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Bioactive compounds,quercetin, curcumin and β-glucan,regulate innate immunity via the gut-liver-brain axis

Duan et al., Trends in Food Science & Technology, doi:10.1016/j.tifs.2024.104864
Dec 2024  
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Quercetin for COVID-19
24th treatment shown to reduce risk in July 2021, now with p = 0.002 from 12 studies.
No treatment is 100% effective. Protocols combine treatments.
5,200+ studies for 112 treatments. c19early.org
Review of how bioactive compounds quercetin, curcumin, and β-glucan regulate innate immunity through the gut-liver-brain axis, with focus on COVID-19. Authors describe how SARS-CoV-2 infection triggers excessive immune activation and cytokine storm, highlighting the potential benefit of immunomodulatory interventions. The review examines how these three compounds can help regulate innate immunity through multiple mechanisms including enhancing macrophage phagocytosis, inhibiting inflammatory pathways, and maintaining blood-brain barrier integrity. Quercetin is shown to work primarily by inhibiting oxidative stress and modulating the NF-κB pathway, while curcumin acts by inhibiting immune signaling molecules and protecting the blood-brain barrier. β-glucan functions by stimulating TLR4 receptors and activating macrophages while maintaining pro- and anti-inflammatory balance. Authors explain how these compounds work through the gut-liver-brain axis by preventing harmful microbial entry, inhibiting inflammatory nuclear factors through metabolites like short-chain fatty acids, and modulating the intestinal microbiota. Authors emphasize how dietary interventions with these bioactive compounds, naturally found in fruits, vegetables and whole grains, represents a promising strategy for enhancing innate immunity against viral infections like COVID-19.
Reviews covering quercetin for COVID-19 include1-18.
Study covers quercetin and curcumin.
Duan et al., 31 Dec 2024, peer-reviewed, 3 authors.
This PaperQuercetinAll
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'year': '2007', 'journal-title': 'Molecular Targets and Therapeutic Uses of Curcumin in Health and ' 'Disease'}, { 'issue': '5', 'key': '10.1016/j.tifs.2024.104864_bib5', 'article-title': 'Pathogen recognition receptors and innate immunity', 'volume': '20', 'author': 'Akira', 'year': '2013', 'journal-title': 'Xenotransplantation'}, { 'issue': '4', 'key': '10.1016/j.tifs.2024.104864_bib6', 'doi-asserted-by': 'crossref', 'first-page': '783', 'DOI': '10.1016/j.cell.2006.02.015', 'article-title': 'Pathogen recognition and innate immunity', 'volume': '124', 'author': 'Akira', 'year': '2006', 'journal-title': 'Cell'}, { 'issue': '4', 'key': '10.1016/j.tifs.2024.104864_bib7', 'doi-asserted-by': 'crossref', 'first-page': '143', 'DOI': '10.2183/pjab.85.143', 'article-title': 'Pathogen recognition by innate immunity and its signaling', 'volume': '85', 'author': 'Akira', 'year': '2009', 'journal-title': 'Proceedings of the Japan Academy Series B-Physical and Biological ' 'Sciences'}, { 'issue': '20', 'key': '10.1016/j.tifs.2024.104864_bib8', 'doi-asserted-by': 'crossref', 'first-page': '84', 'DOI': '10.4103/0973-7847.194044', 'article-title': 'Overviews of biological importance of quercetin: a bioactive flavonoid', 'volume': '10', 'author': 'Anand David', 'year': '2016', 'journal-title': 'Pharmacognosy Review'}, { 'key': '10.1016/j.tifs.2024.104864_bib9', 'doi-asserted-by': 'crossref', 'first-page': '437', 'DOI': '10.1016/j.neubiorev.2021.07.004', 'article-title': 'The neuroprotective effects of polyphenols, their role in innate ' 'immunity and the interplay with the microbiota', 'volume': '128', 'author': 'Annunziata', 'year': '2021', 'journal-title': 'Neuroscience and Biobehavioral Reviews'}, { 'issue': '5-6', 'key': '10.1016/j.tifs.2024.104864_bib10', 'doi-asserted-by': 'crossref', 'first-page': '593', 'DOI': '10.1007/s10557-017-6752-z', 'article-title': 'Immunity, inflammation, and oxidative stress in heart failure: emerging ' 'molecular targets', 'volume': '31', 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'2010', 'journal-title': 'Annual Review of Immunology'}, { 'issue': '9', 'key': '10.1016/j.tifs.2024.104864_bib17', 'doi-asserted-by': 'crossref', 'first-page': '844', 'DOI': '10.1016/j.molmed.2021.06.007', 'article-title': 'The gut vascular barrier: a new player in the gut-liver-brain axis', 'volume': '27', 'author': 'Brescia', 'year': '2021', 'journal-title': 'Trends in Molecular Medicine'}, { 'issue': '37', 'key': '10.1016/j.tifs.2024.104864_bib18', 'doi-asserted-by': 'crossref', 'first-page': '599', 'DOI': '10.1146/annurev-immunol-042718-041841', 'article-title': 'Gut Microbiota regulation of T cells during inflammation and ' 'autoimmunity', 'volume': '37', 'author': 'Brown', 'year': '2019', 'journal-title': 'Annual Review of Immunology'}, { 'issue': '14', 'key': '10.1016/j.tifs.2024.104864_bib19', 'doi-asserted-by': 'crossref', 'first-page': '153', 'DOI': '10.1146/annurev-pathmechdis-012418-013003', 'article-title': 'Innate immune signaling in nonalcoholic fatty liver disease and ' 'cardiovascular diseases', 'volume': '14', 'author': 'Cai', 'year': '2019', 'journal-title': 'Annual Review of Pathology: Mechanisms of Disease'}, { 'issue': '1', 'key': '10.1016/j.tifs.2024.104864_bib20', 'doi-asserted-by': 'crossref', 'DOI': '10.1080/19490976.2024.2399360', 'article-title': 'Effect of diet on the gut mycobiome and potential implications in ' 'inflammatory bowel disease', 'volume': '16', 'author': 'Buttar', 'year': '2024', 'journal-title': 'Gut Microbes'}, { 'key': '10.1016/j.tifs.2024.104864_bib21', 'doi-asserted-by': 'crossref', 'first-page': '355', 'DOI': '10.1146/annurev-food-062420-124437', 'article-title': 'Hormesis mediates acquired resilience: using plant-derived chemicals to ' 'enhance health', 'volume': '12', 'author': 'Calabrese', 'year': '2021', 'journal-title': 'Annual Review of Food Science and Technology'}, { 'issue': '2', 'key': '10.1016/j.tifs.2024.104864_bib22', 'doi-asserted-by': 'crossref', 'first-page': '424', 'DOI': 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response', 'volume': '28', 'author': 'Chan', 'year': '2021', 'journal-title': 'Reproductive Sciences'}, { 'issue': '1', 'key': '10.1016/j.tifs.2024.104864_bib26', 'doi-asserted-by': 'crossref', 'first-page': '14', 'DOI': '10.1016/j.immuni.2021.12.012', 'article-title': 'Metabolic adaptation of lymphocytes in immunity and disease', 'volume': '55', 'author': 'Chapman', 'year': '2022', 'journal-title': 'Immunity'}, { 'key': '10.1016/j.tifs.2024.104864_bib27', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.ejphar.2023.176161', 'article-title': 'β-glucan, a specific immuno-stimulant, produces rapid antidepressant ' 'effects by stimulating ERK1/2-dependent synthesis of BDNF in the ' 'hippocampus', 'volume': '961', 'author': 'Chen', 'year': '2023', 'journal-title': 'European Journal of Pharmacology'}, { 'key': '10.1016/j.tifs.2024.104864_bib28', 'article-title': 'Effects of cubeba essential oil on growth performance, blood ' 'antioxidation, immune function, apparent digestibility of nutrients, ' 'and fecal microflora of pigs', 'volume': '14', 'author': 'Chen', 'year': '2023', 'journal-title': 'Frontiers in Pharmacology'}, { 'issue': '19', 'key': '10.1016/j.tifs.2024.104864_bib29', 'doi-asserted-by': 'crossref', 'DOI': '10.3390/ijms231911710', 'article-title': 'Research progress on the therapeutic effect of polysaccharides on ' 'non-alcoholic fatty liver disease through the regulation of the ' 'gut-liver axis', 'volume': '23', 'author': 'Chen', 'year': '2022', 'journal-title': 'International Journal of Molecular Sciences'}, { 'key': '10.1016/j.tifs.2024.104864_bib30', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.ejphar.2020.173358', 'article-title': 'Monotropein alleviates secondary liver injury in chronic colitis by ' 'regulating TLR4/NF-κ B signaling and NLRP3 inflammasome', 'volume': '883', 'author': 'Chen', 'year': '2020', 'journal-title': 'European Journal of Pharmacology'}, { 'issue': '10', 'key': '10.1016/j.tifs.2024.104864_bib31', 'doi-asserted-by': 'crossref', 'first-page': '686', 'DOI': '10.1016/j.tem.2018.08.002', 'article-title': 'Nutritional modulation of innate immunity: the fat-bile-gut connection', 'volume': '29', 'author': 'Chevre', 'year': '2018', 'journal-title': 'Trends in Endocrinology and Metabolism'}, { 'key': '10.1016/j.tifs.2024.104864_bib32', 'article-title': 'Serotonin signals through a gut-liver axis to regulate hepatic ' 'steatosis (vol 9, 4824, 2018)', 'volume': '10', 'author': 'Choi', 'year': '2019', 'journal-title': 'Nature Communications'}, { 'issue': '3', 'key': '10.1016/j.tifs.2024.104864_bib33', 'doi-asserted-by': 'crossref', 'first-page': '337', 'DOI': '10.1038/s41423-021-00780-y', 'article-title': 'Impact of intracellular innate immune receptors on immunometabolism', 'volume': '19', 'author': 'Chou', 'year': '2022', 'journal-title': 'Cellular & Molecular Immunology'}, { 'issue': '5', 'key': '10.1016/j.tifs.2024.104864_bib34', 'doi-asserted-by': 'crossref', 'first-page': '794', 'DOI': '10.1016/j.immuni.2019.09.020', 'article-title': 'Western diet and the immune system: an inflammatory connection', 'volume': '51', 'author': 'Christ', 'year': '2019', 'journal-title': 'Immunity'}, { 'issue': '2', 'key': '10.1016/j.tifs.2024.104864_bib35', 'doi-asserted-by': 'crossref', 'first-page': '210', 'DOI': '10.1016/j.immuni.2022.01.004', 'article-title': 'Control of immunity via nutritional interventions', 'volume': '55', 'author': 'Collins', 'year': '2022', 'journal-title': 'Immunity'}, { 'issue': '1', 'key': '10.1016/j.tifs.2024.104864_bib36', 'doi-asserted-by': 'crossref', 'first-page': '306', 'DOI': '10.1002/hep.30866', 'article-title': 'Diagnosis and treatment of alcohol-associated liver diseases: 2019 ' 'practice guidance from the American association for the study of liver ' 'diseases', 'volume': '71', 'author': 'Crabb', 'year': '2020', 'journal-title': 'Hepatology'}, { 'key': '10.1016/j.tifs.2024.104864_bib37', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.redox.2022.102273', 'article-title': 'A randomized placebo-controlled cross-over study on the effects of ' 'anthocyanins on inflammatory and metabolic responses to a high-fat meal ' 'in healthy subjects', 'volume': '51', 'author': 'Cremonini', 'year': '2022', 'journal-title': 'Redox Biology'}, { 'key': '10.1016/j.tifs.2024.104864_bib38', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.scib.2024.10.027', 'article-title': 'Targeting modulation of intestinal flora through oral route by an ' 'antimicrobial nucleic acid-loaded exosome-like nanovesicles to improve ' 'Parkinson s disease', 'author': 'Cui', 'year': '2024', 'journal-title': 'Science Bulletin'}, { 'issue': '7484', 'key': '10.1016/j.tifs.2024.104864_bib39', 'doi-asserted-by': 'crossref', 'first-page': '559', 'DOI': '10.1038/nature12820', 'article-title': 'Diet rapidly and reproducibly alters the human gut microbiome', 'volume': '505', 'author': 'David', 'year': '2014', 'journal-title': 'Nature'}, { 'issue': '4', 'key': '10.1016/j.tifs.2024.104864_bib40', 'doi-asserted-by': 'crossref', 'first-page': '715', 'DOI': '10.1113/JP281830', 'article-title': 'Altered immunometabolism in adipose tissue: A major contributor to the ' 'ageing process?', 'volume': '600', 'author': 'Delaney', 'year': '2022', 'journal-title': 'Journal of Physiology'}, { 'issue': '3', 'key': '10.1016/j.tifs.2024.104864_bib41', 'doi-asserted-by': 'crossref', 'first-page': '437', 'DOI': '10.1016/j.immuni.2021.01.018', 'article-title': 'Autophagy in inflammation, infection, and immunometabolism', 'volume': '54', 'author': 'Deretic', 'year': '2021', 'journal-title': 'Immunity'}, { 'key': '10.1016/j.tifs.2024.104864_bib42', 'doi-asserted-by': 'crossref', 'first-page': '369', 'DOI': '10.1016/j.ijbiomac.2017.12.113', 'article-title': 'Dectin-1 mediates the immunoenhancement effect of the polysaccharide ' 'from Dictyophora indusiata', 'volume': '109', 'author': 'Deng', 'year': '2018', 'journal-title': 'International Journal of Biological Macromolecules'}, { 'issue': '10', 'key': '10.1016/j.tifs.2024.104864_bib43', 'doi-asserted-by': 'crossref', 'DOI': '10.3390/nu11102426', 'article-title': 'Curcumin, gut microbiota, and neuroprotection', 'volume': '11', 'author': 'Di Meo', 'year': '2019', 'journal-title': 'Nutrients'}, { 'issue': '2', 'key': '10.1016/j.tifs.2024.104864_bib44', 'doi-asserted-by': 'crossref', 'first-page': '165', 'DOI': '10.1038/s41590-021-01091-0', 'article-title': 'Innate immunity: the first line of defense against SARS-CoV-2', 'volume': '23', 'author': 'Diamond', 'year': '2022', 'journal-title': 'Nature Immunology'}, { 'issue': '2', 'key': '10.1016/j.tifs.2024.104864_bib45', 'doi-asserted-by': 'crossref', 'first-page': '128', 'DOI': '10.1007/s11904-021-00544-3', 'article-title': 'Gut innate immunity and HIV pathogenesis', 'volume': '18', 'author': 'Dillon', 'year': '2021', 'journal-title': 'Current Hiv/Aids Reports'}, { 'issue': '26', 'key': '10.1016/j.tifs.2024.104864_bib46', 'doi-asserted-by': 'crossref', 'first-page': '34121', 'DOI': '10.1007/s11356-021-14109-9', 'article-title': 'Management of oxidative stress and inflammation in cardiovascular ' 'diseases: mechanisms and challenges', 'volume': '28', 'author': 'Donia', 'year': '2021', 'journal-title': 'Environmental Science Pollution Research'}, { 'key': '10.1016/j.tifs.2024.104864_bib47', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.tifs.2024.104747', 'article-title': 'Structural characteristics and immunomodulatory effects of ' 'polysaccharides extracted from plant seeds: a review', 'volume': '153', 'author': 'Dong', 'year': '2024', 'journal-title': 'Trends in Food Science & Technology'}, { 'key': '10.1016/j.tifs.2024.104864_bib48', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.psyneuen.2020.104673', 'article-title': 'Polyphenols selectively reverse early-life stress-induced behavioural, ' 'neurochemical and microbiota changes in the rat', 'volume': '116', 'author': 'Donoso', 'year': '2020', 'journal-title': 'Psychoneuroendocrinology'}, { 'issue': '1', 'key': '10.1016/j.tifs.2024.104864_bib49', 'doi-asserted-by': 'crossref', 'first-page': '130', 'DOI': '10.1161/CIRCRESAHA.121.319822', 'article-title': 'Inflammation resolution: implications for atherosclerosis', 'volume': '130', 'author': 'Doran', 'year': '2022', 'journal-title': 'Circulation Research'}, { 'issue': '7', 'key': '10.1016/j.tifs.2024.104864_bib50', 'doi-asserted-by': 'crossref', 'first-page': '1459', 'DOI': '10.3945/jn.115.211888', 'article-title': 'Supplementation of the pure flavonoids epicatechin and quercetin ' 'affects some biomarkers of endothelial dysfunction and inflammation in ' '(Pre)hypertensive adults: a randomized double-blind, ' 'placebo-controlled, crossover trial', 'volume': '145', 'author': 'Dower', 'year': '2015', 'journal-title': 'Journal of Nutrition'}, { 'issue': '4', 'key': '10.1016/j.tifs.2024.104864_bib51', 'doi-asserted-by': 'crossref', 'DOI': '10.1111/cns.14489', 'article-title': 'A 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'10.1016/j.tifs.2024.104864_bib54', 'doi-asserted-by': 'crossref', 'first-page': '826', 'DOI': '10.7326/M20-2504', 'article-title': 'Eat even more vegetables and fruits to protect your heart', 'volume': '172', 'author': 'Estruch', 'year': '2020', 'journal-title': 'Annals of Internal Medicine'}, { 'key': '10.1016/j.tifs.2024.104864_bib55', 'doi-asserted-by': 'crossref', 'first-page': '32', 'DOI': '10.1016/j.imlet.2020.11.009', 'article-title': 'Neuroimmune communication in infection and pain: Friends or foes?', 'volume': '229', 'author': 'Fattori', 'year': '2021', 'journal-title': 'Immunology Letters'}, { 'key': '10.1016/j.tifs.2024.104864_bib56', 'doi-asserted-by': 'crossref', 'first-page': '79', 'DOI': '10.1186/s12986-019-0410-3', 'article-title': 'Curcumin prevents high-fat diet-induced hepatic steatosis in ApoE(-/-) ' 'mice by improving intestinal barrier function and reducing endotoxin ' 'and liver TLR4/NF-κB inflammation', 'volume': '16', 'author': 'Feng', 'year': '2019', 'journal-title': 'Nutrion Metabolism (Lond)'}, { 'key': '10.1016/j.tifs.2024.104864_bib57', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.pestbp.2024.106066', 'article-title': 'Quercetin alleviates difenoconazole-induced growth inhibition in carp ' 'through intestinal-brain axis', 'volume': '204', 'author': 'Feng', 'year': '2024', 'journal-title': 'Pesticide Biochemistry and Physiology'}, { 'issue': '1', 'key': '10.1016/j.tifs.2024.104864_bib58', 'doi-asserted-by': 'crossref', 'first-page': '10', 'DOI': '10.1016/j.tem.2007.10.004', 'article-title': 'Innate immunity, insulin resistance and type 2 diabetes', 'volume': '19', 'author': 'Fernandez-Real', 'year': '2008', 'journal-title': 'Trends in Endocrinology and Metabolism'}, { 'issue': '12', 'key': '10.1016/j.tifs.2024.104864_bib59', 'doi-asserted-by': 'crossref', 'first-page': '1061', 'DOI': '10.1016/0278-6915(95)00077-1', 'article-title': 'Review of the biology of quercetin and related bioflavonoids', 'volume': '33', 'author': 'Formica', 'year': '1995', 'journal-title': 'Food and Chemical Toxicology'}, { 'key': '10.1016/j.tifs.2024.104864_bib60', 'doi-asserted-by': 'crossref', 'first-page': '38', 'DOI': '10.1111/j.1600-065X.2009.00793.x', 'article-title': 'β-glucan recognition by the innate immune system', 'volume': '230', 'author': 'Goodridge', 'year': '2009', 'journal-title': 'Immunological Reviews'}, { 'key': '10.1016/j.tifs.2024.104864_bib61', 'doi-asserted-by': 'crossref', 'first-page': '50', 'DOI': '10.1016/j.redox.2017.01.023', 'article-title': 'Redox regulation in metabolic programming and inflammation', 'volume': '12', 'author': 'Griffiths', 'year': '2017', 'journal-title': 'Redox Biology'}, { 'issue': '2', 'key': '10.1016/j.tifs.2024.104864_bib62', 'first-page': '270', 'article-title': 'Resveratrol protects dopaminergic neurons in a mouse model of ' "Parkinson's disease by regulating the gut-brain axis via inhibiting the " 'TLR4 signaling pathway', 'volume': '44', 'author': 'Gui', 'year': '2024', 'journal-title': 'Journal of Southern Medical University'}, { 'issue': '5', 'key': '10.1016/j.tifs.2024.104864_bib63', 'doi-asserted-by': 'crossref', 'first-page': '929', 'DOI': '10.1002/cpt.1870', 'article-title': 'The microbiome and the gut-liver-brain axis for central nervous system ' 'clinical pharmacology: challenges in specifying and integrating in ' 'vitro and in silico models', 'volume': '108', 'author': 'Hawkins', 'year': '2020', 'journal-title': 'Clinical Pharmacology & Therapeutics'}, { 'key': '10.1016/j.tifs.2024.104864_bib64', 'doi-asserted-by': 'crossref', 'first-page': '489', 'DOI': '10.1146/annurev-food-052720-011032', 'article-title': 'The influence of the western diet on microbiota and gastrointestinal ' 'immunity', 'volume': '13', 'author': 'Heras', 'year': '2022', 'journal-title': 'Annual Review of Food Science Technology'}, { 'issue': '8', 'key': '10.1016/j.tifs.2024.104864_bib65', 'doi-asserted-by': 'crossref', 'first-page': '1321', 'DOI': '10.1080/10408398.2019.1570913', 'article-title': 'Phytochemicals and inflammatory bowel disease: a review', 'volume': '60', 'author': 'Hossen', 'year': '2020', 'journal-title': 'Critical Reviews in Food Science and Nutrition'}, { 'issue': '2', 'key': '10.1016/j.tifs.2024.104864_bib66', 'doi-asserted-by': 'crossref', 'first-page': '329', 'DOI': '10.1016/j.bbrc.2012.04.009', 'article-title': 'Discharge of solubilized and Dectin-1-reactive β-glucan from macrophage ' 'cells phagocytizing insoluble β-glucan particles: Involvement of ' 'reactive oxygen species (ROS)-driven degradation', 'volume': '421', 'author': 'Hino', 'year': '2012', 'journal-title': 'Biochemical and Biophysical Research Communications'}, { 'issue': '2', 'key': '10.1016/j.tifs.2024.104864_bib67', 'doi-asserted-by': 'crossref', 'first-page': '73', 'DOI': '10.1016/j.copbio.2008.03.003', 'article-title': 'Nutrients and phytochemicals: from bioavailability to bioefficacy ' 'beyond antioxidants', 'volume': '19', 'author': 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'10.1016/j.tifs.2024.104864_bib70', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.lfs.2023.122380', 'article-title': 'Bile acids metabolism in the gut-liver axis mediates liver injury ' 'during lactation', 'volume': '338', 'author': 'Huang', 'year': '2024', 'journal-title': 'Life Sciences'}, { 'key': '10.1016/j.tifs.2024.104864_bib71', 'doi-asserted-by': 'crossref', 'first-page': '85', 'DOI': '10.1146/annurev-pharmtox-051920-093829', 'article-title': 'The gut microbiome, metformin, and aging', 'volume': '62', 'author': 'Induri', 'year': '2022', 'journal-title': 'Annual Review of Pharmacology and Toxicology'}, { 'issue': '2', 'key': '10.1016/j.tifs.2024.104864_bib72', 'doi-asserted-by': 'crossref', 'first-page': '451', 'DOI': '10.1016/j.jhep.2020.03.044', 'article-title': 'Non-alcoholic fatty liver diseases in patients with COVID-19: A ' 'retrospective study', 'volume': '73', 'author': 'Ji', 'year': '2020', 'journal-title': 'Journal of Hepatology'}, { 'issue': '11', 'key': '10.1016/j.tifs.2024.104864_bib73', 'doi-asserted-by': 'crossref', 'first-page': '1596', 'DOI': '10.1111/bph.16306', 'article-title': 'Oat β-glucan repairs the epidermal barrier by upregulating the levels ' 'of epidermal differentiation, cell-cell junctions and lipids via ' 'Dectin-1', 'volume': '181', 'author': 'Jing', 'year': '2024', 'journal-title': 'British Journal of Pharmacology'}, { 'issue': '8', 'key': '10.1016/j.tifs.2024.104864_bib74', 'doi-asserted-by': 'crossref', 'DOI': '10.3390/foods10081854', 'article-title': 'Dietary regulation of oxidative stress in chronic metabolic diseases', 'volume': '10', 'author': 'Jiang', 'year': '2021', 'journal-title': 'Foods'}, { 'issue': '2', 'key': '10.1016/j.tifs.2024.104864_bib75', 'doi-asserted-by': 'crossref', 'first-page': '150', 'DOI': '10.1055/s-0041-1723031', 'article-title': 'Novel mechanisms for resolution of liver inflammation: therapeutic ' 'implications', 'volume': '41', 'author': 'Kaufmann', 'year': '2021', 'journal-title': 'Seminars in Liver Disease'}, { 'issue': '1', 'key': '10.1016/j.tifs.2024.104864_bib76', 'article-title': 'Developmental exposure of California mice to endocrine disrupting ' 'chemicals and potential effects on the microbiome-gut-brain axis at ' 'adulthood', 'volume': '10', 'author': 'Kaur', 'year': '2020', 'journal-title': 'Scientific Reports'}, { 'key': '10.1016/j.tifs.2024.104864_bib77', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.lfs.2020.118627', 'article-title': 'Role of gut-brain axis, gut microbial composition, and probiotic ' "intervention in Alzheimer's disease", 'volume': '264', 'author': 'Kesika', 'year': '2021', 'journal-title': 'Life Sciences'}, { 'issue': '6', 'key': '10.1016/j.tifs.2024.104864_bib78', 'doi-asserted-by': 'crossref', 'first-page': '1034', 'DOI': '10.1016/j.ahj.2004.05.049', 'article-title': 'Toll-like receptor 4 gene Asp299Gly polymorphism is associated with ' 'reductions in vascular inflammation, angiographic coronary artery ' 'disease, and clinical 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aging and atherosclerotic ' 'ischemic stroke', 'volume': '29', 'author': 'Koutsaliaris', 'year': '2021', 'journal-title': 'Current Medical Chemistry'}, { 'issue': '10', 'key': '10.1016/j.tifs.2024.104864_bib82', 'article-title': 'Molecular mechanism underlying the TLR4 antagonistic and antiseptic ' 'activities of papiliocin, an insect innate immune response molecule', 'volume': '119', 'author': 'Krishnan', 'year': '2022', 'journal-title': 'Proceedings of the National Academy of Sciences of the United States of ' 'America'}, { 'issue': '3', 'key': '10.1016/j.tifs.2024.104864_bib83', 'doi-asserted-by': 'crossref', 'first-page': '665', 'DOI': '10.1016/j.jhep.2021.11.008', 'article-title': 'Gut-derived systemic inflammation as a driver of depression in chronic ' 'liver disease', 'volume': '76', 'author': 'Kronsten', 'year': '2022', 'journal-title': 'Journal of Hepatology'}, { 'issue': '3', 'key': '10.1016/j.tifs.2024.104864_bib84', 'doi-asserted-by': 'crossref', 'first-page': '619', 'DOI': '10.1080/10408398.2020.1825286', 'article-title': 'Health-promoting role of dietary bioactive compounds through epigenetic ' 'modulations: a novel prophylactic and therapeutic approach', 'volume': '62', 'author': 'Kumari', 'year': '2022', 'journal-title': 'Critical Reviews in Food Science and Nutrition'}, { 'issue': '10', 'key': '10.1016/j.tifs.2024.104864_bib85', 'doi-asserted-by': 'crossref', 'first-page': '4240', 'DOI': '10.3382/ps/pey407', 'article-title': 'From oxidative stress to inflammation: redox balance and immune system', 'volume': '98', 'author': 'Lauridsen', 'year': '2019', 'journal-title': 'Poult Sci'}, { 'issue': '12', 'key': '10.1016/j.tifs.2024.104864_bib86', 'doi-asserted-by': 'crossref', 'first-page': '1291', 'DOI': '10.1038/nm1201-1291', 'article-title': 'Possible new role for NF-κB in the resolution of inflammation', 'volume': '7', 'author': 'Lawrence', 'year': '2001', 'journal-title': 'Nature Medicine'}, { 'issue': '1', 'key': '10.1016/j.tifs.2024.104864_bib87', 'doi-asserted-by': 'crossref', 'first-page': '3611', 'DOI': '10.1038/s41467-021-23929-9', 'article-title': 'Structural specificities of cell surface beta-glucan polysaccharides ' 'determine commensal yeast mediated immuno-modulatory activities', 'volume': '12', 'author': 'Lee', 'year': '2021', 'journal-title': 'Nature Communications'}, { 'key': '10.1016/j.tifs.2024.104864_bib88', 'doi-asserted-by': 'crossref', 'first-page': '88', 'DOI': '10.1016/j.intimp.2015.12.008', 'article-title': 'The immunostimulating activity of quercetin 3-O-xyloside in murine ' 'macrophages via activation of the ASK1/MAPK/NF-κB signaling pathway', 'volume': '31', 'author': 'Lee', 'year': '2016', 'journal-title': 'International Immunopharmacology'}, { 'issue': '8', 'key': '10.1016/j.tifs.2024.104864_bib89', 'doi-asserted-by': 'crossref', 'DOI': '10.3390/jcm10081758', 'article-title': 'PCSK9 and the gut-liver-brain axis: a novel therapeutic target for ' 'immune regulation in alcohol use disorder', 'volume': 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'metabolism in mice', 'volume': '16', 'author': 'Loman', 'year': '2024', 'journal-title': 'Gut Microbes'}, { 'issue': '1', 'key': '10.1016/j.tifs.2024.104864_bib99', 'doi-asserted-by': 'crossref', 'first-page': '41', 'DOI': '10.1093/advances/nmx011', 'article-title': 'The problem of curcumin and its bioavailability: could its ' 'gastrointestinal influence contribute to its overall health-enhancing ' 'effects?', 'volume': '9', 'author': 'Lopresti', 'year': '2018', 'journal-title': 'Advances in Nutrition'}, { 'issue': '2', 'key': '10.1016/j.tifs.2024.104864_bib100', 'doi-asserted-by': 'crossref', 'first-page': '203', 'DOI': '10.1515/hsz-2013-0241', 'article-title': 'The role of oxidative stress during inflammatory processes', 'volume': '395', 'author': 'Lugrin', 'year': '2014', 'journal-title': 'Biological Chemistry'}, { 'key': '10.1016/j.tifs.2024.104864_bib101', 'doi-asserted-by': 'crossref', 'first-page': '4371', 'DOI': '10.1080/10408398.2021.1875189', 'article-title': 'Functional foods modulating inflammation and metabolism in chronic ' 'diseases: a systematic review', 'volume': '62', 'author': 'Luvian-Morales', 'year': '2021', 'journal-title': 'Critical Reviews in Food Science and Nutrition'}, { 'issue': '10', 'key': '10.1016/j.tifs.2024.104864_bib102', 'doi-asserted-by': 'crossref', 'DOI': '10.3390/nu12103054', 'article-title': 'Involvement of gut microbiota, microbial metabolites and interaction ' 'with polyphenol in host immunometabolism', 'volume': '12', 'author': 'Man', 'year': '2020', 'journal-title': 'Nutrients'}, { 'issue': '4', 'key': '10.1016/j.tifs.2024.104864_bib103', 'doi-asserted-by': 'crossref', 'first-page': '247', 'DOI': '10.1016/j.tem.2022.01.002', 'article-title': 'Gut barrier disruption and chronic disease', 'volume': '33', 'author': 'Martel', 'year': '2022', 'journal-title': 'Trends in Endocrinology and Metabolism'}, { 'key': '10.1016/j.tifs.2024.104864_bib104', 'first-page': '1', 'article-title': 'Curcumin, autoimmune and inflammatory diseases: going beyond ' 'conventional therapy - a systematic review', 'author': 'Marton', 'year': '2020', 'journal-title': 'Critical Reviews in Food Science Nutrition'}, { 'key': '10.1016/j.tifs.2024.104864_bib105', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.neuropharm.2021.108915', 'article-title': 'Organ and brain crosstalk: The liver-brain axis in gastrointestinal, ' 'liver, and pancreatic diseases', 'volume': '205', 'author': 'Matsubara', 'year': '2022', 'journal-title': 'Neuropharmacology'}, { 'issue': '21', 'key': '10.1016/j.tifs.2024.104864_bib106', 'doi-asserted-by': 'crossref', 'first-page': '3693', 'DOI': '10.1080/10408398.2019.1706444', 'article-title': 'A comprehensive review on cereal beta-glucan: extraction, ' 'characterization, causes of degradation, and food application', 'volume': '60', 'author': 'Mejia', 'year': '2020', 'journal-title': 'Critical Reviews in Food Science Nutrition'}, { 'issue': '1', 'key': '10.1016/j.tifs.2024.104864_bib107', 'article-title': "Amelioration of alzheimer's disease by gut-pancreas-liver-brain " 'interaction in an app knock-in mouse model', 'volume': '12', 'author': 'Minamisawa', 'year': '2022', 'journal-title': 'Life-Basel'}, { 'key': '10.1016/j.tifs.2024.104864_bib108', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.ijbiomac.2024.134939', 'article-title': "Yeast β-glucan alleviates high-fat diet-induced Alzheimer's " 'disease-like pathologies in rats via the gut-brain axis', 'volume': '278', 'author': 'Mo', 'year': '2024', 'journal-title': 'International Journal of Biological Macromolecules'}, { 'issue': '118', 'key': '10.1016/j.tifs.2024.104864_bib109', 'doi-asserted-by': 'crossref', 'first-page': '97547', 'DOI': '10.1039/C5RA18896B', 'article-title': 'Quercetin in anti-diabetic research and strategies for improved ' 'quercetin bioavailability using polymer-based carriers - a review', 'volume': '5', 'author': 'Mukhopadhyay', 'year': '2015', 'journal-title': 'RSC Advances'}, { 'key': '10.1016/j.tifs.2024.104864_bib110', 'first-page': '6908', 'article-title': 'β-glucan, "the knight of health sector": critical insights on ' 'physiochemical heterogeneities, action mechanisms and health ' 'implications', 'author': 'Muthuramalingam', 'year': '2021', 'journal-title': 'Critical Reviews in Food Science and Nutrition'}, { 'issue': '3', 'key': '10.1016/j.tifs.2024.104864_bib111', 'doi-asserted-by': 'crossref', 'first-page': '770', 'DOI': '10.1021/acs.jnatprod.9b01285', 'article-title': 'Natural products as sources of new drugs over the nearly four decades ' 'from 01/1981 to 09/2019', 'volume': '83', 'author': 'Newman', 'year': '2020', 'journal-title': 'Journal of Natural Products'}, { 'issue': '5', 'key': '10.1016/j.tifs.2024.104864_bib112', 'doi-asserted-by': 'crossref', 'DOI': '10.3390/nu13051436', 'article-title': 'Prebiotic effect of berberine and curcumin is associated with the ' 'improvement of obesity in mice', 'volume': '13', 'author': 'Neyrinck', 'year': '2021', 'journal-title': 'Nutrients'}, { 'key': '10.1016/j.tifs.2024.104864_bib113', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.chemosphere.2021.130952', 'article-title': 'Bisphenol A impairs cognitive function and 5-HT metabolism in adult ' 'male mice by modulating the microbiota-gut-brain axis', 'volume': '282', 'author': 'Ni', 'year': '2021', 'journal-title': 'Chemosphere'}, { 'key': '10.1016/j.tifs.2024.104864_bib114', 'doi-asserted-by': 'crossref', 'first-page': '341', 'DOI': '10.1146/annurev-food-032818-121316', 'article-title': 'Immunometabolism: a multi-omics approach to interpreting the influence ' 'of exercise and diet on the immune system', 'volume': '10', 'author': 'Nieman', 'year': '2019', 'journal-title': 'Annual Review Food Science and Technology'}, { 'key': '10.1016/j.tifs.2024.104864_bib115', 'doi-asserted-by': 'crossref', 'first-page': '189', 'DOI': '10.1146/annurev-nutr-120919-094440', 'article-title': 'Nutrition regulates innate immunity in health and disease', 'volume': '40', 'author': 'Nobs', 'year': '2020', 'journal-title': 'Annual Review of Nutrition'}, { 'issue': '12', 'key': '10.1016/j.tifs.2024.104864_bib116', 'doi-asserted-by': 'crossref', 'first-page': '1947', 'DOI': '10.1080/10408398.2019.1619160', 'article-title': 'Bioavailability and metabolism of selected cocoa bioactive compounds: A ' 'comprehensive review', 'volume': '60', 'author': 'Oracz', 'year': '2020', 'journal-title': 'Critical Reviews in Food Science and Nutrition'}, { 'issue': '67', 'key': '10.1016/j.tifs.2024.104864_bib117', 'doi-asserted-by': 'crossref', 'DOI': '10.1126/sciimmunol.abm5505', 'article-title': 'Innate immunological pathways in COVID-19 pathogenesis', 'volume': '7', 'author': 'Paludan', 'year': '2022', 'journal-title': 'Science Immunology'}, { 'issue': '3', 'key': '10.1016/j.tifs.2024.104864_bib118', 'doi-asserted-by': 'crossref', 'first-page': '137', 'DOI': '10.1038/s41577-020-0391-5', 'article-title': 'Constitutive immune mechanisms: mediators of host defence and immune ' 'regulation', 'volume': '21', 'author': 'Paludan', 'year': '2021', 'journal-title': 'Nature Reviews Immunology'}, { 'issue': '1', 'key': '10.1016/j.tifs.2024.104864_bib119', 'doi-asserted-by': 'crossref', 'DOI': '10.1186/s12967-021-02724-6', 'article-title': 'β-Glucan from Lentinula edodes prevents cognitive impairments in ' 'high-fat diet-induced obese mice: involvement of colon-brain axis', 'volume': '19', 'author': 'Pan', 'year': '2021', 'journal-title': 'Journal of Translational Medicine'}, { 'issue': '9', 'key': '10.1016/j.tifs.2024.104864_bib120', 'doi-asserted-by': 'crossref', 'first-page': '1619', 'DOI': '10.3945/jn.109.104638', 'article-title': 'Butyrate enhances the intestinal barrier by facilitating tight junction ' 'assembly via activation of AMP-activated protein kinase in Caco-2 cell ' 'monolayers12', 'volume': '139', 'author': 'Peng', 'year': '2009', 'journal-title': 'The Journal of nutrition'}, { 'key': '10.1016/j.tifs.2024.104864_bib121', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.foodres.2019.108952', 'article-title': 'Effects of long-term intake of anthocyanins from Lycium ruthenicum ' 'Murray on the organism health and gut microbiota in vivo', 'volume': '130', 'author': 'Peng', 'year': '2020', 'journal-title': 'Food Research International'}, { 'issue': '3', 'key': '10.1016/j.tifs.2024.104864_bib122', 'doi-asserted-by': 'crossref', 'first-page': '813', 'DOI': '10.2337/diacare.27.3.813', 'article-title': 'Inflammation and activated innate immunity in the pathogenesis of type ' '2 diabetes', 'volume': '27', 'author': 'Pickup', 'year': '2004', 'journal-title': 'Diabetes Care'}, { 'key': '10.1016/j.tifs.2024.104864_bib123', 'doi-asserted-by': 'crossref', 'first-page': '965', 'DOI': '10.1038/s41587-021-01169-y', 'article-title': 'Imaging of innate immunity activation in vivo with a redox-tuned PET ' 'reporter', 'volume': '40', 'author': 'Pisaneschi', 'year': '2022', 'journal-title': 'Nature Biotechnology'}, { 'key': '10.1016/j.tifs.2024.104864_bib124', 'doi-asserted-by': 'crossref', 'first-page': '188', 'DOI': '10.1016/j.freeradbiomed.2016.11.037', 'article-title': 'Protective effect of quercetin on high-fat diet-induced non-alcoholic ' 'fatty liver disease in mice is mediated by modulating intestinal ' 'microbiota imbalance and related gut-liver axis activation', 'volume': '102', 'author': 'Porras', 'year': '2017', 'journal-title': 'Free Radical Biology and Medicine'}, { 'issue': '11', 'key': '10.1016/j.tifs.2024.104864_bib125', 'doi-asserted-by': 'crossref', 'DOI': '10.3390/nu13113839', 'article-title': 'Intestinal Microbiota as a Contributor to Chronic Inflammation and Its ' 'Potential Modifications', 'volume': '13', 'author': 'Potrykus', 'year': '2021', 'journal-title': 'Nutrients'}, { 'issue': '3', 'key': '10.1016/j.tifs.2024.104864_bib126', 'doi-asserted-by': 'crossref', 'first-page': '143', 'DOI': '10.1038/nrgastro.2016.191', 'article-title': 'The mucosal immune system: master regulator of bidirectional gut-brain ' 'communications', 'volume': '14', 'author': 'Powell', 'year': '2017', 'journal-title': 'Nature Reviews Gastroenterology & Hepatology'}, { 'issue': '12', 'key': '10.1016/j.tifs.2024.104864_bib127', 'doi-asserted-by': 'crossref', 'DOI': '10.3390/ijms19124126', 'article-title': 'Isoquercetin improves hepatic lipid accumulation by activating AMPK ' 'pathway and suppressing TGF-β signaling on an HFD-Induced nonalcoholic ' 'fatty liver disease rat model', 'volume': '19', 'author': 'Qin', 'year': '2018', 'journal-title': 'International Journal of Molecular Sciences'}, { 'issue': '1', 'key': '10.1016/j.tifs.2024.104864_bib128', 'doi-asserted-by': 'crossref', 'first-page': '140', 'DOI': '10.1189/jlb.72.1.140', 'article-title': 'Human monocyte scavenger receptors are pattern recognition receptors ' 'for (1→3)-β-D-glucans', 'volume': '72', 'author': 'Rice', 'year': '2002', 'journal-title': 'Journal of Leukocyte Biology'}, { 'issue': '5', 'key': '10.1016/j.tifs.2024.104864_bib129', 'doi-asserted-by': 'crossref', 'DOI': '10.1186/alzrt146', 'article-title': "Oral curcumin for Alzheimer's disease: tolerability and efficacy in a " '24-week randomized, double blind, placebo-controlled study', 'volume': '4', 'author': 'Ringman', 'year': '2012', 'journal-title': 'Alzheimers Research & Therapy'}, { 'issue': '9', 'key': '10.1016/j.tifs.2024.104864_bib130', 'doi-asserted-by': 'crossref', 'first-page': '469', 'DOI': '10.1089/met.2021.0022', 'article-title': 'Inflammation parameters associated with metabolic disorders: ' 'relationship between diet and microbiota', 'volume': '19', 'author': 'Rodriguez-Vera', 'year': '2021', 'journal-title': 'Metabolic Syndrome and Related Disorders'}, { 'key': '10.1016/j.tifs.2024.104864_bib131', 'first-page': '2990', 'article-title': 'The roles of quercetin in diabetes mellitus and related metabolic ' 'disorders; special focus on the modulation of gut microbiota: A ' 'comprehensive review', 'author': 'Roshanravan', 'year': '2021', 'journal-title': 'Critical Reviews in Food Science and Nutrition'}, { 'key': '10.1016/j.tifs.2024.104864_bib132', 'doi-asserted-by': 'crossref', 'first-page': '251', 'DOI': '10.1038/s41577-021-00584-1', 'article-title': 'How the immune system shapes atherosclerosis: roles of innate and ' 'adaptive immunity', 'volume': '22', 'author': 'Roy', 'year': '2021', 'journal-title': 'Nature Reviews Immunology'}, { 'key': '10.1016/j.tifs.2024.104864_bib133', 'doi-asserted-by': 'crossref', 'first-page': '42', 'DOI': '10.1016/j.fct.2018.10.042', 'article-title': 'Ginsenosides, catechins, quercetin and gut microbiota: Current evidence ' 'of challenging interactions', 'volume': '123', 'author': 'Santangelo', 'year': '2019', 'journal-title': 'Food and Chemical Toxicology'}, { 'key': '10.1016/j.tifs.2024.104864_bib134', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.mtla.2020.100605', 'article-title': 'Albumin coated polymer nanoparticles loaded with plant extract derived ' 'quercetin for modulation of inflammation', 'volume': '9', 'author': 'Saha', 'year': '2020', 'journal-title': 'Materialia'}, { 'key': '10.1016/j.tifs.2024.104864_bib135', 'doi-asserted-by': 'crossref', 'first-page': '3281', 'DOI': '10.1080/10408398.2020.1864619', 'article-title': 'Cereal β-glucans: an underutilized health endorsing food ingredient', 'volume': '62', 'author': 'Schmidt', 'year': '2020', 'journal-title': 'Critical Reviews in Food Science and Nutrition'}, { 'key': '10.1016/j.tifs.2024.104864_bib136', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.jnutbio.2024.109768', 'article-title': 'Curcumin attenuates neuroinflammatory damage induced by LPS: ' 'Implications for the role of S100B', 'volume': '135', 'author': 'Seady', 'year': '2025', 'journal-title': 'Journal of Nutritional Biochemistry'}, { 'issue': '11', 'key': '10.1016/j.tifs.2024.104864_bib137', 'doi-asserted-by': 'crossref', 'first-page': '1308', 'DOI': '10.1016/j.jnutbio.2015.06.005', 'article-title': 'The inhibitory effects of quercetin on obesity and obesity-induced ' 'inflammation by regulation of MAPK signaling', 'volume': '26', 'author': 'Seo', 'year': '2015', 'journal-title': 'Journal of Nutritional Biochemistry'}, { 'issue': '1', 'key': '10.1016/j.tifs.2024.104864_bib138', 'doi-asserted-by': 'crossref', 'DOI': '10.1186/s12974-024-03282-6', 'article-title': 'Gut microbiota modulates depressive-like behaviors induced by chronic ' 'ethanol exposure through short-chain fatty acids', 'volume': '21', 'author': 'Shen', 'year': '2024', 'journal-title': 'Journal of Neuroinflammation'}, { 'issue': '1', 'key': '10.1016/j.tifs.2024.104864_bib139', 'doi-asserted-by': 'crossref', 'DOI': '10.1186/s40168-020-00920-y', 'article-title': 'β-glucan attenuates cognitive impairment via the gut-brain axis in ' 'diet-induced obese mice', 'volume': '8', 'author': 'Shi', 'year': '2020', 'journal-title': 'Microbiome'}, { 'issue': '2', 'key': '10.1016/j.tifs.2024.104864_bib140', 'doi-asserted-by': 'crossref', 'first-page': '171', 'DOI': '10.1038/s41423-023-01104-y', 'article-title': 'SARS-CoV-2 and innate immunity: the good, the bad, and the “goldilocks”', 'volume': '21', 'author': 'Sievers', 'year': '2024', 'journal-title': 'Cellular & Molecular Immunology'}, { 'issue': '5', 'key': '10.1016/j.tifs.2024.104864_bib141', 'doi-asserted-by': 'crossref', 'first-page': '765', 'DOI': '10.1016/j.cell.2007.08.024', 'article-title': 'From exotic spice to modern drug?', 'volume': '130', 'author': 'Singh', 'year': '2007', 'journal-title': 'Cell'}, { 'issue': '3', 'key': '10.1016/j.tifs.2024.104864_bib142', 'doi-asserted-by': 'crossref', 'first-page': '1489', 'DOI': '10.1039/D3FO03667G', 'article-title': 'Integrated multi-omics profiling highlights the benefits of resveratrol ' 'hydroxypropyl-β-cyclodextrin inclusion complex for A53T transgenic mice ' 'through the microbiota-gut-brain axis', 'volume': '15', 'author': 'Sun', 'year': '2024', 'journal-title': 'Food & Function'}, { 'key': '10.1016/j.tifs.2024.104864_bib143', 'doi-asserted-by': 'crossref', 'first-page': '657', 'DOI': '10.1038/s41577-022-00684-6', 'article-title': 'Inflammation and immune dysfunction in Parkinson disease', 'volume': '22', 'author': 'Tansey', 'year': '2022', 'journal-title': 'Nature Review Immunology'}, { 'key': '10.1016/j.tifs.2024.104864_bib144', 'doi-asserted-by': 'crossref', 'first-page': '432', 'DOI': '10.1016/j.nbd.2019.02.015', 'article-title': "Curcumin restores innate immune Alzheimer's disease risk gene " 'expression to ameliorate Alzheimer pathogenesis', 'volume': '127', 'author': 'Teter', 'year': '2019', 'journal-title': 'Neurobiology of Disease'}, { 'issue': '12', 'key': '10.1016/j.tifs.2024.104864_bib145', 'doi-asserted-by': 'crossref', 'first-page': '1596', 'DOI': '10.1038/s42255-021-00501-9', 'article-title': 'Non-alcoholic fatty liver disease: the interplay between metabolism, ' 'microbes and immunity', 'volume': '3', 'author': 'Tilg', 'year': '2021', 'journal-title': 'Nature Metabolism'}, { 'key': '10.1016/j.tifs.2024.104864_bib146', 'doi-asserted-by': 'crossref', 'first-page': '66', 'DOI': '10.1016/j.tifs.2021.01.069', 'article-title': 'Role of food nutrients and supplementation in fighting against viral ' 'infections and boosting immunity: a review', 'volume': '110', 'author': 'Thirumdas', 'year': '2021', 'journal-title': 'Trends in Food Science & Technology'}, { 'issue': '5', 'key': '10.1016/j.tifs.2024.104864_bib147', 'doi-asserted-by': 'crossref', 'DOI': '10.1126/sciadv.abd1707', 'article-title': 'Human physiomimetic model integrating microphysiological systems of the ' 'gut, liver, and brain for studies of neurodegenerative diseases', 'volume': '7', 'author': 'Trapecar', 'year': '2021', 'journal-title': 'Science Advances'}, { 'issue': '12', 'key': '10.1016/j.tifs.2024.104864_bib148', 'doi-asserted-by': 'crossref', 'first-page': '4990', 'DOI': '10.1021/acs.jafc.3c01283', 'article-title': 'Gallate moiety of catechin is essential for inhibiting CCL2 ' 'chemokine-mediated monocyte recruitment', 'volume': '71', 'author': 'Tripathi', 'year': '2023', 'journal-title': 'Journal of Agricultural and Food Chemistry'}, { 'issue': '1', 'key': '10.1016/j.tifs.2024.104864_bib149', 'doi-asserted-by': 'crossref', 'DOI': '10.3390/nu14010067', 'article-title': 'Regulatory effects of quercetin on M1/M2 macrophage polarization and ' 'oxidative/antioxidative balance', 'volume': '14', 'author': 'Tsai', 'year': '2022', 'journal-title': 'Nutrients'}, { 'issue': '4', 'key': '10.1016/j.tifs.2024.104864_bib150', 'doi-asserted-by': 'crossref', 'first-page': '307', 'DOI': '10.1002/path.5642', 'article-title': 'COVID-19: immunopathology, pathophysiological mechanisms, and treatment ' 'options', 'volume': '254', 'author': 'Van Eijk', 'year': '2021', 'journal-title': 'Journal of Pathology'}, { 'issue': '1', 'key': '10.1016/j.tifs.2024.104864_bib151', 'doi-asserted-by': 'crossref', 'DOI': '10.1038/s41598-022-13825-7', 'article-title': 'High generation of reactive oxygen species from neutrophils in patients ' 'with severe COVID-19', 'volume': '12', 'author': 'Veenith', 'year': '2022', 'journal-title': 'Scientific Reports'}, { 'issue': '7', 'key': '10.1016/j.tifs.2024.104864_bib152', 'doi-asserted-by': 'crossref', 'first-page': '1558', 'DOI': '10.2174/1570159X20666220810105421', 'article-title': 'Expanding arsenal against neurodegenerative diseases using quercetin ' 'based nanoformulations: breakthroughs and bottlenecks', 'volume': '21', 'author': 'Vishwas', 'year': '2023', 'journal-title': 'Current Neuropharmacology'}, { 'key': '10.1016/j.tifs.2024.104864_bib153', 'first-page': '1', 'article-title': 'Bioactive compounds: application of albumin nanocarriers as delivery ' 'systems', 'author': 'Visentini', 'year': '2022', 'journal-title': 'Critical Reviews in Food Science and Nutrition'}, { 'issue': '2', 'key': '10.1016/j.tifs.2024.104864_bib154', 'doi-asserted-by': 'crossref', 'first-page': '276', 'DOI': '10.1016/j.physbeh.2007.11.045', 'article-title': 'Dietary modulation of immune function by beta-glucans', 'volume': '94', 'author': 'Volman', 'year': '2008', 'journal-title': 'Physiology & Behavior'}, { 'issue': '1', 'key': '10.1016/j.tifs.2024.104864_bib155', 'doi-asserted-by': 'crossref', 'first-page': '17', 'DOI': '10.1002/JLB.3COVR0520-272R', 'article-title': 'Cytokine storm and leukocyte changes in mild versus severe SARS-CoV-2 ' 'infection: Review of 3939 COVID-19 patients in China and emerging ' 'pathogenesis and therapy concepts', 'volume': '108', 'author': 'Wang', 'year': '2020', 'journal-title': 'Journal of Leukocyte Biology'}, { 'issue': '1', 'key': '10.1016/j.tifs.2024.104864_bib156', 'doi-asserted-by': 'crossref', 'first-page': '1360', 'DOI': '10.1080/10717544.2017.1375576', 'article-title': 'Investigation of the transport and absorption of polysaccharide through ' 'gastrointestinal tract both in vitro and in vivo', 'volume': '24', 'author': 'Wang', 'year': '2017', 'journal-title': 'Drug Delivery'}, { 'key': '10.1016/j.tifs.2024.104864_bib157', 'doi-asserted-by': 'crossref', 'first-page': '158', 'DOI': '10.1038/s41584-021-00738-4', 'article-title': 'The role of neutrophils in rheumatic disease-associated vascular ' 'inflammation', 'volume': '18', 'author': 'Wang', 'year': '2022', 'journal-title': 'Nature Reviews Rheumatology'}, { 'issue': '22', 'key': '10.1016/j.tifs.2024.104864_bib158', 'doi-asserted-by': 'crossref', 'first-page': '8317', 'DOI': '10.1021/acs.jafc.3c01087', 'article-title': 'Biotransformation and gut microbiota-mediated bioactivity of flavonols', 'volume': '71', 'author': 'Wang', 'year': '2023', 'journal-title': 'Journal of Agricultural and Food Chemistry'}, { 'issue': '12', 'key': '10.1016/j.tifs.2024.104864_bib159', 'doi-asserted-by': 'crossref', 'first-page': '1527', 'DOI': '10.1038/aps.2014.119', 'article-title': 'Resveratrol effectively attenuates α-naphthyl-isothiocyanate-induced ' 'acute cholestasis and liver injury through choleretic and ' 'anti-inflammatory mechanisms', 'volume': '35', 'author': 'Wang', 'year': '2014', 'journal-title': 'Acta Pharmacologica Sinica'}, { 'issue': '6', 'key': '10.1016/j.tifs.2024.104864_bib160', 'doi-asserted-by': 'crossref', 'first-page': '1088', 'DOI': '10.1002/mnfr.201400567', 'article-title': 'Quercetin and isorhamnetin aglycones are the main metabolites of ' 'dietary quercetin in cerebrospinal fluid', 'volume': '59', 'author': 'Wiczkowski', 'year': '2015', 'journal-title': 'Molecular Nutrition & Food Research'}, { 'key': '10.1016/j.tifs.2024.104864_bib161', 'doi-asserted-by': 'crossref', 'first-page': '445', 'DOI': '10.1146/annurev-immunol-032414-112043', 'article-title': 'Innate immune recognition of cancer', 'volume': '37', 'author': 'Woo', 'year': '2015', 'journal-title': 'Annual Review of Immunology'}, { 'issue': '11', 'key': '10.1016/j.tifs.2024.104864_bib162', 'doi-asserted-by': 'crossref', 'first-page': '1191', 'DOI': '10.1007/s11427-017-9128-3', 'article-title': 'Gut-liver axis: gut microbiota in shaping hepatic innate immunity', 'volume': '60', 'author': 'Wu', 'year': '2017', 'journal-title': 'Science China-Life Sciences'}, { 'key': '10.1016/j.tifs.2024.104864_bib163', 'doi-asserted-by': 'crossref', 'DOI': '10.3389/fimmu.2021.787797', 'article-title': 'The prebiotic effects of oats on blood lipids, gut microbiota, and ' 'short-chain fatty acids in mildly hypercholesterolemic subjects ' 'compared with rice: a randomized, controlled trial', 'volume': '12', 'author': 'Xu', 'year': '2021', 'journal-title': 'Frontiers in Immunology'}, { 'issue': '36', 'key': '10.1016/j.tifs.2024.104864_bib164', 'doi-asserted-by': 'crossref', 'first-page': '31194', 'DOI': '10.1074/jbc.M111.246470', 'article-title': 'Immunomodulatory β-Glucan from Lentinus edodes activates ' 'mitogen-activated protein kinases and nuclear factor-κB in murine RAW ' '264.7 macrophages', 'volume': '286', 'author': 'Xu', 'year': '2011', 'journal-title': 'Journal of Biological Chemistry'}, { 'key': '10.1016/j.tifs.2024.104864_bib165', 'doi-asserted-by': 'crossref', 'DOI': '10.3389/fnut.2021.803691', 'article-title': 'Lentinan supplementation protects the gut-liver axis and prevents ' 'steatohepatitis: The Role of Gut Microbiota Involved', 'volume': '8', 'author': 'Yang', 'year': '2022', 'journal-title': 'Frontiers in Nutrition'}, { 'key': '10.1016/j.tifs.2024.104864_bib166', 'doi-asserted-by': 'crossref', 'DOI': '10.1002/mnfr.202000566', 'article-title': 'Lactobacillus rhamnosus GG and oat beta-glucan regulated fatty acid ' 'profiles along the gut-liver-brain axis of mice fed with high fat diet ' 'and demonstrated antioxidant and anti-inflammatory potentials', 'volume': '64', 'author': 'Yau', 'year': '2020', 'journal-title': 'Molecular Nutrition & Food Research'}, { 'key': '10.1016/j.tifs.2024.104864_bib167', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.fct.2020.111311', 'article-title': 'Salidroside ameliorates liver metabonomics in relation to modified ' 'gut-liver FXR 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'1333', 'DOI': '10.1111/jgh.16205', 'article-title': 'The improvement of intestinal dysbiosis and hepatic metabolic ' 'dysfunction in dextran sulfate sodium-induced colitis mice: effects of ' 'curcumin', 'volume': '38', 'author': 'Zhou', 'year': '2023', 'journal-title': 'Journal of Gastroenterology and Hepatology'}, { 'key': '10.1016/j.tifs.2024.104864_bib183', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/S0140-6736(20)30566-3', 'article-title': 'Clinical course and risk factors for mortality of adult inpatients with ' 'COVID-19 in Wuhan, China: a retrospective cohort study (vol 395, pg ' '1054, 2020)', 'volume': '395', 'author': 'Zhou', 'year': '2020', 'journal-title': 'Lancet'}, { 'issue': '8', 'key': '10.1016/j.tifs.2024.104864_bib184', 'doi-asserted-by': 'crossref', 'DOI': '10.1111/pai.13835', 'article-title': 'allergen Der p 22: Cloning, expression, IgE-binding in asthmatic ' 'children, and immunogenicity', 'volume': '33', 'author': 'Zhou', 'year': '2022', 'journal-title': 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