The pharmacological mechanism of quercetin as adjuvant therapy of COVID-19
Review of in silico and clinical evidence supporting the use of quercetin for COVID-19.
Rizky et al., 15 May 2022, peer-reviewed, 5 authors.
Abstract: Life Research
doi: 10.53388/life2022-0202-302
Life Research
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01
Life Research
doi: 10.53388/life2022-0202-302
Review
The pharmacological mechanism of quercetin as
adjuvant therapy of COVID-19
Wahyu Choirur Rizky
Mushtaq
1
, Muhammad Candragupta Jihwaprani
1
, Avicena Al Kindi1, Arif Nur Muhammad Ansori
2
, Mazhar
3*
Abstract
The emergence of novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused the global outbreak and
major public health concern. After the outbreak human-to-human transmission was confirmed with or without symptoms of
upper and lower respiratory tract involvement. Up to date, there has been evidence that COVID-19 is beyond that of a typical pulmonary disease and revealing pathomechanics of COVID-19-associated acute respiratory distress syndrome (CARDS),
which include severe inflammation and pulmonary edema leading to impaired alveolar homeostasis, and resulting in an alteration of lung physiology, lung fibrosis, inflammation of endothelium, vascular thrombosis, as well as exaggerated immune response. Concerning this pathophysiology, the use of quercetin as phytotherapeutic may merit in the management of COVID-19
patients. In this review, the authors wish to elaborate on the molecular effect of quercetin on SARS-CoV-2 by giving a detailed
mechanism of quercetin against the binding of the S-protein of the virus to angiotensin-converting enzyme 2 (ACE2) receptors, the main protease (Mpro) or 3C-like protease (3CLpro), papain-like protease (PLpro), and RNA-dependent RNA polymerase
(RdRP). Recent clinical evidence supporting the use of quercetin in COVID-19 management is also discussed in this paper.
Keywords: Quercetin; phytotherapeutic; COVID-19; antiviral; anti-inflammatory; anti-fibrosis
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