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Quercetin: A Functional Food-Flavonoid Incredibly Attenuates Emerging and Re-Emerging Viral Infections through Immunomodulatory Actions

Shorobi et al., Molecules, doi:10.3390/molecules28030938
Jan 2023  
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Quercetin for COVID-19
22nd treatment shown to reduce risk in July 2021
 
*, now with p = 0.0031 from 11 studies.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 77 treatments. c19early.org
Review of the antiviral properties of quercetin and derivatives, and potential mechanisms of action.
Reviews covering quercetin for COVID-19 include1-17.
Shorobi et al., 17 Jan 2023, peer-reviewed, 7 authors. Contact: atiar@cu.ac.bd (corresponding author).
This PaperQuercetinAll
Quercetin: A Functional Food-Flavonoid Incredibly Attenuates Emerging and Re-Emerging Viral Infections through Immunomodulatory Actions
Fauzia Mahanaz Shorobi, Fatema Yasmin Nisa, Srabonti Saha, Muhammad Abid Hasan Chowdhury, Mayuna Srisuphanunt, Kazi Helal Hossain, Md. Atiar Rahman
Molecules, doi:10.3390/molecules28030938
Many of the medicinally active molecules in the flavonoid class of phytochemicals are being researched for their potential antiviral activity against various DNA and RNA viruses. Quercetin is a flavonoid that can be found in a variety of foods, including fruits and vegetables. It has been reported to be effective against a variety of viruses. This review, therefore, deciphered the mechanistic of how Quercetin works against some of the deadliest viruses, such as influenza A, Hepatitis C, Dengue type 2 and Ebola virus, which cause frequent outbreaks worldwide and result in significant morbidity and mortality in humans through epidemics or pandemics. All those have an alarming impact on both human health and the global and national economies. The review extended computing the Quercetin-contained natural recourse and its modes of action in different experimental approaches leading to antiviral actions. The gap in effective treatment emphasizes the necessity of a search for new effective antiviral compounds. Quercetin shows potential antiviral activity and inhibits it by targeting viral infections at multiple stages. The suppression of viral neuraminidase, proteases and DNA/RNA polymerases and the alteration of many viral proteins as well as their immunomodulation are the main molecular mechanisms of Quercetin's antiviral activities. Nonetheless, the huge potential of Quercetin and its extensive use is inadequately approached as a therapeutic for emerging and re-emerging viral infections. Therefore, this review enumerated the food-functioned Quercetin source, the modes of action of Quercetin for antiviral effects and made insights on the mechanism-based antiviral action of Quercetin.
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This review, ' 'therefore, deciphered the mechanistic of how Quercetin works against some of the deadliest ' 'viruses, such as influenza A, Hepatitis C, Dengue type 2 and Ebola virus, which cause ' 'frequent outbreaks worldwide and result in significant morbidity and mortality in humans ' 'through epidemics or pandemics. All those have an alarming impact on both human health and ' 'the global and national economies. The review extended computing the Quercetin-contained ' 'natural recourse and its modes of action in different experimental approaches leading to ' 'antiviral actions. The gap in effective treatment emphasizes the necessity of a search for ' 'new effective antiviral compounds. Quercetin shows potential antiviral activity and inhibits ' 'it by targeting viral infections at multiple stages. The suppression of viral neuraminidase, ' 'proteases and DNA/RNA polymerases and the alteration of many viral proteins as well as their ' 'immunomodulation are the main molecular mechanisms of Quercetin’s antiviral activities. ' 'Nonetheless, the huge potential of Quercetin and its extensive use is inadequately approached ' 'as a therapeutic for emerging and re-emerging viral infections. Therefore, this review ' 'enumerated the food-functioned Quercetin source, the modes of action of Quercetin for ' 'antiviral effects and made insights on the mechanism-based antiviral action of ' 'Quercetin.</jats:p>', 'DOI': '10.3390/molecules28030938', 'type': 'journal-article', 'created': {'date-parts': [[2023, 1, 18]], 'date-time': '2023-01-18T08:04:44Z', 'timestamp': 1674029084000}, 'page': '938', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Quercetin: A Functional Food-Flavonoid Incredibly Attenuates Emerging and Re-Emerging Viral ' 'Infections through Immunomodulatory Actions', 'prefix': '10.3390', 'volume': '28', 'author': [ { 'given': 'Fauzia Mahanaz', 'family': 'Shorobi', 'sequence': 'first', 'affiliation': [ { 'name': 'Department of Environmental and Biological Chemistry, Chungbuk ' 'National University, Cheongju 28644, Republic of Korea'}]}, { 'given': 'Fatema Yasmin', 'family': 'Nisa', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Biochemistry and Molecular Biology, University of ' 'Chittagong, Chittagong 4331, Bangladesh'}]}, { 'ORCID': 'http://orcid.org/0000-0002-8844-345X', 'authenticated-orcid': False, 'given': 'Srabonti', 'family': 'Saha', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Biochemistry and Molecular Biology, University of ' 'Chittagong, Chittagong 4331, Bangladesh'}]}, { 'ORCID': 'http://orcid.org/0000-0003-4601-1074', 'authenticated-orcid': False, 'given': 'Muhammad Abid Hasan', 'family': 'Chowdhury', 'sequence': 'additional', 'affiliation': [ { 'name': 'Bangladesh Tea Research Institute, Sreemangal-3210, Moulvibazar ' 'District, Sylhet 3100, Bangladesh'}]}, { 'ORCID': 'http://orcid.org/0000-0002-7421-4410', 'authenticated-orcid': False, 'given': 'Mayuna', 'family': 'Srisuphanunt', 'sequence': 'additional', 'affiliation': [ { 'name': 'School of Allied Health Sciences, Walailak University, Nakhon Si ' 'Thammarat 80160, Thailand'}]}, { 'given': 'Kazi Helal', 'family': 'Hossain', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Neuroscience, Lerner Research Institute, Cleveland ' 'Clinic, 9620 Carnegie Avenue, Cleveland, OH 44195, USA'}]}, { 'ORCID': 'http://orcid.org/0000-0002-4902-8923', 'authenticated-orcid': False, 'given': 'Md. Atiar', 'family': 'Rahman', 'sequence': 'additional', 'affiliation': [ { 'name': 'School of Allied Health Sciences, Walailak University, Nakhon Si ' 'Thammarat 80160, Thailand'}, { 'name': 'Department of Biochemistry and Molecular Biology, University of ' 'Chittagong, Chittagong 4331, Bangladesh'}]}], 'member': '1968', 'published-online': {'date-parts': [[2023, 1, 17]]}, 'reference': [ { 'key': 'ref_1', 'doi-asserted-by': 'crossref', 'unstructured': 'Campos, F.S., de Arruda, L.B., and da Fonseca, F.G. (2022). Special ' 'Issue “Viral Infections in Developing Countries”. Viruses, 14.', 'DOI': '10.3390/v14020405'}, { 'key': 'ref_2', 'doi-asserted-by': 'crossref', 'first-page': '732891', 'DOI': '10.3389/fphar.2021.732891', 'article-title': 'A Review of Medicinal Plants with Antiviral Activity Available in ' 'Bangladesh and Mechanistic Insight Into Their Bioactive Metabolites on ' 'SARS-CoV-2, HIV and HBV', 'volume': '12', 'author': 'Bachar', 'year': '2021', 'journal-title': 'Front. 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