Effect and mechanism of quercetin or quercetin‐containing formulas against COVID‐19: From bench to bedside

{ 'indexed': {'date-parts': [[2024, 3, 14]], 'date-time': '2024-03-14T00:48:51Z', 'timestamp': 1710377331052}, 'reference-count': 192, 'publisher': 'Wiley', 'license': [ { 'start': { 'date-parts': [[2024, 3, 13]], 'date-time': '2024-03-13T00:00:00Z', 'timestamp': 1710288000000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'http://onlinelibrary.wiley.com/termsAndConditions#vor'}], 'content-domain': {'domain': ['onlinelibrary.wiley.com'], 'crossmark-restriction': True}, 'abstract': '<jats:title>Abstract</jats:title><jats:p>Severe acute respiratory syndrome coronavirus 2 ' '(SARS‐CoV‐2) has caused the global coronavirus disease 2019 (COVID‐19) pandemic since 2019. ' 'Immunopathogenesis and thromboembolic events are central to its pathogenesis. Quercetin ' 'exhibits several beneficial activities against COVID‐19, including antiviral, ' 'anti‐inflammatory, immunomodulatory, antioxidative, and antithrombotic effects. Although ' 'several reviews have been published, these reviews are incomplete from the viewpoint of ' 'translational medicine. The authors comprehensively evaluated the evidence of quercetin ' 'against COVID‐19, both basically and clinically, to apply quercetin and/or its derivatives in ' 'the future. The authors searched the PubMed, Embase, and the Cochrane Library databases ' 'without any restrictions. The search terms included COVID‐19, SARS‐CoV‐2, quercetin, ' 'antiviral, anti‐inflammatory, immunomodulatory, thrombosis, embolism, oxidative, and ' 'microbiota. The references of relevant articles were also reviewed. All authors independently ' 'screened and reviewed the quality of each included manuscript. The Cochrane Risk of Bias ' 'Tool, version 2 (RoB 2) was used to assess the quality of the included randomized controlled ' 'trials (RCTs). All selected studies were discussed monthly. The effectiveness of quercetin ' 'against COVID‐19 is not solid due to methodological flaws in the clinical trials. ' 'High‐quality studies are also required for quercetin‐containing traditional Chinese ' 'medicines. The low bioavailability and highly variable pharmacokinetics of quercetin hinder ' 'its clinical applications. Its positive impact on immunomodulation through reverting ' 'dysbiosis of gut microbiota still lacks robust evidence. Quercetin against COVID‐19 does not ' 'have tough clinical evidence. Strategies to improve its bioavailability and/or to develop its ' 'effective derivatives are needed. Well‐designed RCTs are also crucial to confirm their ' 'effectiveness in the future.</jats:p>', 'DOI': '10.1002/ptr.8175', 'type': 'journal-article', 'created': {'date-parts': [[2024, 3, 13]], 'date-time': '2024-03-13T23:24:21Z', 'timestamp': 1710372261000}, 'update-policy': 'http://dx.doi.org/10.1002/crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Effect and mechanism of quercetin or quercetin‐containing formulas against <scp>COVID</scp>‐19: ' 'From bench to bedside', 'prefix': '10.1002', 'author': [ { 'given': 'Jhong Yuan', 'family': 'Chen', 'sequence': 'first', 'affiliation': [ { 'name': 'Department of Traditional Chinese Medicine Kaohsiung Medical ' 'University Hospital, Kaohsiung Medical University Kaohsiung ' 'Taiwan'}]}, { 'given': 'Tsung Rung', 'family': 'Huang', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Traditional Chinese Medicine Kaohsiung Medical ' 'University Hospital, Kaohsiung Medical University Kaohsiung ' 'Taiwan'}]}, { 'given': 'Shih Yun', 'family': 'Hsu', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Traditional Chinese Medicine Kaohsiung Medical ' 'University Hospital, Kaohsiung Medical University Kaohsiung ' 'Taiwan'}]}, { 'given': 'Ching Chun', 'family': 'Huang', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Traditional Chinese Medicine Kaohsiung Medical ' 'University Hospital, Kaohsiung Medical University Kaohsiung ' 'Taiwan'}]}, { 'ORCID': 'http://orcid.org/0009-0002-3499-2573', 'authenticated-orcid': False, 'given': 'Huei Syun', 'family': 'Wang', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Traditional Chinese Medicine Kaohsiung Medical ' 'University Hospital, Kaohsiung Medical University Kaohsiung ' 'Taiwan'}]}, { 'given': 'Jung San', 'family': 'Chang', 'sequence': 'additional', 'affiliation': [ { 'name': 'Division of Gastroenterology, Department of Internal Medicine ' 'Kaohsiung Medical University Hospital, Kaohsiung Medical ' 'University Kaohsiung Taiwan'}, { 'name': 'Department of Medical Research Kaohsiung Medical University ' 'Hospital, Kaohsiung Medical University Kaohsiung Taiwan'}, { 'name': 'PhD Program in Toxicology, College of Pharmacy Kaohsiung Medical ' 'University Kaohsiung Taiwan'}]}], 'member': '311', 'published-online': {'date-parts': [[2024, 3, 13]]}, 'reference': [ {'key': 'e_1_2_13_2_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.lfs.2020.118167'}, { 'key': 'e_1_2_13_3_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.cytogfr.2021.11.001'}, { 'key': 'e_1_2_13_4_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.biopha.2022.112658'}, {'key': 'e_1_2_13_5_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1111/1541-4337.12342'}, {'key': 'e_1_2_13_6_1', 'doi-asserted-by': 'publisher', 'DOI': '10.55519/jamc-02-9899'}, { 'key': 'e_1_2_13_7_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1080/07391102.2020.1775123'}, { 'key': 'e_1_2_13_8_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.yebeh.2021.108207'}, { 'key': 'e_1_2_13_9_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.jnutbio.2021.108787'}, {'key': 'e_1_2_13_10_1', 'doi-asserted-by': 'publisher', 'DOI': '10.3389/fncel.2021.670298'}, {'key': 'e_1_2_13_11_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.imu.2021.100515'}, { 'key': 'e_1_2_13_12_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.ejphar.2010.05.019'}, {'key': 'e_1_2_13_13_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1002/ptr.7436'}, {'key': 'e_1_2_13_14_1', 'doi-asserted-by': 'publisher', 'DOI': '10.3390/foods9030374'}, { 'key': 'e_1_2_13_15_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.semarthrit.2022.152047'}, { 'key': 'e_1_2_13_16_1', 'article-title': 'A review of quercetin: Chemistry, antioxident properties, and ' 'bioavailability', 'author': 'Bentz A. 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