Abstract: Received: 24 May 2020
Revised: 5 September 2020
Accepted: 13 September 2020
DOI: 10.1002/ptr.6887
REVIEW
A role for quercetin in coronavirus disease 2019 (COVID-19)
Giuseppe Derosa1,2
|
Pamela Maffioli1 |
1
Department of Internal Medicine and
Therapeutics, University of Pavia, Pavia, Italy
2
Laboratory of Molecular Medicine, University
of Pavia, Pavia, Italy
3
Velleja Research S.r.l., Milan, Italy
Correspondence
Giuseppe Derosa, Department of Internal
Medicine and Therapeutics, University of
Pavia, Via Aselli, 43/45, 27100 Pavia, Italy.
Email: giuseppe.derosa@unipv.it
Angela D'Angelo2 |
Francesco Di Pierro3
Several months ago, an outbreak of pneumonia of unknown aetiology was detected
in Wuhan City (China) and the aetiological agent of the atypical pneumonia was isolated by the Chinese authorities as novel coronavirus (2019-nCoV or SARS-CoV-2).
The WHO announced this new disease was to be known as “COVID-19.” When
looking for new antiviral compounds, knowledge of the main viral proteins is fundamental. The major druggable targets of SARS-CoV-2 include 3-chymotrypsin-like protease (3CLpro), papain-like protease (PLpro), RNA-dependent RNA polymerase, and
spike (S) protein. Quercetin inhibits 3CLpro and PLpro with a docking binding energy
corresponding to −6.25 and −4.62 kcal/mol, respectively. Quercetin has a theoretical, but significant, capability to interfere with SARS-CoV-2 replication, with the
results showing this to be the fifth best compound out of 18 candidates. On the basis
of the clinical COVID-19 manifestations, the multifaceted aspect of quercetin as both
antiinflammatory
and
thrombin-inhibitory
actions,
should
be
taken
into
consideration.
KEYWORDS
COVID-19, infectious diseases, nutraceutical, quercetin, SARS-CoV-2
1
|
I N T RO DU CT I O N
appeared in Europe. The virus was isolated in Bavaria (Germany) from
a German patient infected by an individual from Shanghai (China).
Viral diseases continue to pose a serious threat to public health. The
Subsequently, the virus was present in Italy on January 25, 2020. The
world has witnessed several viral epidemics over the past 20 years,
unsuspecting individuals infected with the virus are thought to have
including severe acute respiratory syndrome (SARS) coronavirus
been able to circulate in the area of Basso Lodigiano with few symp-
(SARS-CoV-1) in 2003, the influenza disease called H1N1 in 2009,
toms or with symptoms mistaken for those of influenza.
and the middle east respiratory syndrome (MERS) coronavirus (MERS-
On January 30, 2020, the WHO declared the situation a public
CoV) in 2012. Several months ago, an outbreak of pneumonia of
health
unknown aetiology was detected in Wuhan City, Province of Hubei
Organization, 2020a) and on February 11, 2020, the WHO announced
emergency
of
international
concern
(World
Health
(China) and reported to the China Country Office of the World Health
that the disease caused by this new virus was to be known as
Organization (WHO) on December 31, 2019. The National Health
“COVID-19,” which is an acronym of “coronavirus disease-2019.”
Commission of China reported the outbreak was associated with
On February 20, 2020, the first symptomatic COVID-19 patient
exposure in one seafood market in Wuhan City. The aetiological agent
was identified in Italy at the Emergency Department of Codogno Hos-
of the atypical pneumonia was isolated on January 7, 2020 by the
pital, Basso Lodigiano, Province of..
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'abstract': '<jats:p>Several months ago, an outbreak of pneumonia of unknown aetiology was detected in '
'Wuhan City (China) and the aetiological agent of the atypical pneumonia was isolated by the '
'Chinese authorities as novel coronavirus (2019‐nCoV or SARS‐CoV‐2). The WHO announced this '
'new disease was to be known as “COVID‐19.” When looking for new antiviral compounds, '
'knowledge of the main viral proteins is fundamental. The major druggable targets of '
'SARS‐CoV‐2 include 3‐chymotrypsin‐like protease (3CLpro), papain‐like protease (PLpro), '
'RNA‐dependent RNA polymerase, and spike (S) protein. Quercetin inhibits 3CLpro and PLpro with '
'a docking binding energy corresponding to −6.25 and −4.62\u2009kcal/mol, respectively. '
'Quercetin has a theoretical, but significant, capability to interfere with SARS‐CoV‐2 '
'replication, with the results showing this to be the fifth best compound out of 18 '
'candidates. On the basis of the clinical COVID‐19 manifestations, the multifaceted aspect of '
'quercetin as both antiinflammatory and thrombin‐inhibitory actions, should be taken into '
'consideration.</jats:p>',
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