All Studies Meta Analysis Recent:

Relationship of quercetin intake and oxidative stress in persistent Covid

Matías-Pérez et al., Frontiers in Nutrition, doi:10.3389/fnut.2023.1278039

Dec 2023

Post
Facebook

Source PDF All Studies Meta AnalysisMeta

Quercetin for COVID-19

22nd treatment shown to reduce risk in July 2021

^*, now known with p = 0.0031 from 11 studies.

Lower risk for ICU admission, hospitalization, recovery, cases, and viral clearance.

No treatment is 100% effective. Protocols combine complementary and synergistic treatments. ^* >10% efficacy in meta analysis with ≥3 clinical studies.

4,100+ studies for 60+ treatments. c19early.org

Discussion of the potential of quercetin for persistent COVID-19 symptoms resulting from oxidative stress. Authors explain how COVID-19 leads to oxidative stress through inflammation, cytokine storms, and coagulation abnormalities. Quercetin is a naturally occurring flavonoid antioxidant that can neutralize free radicals, inhibit viral enzymes, reduce platelet aggregation, and have immunoprotective effects. Studies show quercetin inhibits replication of various viruses. Authors suggest a mixture of quercetin and vitamin C could disrupt SARS-CoV-2 entry, replication, and assembly while strengthening the immune response. Authors note the challenges of quercetin's bioavailability indicating that formulations for improved bioavailability are important.

Reviews covering quercetin for COVID-19 include Agrawal, Biancatelli, Chen, Derosa, Dinda, Gasmi, Georgiou, Imran, Massimo Magro, Matías-Pérez, Mirza, Rizky, Shorobi, Vajdi, Yong.

Important missing comments or errors? Let us know.

1. Agrawal et al., Antiviral Significance of Isoquercetin (Quercetin-3-O-Glucoside) With Special Reference to its Anti-Coronaviral Potential, Natural Product Communications, doi:10.1177/1934578X231219560.sagepub.com, doi.org.

2. Biancatelli et al., Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19), Frontiers in Immunology, doi:10.3389/fimmu.2020.01451.frontiersin.org, doi.org.

3. Chen et al., Effect and mechanism of quercetin or quercetin‐containing formulas against COVID‐19: From bench to bedside, Phytotherapy Research, doi:10.1002/ptr.8175.wiley.com, doi.org.

4. Derosa et al., A role for quercetin in coronavirus disease 2019 (COVID-19), Phytotherapy Research, doi:10.1002/ptr.6887.wiley.com, doi.org.

5. Dinda et al., Anti-SARS-CoV-2, antioxidant and immunomodulatory potential of dietary flavonol quercetin: Focus on molecular targets and clinical efficacy, European Journal of Medicinal Chemistry Reports, doi:10.1016/j.ejmcr.2023.100125.sciencedirect.com, doi.org.

6. Gasmi et al., Quercetin in the Prevention and Treatment of Coronavirus Infections: A Focus on SARS-CoV-2, Pharmaceuticals, doi:10.3390/ph15091049.mdpi.com, doi.org.

7. Georgiou et al., Quercetin: A Potential Polydynamic Drug, Molecules, doi:10.3390/molecules28248141.mdpi.com, doi.org.

8. Imran et al., The Therapeutic and Prophylactic Potential of Quercetin against COVID-19: An Outlook on the Clinical Studies, Inventive Compositions, and Patent Literature, Antioxidants, doi:10.3390/antiox11050876.mdpi.com, doi.org.

9. Massimo Magro et al., Use of Quercetin for Therapeutic Purposes in COVID-19 Infections: The Opinion of the Geriatrician Doctor, Journal of Modern Biology and Drug Discovery, doi:10.53964/jmbdd.2023004.innovationforever.com, doi.org.

10. Matías-Pérez et al., Relationship of quercetin intake and oxidative stress in persistent Covid, Frontiers in Nutrition, doi:10.3389/fnut.2023.1278039.frontiersin.org, doi.org.

11. Mirza et al., Quercetin as a Therapeutic Product: Evaluation of Its Pharmacological Action and Clinical Applications—A Review, Pharmaceuticals, doi:10.3390/ph16111631.mdpi.com, doi.org.

12. Rizky et al., The pharmacological mechanism of quercetin as adjuvant therapy of COVID-19, Life Research, doi:10.53388/life2022-0205-302.tmrjournals.com, doi.org.

13. Shorobi et al., Quercetin: A Functional Food-Flavonoid Incredibly Attenuates Emerging and Re-Emerging Viral Infections through Immunomodulatory Actions, Molecules, doi:10.3390/molecules28030938.mdpi.com, doi.org.

14. Vajdi et al., Effect of polyphenols against complications of COVID-19: current evidence and potential efficacy, Pharmacological Reports, doi:10.1007/s43440-024-00585-6.springer.com, doi.org.

15. Yong et al., Natural Products-Based Inhaled Formulations for Treating Pulmonary Diseases, International Journal of Nanomedicine, doi:10.2147/ijn.s451206.dovepress.com, doi.org.

Matías-Pérez et al., 26 Dec 2023, peer-reviewed, 5 authors.

This Paper Quercetin All

Download Image

Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.

Submit

Post

@CovidAnalysis

FAQ

Public domain CC0 1.0