicki AG, Lysaght J, Todryk S, Mills KH. Suppression of antitumor immunity by IL-10 and TGF-β-producing T cells infiltrating the growing tumor: influence of tumor environment on the induction of CD4+ and CD8+ regulatory T cells. J Immunol. 2006;177:896–904.", "volume": "177", "year": "2006" }, { "DOI": "10.1016/j.intimp.2007.12.006", "author": "Y Yang", "doi-asserted-by": "publisher", "first-page": "542", "journal-title": "Int Immunopharmacol", "key": "585_CR192", "unstructured": "Yang Y, Paik JH, Cho D, Cho J-A, Kim C-W. Resveratrol induces the suppression of tumor-derived CD4+CD25+ regulatory T cells. Int Immunopharmacol. 2008;8:542–7.", "volume": "8", "year": "2008" }, { "DOI": "10.1016/j.biopha.2020.109946", "author": "Y-S Chai", "doi-asserted-by": "publisher", "first-page": "109946", "journal-title": "Biomed Pharmacother", "key": "585_CR193", "unstructured": "Chai Y-S, Chen Y-Q, Lin S-H, Xie K, Wang C-J, Yang Y-Z, et al. Curcumin regulates the differentiation of naïve CD4+ T cells and activates IL-10 immune modulation against acute lung injury in mice. Biomed Pharmacother. 2020;125:109946.", "volume": "125", "year": "2020" }, { "DOI": "10.1016/j.imbio.2020.151929", "author": "J Michalski", "doi-asserted-by": "publisher", "journal-title": "Immunobiology", "key": "585_CR194", "unstructured": "Michalski J, Deinzer A, Stich L, Zinser E, Steinkasserer A, Knippertz I. Quercetin induces an immunoregulatory phenotype in maturing human dendritic cells. Immunobiology. 2020;225: 151929.", "volume": "225", "year": "2020" }, { "DOI": "10.4049/jimmunol.174.12.8116", "author": "G-Y Kim", "doi-asserted-by": "publisher", "first-page": "8116", "journal-title": "J Immunol", "key": "585_CR195", "unstructured": "Kim G-Y, Kim K-H, Lee S-H, Yoon M-S, Lee H-J, Moon D-O, et al. Curcumin inhibits immunostimulatory function of dendritic cells: MAPKs and translocation of NF-κB as potential targets. J Immunol. 2005;174:8116–24.", "volume": "174", "year": "2005" }, { "DOI": "10.1016/j.drudis.2021.01.014", "author": "P VasanthiDharmalingam", "doi-asserted-by": "publisher", "first-page": "1265", "journal-title": "Drug Discov Today", "key": "585_CR196", "unstructured": "VasanthiDharmalingam P, Karuppagounder V, Watanabe K, Karmouty-Quintana H, Palaniyandi SS, Guha A, et al. SARS–CoV-2 mediated hyperferritinemia and cardiac arrest: preliminary insights. Drug Discov Today. 2021;26:1265.", "volume": "26", "year": "2021" }, { "DOI": "10.4155/fmc-2021-0111", "author": "P Prasher", "doi-asserted-by": "publisher", "first-page": "681", "issue": "10", "journal-title": "Future Med Chem", "key": "585_CR197", "unstructured": "Prasher P, Sharma M. Targeting mucin hypersecretion in COVID-19 therapy. Future Med Chem. 2022;14(10):681–4.", "volume": "14", "year": "2022" }, { "DOI": "10.2147/JIR.S271292", "author": "MA Khan", "doi-asserted-by": "publisher", "first-page": "175", "journal-title": "J Inflamm Res", "key": "585_CR198", "unstructured": "Khan MA, Khan ZA, Charles M, Pratap P, Naeem A, Siddiqui Z, et al. Cytokine storm and mucus hypersecretion in COVID-19: review of mechanisms. J Inflamm Res. 2021;14:175.", "volume": "14", "year": "2021" }, { "DOI": "10.1128/mBio.00398-20", "author": "DS Fedson", "doi-asserted-by": "publisher", "first-page": "e00398", "journal-title": "MBio", "key": "585_CR199", "unstructured": "Fedson DS, Opal SM, Rordam OM. Hiding in plain sight: an approach to treating patients with severe COVID-19 infection. MBio. 2020;11:e00398-e420.", "volume": "11", "year": "2020" }, { "DOI": "10.3389/fphar.2017.00618", "author": "Y Liang", "doi-asserted-by": "publisher", "first-page": "618", "journal-title": "Front Pharmacol", "key": "585_CR200", "unstructured": "Liang Y, Liu KWK, Yeung SC, Li X, Ip MSM, Mak JCW. (−)-Epigallocatechin-3-gallate reduces cigarette smoke-induced airway neutrophilic inflammation and mucin hypersecretion in rats. Front Pharmacol. 2017;8:618.", "volume": "8", "year": "2017" }, { "DOI": "10.1016/j.intimp.2012.07.008", "author": "N Li", "doi-asserted-by": "publisher", "first-page": "195", "journal-title": "Int Immunopharmacol", "key": "585_CR201", "unstructured": "Li N, Li Q, Zhou XD, Kolosov VP, Perelman JM. The effect of quercetin on human neutrophil elastase-induced mucin5AC expression in human airway epithelial cells. Int Immunopharmacol. 2012;14:195–201.", "volume": "14", "year": "2012" }, { "DOI": "10.4103/0366-6999.235863", "author": "X-P Lin", "doi-asserted-by": "publisher", "first-page": "1686", "journal-title": "Chin Med J", "key": "585_CR202", "unstructured": "Lin X-P, Xue C, Zhang J-M, Wu W-J, Chen X-Y, Zeng Y-M, et al. Curcumin inhibits lipopolysaccharide-induced mucin 5AC hypersecretion and airway inflammation via nuclear factor erythroid 2-related factor 2. Chin Med J. 2018;131:1686–93.", "volume": "131", "year": "2018" }, { "DOI": "10.1155/2019/4927430", "author": "T Zhu", "doi-asserted-by": "publisher", "first-page": "4927430", "journal-title": "Mediat Inflamm", "key": "585_CR203", "unstructured": "Zhu T, Chen Z, Chen G, Wang D, Tang S, Deng H, et al. Curcumin attenuates asthmatic airway inflammation and mucus hypersecretion involving a PPAR<i>γ</i>-dependent NF-<i>κ</i>B signaling pathway in vivo and in vitro. Mediat Inflamm. 2019;2019:4927430.", "volume": "2019", "year": "2019" }, { "DOI": "10.1038/nrmicro2090", "author": "L Du", "doi-asserted-by": "publisher", "first-page": "226", "journal-title": "Nat Rev Microbiol", "key": "585_CR204", "unstructured": "Du L, He Y, Zhou Y, Liu S, Zheng B-J, Jiang S. The spike protein of SARS-CoV—a target for vaccine and therapeutic development. Nat Rev Microbiol. 2009;7:226–36.", "volume": "7", "year": "2009" }, { "DOI": "10.1006/viro.2000.0757", "author": "TM Gallagher", "doi-asserted-by": "publisher", "first-page": "371", "journal-title": "Virology", "key": "585_CR205", "unstructured": "Gallagher TM, Buchmeier MJ. Coronavirus spike proteins in viral entry and pathogenesis. Virology. 2001;279:371–4.", "volume": "279", "year": "2001" }, { "DOI": "10.1128/JVI.77.16.8801-8811.2003", "author": "BJ Bosch", "doi-asserted-by": "publisher", "first-page": "8801", "journal-title": "J Virol", "key": "585_CR206", "unstructured": "Bosch BJ, Van der Zee R, De Haan CA, Rottier PJ. The coronavirus spike protein is a class I virus fusion protein: structural and functional characterization of the fusion core complex. J Virol. 2003;77:8801–11.", "volume": "77", "year": "2003" }, { "DOI": "10.1128/JVI.78.20.11334-11339.2004", "author": "L Yi", "doi-asserted-by": "publisher", "first-page": "11334", "journal-title": "J Virol", "key": "585_CR207", "unstructured": "Yi L, Li Z, Yuan K, Qu X, Chen J, Wang G, et al. Small molecules blocking the entry of severe acute respiratory syndrome coronavirus into host cells. J Virol. 2004;78:11334–9.", "volume": "78", "year": "2004" }, { "DOI": "10.3389/fphar.2022.902626", "author": "Q Shao", "doi-asserted-by": "publisher", "journal-title": "Front pharmacol", "key": "585_CR208", "unstructured": "Shao Q, Liu T, Wang W, Liu T, Jin X, Chen Z. Promising role of emodin as therapeutics to against viral infections. Front pharmacol. 2022;13: 902626.", "volume": "13", "year": "2022" }, { "DOI": "10.1016/j.ejphar.2020.173348", "author": "CA Omolo", "doi-asserted-by": "publisher", "journal-title": "Eur J Pharmacol", "key": "585_CR209", "unstructured": "Omolo CA, Soni N, Fasiku VO, Mackraj I, Govender T. Update on therapeutic approaches and emerging therapies for SARS-CoV-2 virus. Eur J Pharmacol. 2020;883: 173348.", "volume": "883", "year": "2020" }, { "DOI": "10.1016/j.antiviral.2006.04.014", "author": "T-Y Ho", "doi-asserted-by": "publisher", "first-page": "92", "journal-title": "Antivir Res", "key": "585_CR210", "unstructured": "Ho T-Y, Wu S-L, Chen J-C, Li C-C, Hsiang C-Y. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction. Antivir Res. 2007;74:92–101.", "volume": "74", "year": "2007" }, { "DOI": "10.1007/s13205-020-02578-7", "author": "S Hiremath", "doi-asserted-by": "publisher", "first-page": "1", "journal-title": "3 Biotech", "key": "585_CR211", "unstructured": "Hiremath S, Kumar H, Nandan M, Mantesh M, Shankarappa K, Venkataravanappa V, et al. In silico docking analysis revealed the potential of phytochemicals present in Phyllanthus amarus and Andrographis paniculata, used in Ayurveda medicine in inhibiting SARS-CoV-2. 3 Biotech. 2021;11:1–8.", "volume": "11", "year": "2021" }, { "DOI": "10.3390/antiox9080742", "author": "P Bellavite", "doi-asserted-by": "publisher", "first-page": "742", "issue": "8", "journal-title": "Antioxidants", "key": "585_CR212", "unstructured": "Bellavite P, Donzelli A. Hesperidin and SARS-CoV-2: new light on the healthy function of citrus fruits. Antioxidants. 2020;9(8):742.", "volume": "9", "year": "2020" }, { "DOI": "10.1016/j.matpr.2021.05.595", "author": "R Davella", "doi-asserted-by": "publisher", "first-page": "522", "journal-title": "Mater Today Proc", "key": "585_CR213", "unstructured": "Davella R, Gurrapu S, Mamidala E. Phenolic compounds as promising drug candidates against COVID-19-an integrated molecular docking and dynamics simulation study. Mater Today Proc. 2022;51:522–7.", "volume": "51", "year": "2022" }, { "DOI": "10.1186/s43094-020-00150-x", "author": "M Haridas", "doi-asserted-by": "crossref", "first-page": "1", "journal-title": "Future J Pharm Sci", "key": "585_CR214", "unstructured": "Haridas M, Sasidhar V, Nath P, Abhithaj J, Sabu A, Rammanohar P. Compounds of Citrus medica and Zingiber officinale for COVID-19 inhibition: in silico evidence for cues from Ayurveda. Future J Pharm Sci. 2021;7:1–9.", "volume": "7", "year": "2021" }, { "DOI": "10.1016/j.apsb.2020.02.008", "author": "C Wu", "doi-asserted-by": "publisher", "first-page": "766", "journal-title": "Acta Pharm Sin B", "key": "585_CR215", "unstructured": "Wu C, Liu Y, Yang Y, Zhang P, Zhong W, Wang Y, et al. Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods. Acta Pharm Sin B. 2020;10:766–88.", "volume": "10", "year": "2020" }, { "DOI": "10.12688/f1000research.25076.1", "author": "A Ubani", "doi-asserted-by": "publisher", "first-page": "1157", "journal-title": "F1000Research.", "key": "585_CR216", "unstructured": "Ubani A, Agwom F, Morenikeji OR, Shehu NY, Umera EA, Umar U, et al. Molecular docking analysis of selected phytochemicals on two SARS-CoV-2 targets. F1000Research. 2020;9:1157.", "volume": "9", "year": "2020" }, { "DOI": "10.1155/2020/6307457", "author": "TE Tallei", "doi-asserted-by": "publisher", "first-page": "6307457", "journal-title": "Scientifica", "key": "585_CR217", "unstructured": "Tallei TE, Tumilaar SG, Niode NJ, Kepel BJ, Idroes R, Effendi Y, et al. Potential of plant bioactive compounds as SARS-CoV-2 main protease (Mpro) and spike (S) glycoprotein inhibitors: a molecular docking study. Scientifica. 2020;2020:6307457.", "volume": "2020", "year": "2020" }, { "DOI": "10.1038/nature02145", "author": "W Li", "doi-asserted-by": "publisher", "first-page": "450", "journal-title": "Nature", "key": "585_CR218", "unstructured": "Li W, Moore MJ, Vasilieva N, Sui J, Wong SK, Berne MA, et al. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature. 2003;426:450–4.", "volume": "426", "year": "2003" }, { "DOI": "10.1161/01.RES.87.5.e1", "author": "M Donoghue", "doi-asserted-by": "publisher", "first-page": "e1", "journal-title": "Circ Res", "key": "585_CR219", "unstructured": "Donoghue M, Hsieh F, Baronas E, Godbout K, Gosselin M, Stagliano N, et al. A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1–9. Circ Res. 2000;87:e1–9.", "volume": "87", "year": "2000" }, { "DOI": "10.1016/j.lfs.2020.118275", "author": "V Parvathaneni", "doi-asserted-by": "publisher", "journal-title": "Life Sci", "key": "585_CR220", "unstructured": "Parvathaneni V, Gupta V. Utilizing drug repurposing against COVID-19—efficacy, limitations, and challenges. Life Sci. 2020;259: 118275.", "volume": "259", "year": "2020" }, { "DOI": "10.1038/s41598-021-81462-7", "author": "AB Jena", "doi-asserted-by": "publisher", "first-page": "2043", "journal-title": "Sci Rep", "key": "585_CR221", "unstructured": "Jena AB, Kanungo N, Nayak V, Chainy GB, Dandapat J. Catechin and curcumin interact with S protein of SARS-CoV2 and ACE2 of human cell membrane: insights from computational studies. Sci Rep. 2021;11:2043.", "volume": "11", "year": "2021" }, { "DOI": "10.1016/j.atherosclerosis.2018.01.043", "author": "EN Kim", "doi-asserted-by": "publisher", "first-page": "123", "journal-title": "Atherosclerosis", "key": "585_CR222", "unstructured": "Kim EN, Kim MY, Lim JH, Kim Y, Shin SJ, Park CW, et al. The protective effect of resveratrol on vascular aging by modulation of the renin–angiotensin system. Atherosclerosis. 2018;270:123–31.", "volume": "270", "year": "2018" }, { "DOI": "10.1002/ptr.6738", "author": "F Zahedipour", "doi-asserted-by": "publisher", "first-page": "2911", "journal-title": "Phytother Res", "key": "585_CR223", "unstructured": "Zahedipour F, Hosseini SA, Sathyapalan T, Majeed M, Jamialahmadi T, Al-Rasadi K, et al. Potential effects of curcumin in the treatment of COVID-19 infection. Phytother Res. 2020;34:2911–20.", "volume": "34", "year": "2020" }, { "DOI": "10.1016/j.fbio.2021.100891", "author": "T Mehany", "doi-asserted-by": "publisher", "journal-title": "Food Biosci", "key": "585_CR224", "unstructured": "Mehany T, Khalifa I, Barakat H, Althwab SA, Alharbi YM, El-Sohaimy S. Polyphenols as promising biologically active substances for preventing SARS-CoV-2: a review with research evidence and underlying mechanisms. Food Biosci. 2021;40: 100891.", "volume": "40", "year": "2021" }, { "DOI": "10.1007/s13238-013-2841-3", "author": "Z Ren", "doi-asserted-by": "publisher", "first-page": "248", "journal-title": "Protein Cell", "key": "585_CR225", "unstructured": "Ren Z, Yan L, Zhang N, Guo Y, Yang C, Lou Z, et al. The newly emerged SARS-like coronavirus HCoV-EMC also has an\" Achilles’ heel\": current effective inhibitor targeting a 3C-like protease. Protein Cell. 2013;4:248–50.", "volume": "4", "year": "2013" }, { "DOI": "10.1126/science.abb4489", "author": "W Dai", "doi-asserted-by": "publisher", "first-page": "1331", "journal-title": "Science", "key": "585_CR226", "unstructured": "Dai W, Zhang B, Jiang X-M, Su H, Li J, Zhao Y, et al. Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease. Science. 2020;368:1331–5.", "volume": "368", "year": "2020" }, { "DOI": "10.1038/s41586-020-2223-y", "author": "Z Jin", "doi-asserted-by": "publisher", "first-page": "289", "journal-title": "Nature", "key": "585_CR227", "unstructured": "Jin Z, Du X, Xu Y, Deng Y, Liu M, Zhao Y, et al. Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors. Nature. 2020;582:289–93.", "volume": "582", "year": "2020" }, { "DOI": "10.1016/j.cofs.2020.08.004", "author": "IL Paraiso", "doi-asserted-by": "publisher", "first-page": "149", "journal-title": "Curr Opin Food Sci", "key": "585_CR228", "unstructured": "Paraiso IL, Revel JS, Stevens JF. Potential use of polyphenols in the battle against COVID-19. Curr Opin Food Sci. 2020;32:149–55.", "volume": "32", "year": "2020" }, { "DOI": "10.1016/j.bmc.2012.07.038", "author": "J-Y Park", "doi-asserted-by": "publisher", "first-page": "5928", "journal-title": "Bioorg Med Chem", "key": "585_CR229", "unstructured": "Park J-Y, Kim JH, Kim YM, Jeong HJ, Kim DW, Park KH, et al. Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases. Bioorg Med Chem. 2012;20:5928–35.", "volume": "20", "year": "2012" }, { "DOI": "10.1080/07391102.2020.1777901", "author": "NA Murugan", "doi-asserted-by": "publisher", "first-page": "4415", "journal-title": "J Biomol Struct Dyn", "key": "585_CR230", "unstructured": "Murugan NA, Pandian CJ, Jeyakanthan J. Computational investigation on Andrographis paniculata phytochemicals to evaluate their potency against SARS-CoV-2 in comparison to known antiviral compounds in drug trials. J Biomol Struct Dyn. 2021;39:4415–26.", "volume": "39", "year": "2021" }, { "DOI": "10.3109/14756366.2012.753591", "author": "DW Kim", "doi-asserted-by": "publisher", "first-page": "59", "journal-title": "J Enzyme Inhib Med Chem", "key": "585_CR231", "unstructured": "Kim DW, Seo KH, Curtis-Long MJ, Oh KY, Oh J-W, Cho JK, et al. Phenolic phytochemical displaying SARS-CoV papain-like protease inhibition from the seeds of Psoralea corylifolia. J Enzyme Inhib Med Chem. 2014;29:59–63.", "volume": "29", "year": "2014" }, { "DOI": "10.1080/14756366.2016.1265519", "author": "J-Y Park", "doi-asserted-by": "publisher", "first-page": "504", "journal-title": "J Enzyme Inhib Med Chem", "key": "585_CR232", "unstructured": "Park J-Y, Yuk HJ, Ryu HW, Lim SH, Kim KS, Park KH, et al. Evaluation of polyphenols from Broussonetia papyrifera as coronavirus protease inhibitors. J Enzyme Inhib Med Chem. 2017;32:504–12.", "volume": "32", "year": "2017" }, { "DOI": "10.1007/s10529-011-0845-8", "author": "TTH Nguyen", "doi-asserted-by": "publisher", "first-page": "831", "journal-title": "Biotechnol Lett", "key": "585_CR233", "unstructured": "Nguyen TTH, Woo H-J, Kang H-K, Nguyen VD, Kim Y-M, Kim D-W, et al. Flavonoid-mediated inhibition of SARS coronavirus 3C-like protease expressed in Pichia pastoris. Biotechnol Lett. 2012;34:831–8.", "volume": "34", "year": "2012" }, { "DOI": "10.1248/bpb.b14-00026", "author": "YH Song", "doi-asserted-by": "publisher", "first-page": "1021", "journal-title": "Biol Pharm Bull", "key": "585_CR234", "unstructured": "Song YH, Kim DW, Curtis-Long MJ, Yuk HJ, Wang Y, Zhuang N, et al. Papain-like protease (PLpro) inhibitory effects of cinnamic amides from Tribulus terrestris fruits. Biol Pharm Bull. 2014;37:1021–8.", "volume": "37", "year": "2014" }, { "DOI": "10.1248/bpb.b12-00623", "author": "J-Y Park", "doi-asserted-by": "publisher", "first-page": "2036", "journal-title": "Biol Pharm Bull", "key": "585_CR235", "unstructured": "Park J-Y, Jeong HJ, Kim JH, Kim YM, Park S-J, Kim D, et al. Diarylheptanoids from Alnus japonica inhibit papain-like protease of severe acute respiratory syndrome coronavirus. Biol Pharm Bull. 2012;35:2036–42.", "volume": "35", "year": "2012" }, { "author": "S Das", "first-page": "3347", "journal-title": "J Biomol Struct Dyn", "key": "585_CR236", "unstructured": "Das S, Sarmah S, Lyndem S, Singha RA. An investigation into the identification of potential inhibitors of SARS-CoV-2 main protease using molecular docking study. J Biomol Struct Dyn. 2021;39:3347–57.", "volume": "39", "year": "2021" }, { "DOI": "10.3109/14756366.2014.1003215", "author": "J-Y Park", "doi-asserted-by": "publisher", "first-page": "23", "journal-title": "J Enzyme Inhib Med Chem", "key": "585_CR237", "unstructured": "Park J-Y, Ko J-A, Kim DW, Kim YM, Kwon H-J, Jeong HJ, et al. Chalcones isolated from Angelica keiskei inhibit cysteine proteases of SARS-CoV. J Enzyme Inhib Med Chem. 2016;31:23–30.", "volume": "31", "year": "2016" }, { "DOI": "10.1080/07391102.2020.1779818", "author": "R Ghosh", "doi-asserted-by": "publisher", "first-page": "4362", "journal-title": "J Biomol Struct Dyn", "key": "585_CR238", "unstructured": "Ghosh R, Chakraborty A, Biswas A, Chowdhuri S. Evaluation of green tea polyphenols as novel corona virus (SARS CoV-2) main protease (Mpro) inhibitors—an in silico docking and molecular dynamics simulation study. J Biomol Struct Dyn. 2021;39:4362–74.", "volume": "39", "year": "2021" }, { "DOI": "10.3389/fphar.2022.830205", "author": "M Mbikay", "doi-asserted-by": "publisher", "journal-title": "Front pharmacol", "key": "585_CR239", "unstructured": "Mbikay M, Chrétien M. Isoquercetin as an anti-covid-19 medication: a potential to realize. Front pharmacol. 2022;13: 830205.", "volume": "13", "year": "2022" }, { "DOI": "10.1016/0006-2952(83)90262-9", "author": "B Havsteen", "doi-asserted-by": "publisher", "first-page": "1141", "journal-title": "Biochem Pharmacol", "key": "585_CR240", "unstructured": "Havsteen B. Flavonoids, a class of natural products of high pharmacological potency. Biochem Pharmacol. 1983;32:1141–8.", "volume": "32", "year": "1983" }, { "DOI": "10.3390/medicina56080386", "author": "ME Soto", "doi-asserted-by": "publisher", "first-page": "386", "journal-title": "Medicina", "key": "585_CR241", "unstructured": "Soto ME, Guarner-Lans V, Soria-Castro E, Manzano Pech L, Pérez-Torres I. Is antioxidant therapy a useful complementary measure for covid-19 treatment? An algorithm for its application. Medicina. 2020;56:386.", "volume": "56", "year": "2020" }, { "DOI": "10.1111/j.1742-4658.2005.04888.x", "author": "CP Wu", "doi-asserted-by": "publisher", "first-page": "4725", "journal-title": "FEBS J", "key": "585_CR242", "unstructured": "Wu CP, Calcagno AM, Hladky SB, Ambudkar SV, Barrand MA. Modulatory effects of plant phenols on human multidrug-resistance proteins 1, 4 and 5 (ABCC1, 4 and 5). FEBS J. 2005;272:4725–40.", "volume": "272", "year": "2005" }, { "DOI": "10.1021/acs.jproteome.0c00392", "author": "M Chien", "doi-asserted-by": "publisher", "first-page": "4690", "journal-title": "J Proteome Res", "key": "585_CR243", "unstructured": "Chien M, Anderson TK, Jockusch S, Tao C, Li X, Kumar S, et al. Nucleotide analogues as inhibitors of SARS-CoV-2 polymerase, a key drug target for COVID-19. J Proteome Res. 2020;19:4690–7.", "volume": "19", "year": "2020" }, { "DOI": "10.1080/07391102.2020.1796810", "author": "S Singh", "doi-asserted-by": "publisher", "first-page": "6249", "journal-title": "J Biomol Struct Dyn", "key": "585_CR244", "unstructured": "Singh S, Sk MF, Sonawane A, Kar P, Sadhukhan S. Plant-derived natural polyphenols as potential antiviral drugs against SARS-CoV-2 via RNA-dependent RNA polymerase (RdRp) inhibition: an in-silico analysis. J Biomol Struct Dyn. 2021;39:6249–64.", "volume": "39", "year": "2021" }, { "DOI": "10.1177/11779322211027403", "author": "K Pandey", "doi-asserted-by": "publisher", "first-page": "117793222110274", "journal-title": "Bioinform Biol Insights", "key": "585_CR245", "unstructured": "Pandey K, Lokhande KB, Swamy KV, Nagar S, Dake M. In silico exploration of phytoconstituents from Phyllanthus emblica and Aegle marmelos as potential therapeutics against SARS-CoV-2 RdRp. Bioinform Biol Insights. 2021;15:11779322211027404.", "volume": "15", "year": "2021" }, { "DOI": "10.3390/v10090465", "author": "K Morán-Santibañez", "doi-asserted-by": "publisher", "first-page": "465", "journal-title": "Viruses", "key": "585_CR246", "unstructured": "Morán-Santibañez K, Peña-Hernández MA, Cruz-Suárez LE, Ricque-Marie D, Skouta R, Vasquez AH, et al. Virucidal and synergistic activity of polyphenol-rich extracts of seaweeds against measles virus. Viruses. 2018;10:465.", "volume": "10", "year": "2018" }, { "DOI": "10.1126/science.897670", "author": "M Brugh Jr", "doi-asserted-by": "publisher", "first-page": "1291", "journal-title": "Science", "key": "585_CR247", "unstructured": "Brugh M Jr. Butylated hydroxytoluene protects chickens exposed to Newcastle disease virus. Science. 1977;197:1291–2.", "volume": "197", "year": "1977" }, { "DOI": "10.1002/mnfr.201700447", "author": "S Andres", "doi-asserted-by": "publisher", "first-page": "1700447", "journal-title": "Mol Nutr Food Res", "key": "585_CR248", "unstructured": "Andres S, Pevny S, Ziegenhagen R, Bakhiya N, Schäfer B, Hirsch-Ernst KI, et al. Safety aspects of the use of quercetin as a dietary supplement. Mol Nutr Food Res. 2018;62:1700447.", "volume": "62", "year": "2018" }, { "DOI": "10.1155/2020/9723686", "author": "J Ouyang", "doi-asserted-by": "publisher", "first-page": "9723686", "journal-title": "Oxid Med Cell Longev", "key": "585_CR249", "unstructured": "Ouyang J, Zhu K, Liu Z, Huang J. Prooxidant effects of epigallocatechin-3-gallate in health benefits and potential adverse effect. Oxid Med Cell Longev. 2020;2020:9723686.", "volume": "2020", "year": "2020" }, { "DOI": "10.1016/j.taap.2006.11.024", "author": "CS Yang", "doi-asserted-by": "publisher", "first-page": "265", "journal-title": "Toxicol Appl Pharmacol", "key": "585_CR250", "unstructured": "Yang CS, Lambert JD, Ju J, Lu G, Sang S. Tea and cancer prevention: molecular mechanisms and human relevance. Toxicol Appl Pharmacol. 2007;224:265–73.", "volume": "224", "year": "2007" } ], "reference-count": 250, "references-count": 250, "relation": {}, "resource": { "primary": { "URL": "https://link.springer.com/10.1007/s43440-024-00585-6" } }, "score": 1, "short-title": [], "source": "Crossref", "subject": [ "Pharmacology", "General Medicine" ], "subtitle": [], "title": "Effect of polyphenols against complications of COVID-19: current evidence and potential efficacy", "type": "journal-article", "update-policy": "http://dx.doi.org/10.1007/springer_crossmark_policy" }

Download Image

Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.

Submit

Post

@CovidAnalysis

FAQ

Public domain CC0 1.0