Therapeutic Implications of Quercetin and its Derived-products in COVID-19 Protection and Prophylactic

DOI record: { "DOI": "10.1016/j.heliyon.2024.e30080", "ISSN": [ "2405-8440" ], "URL": "http://dx.doi.org/10.1016/j.heliyon.2024.e30080", "alternative-id": [ "S2405844024061115" ], "article-number": "e30080", "assertion": [ { "label": "This article is maintained by", "name": "publisher", "value": "Elsevier" }, { "label": "Article Title", "name": "articletitle", "value": "Therapeutic Implications of Quercetin and its Derived-products in COVID-19 Protection and Prophylactic" }, { "label": "Journal Title", "name": "journaltitle", "value": "Heliyon" }, { "label": "CrossRef DOI link to publisher maintained version", "name": "articlelink", "value": "https://doi.org/10.1016/j.heliyon.2024.e30080" }, { "label": "Content Type", "name": "content_type", "value": "article" }, { "label": "Copyright", "name": "copyright", "value": "© 2024 The Author(s). Published by Elsevier Ltd." } ], "author": [ { "affiliation": [], "family": "Ho", "given": "Wan-Yi", "sequence": "first" }, { "affiliation": [], "family": "Shen", "given": "Zi-han", "sequence": "additional" }, { "affiliation": [], "family": "Chen", "given": "Yijing", "sequence": "additional" }, { "affiliation": [], "family": "Chen", "given": "Ting-Hsu", "sequence": "additional" }, { "affiliation": [], "family": "Lu", "given": "XiaoLin", "sequence": "additional" }, { "affiliation": [], "family": "Fu", "given": "Yaw-Syan", "sequence": "additional" } ], "container-title": "Heliyon", "container-title-short": "Heliyon", "content-domain": { "crossmark-restriction": true, "domain": [ "cell.com", "elsevier.com", "sciencedirect.com" ] }, "created": { "date-parts": [ [ 2024, 4, 30 ] ], "date-time": "2024-04-30T08:34:46Z", "timestamp": 1714466086000 }, "deposited": { "date-parts": [ [ 2024, 4, 30 ] ], "date-time": "2024-04-30T08:36:26Z", "timestamp": 1714466186000 }, "indexed": { "date-parts": [ [ 2024, 5, 1 ] ], "date-time": "2024-05-01T00:28:03Z", "timestamp": 1714523283453 }, "is-referenced-by-count": 0, "issued": { "date-parts": [ [ 2024, 4 ] ] }, "language": "en", "license": [ { "URL": "https://www.elsevier.com/tdm/userlicense/1.0/", "content-version": "tdm", "delay-in-days": 0, "start": { "date-parts": [ [ 2024, 4, 1 ] ], "date-time": "2024-04-01T00:00:00Z", "timestamp": 1711929600000 } }, { "URL": "https://www.elsevier.com/legal/tdmrep-license", "content-version": "tdm", "delay-in-days": 0, "start": { "date-parts": [ [ 2024, 4, 1 ] ], "date-time": "2024-04-01T00:00:00Z", "timestamp": 1711929600000 } }, { "URL": "http://creativecommons.org/licenses/by/4.0/", "content-version": "vor", "delay-in-days": 18, "start": { "date-parts": [ [ 2024, 4, 19 ] ], "date-time": "2024-04-19T00:00:00Z", "timestamp": 1713484800000 } } ], "link": [ { "URL": "https://api.elsevier.com/content/article/PII:S2405844024061115?httpAccept=text/xml", "content-type": "text/xml", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://api.elsevier.com/content/article/PII:S2405844024061115?httpAccept=text/plain", "content-type": "text/plain", "content-version": "vor", "intended-application": "text-mining" } ], "member": "78", "original-title": [], "page": "e30080", "prefix": "10.1016", "published": { "date-parts": [ [ 2024, 4 ] ] }, "published-print": { "date-parts": [ [ 2024, 4 ] ] }, "publisher": "Elsevier BV", "reference": [ { "DOI": "10.1159/000507423", "article-title": "COVID-19 outbreak: An overview", "author": "Ciotti", "doi-asserted-by": "crossref", "first-page": "215", "issue": "5-6", "journal-title": "Chemotherapy", "key": "10.1016/j.heliyon.2024.e30080_bib1", "volume": "64", "year": "2019" }, { "DOI": "10.3389/fimmu.2023.1264502", "article-title": "Virulence traits and novel drug delivery strategies for mucormycosis post-COVID-19: A comprehensive review", "author": "Faiyazuddin", "doi-asserted-by": "crossref", "journal-title": "Front. Immunol.", "key": "10.1016/j.heliyon.2024.e30080_bib2", "volume": "14", "year": "2023" }, { "DOI": "10.1016/j.cell.2020.02.052", "article-title": "SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor", "author": "Hoffmann", "doi-asserted-by": "crossref", "first-page": "271", "issue": "2", "journal-title": "Cell", "key": "10.1016/j.heliyon.2024.e30080_bib3", "volume": "181", "year": "2020" }, { "DOI": "10.1177/19458924211059639", "article-title": "Co-Expression and localization of angiotensin-converting enzyme-2 (ACE2) and the transmembrane serine protease 2 (TMPRSS2) in paranasal ciliated epithelium of patients with chronic Rhinosinusitis", "author": "Kawasumi", "doi-asserted-by": "crossref", "first-page": "313", "issue": "3", "journal-title": "Am. J. Rhinol. Allergy36", "key": "10.1016/j.heliyon.2024.e30080_bib4", "year": "2022" }, { "DOI": "10.1080/22221751.2023.2292071", "article-title": "Risk of reinfection and severity with the predominant BA.5 Omicron subvariant China, from December 2022 to January 2023", "author": "Cai", "doi-asserted-by": "crossref", "issue": "1", "journal-title": "Emerg. Microbes. Infect.", "key": "10.1016/j.heliyon.2024.e30080_bib5", "volume": "13", "year": "2024" }, { "DOI": "10.3389/fpubh.2024.1337646", "article-title": "Comparative outcomes of SARS-CoV-2 primary and reinfection in older adult patients", "author": "Tey", "doi-asserted-by": "crossref", "journal-title": "Front. Public Health", "key": "10.1016/j.heliyon.2024.e30080_bib6", "volume": "12", "year": "2024" }, { "DOI": "10.1016/j.tmaid.2023.102636", "article-title": "Addressing the resurgence of global monkeypox (Mpox) through advanced drug delivery platforms", "author": "Mohanto", "doi-asserted-by": "crossref", "journal-title": "Travel Med. Infect. Dis.", "key": "10.1016/j.heliyon.2024.e30080_bib7", "volume": "56", "year": "2023" }, { "DOI": "10.1007/978-3-030-63761-3_1", "article-title": "Introduction on coronavirus disease (COVID-19) pandemic: The global challenge", "author": "Rezaei", "doi-asserted-by": "crossref", "first-page": "1", "journal-title": "Adv. Exp. Med. Biol.", "key": "10.1016/j.heliyon.2024.e30080_bib8", "volume": "1318", "year": "2021" }, { "DOI": "10.1093/ofid/ofac138", "article-title": "A Systematic Review of Coronavirus Disease 2019 Vaccine Efficacy and Effectiveness Against Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Disease", "author": "Higdon", "doi-asserted-by": "crossref", "first-page": "ofac138", "issue": "6", "journal-title": "Open Forum Infect. Dis.", "key": "10.1016/j.heliyon.2024.e30080_bib9", "volume": "9", "year": "2022" }, { "DOI": "10.1177/11779322211025876", "article-title": "Structure and Function of Major SARS-CoV-2 and SARS-CoV Proteins", "author": "Gorkhali", "doi-asserted-by": "crossref", "journal-title": "Bioinform. Biol. Insights", "key": "10.1016/j.heliyon.2024.e30080_bib10", "volume": "15", "year": "2021" }, { "DOI": "10.1016/j.cell.2020.09.018", "article-title": "Molecular Architecture of the SARS-CoV-2 Virus", "author": "Yao", "doi-asserted-by": "crossref", "first-page": "730", "issue": "3", "journal-title": "Cell", "key": "10.1016/j.heliyon.2024.e30080_bib11", "volume": "183", "year": "2020" }, { "DOI": "10.1007/978-1-4939-2438-7_1", "article-title": "Coronaviruses: an overview of their replication and pathogenesis", "author": "Fehr", "doi-asserted-by": "crossref", "first-page": "1", "journal-title": "Methods Mol. Biol.", "key": "10.1016/j.heliyon.2024.e30080_bib12", "volume": "1282", "year": "2015" }, { "DOI": "10.1039/D2NR01385A", "article-title": "A detailed study of ion transport through the SARS-CoV-2 E protein ion channel", "author": "Saurabh", "doi-asserted-by": "crossref", "first-page": "8291", "issue": "23", "journal-title": "Nanoscale", "key": "10.1016/j.heliyon.2024.e30080_bib13", "volume": "14", "year": "2022" }, { "DOI": "10.3389/fcimb.2020.00405", "article-title": "Functional pangenome analysis shows key features of E protein are preserved in SARS and SARS-CoV-2", "author": "Alam", "doi-asserted-by": "crossref", "first-page": "405", "journal-title": "Front. Cell Infect. Microbiol.", "key": "10.1016/j.heliyon.2024.e30080_bib14", "volume": "10", "year": "2020" }, { "DOI": "10.1038/s41586-020-2180-5", "article-title": "Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor", "author": "Lan", "doi-asserted-by": "crossref", "first-page": "215", "issue": "7807", "journal-title": "Nature", "key": "10.1016/j.heliyon.2024.e30080_bib15", "volume": "581", "year": "2020" }, { "DOI": "10.1126/sciadv.abd4596", "article-title": "Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti-COVID-19 drug design", "author": "Rut", "doi-asserted-by": "crossref", "issue": "42", "journal-title": "Sci. Adv.", "key": "10.1016/j.heliyon.2024.e30080_bib16", "volume": "6", "year": "2020" }, { "DOI": "10.1038/s41467-020-17665-9", "article-title": "Activation and evasion of type I interferon responses by SARS-CoV-2", "author": "Lei", "doi-asserted-by": "crossref", "first-page": "3810", "issue": "1", "journal-title": "Nat. Commun.", "key": "10.1016/j.heliyon.2024.e30080_bib17", "volume": "11", "year": "2020" }, { "DOI": "10.3389/fchem.2022.876212", "article-title": "Inhibitors of SARS-CoV-2 PLpro", "author": "Calleja", "doi-asserted-by": "crossref", "journal-title": "Front. Chem.", "key": "10.1016/j.heliyon.2024.e30080_bib18", "volume": "10", "year": "2022" }, { "DOI": "10.1016/j.micpath.2020.104641", "article-title": "Structural and functional insights into non-structural proteins of coronaviruses", "author": "Rohaim", "doi-asserted-by": "crossref", "journal-title": "Microb. Pathog.", "key": "10.1016/j.heliyon.2024.e30080_bib19", "volume": "150", "year": "2021" }, { "DOI": "10.1016/j.csbj.2021.08.036", "article-title": "An overview of potential inhibitors targeting non-structural proteins 3 (PLpro and Mac1) and 5 (3CLpro/Mpro) of SARS-CoV-2", "author": "Yan", "doi-asserted-by": "crossref", "first-page": "4868", "journal-title": "Comput. Struct. Biotechnol. J.", "key": "10.1016/j.heliyon.2024.e30080_bib20", "volume": "19", "year": "2021" }, { "DOI": "10.1016/j.celrep.2020.107774", "article-title": "Structural and biochemical characterization of the nsp12-nsp7-nsp8 core polymerase complex from SARS-CoV-2", "author": "Peng", "doi-asserted-by": "crossref", "issue": "11", "journal-title": "Cell Rep", "key": "10.1016/j.heliyon.2024.e30080_bib21", "volume": "31", "year": "2020" }, { "DOI": "10.1159/000513686", "article-title": "Structures of SARS-CoV-2 RNA-binding proteins and therapeutic targets", "author": "Khan", "doi-asserted-by": "crossref", "first-page": "55", "issue": "2", "journal-title": "Intervirology", "key": "10.1016/j.heliyon.2024.e30080_bib22", "volume": "64", "year": "2021" }, { "DOI": "10.1016/j.cell.2020.11.016", "article-title": "Cryo-EM structure of an extended SARS-CoV-2 replication and transcription complex reveals an intermediate state in Cap synthesis", "author": "Yan", "doi-asserted-by": "crossref", "first-page": "184", "issue": "1", "journal-title": "Cell", "key": "10.1016/j.heliyon.2024.e30080_bib23", "volume": "184", "year": "2021" }, { "DOI": "10.1016/j.ijbiomac.2020.12.038", "article-title": "Ritonavir may inhibit exoribonuclease activity of nsp14 from the SARS-CoV-2 virus and potentiate the activity of chain terminating drugs", "author": "Narayanan", "doi-asserted-by": "crossref", "first-page": "272", "journal-title": "Int. J. Biol. Macromol.", "key": "10.1016/j.heliyon.2024.e30080_bib24", "volume": "168", "year": "2021" }, { "DOI": "10.1038/s41467-020-17496-8", "article-title": "Structural basis of RNA cap modification by SARS-CoV-2", "author": "Viswanathan", "doi-asserted-by": "crossref", "first-page": "3718", "issue": "1", "journal-title": "Nat. Commun.", "key": "10.1016/j.heliyon.2024.e30080_bib25", "volume": "11", "year": "2020" }, { "DOI": "10.1096/fj.202100280RR", "article-title": "Potential 3-chymotrypsin-like cysteine protease cleavage sites in the coronavirus polyproteins pp1a and pp1ab and their possible relevance to COVID-19 vaccine and drug development", "author": "Yan", "doi-asserted-by": "crossref", "issue": "5", "journal-title": "FASEB J", "key": "10.1016/j.heliyon.2024.e30080_bib26", "volume": "35", "year": "2021" }, { "DOI": "10.1038/s41467-020-19770-1", "article-title": "Architecture of a SARS-CoV-2 mini replication and transcription complex", "author": "Yan", "doi-asserted-by": "crossref", "first-page": "5874", "issue": "1", "journal-title": "Nat. Commun.", "key": "10.1016/j.heliyon.2024.e30080_bib27", "volume": "11", "year": "2020" }, { "DOI": "10.1093/nar/gkz409", "article-title": "Delicate structural coordination of the severe acute respiratory syndrome coronavirus Nsp13 upon ATP hydrolysis", "author": "Jia", "doi-asserted-by": "crossref", "first-page": "6538", "issue": "12", "journal-title": "Nucleic Acids Res", "key": "10.1016/j.heliyon.2024.e30080_bib28", "volume": "47", "year": "2019" }, { "DOI": "10.1073/pnas.1508686112", "article-title": "Structural basis and functional analysis of the SARS coronavirus nsp14-nsp10 complex", "author": "Ma", "doi-asserted-by": "crossref", "first-page": "9436", "issue": "30", "journal-title": "Proc. Natl. Acad. Sci. U.S.A.", "key": "10.1016/j.heliyon.2024.e30080_bib29", "volume": "112", "year": "2015" }, { "DOI": "10.3390/cells9051267", "article-title": "A structural view of SARS-CoV-2 RNA replication machinery: RNA synthesis, proofreading and final capping", "author": "Romano", "doi-asserted-by": "crossref", "first-page": "1267", "issue": "5", "journal-title": "Cells", "key": "10.1016/j.heliyon.2024.e30080_bib30", "volume": "9", "year": "2020" }, { "DOI": "10.1016/j.cell.2021.05.033", "article-title": "Coupling of N7-methyltransferase and 3'-5' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading", "author": "Yan", "doi-asserted-by": "crossref", "first-page": "3474", "issue": "13", "journal-title": "Cell", "key": "10.1016/j.heliyon.2024.e30080_bib31", "volume": "184", "year": "2021" }, { "DOI": "10.1073/pnas.1921485117", "article-title": "Coronavirus endoribonuclease targets viral polyuridine sequences to evade activating host sensors", "author": "Hackbart", "doi-asserted-by": "crossref", "first-page": "8094", "issue": "14", "journal-title": "Proc. Natl. Acad. Sci. U.S.A.", "key": "10.1016/j.heliyon.2024.e30080_bib32", "volume": "117", "year": "2020" }, { "DOI": "10.1038/s41467-020-20608-z", "article-title": "Cryo-EM structures of the SARS-CoV-2 endoribonuclease Nsp15 reveal insight into nuclease specificity and dynamics", "author": "Pillon", "doi-asserted-by": "crossref", "first-page": "636", "issue": "1", "journal-title": "Nat. Commun.", "key": "10.1016/j.heliyon.2024.e30080_bib33", "volume": "12", "year": "2021" }, { "DOI": "10.1371/journal.ppat.1002294", "article-title": "Biochemical and structural insights into the mechanisms of SARS coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex", "author": "Chen", "doi-asserted-by": "crossref", "issue": "10", "journal-title": "PLoS Pathog", "key": "10.1016/j.heliyon.2024.e30080_bib34", "volume": "7", "year": "2011" }, { "DOI": "10.1126/scisignal.abe1202", "article-title": "High-resolution structures of the SARS-CoV-2 2'-O-methyltransferase reveal strategies for structure-based inhibitor design", "author": "Rosas-Lemus", "doi-asserted-by": "crossref", "issue": "651", "journal-title": "Sci. Signal.", "key": "10.1016/j.heliyon.2024.e30080_bib35", "volume": "13", "year": "2020" }, { "DOI": "10.3390/nu7042345", "article-title": "Estimated daily intake and seasonal food sources of quercetin in Japan", "author": "Nishimuro", "doi-asserted-by": "crossref", "first-page": "2345", "issue": "4", "journal-title": "Nutrients", "key": "10.1016/j.heliyon.2024.e30080_bib36", "volume": "7", "year": "2015" }, { "key": "10.1016/j.heliyon.2024.e30080_bib37", "unstructured": "S. Bhagwat, D.B. Haytowitz, USDA database for the flavonoid content of selected foods, Release 3.3 (March 2018), (2022). https://doi.org/10.15482/USDA.ADC/1529181." }, { "DOI": "10.1016/j.redox.2016.08.007", "article-title": "The deleterious effect of cholesterol and protection by quercetin on mitochondrial bioenergetics of pancreatic β-cells, glycemic control and inflammation: In vitro and in vivo studies", "author": "Carrasco-Pozo", "doi-asserted-by": "crossref", "first-page": "229", "journal-title": "Redox. Biol.", "key": "10.1016/j.heliyon.2024.e30080_bib38", "volume": "9", "year": "2016" }, { "DOI": "10.4155/fmc-2016-0186", "article-title": "Quercetin and derivatives: useful tools in inflammation and pain management", "author": "Carullo", "doi-asserted-by": "crossref", "first-page": "79", "issue": "1", "journal-title": "Future Med, Chem.", "key": "10.1016/j.heliyon.2024.e30080_bib39", "volume": "9", "year": "2017" }, { "DOI": "10.2174/1876396001104010189", "article-title": "Beneficial effects of quercetin on obesity and diabetes", "author": "Aguirre", "doi-asserted-by": "crossref", "first-page": "189", "journal-title": "Open Nutraceuticals J", "key": "10.1016/j.heliyon.2024.e30080_bib40", "volume": "4", "year": "2011" }, { "DOI": "10.1002/ptr.6155", "article-title": "Anticancer potential of quercetin: A comprehensive review", "author": "Rauf", "doi-asserted-by": "crossref", "first-page": "2109", "issue": "11", "journal-title": "Phytother. Res.", "key": "10.1016/j.heliyon.2024.e30080_bib41", "volume": "32", "year": "2018" }, { "DOI": "10.3390/molecules24061123", "article-title": "Antioxidant activities of quercetin and its complexes for medicinal application", "author": "Xu", "doi-asserted-by": "crossref", "first-page": "1123", "issue": "6", "journal-title": "Molecules24", "key": "10.1016/j.heliyon.2024.e30080_bib42", "year": "2019" }, { "DOI": "10.1186/s12950-021-00268-6", "article-title": "Anti-inflammatory potential of quercetin in COVID-19 treatment", "author": "Saeedi-Boroujeni", "doi-asserted-by": "crossref", "first-page": "3", "issue": "1", "journal-title": "J. Inflamm. (Lond)", "key": "10.1016/j.heliyon.2024.e30080_bib43", "volume": "18", "year": "2021" }, { "DOI": "10.1007/978-3-319-41342-6_17", "article-title": "Quercetin and its role in chronic diseases", "author": "Oboh", "doi-asserted-by": "crossref", "first-page": "377", "journal-title": "Adv. Exp. Med. Biol.", "key": "10.1016/j.heliyon.2024.e30080_bib44", "volume": "929", "year": "2016" }, { "article-title": "RNA-seq analysis of diet-driven obesity and anti-obesity effects of quercetin glucoside or epigallocatechin gallate in Drosophila adults", "author": "Azuma", "first-page": "857", "issue": "2", "journal-title": "Eur. Rev. Med. Pharmacol. Sci.", "key": "10.1016/j.heliyon.2024.e30080_bib45", "volume": "23", "year": "2019" }, { "DOI": "10.3390/nu12030729", "article-title": "Effect of quercetin treatment on mitochondrial biogenesis and exercise-induced AMP-activated protein kinase activation in rat skeletal muscle", "author": "Koshinaka", "doi-asserted-by": "crossref", "first-page": "729", "issue": "3", "journal-title": "Nutrients", "key": "10.1016/j.heliyon.2024.e30080_bib46", "volume": "12", "year": "2020" }, { "DOI": "10.1016/j.biopha.2021.111867", "article-title": "Binding and antiplatelet activity of quercetin, rutin, diosmetin, and diosmin flavonoids", "author": "Zaragozá", "doi-asserted-by": "crossref", "journal-title": "Biomed. Pharmacother.", "key": "10.1016/j.heliyon.2024.e30080_bib47", "volume": "141", "year": "2021" }, { "DOI": "10.1016/j.ultsonch.2021.105686", "article-title": "Novel extraction, rapid assessment and bioavailability improvement of quercetin: A review, Ultrason", "author": "Manzoor", "doi-asserted-by": "crossref", "journal-title": "Sonochem", "key": "10.1016/j.heliyon.2024.e30080_bib48", "volume": "78", "year": "2021" }, { "DOI": "10.1016/j.foodchem.2015.11.051", "article-title": "Quercetin/β-cyclodextrin inclusion complex embedded nanofibres: Slow release and high solubility", "author": "Aytac", "doi-asserted-by": "crossref", "first-page": "864", "issue": "Pt A", "journal-title": "Food Chem", "key": "10.1016/j.heliyon.2024.e30080_bib49", "volume": "197", "year": "2016" }, { "DOI": "10.1002/ptr.7309", "article-title": "Quercetin and its derivates as antiviral potentials: A comprehensive review", "author": "Di Petrillo", "doi-asserted-by": "crossref", "first-page": "266", "issue": "1", "journal-title": "Phytother. Res.", "key": "10.1016/j.heliyon.2024.e30080_bib50", "volume": "36", "year": "2022" }, { "DOI": "10.3390/nu12061562", "article-title": "Strengthening the immune system and reducing inflammation and oxidative stress through diet and nutrition: Considerations during the COVID-19 Crisis", "author": "Iddir", "doi-asserted-by": "crossref", "first-page": "1562", "issue": "6", "journal-title": "Nutrients", "key": "10.1016/j.heliyon.2024.e30080_bib51", "volume": "12", "year": "2020" }, { "article-title": "Can activation of NRF2 be a strategy against COVID-19? Trends Pharmacol", "author": "Cuadrado", "first-page": "598", "issue": "9", "journal-title": "Sci", "key": "10.1016/j.heliyon.2024.e30080_bib52", "volume": "41", "year": "2020" }, { "DOI": "10.1186/s13601-020-00362-7", "article-title": "Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies", "author": "Bousquet", "doi-asserted-by": "crossref", "first-page": "58", "issue": "1", "journal-title": "Clin. Transl. Allergy", "key": "10.1016/j.heliyon.2024.e30080_bib53", "volume": "10", "year": "2020" }, { "DOI": "10.1183/16000617.0028-2022", "article-title": "Polyphenols, flavonoids and inflammasomes: The role of cigarette smoke in COPD", "author": "Fu", "doi-asserted-by": "crossref", "issue": "164", "journal-title": "Eur. Respir. Rev.", "key": "10.1016/j.heliyon.2024.e30080_bib54", "volume": "31", "year": "2022" }, { "DOI": "10.1016/j.jpha.2021.09.009", "article-title": "Antiviral, immunomodulatory, and anticoagulant effects of quercetin and its derivatives: Potential role in prevention and management of COVID-19", "author": "Manjunath", "doi-asserted-by": "crossref", "first-page": "29", "issue": "1", "journal-title": "J. Pharm. Anal.", "key": "10.1016/j.heliyon.2024.e30080_bib55", "volume": "12", "year": "2022" }, { "DOI": "10.1016/j.biopha.2021.111356", "article-title": "Repurposing potential of Ayurvedic medicinal plants derived active principles against SARS-CoV-2 associated target proteins revealed by molecular docking, molecular dynamics and MM-PBSA studies", "author": "Kumar Verma", "doi-asserted-by": "crossref", "journal-title": "Biomed. Pharmacother.", "key": "10.1016/j.heliyon.2024.e30080_bib56", "volume": "137", "year": "2021" }, { "DOI": "10.1007/s10068-017-0275-z", "article-title": "Sardinian honeys as sources of xanthine oxidase and tyrosinase inhibitors", "author": "Di Petrillo", "doi-asserted-by": "crossref", "first-page": "139", "issue": "1", "journal-title": "Food Sci. Biotechnol.", "key": "10.1016/j.heliyon.2024.e30080_bib57", "volume": "27", "year": "2017" }, { "DOI": "10.12688/f1000research.24218.1", "article-title": "Coronavirus disease 2019 drug discovery through molecular docking", "author": "Singh", "doi-asserted-by": "crossref", "first-page": "502", "journal-title": "F1000Res", "key": "10.1016/j.heliyon.2024.e30080_bib58", "volume": "9", "year": "2020" }, { "DOI": "10.1002/ptr.5591", "article-title": "A critical approach to evaluating clinical efficacy, adverse events and drug interactions of herbal remedies", "author": "Izzo", "doi-asserted-by": "crossref", "first-page": "691", "issue": "5", "journal-title": "Phytother. Res.", "key": "10.1016/j.heliyon.2024.e30080_bib59", "volume": "30", "year": "2016" }, { "DOI": "10.1016/j.ejps.2019.105100", "article-title": "A study to evaluate herb-drug interaction underlying mechanisms: An investigation of ginsenosides attenuating the effect of warfarin on cardiovascular diseases", "author": "Lin", "doi-asserted-by": "crossref", "journal-title": "Eur. J. Pharm. Sci.", "key": "10.1016/j.heliyon.2024.e30080_bib60", "volume": "142", "year": "2020" }, { "DOI": "10.3390/pathogens10091130", "article-title": "Indian herb-derived phytoconstituent-based antiviral, antimicrobial and antifungal formulation: An oral rinse candidate for oral hygiene and the potential prevention of COVID-19 outbreaks", "author": "Sharad", "doi-asserted-by": "crossref", "first-page": "1130", "issue": "9", "journal-title": "Pathogens", "key": "10.1016/j.heliyon.2024.e30080_bib61", "volume": "10", "year": "2021" }, { "DOI": "10.7717/peerj.10480", "article-title": "Repurposing FDA-approved phytomedicines, natural products, antivirals and cell protectives against SARS-CoV-2 (COVID-19) RNA-dependent RNA polymerase", "author": "Kandeel", "doi-asserted-by": "crossref", "journal-title": "PeerJ", "key": "10.1016/j.heliyon.2024.e30080_bib62", "volume": "8", "year": "2020" }, { "DOI": "10.1016/j.jsps.2022.02.014", "article-title": "In silico evaluation of Vitis amurensis Rupr. polyphenol compounds for their inhibition potency against CoVID-19 main enzymes Mpro and RdRp", "author": "Souid", "doi-asserted-by": "crossref", "first-page": "570", "issue": "5", "journal-title": "Saudi. Pharm. J", "key": "10.1016/j.heliyon.2024.e30080_bib63", "volume": "30", "year": "2022" }, { "article-title": "Focus on the high therapeutic potentials of quercetin and its derivatives", "author": "Septembre-Malaterre", "issue": "1", "journal-title": "Phytomed Plus", "key": "10.1016/j.heliyon.2024.e30080_bib64", "volume": "2", "year": "2022" }, { "DOI": "10.1007/s11356-021-14195-9", "article-title": "In silico screening of potent bioactive compounds from honeybee products against COVID-19 target enzymes", "author": "Shaldam", "doi-asserted-by": "crossref", "first-page": "40507", "issue": "30", "journal-title": "Environ. Sci. Pollut. Res. Int.", "key": "10.1016/j.heliyon.2024.e30080_bib65", "volume": "28", "year": "2021" }, { "DOI": "10.1080/07391102.2021.1872419", "article-title": "Prospecting for Cressa cretica to treat COVID-19 via in silico molecular docking models of the SARS-CoV-2", "author": "Shah", "doi-asserted-by": "crossref", "first-page": "5643", "issue": "12", "journal-title": "J. Biomol. Struct. Dyn.", "key": "10.1016/j.heliyon.2024.e30080_bib66", "volume": "40", "year": "2022" }, { "DOI": "10.1016/j.ejphar.2020.173448", "article-title": "In silico pharmacokinetic and molecular docking studies of natural flavonoids and synthetic indole chalcones against essential proteins of SARS-CoV-2", "author": "Vijayakumar", "doi-asserted-by": "crossref", "journal-title": "Eur. J. Pharmacol.", "key": "10.1016/j.heliyon.2024.e30080_bib67", "volume": "886", "year": "2020" }, { "DOI": "10.1080/07391102.2021.1947893", "article-title": "Identification of potential phytochemicals from Citrus Limon against main protease of SARS-CoV-2: molecular docking, molecular dynamic simulations and quantum computations", "author": "Khan", "doi-asserted-by": "crossref", "first-page": "10741", "issue": "21", "journal-title": "J. Biomol. Struct. Dyn.", "key": "10.1016/j.heliyon.2024.e30080_bib68", "volume": "40", "year": "2022" }, { "article-title": "Inhibition of the SARS-CoV-2 3CLpro main protease by plant polyphenols", "author": "Bahun", "issue": "Pt B", "journal-title": "Food Chem", "key": "10.1016/j.heliyon.2024.e30080_bib69", "volume": "373", "year": "2022" }, { "DOI": "10.1080/07391102.2020.1817787", "article-title": "Screening of plant-based natural compounds as a potential COVID-19 main protease inhibitor: an in silico docking and molecular dynamics simulation approach", "author": "Majumder", "doi-asserted-by": "crossref", "first-page": "696", "issue": "2", "journal-title": "J. Biomol. Struct. Dyn.", "key": "10.1016/j.heliyon.2024.e30080_bib70", "volume": "40", "year": "2022" }, { "DOI": "10.1016/j.virol.2022.04.005", "article-title": "Flavonols and dihydroflavonols inhibit the main protease activity of SARS-CoV-2 and the replication of human coronavirus 229E", "author": "Zhu", "doi-asserted-by": "crossref", "first-page": "21", "journal-title": "Virology", "key": "10.1016/j.heliyon.2024.e30080_bib71", "volume": "571", "year": "2022" }, { "article-title": "Molecular docking and ADMET prediction of natural compounds towards SARS spike glycoprotein-human angiotensin-converting enzyme 2 and SARS-CoV-2 main protease", "author": "Oso", "first-page": "453", "issue": "3", "journal-title": "Arch. Razi. Inst.", "key": "10.1016/j.heliyon.2024.e30080_bib72", "volume": "76", "year": "2021" }, { "DOI": "10.1080/07391102.2020.1808077", "article-title": "In-silico screening of plant-derived antivirals against main protease, 3CLpro and endoribonuclease, NSP15 proteins of SARS-CoV-2", "author": "Sharma", "doi-asserted-by": "crossref", "first-page": "86", "issue": "1", "journal-title": "J. Biomol. Struct. Dyn.", "key": "10.1016/j.heliyon.2024.e30080_bib73", "volume": "40", "year": "2022" }, { "DOI": "10.2174/1381612826999201116195851", "article-title": "Natural compounds as inhibitors of SARS-CoV-2 main protease (3CLpro): A molecular docking and simulation approach to combat COVID-19", "author": "Rehman", "doi-asserted-by": "crossref", "first-page": "3577", "issue": "33", "journal-title": "Curr Pharm Des", "key": "10.1016/j.heliyon.2024.e30080_bib74", "volume": "27", "year": "2021" }, { "DOI": "10.1007/s13205-020-02578-7", "article-title": "In silico docking analysis revealed the potential of phytochemicals present in Phyllanthus amarus and Andrographis paniculata, used in Ayurveda medicine in inhibiting SARS-CoV-2", "author": "Hiremath", "doi-asserted-by": "crossref", "first-page": "44", "issue": "2", "journal-title": "3 Biotech", "key": "10.1016/j.heliyon.2024.e30080_bib75", "volume": "11", "year": "2021" }, { "DOI": "10.1080/07391102.2020.1796811", "article-title": "Targeting SARS-CoV-2 spike protein of COVID-19 with naturally occurring phytochemicals: An in silico study for drug development", "author": "Pandey", "doi-asserted-by": "crossref", "first-page": "6306", "issue": "16", "journal-title": "J. Biomol. Struct. Dyn.", "key": "10.1016/j.heliyon.2024.e30080_bib76", "volume": "39", "year": "2021" }, { "DOI": "10.1007/s13337-020-00598-8", "article-title": "Structure-based drug designing for potential antiviral activity of selected natural products from Ayurveda against SARS-CoV-2 spike glycoprotein and its cellular receptor", "author": "Maurya", "doi-asserted-by": "crossref", "first-page": "179", "issue": "2", "journal-title": "Virusdisease", "key": "10.1016/j.heliyon.2024.e30080_bib77", "volume": "31", "year": "2020" }, { "DOI": "10.3389/fphar.2022.863082", "article-title": "Pharmaceutical prospects of curcuminoids for the remedy of COVID-19: Truth or myth", "author": "Fu", "doi-asserted-by": "crossref", "journal-title": "Front. Pharmacol.", "key": "10.1016/j.heliyon.2024.e30080_bib78", "volume": "13", "year": "2022" }, { "DOI": "10.1021/acsptsci.1c00253", "article-title": "Natural compounds inhibit SARS-CoV-2 nsp13 unwinding and ATPase enzyme activities", "author": "Corona", "doi-asserted-by": "crossref", "first-page": "226", "issue": "4", "journal-title": "ACS Pharmacol. Transl. Sci.", "key": "10.1016/j.heliyon.2024.e30080_bib79", "volume": "5", "year": "2022" }, { "DOI": "10.1016/j.molimm.2019.07.003", "article-title": "Porcine deltacoronavirus nsp15 antagonizes interferon-β production independently of its endoribonuclease activity", "author": "Liu", "doi-asserted-by": "crossref", "first-page": "100", "journal-title": "Mol. Immunol.", "key": "10.1016/j.heliyon.2024.e30080_bib80", "volume": "114", "year": "2019" }, { "DOI": "10.1186/s43141-021-00273-5", "article-title": "Molecular docking and pharmacokinetic studies of phytocompounds from Nigerian Medicinal Plants as promising inhibitory agents against SARS-CoV-2 methyltransferase (nsp16)", "author": "Saliu", "doi-asserted-by": "crossref", "first-page": "172", "issue": "1", "journal-title": "J. Genet. Eng. Biotechnol.", "key": "10.1016/j.heliyon.2024.e30080_bib81", "volume": "19", "year": "2021" }, { "DOI": "10.1002/ptr.6843", "article-title": "Aframomum melegueta secondary metabolites exhibit polypharmacology against SARS-CoV-2 drug targets: in vitro validation of furin inhibition", "author": "Omotuyi", "doi-asserted-by": "crossref", "first-page": "908", "issue": "2", "journal-title": "Phytother. Res.", "key": "10.1016/j.heliyon.2024.e30080_bib82", "volume": "35", "year": "2021" }, { "DOI": "10.1186/s43094-021-00348-7", "article-title": "Computational guided identification of potential leads from Acacia pennata (L.) Willd. as inhibitors for cellular entry and viral replication of SARS-CoV-2", "author": "Zothantluanga", "doi-asserted-by": "crossref", "first-page": "201", "issue": "1", "journal-title": "Futur. J. Pharm. Sci.", "key": "10.1016/j.heliyon.2024.e30080_bib83", "volume": "7", "year": "2021" }, { "DOI": "10.1590/0074-02760200207", "article-title": "Flavonoid glycosides and their putative human metabolites as potential inhibitors of the SARS-CoV-2 main protease (Mpro) and RNA-dependent RNA polymerase (RdRp)", "author": "da Silva", "doi-asserted-by": "crossref", "journal-title": "Mem. Inst. Oswaldo. Cruz.", "key": "10.1016/j.heliyon.2024.e30080_bib84", "volume": "115", "year": "2020" }, { "DOI": "10.3390/ijms22179431", "article-title": "Development of effective therapeutic molecule from natural sources against coronavirus protease", "author": "Fadaka", "doi-asserted-by": "crossref", "first-page": "9431", "issue": "17", "journal-title": "Int. J. Mol. Sci.", "key": "10.1016/j.heliyon.2024.e30080_bib85", "volume": "22", "year": "2021" }, { "DOI": "10.3389/fcimb.2021.730288", "article-title": "Identification of natural inhibitors against SARS-CoV-2 drugable targets using molecular docking, molecular dynamics simulation, and MM-PBSA approach", "author": "Kushwaha", "doi-asserted-by": "crossref", "journal-title": "Front. Cell. Infect. Microbiol.", "key": "10.1016/j.heliyon.2024.e30080_bib86", "volume": "11", "year": "2021" }, { "DOI": "10.1186/s43141-022-00314-7", "article-title": "In silico discovery of 3 novel quercetin derivatives against papain-like protease, spike protein, and 3C-like protease of SARS-CoV-2", "author": "Bhattacharya", "doi-asserted-by": "crossref", "first-page": "43", "issue": "1", "journal-title": "J. Genet. Eng. Biotechnol.", "key": "10.1016/j.heliyon.2024.e30080_bib87", "volume": "20", "year": "2022" }, { "DOI": "10.1039/D1RA04107J", "article-title": "Newly designed analogues from SARS-CoV inhibitors mimicking the druggable properties against SARS-CoV-2 and its novel variants", "author": "Ferdous", "doi-asserted-by": "crossref", "first-page": "31460", "issue": "50", "journal-title": "RSC Adv", "key": "10.1016/j.heliyon.2024.e30080_bib88", "volume": "11", "year": "2021" }, { "DOI": "10.3389/fphar.2022.830205", "article-title": "Isoquercetin as an Anti-COVID-19 Medication: A Potential to Realize", "author": "Mbikay", "doi-asserted-by": "crossref", "journal-title": "Front Pharmacol", "key": "10.1016/j.heliyon.2024.e30080_bib89", "volume": "13", "year": "2022" }, { "DOI": "10.1186/s43094-021-00309-0", "article-title": "Flavonoid compounds of buah merah (Pandanus conoideus Lamk) as a potent SARS-CoV-2 main protease inhibitor: in silico approach", "author": "Umar", "doi-asserted-by": "crossref", "first-page": "158", "issue": "1", "journal-title": "Futur. J. Pharm. Sci.", "key": "10.1016/j.heliyon.2024.e30080_bib90", "volume": "7", "year": "2021" }, { "DOI": "10.1007/s13337-021-00683-6", "article-title": "A molecular docking study of SARS-CoV-2 main protease against phytochemicals of Boerhavia diffusa Linn. for novel COVID-19 drug discovery", "author": "Rutwick Surya", "doi-asserted-by": "crossref", "first-page": "46", "issue": "1", "journal-title": "Virusdisease", "key": "10.1016/j.heliyon.2024.e30080_bib91", "volume": "32", "year": "2021" }, { "DOI": "10.1016/j.jmgm.2021.108038", "article-title": "In silico identification of SARS-CoV-2 cell entry inhibitors from selected natural antivirals", "author": "Şimşek", "doi-asserted-by": "crossref", "journal-title": "J. Mol. Graph. Model.", "key": "10.1016/j.heliyon.2024.e30080_bib92", "volume": "109", "year": "2021" }, { "DOI": "10.3390/molecules27092929", "article-title": "Conducting the RBD of SARS-CoV-2 omicron variant with phytoconstituents from Euphorbia dendroides to repudiate the binding of spike glycoprotein using computational molecular search and simulation approach", "author": "Hassan", "doi-asserted-by": "crossref", "first-page": "2929", "issue": "9", "journal-title": "Molecules", "key": "10.1016/j.heliyon.2024.e30080_bib93", "volume": "27", "year": "2022" }, { "DOI": "10.1039/D0RA09632F", "article-title": "Inhibitory activity of quercetin, its metabolite, and standard antiviral drugs towards enzymes essential for SARS-CoV-2: the role of acid-base equilibria", "author": "Milanović", "doi-asserted-by": "crossref", "first-page": "2838", "issue": "5", "journal-title": "RSC Adv", "key": "10.1016/j.heliyon.2024.e30080_bib94", "volume": "11", "year": "2021" }, { "DOI": "10.1007/s11655-021-3504-5", "article-title": "In silico screening of natural products as potential inhibitors of SARS-CoV-2 using molecular docking simulation", "author": "Hossain", "doi-asserted-by": "crossref", "first-page": "249", "issue": "3", "journal-title": "Chin. J. Integr. Med.", "key": "10.1016/j.heliyon.2024.e30080_bib95", "volume": "28", "year": "2022" }, { "DOI": "10.1016/j.csbj.2020.11.010", "article-title": "Chinese herbal compounds against SARS-CoV-2: Puerarin and quercetin impair the binding of viral S-protein to ACE2 receptor", "author": "Pan", "doi-asserted-by": "crossref", "first-page": "3518", "journal-title": "Comput. Struct. Biotechnol. J.", "key": "10.1016/j.heliyon.2024.e30080_bib96", "volume": "18", "year": "2020" }, { "DOI": "10.1007/s00203-021-02351-1", "article-title": "Investigation of potential inhibitor properties of ethanolic propolis extracts against ACE-II receptors for COVID-19 treatment by molecular docking study", "author": "Guler", "doi-asserted-by": "crossref", "first-page": "3557", "issue": "6", "journal-title": "Arch. Microbiol.", "key": "10.1016/j.heliyon.2024.e30080_bib97", "volume": "203", "year": "2021" }, { "DOI": "10.1080/07391102.2019.1696709", "article-title": "Natural analogues inhibiting selective cyclin-dependent kinase protein isoforms: a computational perspective", "author": "Singh", "doi-asserted-by": "crossref", "first-page": "5126", "issue": "17", "journal-title": "J. Biomol. Struct. Dyn.", "key": "10.1016/j.heliyon.2024.e30080_bib98", "volume": "38", "year": "2020" }, { "article-title": "Computational screening of phytochemicals from three medicinal plants as inhibitors of transmembrane protease serine 2 implicated in SARS-CoV-2 infection", "author": "Oyedara", "issue": "4", "journal-title": "Phytomed. Plus", "key": "10.1016/j.heliyon.2024.e30080_bib99", "volume": "1", "year": "2021" }, { "DOI": "10.1186/s12859-022-04724-9", "article-title": "Molecular docking analysis reveals the functional inhibitory effect of genistein and quercetin on TMPRSS2: SARS-COV-2 cell entry facilitator spike protein", "author": "Manjunathan", "doi-asserted-by": "crossref", "first-page": "180", "issue": "1", "journal-title": "BMC Bioinformatics", "key": "10.1016/j.heliyon.2024.e30080_bib100", "volume": "23", "year": "2022" }, { "DOI": "10.1007/s10787-022-00992-2", "article-title": "COVID-19 and the role of cytokines in this disease", "author": "Hasanvand", "doi-asserted-by": "crossref", "first-page": "789", "issue": "3", "journal-title": "Inflammopharmacology", "key": "10.1016/j.heliyon.2024.e30080_bib101", "volume": "30", "year": "2022" }, { "DOI": "10.3390/ijerph19010112", "article-title": "Rescuing the host immune system by targeting the immune evasion complex ORF8-IRF3 in SARS-CoV-2 infection with natural products using molecular modeling approaches", "author": "Albutti", "doi-asserted-by": "crossref", "first-page": "112", "issue": "1", "journal-title": "Int. J. Environ. Res. Public Health", "key": "10.1016/j.heliyon.2024.e30080_bib102", "volume": "19", "year": "2021" }, { "DOI": "10.1007/s11030-022-10405-9", "article-title": "Defective ORF8 dimerization in SARS-CoV-2 delta variant leads to a better adaptive immune response due to abrogation of ORF8-MHC1 interaction", "author": "Chaudhari", "doi-asserted-by": "crossref", "first-page": "45", "issue": "1", "journal-title": "Mol. Divers.", "key": "10.1016/j.heliyon.2024.e30080_bib103", "volume": "27", "year": "2023" }, { "DOI": "10.1371/journal.pone.0237752", "article-title": "Quercetin negatively regulates IL-1β production in Pseudomonas aeruginosa-infected human macrophages through the inhibition of MAPK/NLRP3 inflammasome pathways", "author": "Chanjitwiriya", "doi-asserted-by": "crossref", "issue": "8", "journal-title": "PLoS One", "key": "10.1016/j.heliyon.2024.e30080_bib104", "volume": "15", "year": "2020" }, { "DOI": "10.21037/atm-22-419", "article-title": "Using network pharmacology and molecular docking to explore the underlying anti-inflammatory mechanism of Wuyao-Danshen to treat endometriosis", "author": "Zhu", "doi-asserted-by": "crossref", "first-page": "198", "issue": "4", "journal-title": "Ann. Transl. Med.", "key": "10.1016/j.heliyon.2024.e30080_bib105", "volume": "10", "year": "2022" }, { "DOI": "10.1099/jmm.0.001374", "article-title": "Network pharmacology and molecular docking analysis on mechanisms of Tibetan Hongjingtian (Rhodiola crenulata) in the treatment of COVID-19", "author": "Wang", "doi-asserted-by": "crossref", "issue": "7", "journal-title": "J. Med. Microbiol.", "key": "10.1016/j.heliyon.2024.e30080_bib106", "volume": "70", "year": "2021" }, { "DOI": "10.1016/j.compbiomed.2021.104293", "article-title": "Network pharmacology and RNA-sequencing reveal the molecular mechanism of Xuebijing injection on COVID-19-induced cardiac dysfunction", "author": "He", "doi-asserted-by": "crossref", "journal-title": "Comput. Biol. Med.", "key": "10.1016/j.heliyon.2024.e30080_bib107", "volume": "131", "year": "2021" }, { "DOI": "10.1177/1535370214537743", "article-title": "Protective effect of quercetin on lipopolysaccharide-induced acute lung injury in mice by inhibiting inflammatory cell influx", "author": "Wang", "doi-asserted-by": "crossref", "first-page": "1653", "issue": "12", "journal-title": "Exp. Biol. Med. (Maywood)", "key": "10.1016/j.heliyon.2024.e30080_bib108", "volume": "239", "year": "2014" }, { "DOI": "10.1186/s12931-014-0150-x", "article-title": "Protective effects of intratracheally administered quercetin on lipopolysaccharide-induced acute lung injury", "author": "Takashima", "doi-asserted-by": "crossref", "first-page": "150", "issue": "1", "journal-title": "Respir. Res.", "key": "10.1016/j.heliyon.2024.e30080_bib109", "volume": "15", "year": "2014" }, { "DOI": "10.1016/j.freeradbiomed.2015.03.035", "article-title": "The involvement of p62-Keap1-Nrf2 antioxidative signaling pathway and JNK in the protection of natural flavonoid quercetin against hepatotoxicity", "author": "Ji", "doi-asserted-by": "crossref", "first-page": "12", "journal-title": "Free Radic, Biol, Med", "key": "10.1016/j.heliyon.2024.e30080_bib110", "volume": "85", "year": "2015" }, { "DOI": "10.1111/1750-3841.14483", "article-title": "Purification, characterization, and bioactivities of polyphenols from Platycladus orientalis (L.) Franco", "author": "Ren", "doi-asserted-by": "crossref", "first-page": "667", "issue": "3", "journal-title": "J. Food Sci.", "key": "10.1016/j.heliyon.2024.e30080_bib111", "volume": "84", "year": "2019" }, { "DOI": "10.2174/1386207323999201029122301", "article-title": "Exploring the potential mechanism of Shufeng Jiedu capsule for treating COVID-19 by comprehensive network pharmacological approaches and molecular docking validation", "author": "Zhuang", "doi-asserted-by": "crossref", "first-page": "1377", "issue": "9", "journal-title": "Comb. Chem. High Throughput Screen", "key": "10.1016/j.heliyon.2024.e30080_bib112", "volume": "24", "year": "2021" }, { "DOI": "10.3390/pathogens10060758", "article-title": "Bioactive polyphenolic compounds showing strong antiviral activities against severe acute respiratory syndrome coronavirus 2", "author": "Kandeil", "doi-asserted-by": "crossref", "first-page": "758", "issue": "6", "journal-title": "Pathogens", "key": "10.1016/j.heliyon.2024.e30080_bib113", "volume": "10", "year": "2021" }, { "DOI": "10.1002/ddr.21815", "article-title": "Potential antiviral activity of isorhamnetin against SARS-CoV-2 spike pseudotyped virus in vitro", "author": "Zhan", "doi-asserted-by": "crossref", "first-page": "1124", "issue": "8", "journal-title": "Drug Dev Res", "key": "10.1016/j.heliyon.2024.e30080_bib114", "volume": "82", "year": "2021" }, { "DOI": "10.1021/acs.jafc.0c05064", "article-title": "Quercetin and its metabolites inhibit recombinant human angiotensin-converting enzyme 2 (ACE2) activity", "author": "Liu", "doi-asserted-by": "crossref", "first-page": "13982", "issue": "47", "journal-title": "J. Agric. Food Chem.", "key": "10.1016/j.heliyon.2024.e30080_bib115", "volume": "68", "year": "2020" }, { "DOI": "10.1016/j.bmc.2020.115860", "article-title": "Protease targeted COVID-19 drug discovery and its challenges: Insight into viral main protease (Mpro) and papain-like protease (PLpro) inhibitors", "author": "Amin", "doi-asserted-by": "crossref", "journal-title": "Bioorg. Med. Chem.", "key": "10.1016/j.heliyon.2024.e30080_bib116", "volume": "29", "year": "2021" }, { "DOI": "10.3390/ijms22137048", "article-title": "Seleno-functionalization of quercetin improves the non-covalent inhibition of Mpro and its antiviral activity in cells against SARS-CoV-2", "author": "Mangiavacchi", "doi-asserted-by": "crossref", "first-page": "7048", "issue": "13", "journal-title": "Int. J. Mol. Sci.", "key": "10.1016/j.heliyon.2024.e30080_bib117", "volume": "22", "year": "2021" }, { "DOI": "10.3390/biomedicines9040375", "article-title": "Rutin is a low micromolar inhibitor of SARS-CoV-2 main protease 3CLpro: Implications for drug design of quercetin analogs", "author": "Rizzuti", "doi-asserted-by": "crossref", "first-page": "375", "issue": "4", "journal-title": "Biomedicines", "key": "10.1016/j.heliyon.2024.e30080_bib118", "volume": "9", "year": "2021" }, { "DOI": "10.3390/molecules26196062", "article-title": "L-arginine improves solubility and anti SARS-CoV-2 Mpro activity of rutin but not the antiviral activity in cells", "author": "Sancineto", "doi-asserted-by": "crossref", "first-page": "6062", "issue": "19", "journal-title": "Molecules", "key": "10.1016/j.heliyon.2024.e30080_bib119", "volume": "26", "year": "2021" }, { "DOI": "10.1080/07391102.2020.1868340", "article-title": "Predictive medicinal metabolites from Momordica dioica against comorbidity related proteins of SARS-CoV-2 infections", "author": "Sakshi", "doi-asserted-by": "crossref", "first-page": "5175", "issue": "11", "journal-title": "J. Biomol. Struct. Dyn.", "key": "10.1016/j.heliyon.2024.e30080_bib120", "volume": "40", "year": "2022" }, { "DOI": "10.1093/nar/gkab719", "article-title": "Characterization of SARS2 Nsp15 nuclease activity reveals it's mad about U", "author": "Frazier", "doi-asserted-by": "crossref", "first-page": "10136", "issue": "17", "journal-title": "Nucleic Acids Res", "key": "10.1016/j.heliyon.2024.e30080_bib121", "volume": "49", "year": "2021" }, { "DOI": "10.1021/acs.jafc.1c02050", "article-title": "Epigallocatechin gallate inhibits the uridylate-specific endoribonuclease Nsp15 and efficiently neutralizes the SARS-CoV-2 strain", "author": "Hong", "doi-asserted-by": "crossref", "first-page": "5948", "issue": "21", "journal-title": "J. Agric. Food Chem.", "key": "10.1016/j.heliyon.2024.e30080_bib122", "volume": "69", "year": "2021" }, { "DOI": "10.1556/1886.2021.00022", "article-title": "Inhibitory effects of specific combination of natural compounds against SARS-CoV-2 and its Alpha, Beta, Gamma, Delta, Kappa, and Mu variants", "author": "Goc", "doi-asserted-by": "crossref", "first-page": "87", "issue": "4", "journal-title": "Eur. J. Microbiol. Immunol. (Bp)", "key": "10.1016/j.heliyon.2024.e30080_bib123", "volume": "11", "year": "2022" }, { "DOI": "10.1016/j.bmc.2010.09.035", "article-title": "Biflavonoids from Torreya nucifera displaying SARS-CoV 3CLpro inhibition", "author": "Ryu", "doi-asserted-by": "crossref", "first-page": "7940", "issue": "22", "journal-title": "Bioorg. Med. Chem.", "key": "10.1016/j.heliyon.2024.e30080_bib124", "volume": "18", "year": "2010" }, { "DOI": "10.1016/j.ijbiomac.2020.07.235", "article-title": "Structural stability of SARS-CoV-2 3CLpro and identification of quercetin as an inhibitor by experimental screening", "author": "Abian", "doi-asserted-by": "crossref", "first-page": "1693", "journal-title": "Int. J. Biol. Macromol.", "key": "10.1016/j.heliyon.2024.e30080_bib125", "volume": "164", "year": "2020" }, { "DOI": "10.7150/ijms.53685", "article-title": "A network pharmacology based approach for predicting active ingredients and potential mechanism of Lianhuaqingwen capsule in treating COVID-19", "author": "Zhang", "doi-asserted-by": "crossref", "first-page": "1866", "issue": "8", "journal-title": "Int. J. Med. Sci.", "key": "10.1016/j.heliyon.2024.e30080_bib126", "volume": "18", "year": "2021" }, { "DOI": "10.1038/s41401-021-00697-2", "article-title": "Inhibition of drug-metabolizing enzymes by Jingyin granules: implications of herb-drug interactions in antiviral therapy", "author": "Zhang", "doi-asserted-by": "crossref", "first-page": "1072", "issue": "4", "journal-title": "Acta Pharmacol. Sin.", "key": "10.1016/j.heliyon.2024.e30080_bib127", "volume": "43", "year": "2022" }, { "DOI": "10.2147/IJGM.S318720", "article-title": "Possible therapeutic effects of adjuvant quercetin supplementation against early-stage COVID-19 infection: A prospective, randomized, controlled, and open-label study", "author": "Di Pierro", "doi-asserted-by": "crossref", "first-page": "2359", "journal-title": "Int. J. Gen. Med.", "key": "10.1016/j.heliyon.2024.e30080_bib128", "volume": "14", "year": "2021" }, { "DOI": "10.2147/IJGM.S318949", "article-title": "Potential clinical benefits of quercetin in the early stage of COVID-19: Results of a second, pilot, randomized, controlled and open-label clinical trial", "author": "Di Pierro", "doi-asserted-by": "crossref", "first-page": "2807", "journal-title": "Int. J. Gen. Med.", "key": "10.1016/j.heliyon.2024.e30080_bib129", "volume": "14", "year": "2021" }, { "DOI": "10.1016/j.ejphar.2021.174615", "article-title": "The therapeutic efficacy of quercetin in combination with antiviral drugs in hospitalized COVID-19 patients: A randomized controlled trial", "author": "Shohan", "doi-asserted-by": "crossref", "journal-title": "Eur. J. Pharmacol.", "key": "10.1016/j.heliyon.2024.e30080_bib130", "volume": "914", "year": "2022" }, { "DOI": "10.1016/j.phymed.2021.153784", "article-title": "Yindan Jiedu granules exhibit anti-inflammatory effect in patients with novel Coronavirus disease (COVID-19) by suppressing the NF-κB signaling pathway", "author": "Feng", "doi-asserted-by": "crossref", "journal-title": "Phytomedicine", "key": "10.1016/j.heliyon.2024.e30080_bib131", "volume": "95", "year": "2022" }, { "DOI": "10.1016/j.phymed.2020.153390", "article-title": "Shufeng Jiedu, a promising herbal therapy for moderate COVID-19: Antiviral and anti-inflammatory properties, pathways of bioactive compounds, and a clinical real-world pragmatic study", "author": "Xia", "doi-asserted-by": "crossref", "journal-title": "Phytomedicine", "key": "10.1016/j.heliyon.2024.e30080_bib132", "volume": "85", "year": "2021" }, { "article-title": "20-Week study of clinical outcomes of over-the-counter COVID-19 prophylaxis and treatment, J. Evid. Based Integr", "author": "Margolin", "journal-title": "Med", "key": "10.1016/j.heliyon.2024.e30080_bib133", "volume": "26", "year": "2021" }, { "DOI": "10.3390/biomedicines8050129", "author": "Glinsky", "doi-asserted-by": "crossref", "first-page": "129", "issue": "5", "journal-title": "Biomedicines", "key": "10.1016/j.heliyon.2024.e30080_bib134", "volume": "8", "year": "2020" }, { "DOI": "10.1007/s00044-021-02826-2", "article-title": "A review of natural products, their effects on SARS-CoV-2 and their utility as lead compounds in the discovery of drugs for the treatment of COVID-19", "author": "Chapman", "doi-asserted-by": "crossref", "first-page": "40", "issue": "1", "journal-title": "Med. Chem. Res.", "key": "10.1016/j.heliyon.2024.e30080_bib135", "volume": "31", "year": "2022" }, { "DOI": "10.3389/fphar.2022.1096853", "article-title": "Quercetin as a possible complementary agent for early-stage COVID-19: Concluding results of a randomized clinical trial", "author": "Di Pierro", "doi-asserted-by": "crossref", "journal-title": "Front. Pharmacol.", "key": "10.1016/j.heliyon.2024.e30080_bib136", "volume": "13", "year": "2023" }, { "DOI": "10.3389/fnut.2023.1137407", "article-title": "NASAFYTOL® supplementation in adults hospitalized with COVID-19 infection: results from an exploratory open-label randomized controlled trial", "author": "Gérain", "doi-asserted-by": "crossref", "journal-title": "Front. Nutr.", "key": "10.1016/j.heliyon.2024.e30080_bib137", "volume": "10", "year": "2023" }, { "DOI": "10.3389/fphar.2022.898062", "article-title": "Oral co-supplementation of curcumin, quercetin, and vitamin D3 as an adjuvant therapy for mild to moderate symptoms of COVID-19-results from a pilot open-label, randomized controlled trial", "author": "Khan", "doi-asserted-by": "crossref", "journal-title": "Front. Pharmacol.", "key": "10.1016/j.heliyon.2024.e30080_bib138", "volume": "13", "year": "2022" }, { "DOI": "10.3389/fnut.2022.1023997", "article-title": "The possible therapeutic role of curcumin and quercetin in the early-stage of COVID-19-Results from a pragmatic randomized clinical trial", "author": "Ujjan", "doi-asserted-by": "crossref", "journal-title": "Front. Nutr.", "key": "10.1016/j.heliyon.2024.e30080_bib139", "volume": "9", "year": "2023" }, { "DOI": "10.3390/molecules26133900", "article-title": "Flavonoids as promising antiviral agents against SARS-CoV-2 infection: A mechanistic review", "author": "Khazeei Tabari", "doi-asserted-by": "crossref", "first-page": "3900", "issue": "13", "journal-title": "Molecules", "key": "10.1016/j.heliyon.2024.e30080_bib140", "volume": "26", "year": "2021" }, { "DOI": "10.1186/s13020-020-00346-6", "article-title": "Mechanism of Dayuanyin in the treatment of coronavirus disease 2019 based on network pharmacology and molecular docking", "author": "Ruan", "doi-asserted-by": "crossref", "first-page": "62", "journal-title": "Chin Med", "key": "10.1016/j.heliyon.2024.e30080_bib141", "volume": "15", "year": "2020" }, { "DOI": "10.1093/bioinformatics/btaa645", "article-title": "COVID-19 docking server: A meta server for docking small molecules, peptides and antibodies against potential targets of COVID-19", "author": "Kong", "doi-asserted-by": "crossref", "first-page": "5109", "issue": "20", "journal-title": "Bioinformatics", "key": "10.1016/j.heliyon.2024.e30080_bib142", "volume": "36", "year": "2020" }, { "DOI": "10.3390/biom11020216", "article-title": "In silico screening of natural products isolated from Mexican herbal medicines against COVID-19", "author": "Rivero-Segura", "doi-asserted-by": "crossref", "first-page": "216", "issue": "2", "journal-title": "Biomolecules", "key": "10.1016/j.heliyon.2024.e30080_bib143", "volume": "11", "year": "2021" }, { "DOI": "10.1016/j.arabjc.2021.103353", "article-title": "Exploring the interaction of quercetin-3-O-sophoroside with SARS-CoV-2 main proteins by theoretical studies: A probable prelude to control some variants of coronavirus including Delta", "author": "Khan", "doi-asserted-by": "crossref", "issue": "10", "journal-title": "Arab. J. Chem.", "key": "10.1016/j.heliyon.2024.e30080_bib144", "volume": "14", "year": "2021" }, { "DOI": "10.1007/s13205-020-02630-6", "article-title": "Factual insights of the allosteric inhibition mechanism of SARS-CoV-2 main protease by quercetin: An in silico analysis", "author": "Verma", "doi-asserted-by": "crossref", "first-page": "67", "issue": "2", "journal-title": "3 Biotech.", "key": "10.1016/j.heliyon.2024.e30080_bib145", "volume": "11", "year": "2021" }, { "DOI": "10.1038/s41429-021-00437-y", "article-title": "Proteomics-based target identification of natural products affecting cancer metabolism", "author": "Muroi", "doi-asserted-by": "crossref", "first-page": "639", "issue": "10", "journal-title": "J. Antibiot. (Tokyo)", "key": "10.1016/j.heliyon.2024.e30080_bib146", "volume": "74", "year": "2021" }, { "article-title": "Network pharmacology, molecular docking integrated surface plasmon resonance technology reveals the mechanism of Toujie Quwen Granules against coronavirus disease 2019 pneumonia", "author": "Ye", "journal-title": "Phytomedicine", "key": "10.1016/j.heliyon.2024.e30080_bib147", "volume": "85", "year": "2019" }, { "DOI": "10.1128/JVI.02560-09", "article-title": "Upregulation of the chemokine (C-C motif) ligand 2 via a severe acute respiratory syndrome coronavirus spike-ACE2 signaling pathway", "author": "Chen", "doi-asserted-by": "crossref", "first-page": "7703", "issue": "15", "journal-title": "J. Virol.", "key": "10.1016/j.heliyon.2024.e30080_bib148", "volume": "84", "year": "2010" }, { "DOI": "10.3390/molecules26195803", "article-title": "Natural Polyphenols as Immunomodulators to Rescue Immune Response Homeostasis: Quercetin as a Research Model against Severe COVID-19", "author": "Bernini", "doi-asserted-by": "crossref", "first-page": "5803", "issue": "19", "journal-title": "Molecules", "key": "10.1016/j.heliyon.2024.e30080_bib149", "volume": "26", "year": "2021" }, { "DOI": "10.3390/antiox9111105", "article-title": "Cell clearing systems as targets of polyphenols in viral infections: Potential implications for COVID-19 pathogenesis", "author": "Limanaqi", "doi-asserted-by": "crossref", "first-page": "1105", "issue": "11", "journal-title": "Antioxidants (Basel)", "key": "10.1016/j.heliyon.2024.e30080_bib150", "volume": "9", "year": "2020" }, { "DOI": "10.1080/07391102.2021.1885495", "article-title": "Anti-HIV-drug and phyto-flavonoid combination against SARS-CoV-2: a molecular docking-simulation base assessment", "author": "Swain", "doi-asserted-by": "crossref", "first-page": "6463", "issue": "14", "journal-title": "J. Biomol. Struct. Dyn.", "key": "10.1016/j.heliyon.2024.e30080_bib151", "volume": "40", "year": "2022" }, { "DOI": "10.1002/ptr.7436", "article-title": "Therapeutic and prophylactic effect of flavonoids in post-COVID-19 therapy", "author": "Bardelčíková", "doi-asserted-by": "crossref", "first-page": "2042", "issue": "5", "journal-title": "Phytother. Res.", "key": "10.1016/j.heliyon.2024.e30080_bib152", "volume": "36", "year": "2022" }, { "DOI": "10.1002/biof.1726", "article-title": "Long-COVID syndrome-associated brain fog and chemofog: Luteolin to the rescue", "author": "Theoharides", "doi-asserted-by": "crossref", "first-page": "232", "issue": "2", "journal-title": "Biofactors", "key": "10.1016/j.heliyon.2024.e30080_bib153", "volume": "47", "year": "2021" }, { "article-title": "Antibodies for COVID-19 - which, when and how long?", "author": "Theoharides", "first-page": "417", "issue": "2", "journal-title": "J. Biol. Regul. Homeost. Agents", "key": "10.1016/j.heliyon.2024.e30080_bib154", "volume": "35", "year": "2021" }, { "DOI": "10.1007/s12035-021-02696-0", "article-title": "Could SARS-CoV-2 spike protein be responsible for long-COVID syndrome?", "author": "Theoharides", "doi-asserted-by": "crossref", "first-page": "1850", "issue": "3", "journal-title": "Mol. Neurobiol.", "key": "10.1016/j.heliyon.2024.e30080_bib155", "volume": "59", "year": "2022" }, { "DOI": "10.1007/s12519-021-00499-w", "article-title": "Clinical practice guidelines in multisystem inflammatory syndrome (MIS-C) related to COVID-19: a critical review and recommendations", "author": "Algarni", "doi-asserted-by": "crossref", "first-page": "83", "issue": "2", "journal-title": "World J. Pediatr.", "key": "10.1016/j.heliyon.2024.e30080_bib156", "volume": "18", "year": "2022" }, { "article-title": "MIS-A after COVID-19: points to ponder", "author": "Ish", "first-page": "531", "issue": "4", "journal-title": "Indian J. Crit. Care. Med.", "key": "10.1016/j.heliyon.2024.e30080_bib157", "volume": "26", "year": "2022" }, { "DOI": "10.1007/s11882-022-01031-4", "article-title": "Multisystem inflammatory syndrome in children (MIS-C)", "author": "Patel", "doi-asserted-by": "crossref", "first-page": "53", "issue": "5", "journal-title": "Curr. Allergy Asthma Rep.", "key": "10.1016/j.heliyon.2024.e30080_bib158", "volume": "22", "year": "2022" }, { "DOI": "10.1016/j.jped.2021.08.006", "article-title": "Multisystem inflammatory syndrome (MIS-C): a systematic review and meta-analysis of clinical characteristics, treatment, and outcomes", "author": "Santos", "doi-asserted-by": "crossref", "first-page": "338", "issue": "4", "journal-title": "J. Pediatr. (Rio. J.)", "key": "10.1016/j.heliyon.2024.e30080_bib159", "volume": "98", "year": "2022" }, { "DOI": "10.1007/s11926-021-01028-4", "article-title": "Current understanding of multisystem inflammatory syndrome (MIS-C) following COVID-19 and its distinction from Kawasaki disease", "author": "Bukulmez", "doi-asserted-by": "crossref", "first-page": "58", "issue": "8", "journal-title": "Curr. Rheumatol. Rep.", "key": "10.1016/j.heliyon.2024.e30080_bib160", "volume": "23", "year": "2021" }, { "DOI": "10.1186/s12245-021-00373-6", "article-title": "Multisystem inflammatory syndrome in children (MIS-C): a mini-review", "author": "Giacalone", "doi-asserted-by": "crossref", "first-page": "50", "issue": "1", "journal-title": "Int. J. Emerg. Med.", "key": "10.1016/j.heliyon.2024.e30080_bib161", "volume": "14", "year": "2021" }, { "DOI": "10.1172/JCI146614", "article-title": "HLA class I-associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in children", "author": "Porritt", "doi-asserted-by": "crossref", "issue": "10", "journal-title": "J. Clin. Invest.", "key": "10.1016/j.heliyon.2024.e30080_bib162", "volume": "131", "year": "2021" }, { "DOI": "10.1080/23744235.2021.1924397", "article-title": "Long COVID or post-COVID-19 syndrome: Putative pathophysiology, risk factors, and treatments", "author": "Yong", "doi-asserted-by": "crossref", "first-page": "737", "issue": "10", "journal-title": "Infect. Dis. (Lond)", "key": "10.1016/j.heliyon.2024.e30080_bib163", "volume": "53", "year": "2021" }, { "DOI": "10.12659/MSM.935005", "article-title": "Editorial: Multisystem inflammatory syndrome in adults (MIS-A) and the spectrum of COVID-19", "author": "Parums", "doi-asserted-by": "crossref", "journal-title": "Med. Sci. Monit.", "key": "10.1016/j.heliyon.2024.e30080_bib164", "volume": "27", "year": "2021" }, { "DOI": "10.1080/03639045.2020.1788070", "article-title": "Network pharmacology and molecular docking analysis on molecular targets and mechanisms of Huashi Baidu formula in the treatment of COVID-19", "author": "Tao", "doi-asserted-by": "crossref", "first-page": "1345", "issue": "8", "journal-title": "Drug Dev. Ind. Pharm.", "key": "10.1016/j.heliyon.2024.e30080_bib165", "volume": "46", "year": "2020" }, { "DOI": "10.1016/j.eujim.2020.101241", "article-title": "Analysis of the mechanism of Shufeng Jiedu capsule prevention and treatment for COVID-19 by network pharmacology tools", "author": "Xiong", "doi-asserted-by": "crossref", "journal-title": "Eur. J. Integr. Med.", "key": "10.1016/j.heliyon.2024.e30080_bib166", "volume": "40", "year": "2020" }, { "DOI": "10.3390/antibiotics9120863", "article-title": "Geranii Herba as a potential inhibitor of SARS-CoV-2 main 3CLpro, spike RBD, and regulation of unfolded protein response: An in silico approach", "author": "Arokiyaraj", "doi-asserted-by": "crossref", "first-page": "863", "issue": "12", "journal-title": "Antibiotics (Basel)", "key": "10.1016/j.heliyon.2024.e30080_bib167", "volume": "9", "year": "2020" }, { "article-title": "Perspectives on plant flavonoid quercetin-based drugs for novel SARS-CoV-2, Beni. Suef. Univ. J. Basic", "author": "Saakre", "first-page": "21", "issue": "1", "journal-title": "Appl. Sci.", "key": "10.1016/j.heliyon.2024.e30080_bib168", "volume": "10", "year": "2021" }, { "DOI": "10.3390/ijms21218095", "article-title": "Inhibition of porcine epidemic diarrhea virus replication and viral 3C-like protease by quercetin", "author": "Li", "doi-asserted-by": "crossref", "first-page": "8095", "issue": "21", "journal-title": "Int. J. Mol. Sci.", "key": "10.1016/j.heliyon.2024.e30080_bib169", "volume": "21", "year": "2020" }, { "DOI": "10.1016/j.micpath.2021.104954", "article-title": "Phytochemicals present in Indian ginseng possess potential to inhibit SARS-CoV-2 virulence: A molecular docking and MD simulation study", "author": "Kushwaha", "doi-asserted-by": "crossref", "journal-title": "Microb. Pathog.", "key": "10.1016/j.heliyon.2024.e30080_bib170", "volume": "157", "year": "2021" }, { "DOI": "10.1016/j.molstruc.2021.130380", "article-title": "Rational design of flavonoid based potential inhibitors targeting SARS-CoV 3CL protease for the treatment of COVID-19", "author": "Bhati", "doi-asserted-by": "crossref", "journal-title": "J. Mol. Struct.", "key": "10.1016/j.heliyon.2024.e30080_bib171", "volume": "1237", "year": "2021" }, { "DOI": "10.1007/s40203-020-00073-8", "article-title": "Evaluation of certain medicinal plants compounds as new potential inhibitors of novel corona virus (COVID-19) using molecular docking analysis", "author": "Alrasheid", "doi-asserted-by": "crossref", "first-page": "10", "issue": "1", "journal-title": "Silico. Pharmacol.", "key": "10.1016/j.heliyon.2024.e30080_bib172", "volume": "9", "year": "2021" }, { "DOI": "10.1080/07391102.2020.1784291", "article-title": "Repurposing of FDA-approved antivirals, antibiotics, anthelmintics, antioxidants, and cell protectives against SARS-CoV-2 papain-like protease", "author": "Kandeel", "doi-asserted-by": "crossref", "first-page": "5129", "issue": "14", "journal-title": "J. Biomol. Struct. Dyn.", "key": "10.1016/j.heliyon.2024.e30080_bib173", "volume": "39", "year": "2021" }, { "DOI": "10.1080/07391102.2020.1778539", "article-title": "SARS-CoV-2 host entry and replication inhibitors from Indian ginseng: an in-silico approach", "author": "Chikhale", "doi-asserted-by": "crossref", "first-page": "4510", "issue": "12", "journal-title": "J. Biomol. Struct. Dyn.", "key": "10.1016/j.heliyon.2024.e30080_bib174", "volume": "39", "year": "2021" }, { "DOI": "10.1080/07391102.2021.1900919", "article-title": "Evaluation of the effects of chlorhexidine and several flavonoids as antiviral purposes on SARS-CoV-2 main protease: molecular docking, molecular dynamics simulation studies", "author": "Tatar", "doi-asserted-by": "crossref", "first-page": "7656", "issue": "17", "journal-title": "J. Biomol. Struct. Dyn.", "key": "10.1016/j.heliyon.2024.e30080_bib175", "volume": "40", "year": "2022" } ], "reference-count": 175, "references-count": 175, "relation": {}, "resource": { "primary": { "URL": "https://linkinghub.elsevier.com/retrieve/pii/S2405844024061115" } }, "score": 1, "short-title": [], "source": "Crossref", "subject": [], "subtitle": [], "title": "Therapeutic Implications of Quercetin and its Derived-products in COVID-19 Protection and Prophylactic", "type": "journal-article", "update-policy": "http://dx.doi.org/10.1016/elsevier_cm_policy" }