Effect and mechanism of quercetin or quercetin‐containing formulas against COVID‐19: From bench to bedside

DOI record: { "DOI": "10.1002/ptr.8175", "ISSN": [ "0951-418X", "1099-1573" ], "URL": "http://dx.doi.org/10.1002/ptr.8175", "abstract": "<jats:title>Abstract</jats:title><jats:p>Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has caused the global coronavirus disease 2019 (COVID‐19) pandemic since 2019. Immunopathogenesis and thromboembolic events are central to its pathogenesis. Quercetin exhibits several beneficial activities against COVID‐19, including antiviral, anti‐inflammatory, immunomodulatory, antioxidative, and antithrombotic effects. Although several reviews have been published, these reviews are incomplete from the viewpoint of translational medicine. The authors comprehensively evaluated the evidence of quercetin against COVID‐19, both basically and clinically, to apply quercetin and/or its derivatives in the future. The authors searched the PubMed, Embase, and the Cochrane Library databases without any restrictions. The search terms included COVID‐19, SARS‐CoV‐2, quercetin, antiviral, anti‐inflammatory, immunomodulatory, thrombosis, embolism, oxidative, and microbiota. The references of relevant articles were also reviewed. All authors independently screened and reviewed the quality of each included manuscript. The Cochrane Risk of Bias Tool, version 2 (RoB 2) was used to assess the quality of the included randomized controlled trials (RCTs). All selected studies were discussed monthly. The effectiveness of quercetin against COVID‐19 is not solid due to methodological flaws in the clinical trials. High‐quality studies are also required for quercetin‐containing traditional Chinese medicines. The low bioavailability and highly variable pharmacokinetics of quercetin hinder its clinical applications. Its positive impact on immunomodulation through reverting dysbiosis of gut microbiota still lacks robust evidence. Quercetin against COVID‐19 does not have tough clinical evidence. Strategies to improve its bioavailability and/or to develop its effective derivatives are needed. Well‐designed RCTs are also crucial to confirm their effectiveness in the future.</jats:p>", "alternative-id": [ "10.1002/ptr.8175" ], "assertion": [ { "group": { "label": "Publication History", "name": "publication_history" }, "label": "Received", "name": "received", "order": 0, "value": "2023-08-13" }, { "group": { "label": "Publication History", "name": "publication_history" }, "label": "Accepted", "name": "accepted", "order": 1, "value": "2024-02-14" }, { "group": { "label": "Publication History", "name": "publication_history" }, "label": "Published", "name": "published", "order": 2, "value": "2024-03-13" } ], "author": [ { "affiliation": [ { "name": "Department of Traditional Chinese Medicine Kaohsiung Medical University Hospital, Kaohsiung Medical University Kaohsiung Taiwan" } ], "family": "Chen", "given": "Jhong Yuan", "sequence": "first" }, { "affiliation": [ { "name": "Department of Traditional Chinese Medicine Kaohsiung Medical University Hospital, Kaohsiung Medical University Kaohsiung Taiwan" } ], "family": "Huang", "given": "Tsung Rung", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Traditional Chinese Medicine Kaohsiung Medical University Hospital, Kaohsiung Medical University Kaohsiung Taiwan" } ], "family": "Hsu", "given": "Shih Yun", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Traditional Chinese Medicine Kaohsiung Medical University Hospital, Kaohsiung Medical University Kaohsiung Taiwan" } ], "family": "Huang", "given": "Ching Chun", "sequence": "additional" }, { "ORCID": "http://orcid.org/0009-0002-3499-2573", "affiliation": [ { "name": "Department of Traditional Chinese Medicine Kaohsiung Medical University Hospital, Kaohsiung Medical University Kaohsiung Taiwan" } ], "authenticated-orcid": false, "family": "Wang", "given": "Huei Syun", "sequence": "additional" }, { "affiliation": [ { "name": "Division of Gastroenterology, Department of Internal Medicine Kaohsiung Medical University Hospital, Kaohsiung Medical University Kaohsiung Taiwan" }, { "name": "Department of Medical Research Kaohsiung Medical University Hospital, Kaohsiung Medical University Kaohsiung Taiwan" }, { "name": "PhD Program in Toxicology, College of Pharmacy Kaohsiung Medical University Kaohsiung Taiwan" } ], "family": "Chang", "given": "Jung San", "sequence": "additional" } ], "container-title": "Phytotherapy Research", "container-title-short": "Phytotherapy Research", "content-domain": { "crossmark-restriction": true, "domain": [ "onlinelibrary.wiley.com" ] }, "created": { "date-parts": [ [ 2024, 3, 13 ] ], "date-time": "2024-03-13T23:24:21Z", "timestamp": 1710372261000 }, "deposited": { "date-parts": [ [ 2024, 3, 13 ] ], "date-time": "2024-03-13T23:24:31Z", "timestamp": 1710372271000 }, "indexed": { "date-parts": [ [ 2024, 3, 14 ] ], "date-time": "2024-03-14T00:48:51Z", "timestamp": 1710377331052 }, "is-referenced-by-count": 0, "issued": { "date-parts": [ [ 2024, 3, 13 ] ] }, "language": 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