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Natural Products-Based Inhaled Formulations for Treating Pulmonary Diseases

Yong et al., International Journal of Nanomedicine, doi:10.2147/ijn.s451206
Feb 2024  
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Quercetin for COVID-19
22nd treatment shown to reduce risk in July 2021
*, now known with p = 0.0031 from 11 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments.
Review of nanoformulations for inhaled therapeutics for respiratory diseases including potential for COVID-19. Inhaled formulations deliver treatment directly to both the upper and lower respiratory tract, enabling higher local concentrations while minimizing systemic side effects. They also provide solutions for bioavailability challenges like instability and low solubility. This review discusses recent advances in nano- and microparticles made from lipids, polymers, and nanocomposites to encapsulate natural compounds like curcumin and enhance delivery to lung tissues. Though not specific to COVID-19, properly designed inhaled formulations could fight early viral replication in the upper airways as well as later stage infection in lungs.
Reviews covering quercetin for COVID-19 include Agrawal, Biancatelli, Chen, Derosa, Dinda, Gasmi, Georgiou, Imran, Massimo Magro, Matías-Pérez, Mirza, Rizky, Shorobi, Vajdi, Yong.
Review covers curcumin and quercetin.
Yong et al., 29 Feb 2024, peer-reviewed, 8 authors. Contact:
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Natural Products-Based Inhaled Formulations for Treating Pulmonary Diseases
Jiangyan Yong, Hongli Shu, Xiao Zhang, Kun Yang, Guining Luo, Lu Yu, Jiaqi Li, Hong Huang
International Journal of Nanomedicine, doi:10.2147/ijn.s451206
Given the unique physiological and pathological characteristics of the lung, the direct, inhalable route is more conducive to pulmonary drug delivery and disease control than traditional systemic drug delivery, significantly circumventing drug loss, off-target effects, systemic and organ toxicity, etc., and is widely regarded as the preferred regimen for pulmonary drug delivery. However, very few lung diseases are currently treated with the preferred inhaled formulations, such as asthma, chronic obstructive pulmonary disease and pulmonary hypertension. And there is a lack of appropriate inhaled formulations for other critical lung diseases, such as lung cancer and pulmonary fibrosis, due to the fact that the physicochemical properties of the drugs and their pharmacokinetic profiles do not match the physiology of the lung, and conventional inhalation devices are unable to deliver them to the specific parts of the lung. Phytochemicals of natural origin, due to their wide availability and clear safety profile, hold great promise for the preparation of inhalable formulations to improve the current dilemma in the treatment of lung diseases. In particular, the preparation of inhalable formulations based on nano-and microparticulate carriers for drug delivery to deep lung tissues, which overcome the shortcomings of conventional inhalation therapies while targeting the drug activity directly to a specific part of the lung, may be the best approach to change the current dilemma of lung disease treatment. In this review, we discuss recent advances in nano-and micron-carrier-based inhalation formulations for the delivery of natural products for the treatment of pulmonary diseases, which may represent an opportunity for practical clinical translation of natural products.
Disclosure The authors report no conflicts of interest in this work.
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