Quercetin: A Functional Food-Flavonoid Incredibly Attenuates Emerging and Re-Emerging Viral Infections through Immunomodulatory Actions
Shorobi et al.,
Quercetin: A Functional Food-Flavonoid Incredibly Attenuates Emerging and Re-Emerging Viral Infections through..,
Molecules, doi:10.3390/molecules28030938 (Review)
Review of the antiviral properties of quercetin and derivatives, and potential mechanisms of action.
Shorobi et al., 17 Jan 2023, peer-reviewed, 7 authors.
Contact:
atiar@cu.ac.bd (corresponding author).
Abstract: molecules
Review
Quercetin: A Functional Food-Flavonoid Incredibly Attenuates
Emerging and Re-Emerging Viral Infections through
Immunomodulatory Actions
Fauzia Mahanaz Shorobi 1 , Fatema Yasmin Nisa 3 , Srabonti Saha 3 , Muhammad Abid Hasan Chowdhury 4 ,
Mayuna Srisuphanunt 2 , Kazi Helal Hossain 5 and Md. Atiar Rahman 2,3, *
1
2
3
4
5
*
Citation: Shorobi, F.M.; Nisa, F.Y.;
Saha, S.; Chowdhury, M.A.H.;
Srisuphanunt, M.; Hossain, K.H.;
Rahman, M.A. Quercetin: A
Functional Food-Flavonoid
Incredibly Attenuates Emerging and
Re-Emerging Viral Infections through
Immunomodulatory Actions.
Molecules 2023, 28, 938.
https://doi.org/10.3390/
molecules28030938
Academic Editor: Jolanta Sereikaitė
Received: 11 December 2022
Department of Environmental and Biological Chemistry, Chungbuk National University,
Cheongju 28644, Republic of Korea
School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat 80160, Thailand
Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong 4331, Bangladesh
Bangladesh Tea Research Institute, Sreemangal-3210, Moulvibazar District, Sylhet 3100, Bangladesh
Department of Neuroscience, Lerner Research Institute, Cleveland Clinic, 9620 Carnegie Avenue,
Cleveland, OH 44195, USA
Correspondence: atiar@cu.ac.bd
Abstract: Many of the medicinally active molecules in the flavonoid class of phytochemicals are being
researched for their potential antiviral activity against various DNA and RNA viruses. Quercetin is
a flavonoid that can be found in a variety of foods, including fruits and vegetables. It has been
reported to be effective against a variety of viruses. This review, therefore, deciphered the mechanistic
of how Quercetin works against some of the deadliest viruses, such as influenza A, Hepatitis C,
Dengue type 2 and Ebola virus, which cause frequent outbreaks worldwide and result in significant
morbidity and mortality in humans through epidemics or pandemics. All those have an alarming
impact on both human health and the global and national economies. The review extended computing
the Quercetin-contained natural recourse and its modes of action in different experimental approaches
leading to antiviral actions. The gap in effective treatment emphasizes the necessity of a search for
new effective antiviral compounds. Quercetin shows potential antiviral activity and inhibits it by
targeting viral infections at multiple stages. The suppression of viral neuraminidase, proteases and
DNA/RNA polymerases and the alteration of many viral proteins as well as their immunomodulation
are the main molecular mechanisms of Quercetin’s antiviral activities. Nonetheless, the huge potential
of Quercetin and its extensive use is inadequately approached as a therapeutic for emerging and
re-emerging viral infections. Therefore, this review enumerated the food-functioned Quercetin source,
the modes of action of Quercetin for antiviral effects and made insights on the mechanism-based
antiviral action of Quercetin.
Keywords: quercetin; antiviral action; flavonoid; SARS-CoV-2; Dengue; Ebola; influenza; hepatitis C
virus; mechanisms; medicinal plant
Revised: 5 January 2023
Accepted: 10 January 2023
Published: 17 January 2023
Please send us corrections, updates, or comments. Vaccines and
treatments are complementary. All practical, effective, and safe means should
be used based on risk/benefit analysis. No treatment, vaccine, or intervention
is 100% available and effective for all current and future variants. We do not
provide medical advice. Before taking any medication, consult a qualified
physician who can provide personalized advice and details of risks and
benefits based on your medical history and situation.
FLCCC and
WCH
provide treatment protocols.
Submit