Therapeutic Implications of Quercetin and its Derived-products in COVID-19 Protection and Prophylactic
Wan-Yi Ho, Zi-Han Shen, Yijing Chen, Ting-Hsu Chen, Xiaolin Lu, Yaw-Syan Fu
Heliyon, doi:10.1016/j.heliyon.2024.e30080
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel human coronavirus, which has triggered a global pandemic of the coronavirus infectious disease 2019 . Outbreaks of emerging infectious diseases continue to challenge human health worldwide. The virus conquers human cells through the angiotensin-converting enzyme 2 receptor-driven pathway by mostly targeting the human respiratory tract. Quercetin is a natural flavonoid widely represented in the plant kingdom. Cumulative evidence has demonstrated that quercetin and its derivatives have various pharmacological properties including anti-cancer, anti-hypertension, antihyperlipidemia, anti-hyperglycemia, anti-microbial, antiviral, neuroprotective, and cardio-protective effects, because it is a potential treatment for severe inflammation and acute respiratory distress syndrome. Furthermore, it is the main life-threatening condition in patients with COVID-19. This article provides a comprehensive review of the primary literature on the predictable effectiveness of quercetin and its derivatives docked to multi-target of SARS-CoV-2 and host cells via in silico and some of validation through in vitro, in vivo, and clinically to fight SARS-CoV-2 infections, contribute to the reduction of inflammation, which suggests the preventive and therapeutic latency of quercetin and its derived-products against COVID-19 pandemic, multisystem inflammatory syndromes (MIS), and long-COVID.
AUTHOR CONTRIBUTIONS Conceptualization, Y.S; original draft preparation, Z., and TH.; review and editing, Y.S.; funding acquisition, X., All authors have read and approved the manuscript. J o u r n a l P r e -p r o o f J o u r n a l P r e -p r o o f 6M17 Ser349, Leu441, Asp442, Asn448, Asn450, Arg509 [167] 6VXX Gln314, Ser316, Thr768, Asn317, Asn764, Arg765 [77] Asp88, Asp198, Ile233, Ile235 [168] 6VW1 Thr445, Ile446 [113] 6VYB Ser730, Met731, Lys733, Leu861, Ala1056, Pro1057, His1058, Gly1059, Val860, Pro863, Asp867, Met730, Ile870, [76] 6VSB Thr549, Asp745, Asn978, Arg1000 [75] S-protein (Closed) 6VXX Tyr741 S-protein (Open) 6YVB Tr549, Asn978, Gly744, Arg1000, Thr573, Met740, Tyr741 nsp16 6YZ1 Gly73, Leu100, Asp130, Glu71, Ala72, Ser74, Asp75, Ser98, Asp99, Leu100, Asp114, Cys115, Met131, Tyr132, Asp133, Phe149 [81] 6WJT, 6WKQ Tyr47, Gly71, Asp114, Phe149, Asp130 [82] RdRp (nsp12) 6M71 Glu350, Asn628, Val315, Arg349, Pro461, Pro677 [120] 6NUS Glu350, Pro323, Asn628, Val675 [75] 7BTF, 6M71, 6NUR Tyr619, Cys622, Asp623, Asp761, Ser841 [168] 6W9Q Leu45, Thr109 S-protein/ ACE2 6M0J Ala348, Gly352, Asp382, Phe390, Arg393, Asn394, His401 [120] Rutin Host ACE2 1R4L Asn149, Met270, His345, Lys363, Thr445, Tyr127, Leu144, Glu145, Glu150, Met152, Ala153, Asp269, Trp271, Phe274, Thr276, Cys344, Pro346, Met360, Cys361, Asp367, Asp368, Thr371, Leu503, Phe504 [97] J o u r n a l P r e -p r o o f Thr25, Thr24, Gly143, His164, Asn142, Thr26, Cys145, Arg188,..
References
Abian, Ortega-Alarcon, Jimenez-Alesanco, Structural stability of SARS-CoV-2 3CL pro and identification of quercetin as an inhibitor by experimental screening, Int. J. Biol. Macromol,
doi:10.1016/j.ijbiomac.2020.07.235Aguirre, Arias, Macarulla, Beneficial effects of quercetin on obesity and diabetes, Open Nutraceuticals J
Alam, Kamau, Kulmanov, Functional pangenome analysis shows key features of E protein are preserved in SARS and SARS-CoV-2, Front. Cell Infect. Microbiol,
doi:10.3389/fcimb.2020.00405Albutti, Rescuing the host immune system by targeting the immune evasion complex ORF8-IRF3 in SARS-CoV-2 infection with natural products using molecular modeling approaches, Int. J. Environ. Res. Public Health,
doi:10.3390/ijerph19010112Algarni, Alamri, Khayat, Clinical practice guidelines in multisystem inflammatory syndrome (MIS-C) related to COVID-19: a critical review and recommendations, World J. Pediatr,
doi:10.1007/s12519-021-00499-wAlrasheid, Babiker, Awad, Evaluation of certain medicinal plants compounds as new potential inhibitors of novel corona virus (COVID-19) using molecular docking analysis, Silico. Pharmacol,
doi:10.1007/s40203-020-00073-8Amin, Banerjee, Ghosh, Protease targeted COVID-19 drug discovery and its challenges: Insight into viral main protease (M pro ) and papainlike protease (PL pro ) inhibitors, Bioorg. Med. Chem,
doi:10.1016/j.bmc.2020.115860Arokiyaraj, Stalin, Kannan, Geranii Herba as a potential inhibitor of SARS-CoV-2 main 3CL pro , spike RBD, and regulation of unfolded protein response: An in silico approach, Antibiotics (Basel),
doi:10.3390/antibiotics9120863Azuma, Dat Le, Yoshimoto, RNA-seq analysis of diet-driven obesity and anti-obesity effects of quercetin glucoside or epigallocatechin gallate in Drosophila adults, Eur. Rev. Med. Pharmacol. Sci,
doi:10.26355/eurrev_201901_16901Bardelčíková, Miroššay, Šoltýs, Therapeutic and prophylactic effect of flavonoids in post-COVID-19 therapy, Phytother. Res,
doi:10.1002/ptr.7436Bernini, Velotti, Natural Polyphenols as Immunomodulators to Rescue Immune Response Homeostasis: Quercetin as a Research Model against Severe COVID-19, Molecules,
doi:10.3390/molecules26195803Bhati, Kaushik, Singh, Rational design of flavonoid based potential inhibitors targeting SARS-CoV 3CL protease for the treatment of COVID-19, J. Mol. Struct,
doi:10.1016/j.molstruc.2021.130380Bhattacharya, Bordoloi, Chanu, In silico discovery of 3 novel quercetin derivatives against papain-like protease, spike protein, and 3C-like protease of SARS-CoV-2, J. Genet. Eng. Biotechnol,
doi:10.1186/s43141-022-00314-7Bousquet, Cristol, Czarlewski, Nrf2-interacting nutrients and J o u r n a l P r e -p r o o f COVID-19: time for research to develop adaptation strategies, Clin. Transl. Allergy,
doi:10.1186/s13601-020-00362-7Bukulmez, Current understanding of multisystem inflammatory syndrome (MIS-C) following COVID-19 and its distinction from Kawasaki disease, Curr. Rheumatol. Rep,
doi:10.1007/s11926-021-01028-4Cai, Zhang, Zhu, Risk of reinfection and severity with the predominant BA.5 Omicron subvariant China, from December 2022 to, Emerg. Microbes. Infect,
doi:10.1080/22221751.2023.2292071Cao, Cheng, Inhibition of porcine epidemic diarrhea virus replication and viral 3C-like protease by quercetin, Int. J. Mol. Sci,
doi:10.3390/ijms21218095Carrasco-Pozo, Tan, Reyes-Farias, The deleterious effect of cholesterol and protection by quercetin on mitochondrial bioenergetics of pancreatic β-cells, glycemic control and inflammation: In vitro and in vivo studies, Redox. Biol,
doi:10.1016/j.redox.2016.08.007Carullo, Cappello, Frattaruolo, Quercetin and derivatives: useful tools in inflammation and pain management, Future Med, Chem,
doi:10.4155/fmc-2016-0186JournChanjitwiriya, Roytrakul, Kunthalert, Quercetin negatively regulates IL-1β production in Pseudomonas aeruginosa-infected human macrophages through the inhibition of MAPK/NLRP3 inflammasome pathways, PLoS One,
doi:10.1007/s11030-022-10405-9Chapman, Andurkar, A review of natural products, their effects on SARS-CoV-2 and their utility as lead compounds in the discovery of drugs for the treatment of COVID-19, Med. Chem. Res,
doi:10.1007/s00044-021-02826-2Chaudhari, Singh, Joshi, Defective ORF8 dimerization in SARS-CoV-2 delta variant leads to a better adaptive immune response due to abrogation of ORF8-MHC1 interaction, Mol. Divers,
doi:10.1007/s11030-022-10405-9Chen, Chang, Wu, Upregulation of the chemokine (C-C motif) ligand 2 via a severe acute respiratory syndrome coronavirus spike-ACE2 signaling pathway, J. Virol,
doi:10.1128/JVI.02560-09Chen, Su, Ke, Biochemical and structural insights into the mechanisms of SARS coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex, PLoS Pathog,
doi:10.1371/journal.ppat.1002294Chikhale, Gurav, Patil, SARS-CoV-2 host entry and replication inhibitors from Indian ginseng: an in-silico approach, J. Biomol. Struct. Dyn,
doi:10.1080/07391102.2020.1778539Corona, Wycisk, Talarico, Natural compounds inhibit SARS-CoV-2 nsp13 unwinding and ATPase enzyme activities, ACS Pharmacol. Transl. Sci,
doi:10.1021/acsptsci.1c00253Da Silva, Da Silva, De Oliveira, Flavonoid glycosides and their putative human metabolites as potential inhibitors of the SARS-CoV-2 main protease (M pro ) and RNA-dependent RNA polymerase (RdRp), Mem. Inst. Oswaldo. Cruz,
doi:10.1590/0074-02760200207Di Petrillo, Orrù, Fais, Quercetin and its derivates as antiviral potentials: A comprehensive review, Phytother. Res,
doi:10.1002/ptr.7309Di Petrillo, Santos-Buelga, Era, Sardinian honeys as sources of xanthine oxidase and tyrosinase inhibitors, Food Sci. Biotechnol,
doi:10.1007/s10068-017-0275-zDi Pierro, Derosa, Maffioli, Possible therapeutic effects of adjuvant quercetin supplementation against early-stage COVID-19 infection: A prospective, randomized, controlled, and open-label study, Int. J. Gen. Med,
doi:10.2147/IJGM.S318720Di Pierro, Iqtadar, Khan, Potential clinical benefits of quercetin in the early stage of COVID-19: Results of a second, pilot, randomized, controlled and open-label clinical trial, Int. J. Gen. Med,
doi:10.2147/IJGM.S318949Di Pierro, Khan, Iqtadar, Quercetin as a possible complementary agent for early-stage COVID-19: Concluding results of a randomized clinical trial, Front. Pharmacol,
doi:10.3389/fphar.2022.1096853Fadaka, Sibuyi, Martin, Development of effective therapeutic molecule from natural sources against coronavirus protease, Int. J. Mol. Sci,
doi:10.3390/ijms22179431Faiyazuddin, Sophia, Ashique, Virulence traits and novel drug delivery strategies for mucormycosis post-COVID-19: A comprehensive review, Front. Immunol,
doi:10.3389/fimmu.2023.1264502Feng, Zhu, Liu, Yindan Jiedu granules exhibit antiinflammatory effect in patients with novel Coronavirus disease (COVID-19) by suppressing the NF-κB signaling pathway, Phytomedicine,
doi:10.1016/j.phymed.2021.153784Ferdous, Reza, Islam, Newly designed analogues from SARS-CoV inhibitors mimicking the druggable properties against SARS-CoV-2 and its novel variants, RSC Adv,
doi:10.1039/d1ra04107jFrazier, Dillard, Krahn, Characterization of SARS2 Nsp15 nuclease activity reveals it's mad about U, Nucleic Acids Res,
doi:10.1093/nar/gkab719Fu, Ho, Kang, Pharmaceutical prospects of curcuminoids for the remedy of COVID-19: Truth or myth, Front. Pharmacol,
doi:10.3389/fphar.2022.863082Glinsky, Tripartite combination of candidate pandemic mitigation agents:Vitamin D, quercetin, and estradiol manifest properties of medicinal agents for targeted mitigation of the COVID-19 pandemic defined by genomicsguided tracing of SARS-CoV-2 targets in human cells, Biomedicines,
doi:10.3390/biomedicines8050129Goc, Niedzwiecki, Ivanov, Inhibitory effects of specific combination of natural compounds against SARS-CoV-2 and its Alpha, Beta, Gamma, Delta, Kappa, and Mu variants, Eur. J. Microbiol. Immunol. (Bp),
doi:10.1556/1886.2021.00022Gorkhali, Koirala, Rijal, Structure and Function of Major SARS-CoV-2 and SARS-CoV Proteins, Bioinform. Biol. Insights,
doi:10.1177/11779322211025876Guler, Tatar, Yildiz, Investigation of potential inhibitor properties of ethanolic propolis extracts against ACE-II receptors for COVID-19 treatment by molecular docking study, Arch. Microbiol,
doi:10.1007/s00203-021-02351-1Gérain, Uebelhoer, Costes, NASAFYTOL® supplementation in adults hospitalized with COVID-19 infection: results from an exploratory open-label randomized controlled trial, Front. Nutr,
doi:10.3389/fnut.2023.1137407Hackbart, Deng, Baker, Coronavirus endoribonuclease targets viral polyuridine sequences to evade activating host sensors, Proc. Natl. Acad. Sci. U.S.A,
doi:10.1073/pnas.1921485117Hassan, Hassan, Mohamed, Conducting the RBD of SARS-CoV-2 omicron variant with phytoconstituents from Euphorbia dendroides to repudiate the binding of spike glycoprotein using computational molecular search and simulation approach, Molecules,
doi:10.3390/molecules27092929He, Zhang, Zhu, Network pharmacology and RNAsequencing reveal the molecular mechanism of Xuebijing injection on COVID-19-induced cardiac dysfunction, Comput. Biol. Med,
doi:10.1016/j.compbiomed.2021.104293Higdon, Wahl, Jones, A Systematic Review of Coronavirus Disease 2019 Vaccine Efficacy and Effectiveness Against Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Disease, Open Forum Infect. Dis,
doi:10.1093/ofid/ofac138Hiremath, Kumar, Nandan, In silico docking analysis revealed the potential of phytochemicals present in Phyllanthus amarus and Andrographis paniculata, used in Ayurveda medicine in inhibiting SARS-CoV-2, 3 Biotech,
doi:10.1007/s13205-020-02578-7Hoffmann, Kleine-Weber, Schroeder, SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor, Cell,
doi:10.1016/j.cell.2020.02.052Hong, Seo, Woo, Epigallocatechin gallate inhibits the uridylate-specific endoribonuclease Nsp15 and efficiently neutralizes the SARS-CoV-2 strain, J. Agric. Food Chem,
doi:10.1021/acs.jafc.1c02050Hossain, Sarkar, Hassan, In silico screening of natural products as potential inhibitors of SARS-CoV-2 using molecular docking simulation, Chin. J. Integr. Med,
doi:10.1007/s11655-021-3504-5Iddir, Brito, Dingeo, Strengthening the immune system and reducing inflammation and oxidative stress through diet and nutrition: Considerations during the COVID-19 Crisis, Nutrients,
doi:10.3390/nu12061562Izzo, Hoon-Kim, Radhakrishnan, A critical approach to evaluating clinical efficacy, adverse events and drug interactions of herbal remedies, Phytother. Res,
doi:10.1002/ptr.5591J O U R N A L P R E, None
J O U R N A L P R E, None
J O U R N A L P R E, None
Ji, Sheng, Zheng, The involvement of p62-Keap1-Nrf2 antioxidative signaling pathway and JNK in the protection of natural flavonoid quercetin against hepatotoxicity, Free Radic, Biol, Med,
doi:10.1016/j.freeradbiomed.2015.03.035Jia, Yan, Ren, Delicate structural coordination of the severe acute respiratory syndrome coronavirus Nsp13 upon ATP hydrolysis, Nucleic Acids Res,
doi:10.1093/nar/gkz409Kandeel, Abdelrahman, Oh-Hashi, Repurposing of FDA-approved antivirals, antibiotics, anthelmintics, antioxidants, and cell protectives against SARS-CoV-2 papain-like protease, J. Biomol. Struct. Dyn,
doi:10.1080/07391102.2020.1784291Kandeel, Kitade, Almubarak, Repurposing FDA-approved phytomedicines, natural products, antivirals and cell protectives against SARS-CoV-2 (COVID-19) RNA-dependent RNA polymerase, PeerJ,
doi:10.7717/peerj.10480Kandeil, Mostafa, Kutkat, Bioactive polyphenolic compounds showing strong antiviral activities against severe acute respiratory syndrome coronavirus 2, Pathogens,
doi:10.3390/pathogens10060758Kawasumi, Takeno, Ishino, Co-Expression and localization of angiotensin-converting enzyme-2 (ACE2) and the transmembrane serine protease 2 (TMPRSS2) in paranasal ciliated epithelium of patients with chronic Rhinosinusitis, Am. J. Rhinol. Allergy,
doi:10.1177/19458924211059639Khan, Hussain, Vahdani, Exploring the interaction of quercetin-3-O-sophoroside with SARS-CoV-2 main proteins by theoretical studies: A probable prelude to control some variants of coronavirus including Delta, Arab. J. Chem,
doi:10.1016/j.arabjc.2021.103353Khan, Iqtadar, Mumtaz, Oral co-supplementation of curcumin, quercetin, and vitamin D3 as an adjuvant therapy for mild to moderate symptoms of COVID-19-results from a pilot open-label, randomized controlled trial, Front. Pharmacol,
doi:10.3389/fphar.2022.898062Khan, Irfan, Ahsan, Structures of SARS-CoV-2 RNA-binding proteins and therapeutic targets, Intervirology,
doi:10.1159/000513686Khan, Sakib, Mahmud, Identification of potential phytochemicals from Citrus Limon against main protease of SARS-CoV-2: molecular docking, molecular dynamic simulations and quantum computations, J. Biomol. Struct. Dyn,
doi:10.1080/07391102.2021.1947893Khazeei Tabari, Iranpanah, Bahramsoltani, Flavonoids as promising antiviral agents against SARS-CoV-2 infection: A mechanistic review, Molecules,
doi:10.3390/molecules26133900Kong, Yang, Xue, COVID-19 docking server: A meta server for docking small molecules, peptides and antibodies against potential targets of COVID-19, Bioinformatics,
doi:10.1093/bioinformatics/btaa645Koshinaka, Honda, Masuda, Effect of quercetin treatment on mitochondrial biogenesis and exercise-induced AMP-activated protein kinase activation in rat skeletal muscle, Nutrients,
doi:10.3390/nu12030729Kushwaha, Singh, Bansal, Identification of natural inhibitors against SARS-CoV-2 drugable targets using molecular docking, molecular dynamics simulation, and MM-PBSA approach, Front. Cell. Infect. Microbiol,
doi:10.3389/fcimb.2021.730288Kushwaha, Singh, Prajapati, Phytochemicals present in Indian ginseng possess potential to inhibit SARS-CoV-2 virulence: A molecular docking and MD simulation study, Microb. Pathog,
doi:10.1016/j.micpath.2021.104954Limanaqi, Busceti, Biagioni, Cell clearing systems as targets of polyphenols in viral infections: Potential implications for COVID-19 pathogenesis, Antioxidants (Basel),
doi:10.3390/antiox9111105Lin, Fan, Li, A study to evaluate herb-drug interaction underlying mechanisms: An investigation of ginsenosides attenuating the effect of warfarin on cardiovascular diseases, Eur. J. Pharm. Sci,
doi:10.1016/j.ejps.2019.105100Liu, Fang, Fang, Porcine deltacoronavirus nsp15 antagonizes interferon-β production independently of its endoribonuclease activity, Mol. Immunol,
doi:10.1016/j.molimm.2019.07.003Liu, Raghuvanshi, Ceylan, Quercetin and its metabolites inhibit recombinant human angiotensin-converting enzyme 2 (ACE2) activity, J. Agric. Food Chem,
doi:10.1021/acs.jafc.0c05064Ma, Wu, Shaw, Structural basis and functional analysis of the SARS coronavirus nsp14-nsp10 complex, Proc. Natl. Acad. Sci. U.S.A,
doi:10.1073/pnas.1508686112Majumder, Screening of plant-based natural compounds as a potential COVID-19 main protease inhibitor: an in silico docking and molecular dynamics simulation approach, J. Biomol. Struct. Dyn,
doi:10.1080/07391102.2020.1817787Mangiavacchi, Botwina, Menichetti, Seleno-functionalization of quercetin improves the non-covalent inhibition of M pro and its antiviral activity in cells against SARS-CoV-2, Int. J. Mol. Sci,
doi:10.3390/ijms22137048Manjunath, Thimmulappa, Antiviral, immunomodulatory, and anticoagulant effects of quercetin and its derivatives: Potential role in prevention and management of COVID-19, J. Pharm. Anal,
doi:10.1016/j.jpha.2021.09.009Manjunathan, Periyaswami, Mitra, Molecular docking analysis reveals the functional inhibitory effect of genistein and quercetin on TMPRSS2: SARS-COV-2 cell entry facilitator spike protein, BMC Bioinformatics,
doi:10.1186/s12859-022-04724-9Manzoor, Hussain, Sameen, Novel extraction, rapid assessment and bioavailability improvement of quercetin: A review, Ultrason, Sonochem,
doi:10.1016/j.ultsonch.2021.105686Margolin, Luchins, Margolin, 20-Week study of clinical outcomes of over-the-counter COVID-19 prophylaxis and treatment, J. Evid. Based Integr. Med,
doi:10.1177/2515690X211026193JournMaurya, Kumar, Prasad, Structure-based drug designing for potential antiviral activity of selected natural products from Ayurveda against SARS-CoV-2 spike glycoprotein and its cellular receptor, Virusdisease,
doi:10.1007/s13337-020-00598-8Milanović, Antonijević, Amić, Inhibitory activity of quercetin, its metabolite, and standard antiviral drugs towards enzymes essential for SARS-CoV-2: the role of acid-base equilibria, RSC Adv,
doi:10.1039/d0ra09632fMohanto, Faiyazuddin, Dilip, Gholap, Addressing the resurgence of global monkeypox (Mpox) through advanced drug delivery platforms, Travel Med. Infect. Dis,
doi:10.1016/j.tmaid.2023.102636Muroi, Osada, Proteomics-based target identification of natural products affecting cancer metabolism, J. Antibiot. (Tokyo),
doi:10.1038/s41429-021-00437-yNarayanan, Nair, Ritonavir may inhibit exoribonuclease activity of nsp14 from the SARS-CoV-2 virus and potentiate the activity of chain terminating drugs, Int. J. Biol. Macromol,
doi:10.1016/j.ijbiomac.2020.12.038Nishimuro, Ohnishi, Sato, Estimated daily intake and seasonal food sources of quercetin in Japan, Nutrients,
doi:10.3390/nu7042345Omotuyi, Nash, Ajiboye, Aframomum melegueta secondary metabolites exhibit polypharmacology against SARS-CoV-2 drug targets: in vitro validation of furin inhibition, Phytother. Res,
doi:10.1002/ptr.6843Oso, Olaoye, Omeike Molecular docking and ADMET prediction of natural compounds towards SARS spike glycoprotein-human angiotensinconverting enzyme 2 and SARS-CoV-2 main protease, Arch. Razi. Inst,
doi:10.22092/ari.2020.351202.1517Oyedara, Agbedahunsi, Adeyemi, Computational screening J o u r n a l P r e -p r o o f of phytochemicals from three medicinal plants as inhibitors of transmembrane protease serine 2 implicated in SARS-CoV-2 infection, Phytomed,
doi:10.1016/j.phyplu.2021.100135Pan, Fang, Zhang, Chinese herbal compounds against SARS-CoV-2: Puerarin and quercetin impair the binding of viral S-protein to ACE2 receptor, Comput. Struct. Biotechnol. J,
doi:10.1016/j.csbj.2020.11.010Pandey, Rane, Chatterjee, Targeting SARS-CoV-2 spike protein of COVID-19 with naturally occurring phytochemicals: An in silico study for drug J o u r n a l P r e -p r o o f development, J. Biomol. Struct. Dyn,
doi:10.1080/07391102.2020.1796811Parums, Editorial: Multisystem inflammatory syndrome in adults (MIS-A) and the spectrum of COVID-19, Med. Sci. Monit,
doi:10.12659/MSM.935005Peng, Peng, Yuan, Structural and biochemical characterization of the nsp12-nsp7-nsp8 core polymerase complex from SARS-CoV-2, Cell Rep,
doi:10.1016/j.celrep.2020.107774Pillon, Frazier, Dillard, Cryo-EM structures of the SARS-CoV-2 endoribonuclease Nsp15 reveal insight into nuclease specificity and dynamics, Nat. Commun,
doi:10.1038/s41467-020-20608-zPorritt, Paschold, Rivas, HLA class I-associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in children, J. Clin. Invest,
doi:10.1172/JCI146614Rauf, Imran, Khan, Anticancer potential of quercetin: A comprehensive review, Phytother. Res,
doi:10.1002/ptr.6155Rehman, Alajmi, Hussain, Natural compounds as inhibitors of SARS-CoV-2 main protease (3CLpro): A molecular docking and simulation approach to combat COVID-19, Curr Pharm Des,
doi:10.2174/1381612826999201116195851Ren, Liao, Shang, Purification, characterization, and bioactivities of polyphenols from Platycladus orientalis (L.) Franco, J. Food Sci,
doi:10.1111/1750-3841.14483Rezaei, Ashkevarian, Fathi, Introduction on coronavirus disease (COVID-19) pandemic: The global challenge, Adv. Exp. Med. Biol,
doi:10.1007/978-3-030-63761-3_1Rivero-Segura, Gomez-Verjan, In silico screening of natural products isolated from Mexican herbal medicines against COVID-19, Biomolecules,
doi:10.3390/biom11020216Rizzuti, Grande, Conforti, Rutin is a low micromolar inhibitor of SARS-CoV-2 main protease 3CL pro : Implications for drug design of quercetin analogs, Biomedicines,
doi:10.3390/biomedicines9040375Romano, Ruggiero, Squeglia, A structural view of SARS-CoV-2 RNA replication machinery: RNA synthesis, proofreading and final capping, Cells,
doi:10.3390/cells9051267Rosas-Lemus, Minasov, Shuvalova, High-resolution structures of the SARS-CoV-2 2'-O-methyltransferase reveal strategies for structure-based inhibitor design, Sci. Signal,
doi:10.1126/scisignal.abe1202Ruan, Du, Zhao, Mechanism of Dayuanyin in the treatment of coronavirus disease 2019 based on network pharmacology and molecular docking, Chin Med,
doi:10.1186/s13020-020-00346-6Rut, Lv, Zmudzinski, Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti-COVID-19 drug design, Sci. Adv,
doi:10.1126/sciadv.abd4596Saakre, Mathew, Ravisankar, Perspectives on plant flavonoid quercetin-based drugs for novel SARS-CoV-2, Beni, Suef. Univ. J. Basic. Appl. Sci,
doi:10.1186/s43088-021-00107-wSakshi, Harikrishnan, Jayaraman, Predictive medicinal metabolites from Momordica dioica against comorbidity related proteins of SARS-CoV-2 infections, J. Biomol. Struct. Dyn,
doi:10.1080/07391102.2020.1868340Saliu, Umar, Ogunsile, Molecular docking and pharmacokinetic studies of phytocompounds from Nigerian Medicinal Plants as promising inhibitory agents against SARS-CoV-2 methyltransferase (nsp16), J. Genet. Eng. Biotechnol,
doi:10.1186/s43141-021-00273-5Sancineto, Ostacolo, Ortega-Alarcon, L-arginine improves solubility and anti SARS-CoV-2 M pro activity of rutin but not the antiviral activity in cells, Molecules,
doi:10.3390/molecules26196062Santos, Gonçalves, Silva, Multisystem inflammatory syndrome (MIS-C): a systematic review and meta-analysis of clinical characteristics, treatment, and outcomes, J. Pediatr. (Rio. J.),
doi:10.1016/j.jped.2021.08.006Saurabh, Solovchuk, Sheu, A detailed study of ion transport through the SARS-CoV-2 E protein ion channel, Nanoscale,
doi:10.1039/d2nr01385aSeptembre-Malaterre, Boumendjel, Seteyen, Focus on the high therapeutic potentials of quercetin and its derivatives, Phytomed Plus,
doi:10.1016/j.phyplu.2022.100220Shah, Chaple, Arora, Prospecting for Cressa cretica to treat COVID-19 via in silico molecular docking models of the SARS-CoV-2, J. Biomol. Struct. Dyn,
doi:10.1080/07391102.2021.1872419Shaldam, Yahya, Mohamed, In silico screening of potent J o u r n a l P r e -p r o o f bioactive compounds from honeybee products against COVID-19 target enzymes, Environ. Sci. Pollut. Res. Int,
doi:10.1007/s11356-021-14195-9Sharad, Kapur, Indian herb-derived phytoconstituent-based antiviral, antimicrobial and antifungal formulation: An oral rinse candidate for oral hygiene and the potential prevention of COVID-19 outbreaks, Pathogens,
doi:10.3390/pathogens10091130Sharma, Goyal, Yadav, In-silico screening of plant-derived antivirals against main protease, 3CL pro and endoribonuclease, NSP15 proteins of SARS-CoV-2, J. Biomol. Struct. Dyn,
doi:10.1080/07391102.2020.1808077Shohan, Nashibi, Mahmoudian-Sani, The therapeutic efficacy of quercetin in combination with antiviral drugs in hospitalized COVID-19 patients: A randomized controlled trial, Eur. J. Pharmacol,
doi:10.1016/j.ejphar.2021.174615Singh, Bhardwaj, Das, Natural analogues inhibiting selective cyclin-dependent kinase protein isoforms: a computational perspective, J. Biomol. Struct. Dyn,
doi:10.1080/07391102.2019.1696709Souid, Korchef, Souid, In silico evaluation of Vitis amurensis Rupr. polyphenol compounds for their inhibition potency against CoVID-19 main enzymes M pro and RdRp, Saudi, Pharm. J,
doi:10.1016/j.jsps.2022.02.014Surya, Praveen, A molecular docking study of SARS-CoV-2 main protease against phytochemicals of Boerhavia diffusa Linn. for novel COVID-19 drug discovery, Virusdisease,
doi:10.1007/s13337-021-00683-6Swain, Singh, Sahoo, Anti-HIV-drug and phyto-flavonoid combination against SARS-CoV-2: a molecular docking-simulation base assessment, J. Biomol. Struct. Dyn,
doi:10.1080/07391102.2021.1885495Takashima, Matsushima, Hashimoto, Protective effects of intratracheally administered quercetin on lipopolysaccharide-induced acute lung injury, Respir. Res,
doi:10.1186/s12931-014-0150-xTao, Du, Li, Network pharmacology and molecular docking analysis on molecular targets and mechanisms of Huashi Baidu formula in the treatment of COVID-19, Drug Dev. Ind. Pharm,
doi:10.1080/03639045.2020.1788070Tatar, Salmanli, Dogru, Evaluation of the effects of chlorhexidine and several flavonoids as antiviral purposes on SARS-CoV-2 main protease: molecular docking, molecular dynamics simulation studies, J. Biomol. Struct. Dyn,
doi:10.1080/07391102.2021.1900919Tey, Tsai, Wu, Comparative outcomes of SARS-CoV-2 primary and reinfection in older adult patients, Front. Public Health,
doi:10.3389/fpubh.2024.1337646Theoharides, Cholevas, Polyzoidis, Long-COVID syndrome-associated brain fog and chemofog: Luteolin to the rescue, Biofactors,
doi:10.1002/biof.1726Theoharides, Lauritano, Ronconi, Antibodies for COVID-19 -which, when and how long?, J. Biol. Regul. Homeost. Agents,
doi:10.23812/Theo_editUjjan, Khan, Nigar, The possible therapeutic role of curcumin and quercetin in the early-stage of COVID-19-Results from a pragmatic randomized clinical trial, Front. Nutr,
doi:10.3389/fnut.2022.1023997Umar, Flavonoid compounds of buah merah (Pandanus conoideus Lamk) as a potent SARS-CoV-2 main protease inhibitor: in silico approach, Futur. J. Pharm. Sci,
doi:10.1186/s43094-021-00309-0Verma, Kumar, Singh, Repurposing potential of Ayurvedic medicinal plants derived active principles against SARS-CoV-2 associated target proteins revealed by molecular docking, molecular dynamics and MM-PBSA studies, Biomed. Pharmacother,
doi:10.1016/j.biopha.2021.111356Verma, Pandey, Factual insights of the allosteric inhibition J o u r n a l P r e -p r o o f mechanism of SARS-CoV-2 main protease by quercetin: An in silico analysis, 3 Biotech,
doi:10.1007/s13205-020-02630-6Vijayakumar, Ramesh, Joji, In silico pharmacokinetic and molecular docking studies of natural flavonoids and synthetic indole chalcones against essential proteins of SARS-CoV-2, Eur. J. Pharmacol,
doi:10.1016/j.ejphar.2020.173448Wang, Chen, Wang, Protective effect of quercetin on lipopolysaccharide-induced acute lung injury in mice by inhibiting inflammatory cell influx, Exp. Biol. Med. (Maywood),
doi:10.1177/1535370214537743Wang, Wang, Yang, Network pharmacology and molecular docking analysis on mechanisms of Tibetan Hongjingtian (Rhodiola crenulata) in the treatment of COVID-19, J. Med. Microbiol,
doi:10.1099/jmm.0.001374Xia, Shi, Su, Shufeng Jiedu, a promising herbal therapy for moderate COVID-19: Antiviral and anti-inflammatory properties, pathways of bioactive compounds, and a clinical real-world pragmatic study, Phytomedicine,
doi:10.1016/j.phymed.2020.153390Xiong, Dong, Lou, Analysis of the mechanism of Shufeng Jiedu capsule prevention and treatment for COVID-19 by network pharmacology tools, Eur. J. Integr. Med,
doi:10.1016/j.eujim.2020.101241Yan, Gao, An overview of potential inhibitors targeting non-structural proteins 3 (PL pro and Mac1) and 5 (3CL pro /M pro ) of SARS-CoV-2, Comput. Struct. Biotechnol. J,
doi:10.1016/j.csbj.2021.08.036Yan, Ge, Zheng, Cryo-EM structure of an extended SARS-CoV-2 replication and transcription complex reveals an intermediate state in Cap synthesis, Cell,
doi:10.1016/j.cell.2020.11.016Yan, Wu, Potential 3-chymotrypsin-like cysteine protease cleavage sites in the coronavirus polyproteins pp1a and pp1ab and their possible relevance to COVID-19 vaccine and drug development, FASEB J,
doi:10.1096/fj.202100280RRYan, Yang, Li, Coupling of N7-methyltransferase and 3'-5' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading, Cell,
doi:10.1016/j.cell.2021.05.033Yan, Zhang, Ge, Architecture of a SARS-CoV-2 mini replication J o u r n a l P r e -p r o o f and transcription complex, Nat. Commun,
doi:10.1038/s41467-020-19770-1Ye, Luo, Ye, Network pharmacology, molecular docking integrated surface plasmon resonance technology reveals the mechanism of Toujie Quwen Granules against coronavirus disease 2019 pneumonia, Phytomedicine,
doi:10.1016/j.phymed.2020.153401Zaragozá, Monserrat, Mantecón, Binding and antiplatelet activity of quercetin, rutin, diosmetin, and diosmin flavonoids, Biomed. Pharmacother,
doi:10.1016/j.biopha.2021.111867Zhan, Ta, Tang, Potential antiviral activity of isorhamnetin against SARS-CoV-2 spike pseudotyped virus in vitro, Drug Dev Res,
doi:10.1002/ddr.21815Zhang, Gao, Zhou, A network pharmacology based approach for predicting active ingredients and potential mechanism of Lianhuaqingwen capsule in treating COVID-19, Int. J. Med. Sci,
doi:10.7150/ijms.53685Zhang, Liu, Huang, Inhibition of drug-metabolizing enzymes by Jingyin granules: implications of herb-drug interactions in antiviral therapy, Acta Pharmacol. Sin,
doi:10.1038/s41401-021-00697-2Zhu, Scholle, Kisthardt, Flavonols and dihydroflavonols inhibit the main protease activity of SARS-CoV-2 and the replication of human coronavirus 229E, Virology,
doi:10.1016/j.virol.2022.04.005Zhu, Xue, He, Using network pharmacology and molecular docking to explore the underlying anti-inflammatory mechanism of Wuyao-Danshen to treat endometriosis, Ann. Transl. Med,
doi:10.21037/atm-22-419Zhuang, Zhong, Zhang, Exploring the potential mechanism of Shufeng Jiedu capsule for treating COVID-19 by comprehensive network pharmacological approaches and molecular docking validation, Comb. Chem. High Throughput Screen,
doi:10.2174/1386207323999201029122301Zothantluanga, Gogoi, Shakya, Computational guided identification of potential leads from Acacia pennata (L.) Willd. as inhibitors for cellular entry and viral replication of SARS-CoV-2, Futur, J. Pharm. Sci,
doi:10.1186/s43094-021-00348-7Şimşek, Baran, Aslım, In silico identification of SARS-CoV-2 cell entry inhibitors from selected natural antivirals, J. Mol. Graph. Model,
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'volume': '13',
'author': 'Cai',
'year': '2024',
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'doi-asserted-by': 'crossref',
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'author': 'Tey',
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'DOI': '10.1016/j.tmaid.2023.102636',
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'volume': '56',
'author': 'Mohanto',
'year': '2023',
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'doi-asserted-by': 'crossref',
'first-page': '1',
'DOI': '10.1007/978-3-030-63761-3_1',
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'challenge',
'volume': '1318',
'author': 'Rezaei',
'year': '2021',
'journal-title': 'Adv. Exp. Med. Biol.'},
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'key': '10.1016/j.heliyon.2024.e30080_bib9',
'doi-asserted-by': 'crossref',
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'DOI': '10.1093/ofid/ofac138',
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'Effectiveness Against Severe Acute Respiratory Syndrome Coronavirus 2 '
'Infection and Disease',
'volume': '9',
'author': 'Higdon',
'year': '2022',
'journal-title': 'Open Forum Infect. Dis.'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib10',
'doi-asserted-by': 'crossref',
'DOI': '10.1177/11779322211025876',
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'volume': '15',
'author': 'Gorkhali',
'year': '2021',
'journal-title': 'Bioinform. Biol. Insights'},
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'key': '10.1016/j.heliyon.2024.e30080_bib11',
'doi-asserted-by': 'crossref',
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'DOI': '10.1016/j.cell.2020.09.018',
'article-title': 'Molecular Architecture of the SARS-CoV-2 Virus',
'volume': '183',
'author': 'Yao',
'year': '2020',
'journal-title': 'Cell'},
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'doi-asserted-by': 'crossref',
'first-page': '1',
'DOI': '10.1007/978-1-4939-2438-7_1',
'article-title': 'Coronaviruses: an overview of their replication and pathogenesis',
'volume': '1282',
'author': 'Fehr',
'year': '2015',
'journal-title': 'Methods Mol. Biol.'},
{ 'issue': '23',
'key': '10.1016/j.heliyon.2024.e30080_bib13',
'doi-asserted-by': 'crossref',
'first-page': '8291',
'DOI': '10.1039/D2NR01385A',
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'channel',
'volume': '14',
'author': 'Saurabh',
'year': '2022',
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'doi-asserted-by': 'crossref',
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'DOI': '10.3389/fcimb.2020.00405',
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'preserved in SARS and SARS-CoV-2',
'volume': '10',
'author': 'Alam',
'year': '2020',
'journal-title': 'Front. Cell Infect. Microbiol.'},
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'key': '10.1016/j.heliyon.2024.e30080_bib15',
'doi-asserted-by': 'crossref',
'first-page': '215',
'DOI': '10.1038/s41586-020-2180-5',
'article-title': 'Structure of the SARS-CoV-2 spike receptor-binding domain bound to the '
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'volume': '581',
'author': 'Lan',
'year': '2020',
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'key': '10.1016/j.heliyon.2024.e30080_bib16',
'doi-asserted-by': 'crossref',
'DOI': '10.1126/sciadv.abd4596',
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'papain-like protease: A framework for anti-COVID-19 drug design',
'volume': '6',
'author': 'Rut',
'year': '2020',
'journal-title': 'Sci. Adv.'},
{ 'issue': '1',
'key': '10.1016/j.heliyon.2024.e30080_bib17',
'doi-asserted-by': 'crossref',
'first-page': '3810',
'DOI': '10.1038/s41467-020-17665-9',
'article-title': 'Activation and evasion of type I interferon responses by SARS-CoV-2',
'volume': '11',
'author': 'Lei',
'year': '2020',
'journal-title': 'Nat. Commun.'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib18',
'doi-asserted-by': 'crossref',
'DOI': '10.3389/fchem.2022.876212',
'article-title': 'Inhibitors of SARS-CoV-2 PLpro',
'volume': '10',
'author': 'Calleja',
'year': '2022',
'journal-title': 'Front. Chem.'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib19',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.micpath.2020.104641',
'article-title': 'Structural and functional insights into non-structural proteins of '
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'volume': '150',
'author': 'Rohaim',
'year': '2021',
'journal-title': 'Microb. Pathog.'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib20',
'doi-asserted-by': 'crossref',
'first-page': '4868',
'DOI': '10.1016/j.csbj.2021.08.036',
'article-title': 'An overview of potential inhibitors targeting non-structural proteins 3 '
'(PLpro and Mac1) and 5 (3CLpro/Mpro) of SARS-CoV-2',
'volume': '19',
'author': 'Yan',
'year': '2021',
'journal-title': 'Comput. Struct. Biotechnol. J.'},
{ 'issue': '11',
'key': '10.1016/j.heliyon.2024.e30080_bib21',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.celrep.2020.107774',
'article-title': 'Structural and biochemical characterization of the nsp12-nsp7-nsp8 core '
'polymerase complex from SARS-CoV-2',
'volume': '31',
'author': 'Peng',
'year': '2020',
'journal-title': 'Cell Rep'},
{ 'issue': '2',
'key': '10.1016/j.heliyon.2024.e30080_bib22',
'doi-asserted-by': 'crossref',
'first-page': '55',
'DOI': '10.1159/000513686',
'article-title': 'Structures of SARS-CoV-2 RNA-binding proteins and therapeutic targets',
'volume': '64',
'author': 'Khan',
'year': '2021',
'journal-title': 'Intervirology'},
{ 'issue': '1',
'key': '10.1016/j.heliyon.2024.e30080_bib23',
'doi-asserted-by': 'crossref',
'first-page': '184',
'DOI': '10.1016/j.cell.2020.11.016',
'article-title': 'Cryo-EM structure of an extended SARS-CoV-2 replication and '
'transcription complex reveals an intermediate state in Cap synthesis',
'volume': '184',
'author': 'Yan',
'year': '2021',
'journal-title': 'Cell'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib24',
'doi-asserted-by': 'crossref',
'first-page': '272',
'DOI': '10.1016/j.ijbiomac.2020.12.038',
'article-title': 'Ritonavir may inhibit exoribonuclease activity of nsp14 from the '
'SARS-CoV-2 virus and potentiate the activity of chain terminating drugs',
'volume': '168',
'author': 'Narayanan',
'year': '2021',
'journal-title': 'Int. J. Biol. Macromol.'},
{ 'issue': '1',
'key': '10.1016/j.heliyon.2024.e30080_bib25',
'doi-asserted-by': 'crossref',
'first-page': '3718',
'DOI': '10.1038/s41467-020-17496-8',
'article-title': 'Structural basis of RNA cap modification by SARS-CoV-2',
'volume': '11',
'author': 'Viswanathan',
'year': '2020',
'journal-title': 'Nat. Commun.'},
{ 'issue': '5',
'key': '10.1016/j.heliyon.2024.e30080_bib26',
'doi-asserted-by': 'crossref',
'DOI': '10.1096/fj.202100280RR',
'article-title': 'Potential 3-chymotrypsin-like cysteine protease cleavage sites in the '
'coronavirus polyproteins pp1a and pp1ab and their possible relevance to '
'COVID-19 vaccine and drug development',
'volume': '35',
'author': 'Yan',
'year': '2021',
'journal-title': 'FASEB J'},
{ 'issue': '1',
'key': '10.1016/j.heliyon.2024.e30080_bib27',
'doi-asserted-by': 'crossref',
'first-page': '5874',
'DOI': '10.1038/s41467-020-19770-1',
'article-title': 'Architecture of a SARS-CoV-2 mini replication and transcription complex',
'volume': '11',
'author': 'Yan',
'year': '2020',
'journal-title': 'Nat. Commun.'},
{ 'issue': '12',
'key': '10.1016/j.heliyon.2024.e30080_bib28',
'doi-asserted-by': 'crossref',
'first-page': '6538',
'DOI': '10.1093/nar/gkz409',
'article-title': 'Delicate structural coordination of the severe acute respiratory '
'syndrome coronavirus Nsp13 upon ATP hydrolysis',
'volume': '47',
'author': 'Jia',
'year': '2019',
'journal-title': 'Nucleic Acids Res'},
{ 'issue': '30',
'key': '10.1016/j.heliyon.2024.e30080_bib29',
'doi-asserted-by': 'crossref',
'first-page': '9436',
'DOI': '10.1073/pnas.1508686112',
'article-title': 'Structural basis and functional analysis of the SARS coronavirus '
'nsp14-nsp10 complex',
'volume': '112',
'author': 'Ma',
'year': '2015',
'journal-title': 'Proc. Natl. Acad. Sci. U.S.A.'},
{ 'issue': '5',
'key': '10.1016/j.heliyon.2024.e30080_bib30',
'doi-asserted-by': 'crossref',
'first-page': '1267',
'DOI': '10.3390/cells9051267',
'article-title': 'A structural view of SARS-CoV-2 RNA replication machinery: RNA '
'synthesis, proofreading and final capping',
'volume': '9',
'author': 'Romano',
'year': '2020',
'journal-title': 'Cells'},
{ 'issue': '13',
'key': '10.1016/j.heliyon.2024.e30080_bib31',
'doi-asserted-by': 'crossref',
'first-page': '3474',
'DOI': '10.1016/j.cell.2021.05.033',
'article-title': "Coupling of N7-methyltransferase and 3'-5' exoribonuclease with "
'SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading',
'volume': '184',
'author': 'Yan',
'year': '2021',
'journal-title': 'Cell'},
{ 'issue': '14',
'key': '10.1016/j.heliyon.2024.e30080_bib32',
'doi-asserted-by': 'crossref',
'first-page': '8094',
'DOI': '10.1073/pnas.1921485117',
'article-title': 'Coronavirus endoribonuclease targets viral polyuridine sequences to '
'evade activating host sensors',
'volume': '117',
'author': 'Hackbart',
'year': '2020',
'journal-title': 'Proc. Natl. Acad. Sci. U.S.A.'},
{ 'issue': '1',
'key': '10.1016/j.heliyon.2024.e30080_bib33',
'doi-asserted-by': 'crossref',
'first-page': '636',
'DOI': '10.1038/s41467-020-20608-z',
'article-title': 'Cryo-EM structures of the SARS-CoV-2 endoribonuclease Nsp15 reveal '
'insight into nuclease specificity and dynamics',
'volume': '12',
'author': 'Pillon',
'year': '2021',
'journal-title': 'Nat. Commun.'},
{ 'issue': '10',
'key': '10.1016/j.heliyon.2024.e30080_bib34',
'doi-asserted-by': 'crossref',
'DOI': '10.1371/journal.ppat.1002294',
'article-title': 'Biochemical and structural insights into the mechanisms of SARS '
"coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex",
'volume': '7',
'author': 'Chen',
'year': '2011',
'journal-title': 'PLoS Pathog'},
{ 'issue': '651',
'key': '10.1016/j.heliyon.2024.e30080_bib35',
'doi-asserted-by': 'crossref',
'DOI': '10.1126/scisignal.abe1202',
'article-title': "High-resolution structures of the SARS-CoV-2 2'-O-methyltransferase "
'reveal strategies for structure-based inhibitor design',
'volume': '13',
'author': 'Rosas-Lemus',
'year': '2020',
'journal-title': 'Sci. Signal.'},
{ 'issue': '4',
'key': '10.1016/j.heliyon.2024.e30080_bib36',
'doi-asserted-by': 'crossref',
'first-page': '2345',
'DOI': '10.3390/nu7042345',
'article-title': 'Estimated daily intake and seasonal food sources of quercetin in Japan',
'volume': '7',
'author': 'Nishimuro',
'year': '2015',
'journal-title': 'Nutrients'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib37',
'unstructured': 'S. Bhagwat, D.B. Haytowitz, USDA database for the flavonoid content of '
'selected foods, Release 3.3 (March 2018), (2022). '
'https://doi.org/10.15482/USDA.ADC/1529181.'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib38',
'doi-asserted-by': 'crossref',
'first-page': '229',
'DOI': '10.1016/j.redox.2016.08.007',
'article-title': 'The deleterious effect of cholesterol and protection by quercetin on '
'mitochondrial bioenergetics of pancreatic β-cells, glycemic control and '
'inflammation: In vitro and in vivo studies',
'volume': '9',
'author': 'Carrasco-Pozo',
'year': '2016',
'journal-title': 'Redox. Biol.'},
{ 'issue': '1',
'key': '10.1016/j.heliyon.2024.e30080_bib39',
'doi-asserted-by': 'crossref',
'first-page': '79',
'DOI': '10.4155/fmc-2016-0186',
'article-title': 'Quercetin and derivatives: useful tools in inflammation and pain '
'management',
'volume': '9',
'author': 'Carullo',
'year': '2017',
'journal-title': 'Future Med, Chem.'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib40',
'doi-asserted-by': 'crossref',
'first-page': '189',
'DOI': '10.2174/1876396001104010189',
'article-title': 'Beneficial effects of quercetin on obesity and diabetes',
'volume': '4',
'author': 'Aguirre',
'year': '2011',
'journal-title': 'Open Nutraceuticals J'},
{ 'issue': '11',
'key': '10.1016/j.heliyon.2024.e30080_bib41',
'doi-asserted-by': 'crossref',
'first-page': '2109',
'DOI': '10.1002/ptr.6155',
'article-title': 'Anticancer potential of quercetin: A comprehensive review',
'volume': '32',
'author': 'Rauf',
'year': '2018',
'journal-title': 'Phytother. Res.'},
{ 'issue': '6',
'key': '10.1016/j.heliyon.2024.e30080_bib42',
'doi-asserted-by': 'crossref',
'first-page': '1123',
'DOI': '10.3390/molecules24061123',
'article-title': 'Antioxidant activities of quercetin and its complexes for medicinal '
'application',
'author': 'Xu',
'year': '2019',
'journal-title': 'Molecules24'},
{ 'issue': '1',
'key': '10.1016/j.heliyon.2024.e30080_bib43',
'doi-asserted-by': 'crossref',
'first-page': '3',
'DOI': '10.1186/s12950-021-00268-6',
'article-title': 'Anti-inflammatory potential of quercetin in COVID-19 treatment',
'volume': '18',
'author': 'Saeedi-Boroujeni',
'year': '2021',
'journal-title': 'J. Inflamm. (Lond)'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib44',
'doi-asserted-by': 'crossref',
'first-page': '377',
'DOI': '10.1007/978-3-319-41342-6_17',
'article-title': 'Quercetin and its role in chronic diseases',
'volume': '929',
'author': 'Oboh',
'year': '2016',
'journal-title': 'Adv. Exp. Med. Biol.'},
{ 'issue': '2',
'key': '10.1016/j.heliyon.2024.e30080_bib45',
'first-page': '857',
'article-title': 'RNA-seq analysis of diet-driven obesity and anti-obesity effects of '
'quercetin glucoside or epigallocatechin gallate in Drosophila adults',
'volume': '23',
'author': 'Azuma',
'year': '2019',
'journal-title': 'Eur. Rev. Med. Pharmacol. Sci.'},
{ 'issue': '3',
'key': '10.1016/j.heliyon.2024.e30080_bib46',
'doi-asserted-by': 'crossref',
'first-page': '729',
'DOI': '10.3390/nu12030729',
'article-title': 'Effect of quercetin treatment on mitochondrial biogenesis and '
'exercise-induced AMP-activated protein kinase activation in rat '
'skeletal muscle',
'volume': '12',
'author': 'Koshinaka',
'year': '2020',
'journal-title': 'Nutrients'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib47',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.biopha.2021.111867',
'article-title': 'Binding and antiplatelet activity of quercetin, rutin, diosmetin, and '
'diosmin flavonoids',
'volume': '141',
'author': 'Zaragozá',
'year': '2021',
'journal-title': 'Biomed. Pharmacother.'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib48',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.ultsonch.2021.105686',
'article-title': 'Novel extraction, rapid assessment and bioavailability improvement of '
'quercetin: A review, Ultrason',
'volume': '78',
'author': 'Manzoor',
'year': '2021',
'journal-title': 'Sonochem'},
{ 'issue': 'Pt A',
'key': '10.1016/j.heliyon.2024.e30080_bib49',
'doi-asserted-by': 'crossref',
'first-page': '864',
'DOI': '10.1016/j.foodchem.2015.11.051',
'article-title': 'Quercetin/β-cyclodextrin inclusion complex embedded nanofibres: Slow '
'release and high solubility',
'volume': '197',
'author': 'Aytac',
'year': '2016',
'journal-title': 'Food Chem'},
{ 'issue': '1',
'key': '10.1016/j.heliyon.2024.e30080_bib50',
'doi-asserted-by': 'crossref',
'first-page': '266',
'DOI': '10.1002/ptr.7309',
'article-title': 'Quercetin and its derivates as antiviral potentials: A comprehensive '
'review',
'volume': '36',
'author': 'Di Petrillo',
'year': '2022',
'journal-title': 'Phytother. Res.'},
{ 'issue': '6',
'key': '10.1016/j.heliyon.2024.e30080_bib51',
'doi-asserted-by': 'crossref',
'first-page': '1562',
'DOI': '10.3390/nu12061562',
'article-title': 'Strengthening the immune system and reducing inflammation and oxidative '
'stress through diet and nutrition: Considerations during the COVID-19 '
'Crisis',
'volume': '12',
'author': 'Iddir',
'year': '2020',
'journal-title': 'Nutrients'},
{ 'issue': '9',
'key': '10.1016/j.heliyon.2024.e30080_bib52',
'first-page': '598',
'article-title': 'Can activation of NRF2 be a strategy against COVID-19? Trends Pharmacol',
'volume': '41',
'author': 'Cuadrado',
'year': '2020',
'journal-title': 'Sci'},
{ 'issue': '1',
'key': '10.1016/j.heliyon.2024.e30080_bib53',
'doi-asserted-by': 'crossref',
'first-page': '58',
'DOI': '10.1186/s13601-020-00362-7',
'article-title': 'Nrf2-interacting nutrients and COVID-19: time for research to develop '
'adaptation strategies',
'volume': '10',
'author': 'Bousquet',
'year': '2020',
'journal-title': 'Clin. Transl. Allergy'},
{ 'issue': '164',
'key': '10.1016/j.heliyon.2024.e30080_bib54',
'doi-asserted-by': 'crossref',
'DOI': '10.1183/16000617.0028-2022',
'article-title': 'Polyphenols, flavonoids and inflammasomes: The role of cigarette smoke '
'in COPD',
'volume': '31',
'author': 'Fu',
'year': '2022',
'journal-title': 'Eur. Respir. Rev.'},
{ 'issue': '1',
'key': '10.1016/j.heliyon.2024.e30080_bib55',
'doi-asserted-by': 'crossref',
'first-page': '29',
'DOI': '10.1016/j.jpha.2021.09.009',
'article-title': 'Antiviral, immunomodulatory, and anticoagulant effects of quercetin and '
'its derivatives: Potential role in prevention and management of '
'COVID-19',
'volume': '12',
'author': 'Manjunath',
'year': '2022',
'journal-title': 'J. Pharm. Anal.'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib56',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.biopha.2021.111356',
'article-title': 'Repurposing potential of Ayurvedic medicinal plants derived active '
'principles against SARS-CoV-2 associated target proteins revealed by '
'molecular docking, molecular dynamics and MM-PBSA studies',
'volume': '137',
'author': 'Kumar Verma',
'year': '2021',
'journal-title': 'Biomed. Pharmacother.'},
{ 'issue': '1',
'key': '10.1016/j.heliyon.2024.e30080_bib57',
'doi-asserted-by': 'crossref',
'first-page': '139',
'DOI': '10.1007/s10068-017-0275-z',
'article-title': 'Sardinian honeys as sources of xanthine oxidase and tyrosinase '
'inhibitors',
'volume': '27',
'author': 'Di Petrillo',
'year': '2017',
'journal-title': 'Food Sci. Biotechnol.'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib58',
'doi-asserted-by': 'crossref',
'first-page': '502',
'DOI': '10.12688/f1000research.24218.1',
'article-title': 'Coronavirus disease 2019 drug discovery through molecular docking',
'volume': '9',
'author': 'Singh',
'year': '2020',
'journal-title': 'F1000Res'},
{ 'issue': '5',
'key': '10.1016/j.heliyon.2024.e30080_bib59',
'doi-asserted-by': 'crossref',
'first-page': '691',
'DOI': '10.1002/ptr.5591',
'article-title': 'A critical approach to evaluating clinical efficacy, adverse events and '
'drug interactions of herbal remedies',
'volume': '30',
'author': 'Izzo',
'year': '2016',
'journal-title': 'Phytother. Res.'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib60',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.ejps.2019.105100',
'article-title': 'A study to evaluate herb-drug interaction underlying mechanisms: An '
'investigation of ginsenosides attenuating the effect of warfarin on '
'cardiovascular diseases',
'volume': '142',
'author': 'Lin',
'year': '2020',
'journal-title': 'Eur. J. Pharm. Sci.'},
{ 'issue': '9',
'key': '10.1016/j.heliyon.2024.e30080_bib61',
'doi-asserted-by': 'crossref',
'first-page': '1130',
'DOI': '10.3390/pathogens10091130',
'article-title': 'Indian herb-derived phytoconstituent-based antiviral, antimicrobial and '
'antifungal formulation: An oral rinse candidate for oral hygiene and '
'the potential prevention of COVID-19 outbreaks',
'volume': '10',
'author': 'Sharad',
'year': '2021',
'journal-title': 'Pathogens'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib62',
'doi-asserted-by': 'crossref',
'DOI': '10.7717/peerj.10480',
'article-title': 'Repurposing FDA-approved phytomedicines, natural products, antivirals '
'and cell protectives against SARS-CoV-2 (COVID-19) RNA-dependent RNA '
'polymerase',
'volume': '8',
'author': 'Kandeel',
'year': '2020',
'journal-title': 'PeerJ'},
{ 'issue': '5',
'key': '10.1016/j.heliyon.2024.e30080_bib63',
'doi-asserted-by': 'crossref',
'first-page': '570',
'DOI': '10.1016/j.jsps.2022.02.014',
'article-title': 'In silico evaluation of Vitis amurensis Rupr. polyphenol compounds for '
'their inhibition potency against CoVID-19 main enzymes Mpro and RdRp',
'volume': '30',
'author': 'Souid',
'year': '2022',
'journal-title': 'Saudi. Pharm. J'},
{ 'issue': '1',
'key': '10.1016/j.heliyon.2024.e30080_bib64',
'article-title': 'Focus on the high therapeutic potentials of quercetin and its '
'derivatives',
'volume': '2',
'author': 'Septembre-Malaterre',
'year': '2022',
'journal-title': 'Phytomed Plus'},
{ 'issue': '30',
'key': '10.1016/j.heliyon.2024.e30080_bib65',
'doi-asserted-by': 'crossref',
'first-page': '40507',
'DOI': '10.1007/s11356-021-14195-9',
'article-title': 'In silico screening of potent bioactive compounds from honeybee '
'products against COVID-19 target enzymes',
'volume': '28',
'author': 'Shaldam',
'year': '2021',
'journal-title': 'Environ. Sci. Pollut. Res. Int.'},
{ 'issue': '12',
'key': '10.1016/j.heliyon.2024.e30080_bib66',
'doi-asserted-by': 'crossref',
'first-page': '5643',
'DOI': '10.1080/07391102.2021.1872419',
'article-title': 'Prospecting for Cressa cretica to treat COVID-19 via in silico '
'molecular docking models of the SARS-CoV-2',
'volume': '40',
'author': 'Shah',
'year': '2022',
'journal-title': 'J. Biomol. Struct. Dyn.'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib67',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.ejphar.2020.173448',
'article-title': 'In silico pharmacokinetic and molecular docking studies of natural '
'flavonoids and synthetic indole chalcones against essential proteins of '
'SARS-CoV-2',
'volume': '886',
'author': 'Vijayakumar',
'year': '2020',
'journal-title': 'Eur. J. Pharmacol.'},
{ 'issue': '21',
'key': '10.1016/j.heliyon.2024.e30080_bib68',
'doi-asserted-by': 'crossref',
'first-page': '10741',
'DOI': '10.1080/07391102.2021.1947893',
'article-title': 'Identification of potential phytochemicals from Citrus Limon against '
'main protease of SARS-CoV-2: molecular docking, molecular dynamic '
'simulations and quantum computations',
'volume': '40',
'author': 'Khan',
'year': '2022',
'journal-title': 'J. Biomol. Struct. Dyn.'},
{ 'issue': 'Pt B',
'key': '10.1016/j.heliyon.2024.e30080_bib69',
'article-title': 'Inhibition of the SARS-CoV-2 3CLpro main protease by plant polyphenols',
'volume': '373',
'author': 'Bahun',
'year': '2022',
'journal-title': 'Food Chem'},
{ 'issue': '2',
'key': '10.1016/j.heliyon.2024.e30080_bib70',
'doi-asserted-by': 'crossref',
'first-page': '696',
'DOI': '10.1080/07391102.2020.1817787',
'article-title': 'Screening of plant-based natural compounds as a potential COVID-19 main '
'protease inhibitor: an in silico docking and molecular dynamics '
'simulation approach',
'volume': '40',
'author': 'Majumder',
'year': '2022',
'journal-title': 'J. Biomol. Struct. Dyn.'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib71',
'doi-asserted-by': 'crossref',
'first-page': '21',
'DOI': '10.1016/j.virol.2022.04.005',
'article-title': 'Flavonols and dihydroflavonols inhibit the main protease activity of '
'SARS-CoV-2 and the replication of human coronavirus 229E',
'volume': '571',
'author': 'Zhu',
'year': '2022',
'journal-title': 'Virology'},
{ 'issue': '3',
'key': '10.1016/j.heliyon.2024.e30080_bib72',
'first-page': '453',
'article-title': 'Molecular docking and ADMET prediction of natural compounds towards '
'SARS spike glycoprotein-human angiotensin-converting enzyme 2 and '
'SARS-CoV-2 main protease',
'volume': '76',
'author': 'Oso',
'year': '2021',
'journal-title': 'Arch. Razi. Inst.'},
{ 'issue': '1',
'key': '10.1016/j.heliyon.2024.e30080_bib73',
'doi-asserted-by': 'crossref',
'first-page': '86',
'DOI': '10.1080/07391102.2020.1808077',
'article-title': 'In-silico screening of plant-derived antivirals against main protease, '
'3CLpro and endoribonuclease, NSP15 proteins of SARS-CoV-2',
'volume': '40',
'author': 'Sharma',
'year': '2022',
'journal-title': 'J. Biomol. Struct. Dyn.'},
{ 'issue': '33',
'key': '10.1016/j.heliyon.2024.e30080_bib74',
'doi-asserted-by': 'crossref',
'first-page': '3577',
'DOI': '10.2174/1381612826999201116195851',
'article-title': 'Natural compounds as inhibitors of SARS-CoV-2 main protease (3CLpro): A '
'molecular docking and simulation approach to combat COVID-19',
'volume': '27',
'author': 'Rehman',
'year': '2021',
'journal-title': 'Curr Pharm Des'},
{ 'issue': '2',
'key': '10.1016/j.heliyon.2024.e30080_bib75',
'doi-asserted-by': 'crossref',
'first-page': '44',
'DOI': '10.1007/s13205-020-02578-7',
'article-title': 'In silico docking analysis revealed the potential of phytochemicals '
'present in Phyllanthus amarus and Andrographis paniculata, used in '
'Ayurveda medicine in inhibiting SARS-CoV-2',
'volume': '11',
'author': 'Hiremath',
'year': '2021',
'journal-title': '3 Biotech'},
{ 'issue': '16',
'key': '10.1016/j.heliyon.2024.e30080_bib76',
'doi-asserted-by': 'crossref',
'first-page': '6306',
'DOI': '10.1080/07391102.2020.1796811',
'article-title': 'Targeting SARS-CoV-2 spike protein of COVID-19 with naturally occurring '
'phytochemicals: An in silico study for drug development',
'volume': '39',
'author': 'Pandey',
'year': '2021',
'journal-title': 'J. Biomol. Struct. Dyn.'},
{ 'issue': '2',
'key': '10.1016/j.heliyon.2024.e30080_bib77',
'doi-asserted-by': 'crossref',
'first-page': '179',
'DOI': '10.1007/s13337-020-00598-8',
'article-title': 'Structure-based drug designing for potential antiviral activity of '
'selected natural products from Ayurveda against SARS-CoV-2 spike '
'glycoprotein and its cellular receptor',
'volume': '31',
'author': 'Maurya',
'year': '2020',
'journal-title': 'Virusdisease'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib78',
'doi-asserted-by': 'crossref',
'DOI': '10.3389/fphar.2022.863082',
'article-title': 'Pharmaceutical prospects of curcuminoids for the remedy of COVID-19: '
'Truth or myth',
'volume': '13',
'author': 'Fu',
'year': '2022',
'journal-title': 'Front. Pharmacol.'},
{ 'issue': '4',
'key': '10.1016/j.heliyon.2024.e30080_bib79',
'doi-asserted-by': 'crossref',
'first-page': '226',
'DOI': '10.1021/acsptsci.1c00253',
'article-title': 'Natural compounds inhibit SARS-CoV-2 nsp13 unwinding and ATPase enzyme '
'activities',
'volume': '5',
'author': 'Corona',
'year': '2022',
'journal-title': 'ACS Pharmacol. Transl. Sci.'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib80',
'doi-asserted-by': 'crossref',
'first-page': '100',
'DOI': '10.1016/j.molimm.2019.07.003',
'article-title': 'Porcine deltacoronavirus nsp15 antagonizes interferon-β production '
'independently of its endoribonuclease activity',
'volume': '114',
'author': 'Liu',
'year': '2019',
'journal-title': 'Mol. Immunol.'},
{ 'issue': '1',
'key': '10.1016/j.heliyon.2024.e30080_bib81',
'doi-asserted-by': 'crossref',
'first-page': '172',
'DOI': '10.1186/s43141-021-00273-5',
'article-title': 'Molecular docking and pharmacokinetic studies of phytocompounds from '
'Nigerian Medicinal Plants as promising inhibitory agents against '
'SARS-CoV-2 methyltransferase (nsp16)',
'volume': '19',
'author': 'Saliu',
'year': '2021',
'journal-title': 'J. Genet. Eng. Biotechnol.'},
{ 'issue': '2',
'key': '10.1016/j.heliyon.2024.e30080_bib82',
'doi-asserted-by': 'crossref',
'first-page': '908',
'DOI': '10.1002/ptr.6843',
'article-title': 'Aframomum melegueta secondary metabolites exhibit polypharmacology '
'against SARS-CoV-2 drug targets: in vitro validation of furin '
'inhibition',
'volume': '35',
'author': 'Omotuyi',
'year': '2021',
'journal-title': 'Phytother. Res.'},
{ 'issue': '1',
'key': '10.1016/j.heliyon.2024.e30080_bib83',
'doi-asserted-by': 'crossref',
'first-page': '201',
'DOI': '10.1186/s43094-021-00348-7',
'article-title': 'Computational guided identification of potential leads from Acacia '
'pennata (L.) Willd. as inhibitors for cellular entry and viral '
'replication of SARS-CoV-2',
'volume': '7',
'author': 'Zothantluanga',
'year': '2021',
'journal-title': 'Futur. J. Pharm. Sci.'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib84',
'doi-asserted-by': 'crossref',
'DOI': '10.1590/0074-02760200207',
'article-title': 'Flavonoid glycosides and their putative human metabolites as potential '
'inhibitors of the SARS-CoV-2 main protease (Mpro) and RNA-dependent RNA '
'polymerase (RdRp)',
'volume': '115',
'author': 'da Silva',
'year': '2020',
'journal-title': 'Mem. Inst. Oswaldo. Cruz.'},
{ 'issue': '17',
'key': '10.1016/j.heliyon.2024.e30080_bib85',
'doi-asserted-by': 'crossref',
'first-page': '9431',
'DOI': '10.3390/ijms22179431',
'article-title': 'Development of effective therapeutic molecule from natural sources '
'against coronavirus protease',
'volume': '22',
'author': 'Fadaka',
'year': '2021',
'journal-title': 'Int. J. Mol. Sci.'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib86',
'doi-asserted-by': 'crossref',
'DOI': '10.3389/fcimb.2021.730288',
'article-title': 'Identification of natural inhibitors against SARS-CoV-2 drugable '
'targets using molecular docking, molecular dynamics simulation, and '
'MM-PBSA approach',
'volume': '11',
'author': 'Kushwaha',
'year': '2021',
'journal-title': 'Front. Cell. Infect. Microbiol.'},
{ 'issue': '1',
'key': '10.1016/j.heliyon.2024.e30080_bib87',
'doi-asserted-by': 'crossref',
'first-page': '43',
'DOI': '10.1186/s43141-022-00314-7',
'article-title': 'In silico discovery of 3 novel quercetin derivatives against '
'papain-like protease, spike protein, and 3C-like protease of SARS-CoV-2',
'volume': '20',
'author': 'Bhattacharya',
'year': '2022',
'journal-title': 'J. Genet. Eng. Biotechnol.'},
{ 'issue': '50',
'key': '10.1016/j.heliyon.2024.e30080_bib88',
'doi-asserted-by': 'crossref',
'first-page': '31460',
'DOI': '10.1039/D1RA04107J',
'article-title': 'Newly designed analogues from SARS-CoV inhibitors mimicking the '
'druggable properties against SARS-CoV-2 and its novel variants',
'volume': '11',
'author': 'Ferdous',
'year': '2021',
'journal-title': 'RSC Adv'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib89',
'doi-asserted-by': 'crossref',
'DOI': '10.3389/fphar.2022.830205',
'article-title': 'Isoquercetin as an Anti-COVID-19 Medication: A Potential to Realize',
'volume': '13',
'author': 'Mbikay',
'year': '2022',
'journal-title': 'Front Pharmacol'},
{ 'issue': '1',
'key': '10.1016/j.heliyon.2024.e30080_bib90',
'doi-asserted-by': 'crossref',
'first-page': '158',
'DOI': '10.1186/s43094-021-00309-0',
'article-title': 'Flavonoid compounds of buah merah (Pandanus conoideus Lamk) as a potent '
'SARS-CoV-2 main protease inhibitor: in silico approach',
'volume': '7',
'author': 'Umar',
'year': '2021',
'journal-title': 'Futur. J. Pharm. Sci.'},
{ 'issue': '1',
'key': '10.1016/j.heliyon.2024.e30080_bib91',
'doi-asserted-by': 'crossref',
'first-page': '46',
'DOI': '10.1007/s13337-021-00683-6',
'article-title': 'A molecular docking study of SARS-CoV-2 main protease against '
'phytochemicals of Boerhavia diffusa Linn. for novel COVID-19 drug '
'discovery',
'volume': '32',
'author': 'Rutwick Surya',
'year': '2021',
'journal-title': 'Virusdisease'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib92',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.jmgm.2021.108038',
'article-title': 'In silico identification of SARS-CoV-2 cell entry inhibitors from '
'selected natural antivirals',
'volume': '109',
'author': 'Şimşek',
'year': '2021',
'journal-title': 'J. Mol. Graph. Model.'},
{ 'issue': '9',
'key': '10.1016/j.heliyon.2024.e30080_bib93',
'doi-asserted-by': 'crossref',
'first-page': '2929',
'DOI': '10.3390/molecules27092929',
'article-title': 'Conducting the RBD of SARS-CoV-2 omicron variant with phytoconstituents '
'from Euphorbia dendroides to repudiate the binding of spike '
'glycoprotein using computational molecular search and simulation '
'approach',
'volume': '27',
'author': 'Hassan',
'year': '2022',
'journal-title': 'Molecules'},
{ 'issue': '5',
'key': '10.1016/j.heliyon.2024.e30080_bib94',
'doi-asserted-by': 'crossref',
'first-page': '2838',
'DOI': '10.1039/D0RA09632F',
'article-title': 'Inhibitory activity of quercetin, its metabolite, and standard '
'antiviral drugs towards enzymes essential for SARS-CoV-2: the role of '
'acid-base equilibria',
'volume': '11',
'author': 'Milanović',
'year': '2021',
'journal-title': 'RSC Adv'},
{ 'issue': '3',
'key': '10.1016/j.heliyon.2024.e30080_bib95',
'doi-asserted-by': 'crossref',
'first-page': '249',
'DOI': '10.1007/s11655-021-3504-5',
'article-title': 'In silico screening of natural products as potential inhibitors of '
'SARS-CoV-2 using molecular docking simulation',
'volume': '28',
'author': 'Hossain',
'year': '2022',
'journal-title': 'Chin. J. Integr. Med.'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib96',
'doi-asserted-by': 'crossref',
'first-page': '3518',
'DOI': '10.1016/j.csbj.2020.11.010',
'article-title': 'Chinese herbal compounds against SARS-CoV-2: Puerarin and quercetin '
'impair the binding of viral S-protein to ACE2 receptor',
'volume': '18',
'author': 'Pan',
'year': '2020',
'journal-title': 'Comput. Struct. Biotechnol. J.'},
{ 'issue': '6',
'key': '10.1016/j.heliyon.2024.e30080_bib97',
'doi-asserted-by': 'crossref',
'first-page': '3557',
'DOI': '10.1007/s00203-021-02351-1',
'article-title': 'Investigation of potential inhibitor properties of ethanolic propolis '
'extracts against ACE-II receptors for COVID-19 treatment by molecular '
'docking study',
'volume': '203',
'author': 'Guler',
'year': '2021',
'journal-title': 'Arch. Microbiol.'},
{ 'issue': '17',
'key': '10.1016/j.heliyon.2024.e30080_bib98',
'doi-asserted-by': 'crossref',
'first-page': '5126',
'DOI': '10.1080/07391102.2019.1696709',
'article-title': 'Natural analogues inhibiting selective cyclin-dependent kinase protein '
'isoforms: a computational perspective',
'volume': '38',
'author': 'Singh',
'year': '2020',
'journal-title': 'J. Biomol. Struct. Dyn.'},
{ 'issue': '4',
'key': '10.1016/j.heliyon.2024.e30080_bib99',
'article-title': 'Computational screening of phytochemicals from three medicinal plants '
'as inhibitors of transmembrane protease serine 2 implicated in '
'SARS-CoV-2 infection',
'volume': '1',
'author': 'Oyedara',
'year': '2021',
'journal-title': 'Phytomed. Plus'},
{ 'issue': '1',
'key': '10.1016/j.heliyon.2024.e30080_bib100',
'doi-asserted-by': 'crossref',
'first-page': '180',
'DOI': '10.1186/s12859-022-04724-9',
'article-title': 'Molecular docking analysis reveals the functional inhibitory effect of '
'genistein and quercetin on TMPRSS2: SARS-COV-2 cell entry facilitator '
'spike protein',
'volume': '23',
'author': 'Manjunathan',
'year': '2022',
'journal-title': 'BMC Bioinformatics'},
{ 'issue': '3',
'key': '10.1016/j.heliyon.2024.e30080_bib101',
'doi-asserted-by': 'crossref',
'first-page': '789',
'DOI': '10.1007/s10787-022-00992-2',
'article-title': 'COVID-19 and the role of cytokines in this disease',
'volume': '30',
'author': 'Hasanvand',
'year': '2022',
'journal-title': 'Inflammopharmacology'},
{ 'issue': '1',
'key': '10.1016/j.heliyon.2024.e30080_bib102',
'doi-asserted-by': 'crossref',
'first-page': '112',
'DOI': '10.3390/ijerph19010112',
'article-title': 'Rescuing the host immune system by targeting the immune evasion complex '
'ORF8-IRF3 in SARS-CoV-2 infection with natural products using molecular '
'modeling approaches',
'volume': '19',
'author': 'Albutti',
'year': '2021',
'journal-title': 'Int. J. Environ. Res. Public Health'},
{ 'issue': '1',
'key': '10.1016/j.heliyon.2024.e30080_bib103',
'doi-asserted-by': 'crossref',
'first-page': '45',
'DOI': '10.1007/s11030-022-10405-9',
'article-title': 'Defective ORF8 dimerization in SARS-CoV-2 delta variant leads to a '
'better adaptive immune response due to abrogation of ORF8-MHC1 '
'interaction',
'volume': '27',
'author': 'Chaudhari',
'year': '2023',
'journal-title': 'Mol. Divers.'},
{ 'issue': '8',
'key': '10.1016/j.heliyon.2024.e30080_bib104',
'doi-asserted-by': 'crossref',
'DOI': '10.1371/journal.pone.0237752',
'article-title': 'Quercetin negatively regulates IL-1β production in Pseudomonas '
'aeruginosa-infected human macrophages through the inhibition of '
'MAPK/NLRP3 inflammasome pathways',
'volume': '15',
'author': 'Chanjitwiriya',
'year': '2020',
'journal-title': 'PLoS One'},
{ 'issue': '4',
'key': '10.1016/j.heliyon.2024.e30080_bib105',
'doi-asserted-by': 'crossref',
'first-page': '198',
'DOI': '10.21037/atm-22-419',
'article-title': 'Using network pharmacology and molecular docking to explore the '
'underlying anti-inflammatory mechanism of Wuyao-Danshen to treat '
'endometriosis',
'volume': '10',
'author': 'Zhu',
'year': '2022',
'journal-title': 'Ann. Transl. Med.'},
{ 'issue': '7',
'key': '10.1016/j.heliyon.2024.e30080_bib106',
'doi-asserted-by': 'crossref',
'DOI': '10.1099/jmm.0.001374',
'article-title': 'Network pharmacology and molecular docking analysis on mechanisms of '
'Tibetan Hongjingtian (Rhodiola crenulata) in the treatment of COVID-19',
'volume': '70',
'author': 'Wang',
'year': '2021',
'journal-title': 'J. Med. Microbiol.'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib107',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.compbiomed.2021.104293',
'article-title': 'Network pharmacology and RNA-sequencing reveal the molecular mechanism '
'of Xuebijing injection on COVID-19-induced cardiac dysfunction',
'volume': '131',
'author': 'He',
'year': '2021',
'journal-title': 'Comput. Biol. Med.'},
{ 'issue': '12',
'key': '10.1016/j.heliyon.2024.e30080_bib108',
'doi-asserted-by': 'crossref',
'first-page': '1653',
'DOI': '10.1177/1535370214537743',
'article-title': 'Protective effect of quercetin on lipopolysaccharide-induced acute lung '
'injury in mice by inhibiting inflammatory cell influx',
'volume': '239',
'author': 'Wang',
'year': '2014',
'journal-title': 'Exp. Biol. Med. (Maywood)'},
{ 'issue': '1',
'key': '10.1016/j.heliyon.2024.e30080_bib109',
'doi-asserted-by': 'crossref',
'first-page': '150',
'DOI': '10.1186/s12931-014-0150-x',
'article-title': 'Protective effects of intratracheally administered quercetin on '
'lipopolysaccharide-induced acute lung injury',
'volume': '15',
'author': 'Takashima',
'year': '2014',
'journal-title': 'Respir. Res.'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib110',
'doi-asserted-by': 'crossref',
'first-page': '12',
'DOI': '10.1016/j.freeradbiomed.2015.03.035',
'article-title': 'The involvement of p62-Keap1-Nrf2 antioxidative signaling pathway and '
'JNK in the protection of natural flavonoid quercetin against '
'hepatotoxicity',
'volume': '85',
'author': 'Ji',
'year': '2015',
'journal-title': 'Free Radic, Biol, Med'},
{ 'issue': '3',
'key': '10.1016/j.heliyon.2024.e30080_bib111',
'doi-asserted-by': 'crossref',
'first-page': '667',
'DOI': '10.1111/1750-3841.14483',
'article-title': 'Purification, characterization, and bioactivities of polyphenols from '
'Platycladus orientalis (L.) Franco',
'volume': '84',
'author': 'Ren',
'year': '2019',
'journal-title': 'J. Food Sci.'},
{ 'issue': '9',
'key': '10.1016/j.heliyon.2024.e30080_bib112',
'doi-asserted-by': 'crossref',
'first-page': '1377',
'DOI': '10.2174/1386207323999201029122301',
'article-title': 'Exploring the potential mechanism of Shufeng Jiedu capsule for treating '
'COVID-19 by comprehensive network pharmacological approaches and '
'molecular docking validation',
'volume': '24',
'author': 'Zhuang',
'year': '2021',
'journal-title': 'Comb. Chem. High Throughput Screen'},
{ 'issue': '6',
'key': '10.1016/j.heliyon.2024.e30080_bib113',
'doi-asserted-by': 'crossref',
'first-page': '758',
'DOI': '10.3390/pathogens10060758',
'article-title': 'Bioactive polyphenolic compounds showing strong antiviral activities '
'against severe acute respiratory syndrome coronavirus 2',
'volume': '10',
'author': 'Kandeil',
'year': '2021',
'journal-title': 'Pathogens'},
{ 'issue': '8',
'key': '10.1016/j.heliyon.2024.e30080_bib114',
'doi-asserted-by': 'crossref',
'first-page': '1124',
'DOI': '10.1002/ddr.21815',
'article-title': 'Potential antiviral activity of isorhamnetin against SARS-CoV-2 spike '
'pseudotyped virus in vitro',
'volume': '82',
'author': 'Zhan',
'year': '2021',
'journal-title': 'Drug Dev Res'},
{ 'issue': '47',
'key': '10.1016/j.heliyon.2024.e30080_bib115',
'doi-asserted-by': 'crossref',
'first-page': '13982',
'DOI': '10.1021/acs.jafc.0c05064',
'article-title': 'Quercetin and its metabolites inhibit recombinant human '
'angiotensin-converting enzyme 2 (ACE2) activity',
'volume': '68',
'author': 'Liu',
'year': '2020',
'journal-title': 'J. Agric. Food Chem.'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib116',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.bmc.2020.115860',
'article-title': 'Protease targeted COVID-19 drug discovery and its challenges: Insight '
'into viral main protease (Mpro) and papain-like protease (PLpro) '
'inhibitors',
'volume': '29',
'author': 'Amin',
'year': '2021',
'journal-title': 'Bioorg. Med. Chem.'},
{ 'issue': '13',
'key': '10.1016/j.heliyon.2024.e30080_bib117',
'doi-asserted-by': 'crossref',
'first-page': '7048',
'DOI': '10.3390/ijms22137048',
'article-title': 'Seleno-functionalization of quercetin improves the non-covalent '
'inhibition of Mpro and its antiviral activity in cells against '
'SARS-CoV-2',
'volume': '22',
'author': 'Mangiavacchi',
'year': '2021',
'journal-title': 'Int. J. Mol. Sci.'},
{ 'issue': '4',
'key': '10.1016/j.heliyon.2024.e30080_bib118',
'doi-asserted-by': 'crossref',
'first-page': '375',
'DOI': '10.3390/biomedicines9040375',
'article-title': 'Rutin is a low micromolar inhibitor of SARS-CoV-2 main protease 3CLpro: '
'Implications for drug design of quercetin analogs',
'volume': '9',
'author': 'Rizzuti',
'year': '2021',
'journal-title': 'Biomedicines'},
{ 'issue': '19',
'key': '10.1016/j.heliyon.2024.e30080_bib119',
'doi-asserted-by': 'crossref',
'first-page': '6062',
'DOI': '10.3390/molecules26196062',
'article-title': 'L-arginine improves solubility and anti SARS-CoV-2 Mpro activity of '
'rutin but not the antiviral activity in cells',
'volume': '26',
'author': 'Sancineto',
'year': '2021',
'journal-title': 'Molecules'},
{ 'issue': '11',
'key': '10.1016/j.heliyon.2024.e30080_bib120',
'doi-asserted-by': 'crossref',
'first-page': '5175',
'DOI': '10.1080/07391102.2020.1868340',
'article-title': 'Predictive medicinal metabolites from Momordica dioica against '
'comorbidity related proteins of SARS-CoV-2 infections',
'volume': '40',
'author': 'Sakshi',
'year': '2022',
'journal-title': 'J. Biomol. Struct. Dyn.'},
{ 'issue': '17',
'key': '10.1016/j.heliyon.2024.e30080_bib121',
'doi-asserted-by': 'crossref',
'first-page': '10136',
'DOI': '10.1093/nar/gkab719',
'article-title': "Characterization of SARS2 Nsp15 nuclease activity reveals it's mad "
'about U',
'volume': '49',
'author': 'Frazier',
'year': '2021',
'journal-title': 'Nucleic Acids Res'},
{ 'issue': '21',
'key': '10.1016/j.heliyon.2024.e30080_bib122',
'doi-asserted-by': 'crossref',
'first-page': '5948',
'DOI': '10.1021/acs.jafc.1c02050',
'article-title': 'Epigallocatechin gallate inhibits the uridylate-specific '
'endoribonuclease Nsp15 and efficiently neutralizes the SARS-CoV-2 '
'strain',
'volume': '69',
'author': 'Hong',
'year': '2021',
'journal-title': 'J. Agric. Food Chem.'},
{ 'issue': '4',
'key': '10.1016/j.heliyon.2024.e30080_bib123',
'doi-asserted-by': 'crossref',
'first-page': '87',
'DOI': '10.1556/1886.2021.00022',
'article-title': 'Inhibitory effects of specific combination of natural compounds against '
'SARS-CoV-2 and its Alpha, Beta, Gamma, Delta, Kappa, and Mu variants',
'volume': '11',
'author': 'Goc',
'year': '2022',
'journal-title': 'Eur. J. Microbiol. Immunol. (Bp)'},
{ 'issue': '22',
'key': '10.1016/j.heliyon.2024.e30080_bib124',
'doi-asserted-by': 'crossref',
'first-page': '7940',
'DOI': '10.1016/j.bmc.2010.09.035',
'article-title': 'Biflavonoids from Torreya nucifera displaying SARS-CoV 3CLpro '
'inhibition',
'volume': '18',
'author': 'Ryu',
'year': '2010',
'journal-title': 'Bioorg. Med. Chem.'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib125',
'doi-asserted-by': 'crossref',
'first-page': '1693',
'DOI': '10.1016/j.ijbiomac.2020.07.235',
'article-title': 'Structural stability of SARS-CoV-2 3CLpro and identification of '
'quercetin as an inhibitor by experimental screening',
'volume': '164',
'author': 'Abian',
'year': '2020',
'journal-title': 'Int. J. Biol. Macromol.'},
{ 'issue': '8',
'key': '10.1016/j.heliyon.2024.e30080_bib126',
'doi-asserted-by': 'crossref',
'first-page': '1866',
'DOI': '10.7150/ijms.53685',
'article-title': 'A network pharmacology based approach for predicting active ingredients '
'and potential mechanism of Lianhuaqingwen capsule in treating COVID-19',
'volume': '18',
'author': 'Zhang',
'year': '2021',
'journal-title': 'Int. J. Med. Sci.'},
{ 'issue': '4',
'key': '10.1016/j.heliyon.2024.e30080_bib127',
'doi-asserted-by': 'crossref',
'first-page': '1072',
'DOI': '10.1038/s41401-021-00697-2',
'article-title': 'Inhibition of drug-metabolizing enzymes by Jingyin granules: '
'implications of herb-drug interactions in antiviral therapy',
'volume': '43',
'author': 'Zhang',
'year': '2022',
'journal-title': 'Acta Pharmacol. Sin.'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib128',
'doi-asserted-by': 'crossref',
'first-page': '2359',
'DOI': '10.2147/IJGM.S318720',
'article-title': 'Possible therapeutic effects of adjuvant quercetin supplementation '
'against early-stage COVID-19 infection: A prospective, randomized, '
'controlled, and open-label study',
'volume': '14',
'author': 'Di Pierro',
'year': '2021',
'journal-title': 'Int. J. Gen. Med.'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib129',
'doi-asserted-by': 'crossref',
'first-page': '2807',
'DOI': '10.2147/IJGM.S318949',
'article-title': 'Potential clinical benefits of quercetin in the early stage of '
'COVID-19: Results of a second, pilot, randomized, controlled and '
'open-label clinical trial',
'volume': '14',
'author': 'Di Pierro',
'year': '2021',
'journal-title': 'Int. J. Gen. Med.'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib130',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.ejphar.2021.174615',
'article-title': 'The therapeutic efficacy of quercetin in combination with antiviral '
'drugs in hospitalized COVID-19 patients: A randomized controlled trial',
'volume': '914',
'author': 'Shohan',
'year': '2022',
'journal-title': 'Eur. J. Pharmacol.'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib131',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.phymed.2021.153784',
'article-title': 'Yindan Jiedu granules exhibit anti-inflammatory effect in patients with '
'novel Coronavirus disease (COVID-19) by suppressing the NF-κB signaling '
'pathway',
'volume': '95',
'author': 'Feng',
'year': '2022',
'journal-title': 'Phytomedicine'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib132',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.phymed.2020.153390',
'article-title': 'Shufeng Jiedu, a promising herbal therapy for moderate COVID-19: '
'Antiviral and anti-inflammatory properties, pathways of bioactive '
'compounds, and a clinical real-world pragmatic study',
'volume': '85',
'author': 'Xia',
'year': '2021',
'journal-title': 'Phytomedicine'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib133',
'article-title': '20-Week study of clinical outcomes of over-the-counter COVID-19 '
'prophylaxis and treatment, J. Evid. Based Integr',
'volume': '26',
'author': 'Margolin',
'year': '2021',
'journal-title': 'Med'},
{ 'issue': '5',
'key': '10.1016/j.heliyon.2024.e30080_bib134',
'doi-asserted-by': 'crossref',
'first-page': '129',
'DOI': '10.3390/biomedicines8050129',
'volume': '8',
'author': 'Glinsky',
'year': '2020',
'journal-title': 'Biomedicines'},
{ 'issue': '1',
'key': '10.1016/j.heliyon.2024.e30080_bib135',
'doi-asserted-by': 'crossref',
'first-page': '40',
'DOI': '10.1007/s00044-021-02826-2',
'article-title': 'A review of natural products, their effects on SARS-CoV-2 and their '
'utility as lead compounds in the discovery of drugs for the treatment '
'of COVID-19',
'volume': '31',
'author': 'Chapman',
'year': '2022',
'journal-title': 'Med. Chem. Res.'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib136',
'doi-asserted-by': 'crossref',
'DOI': '10.3389/fphar.2022.1096853',
'article-title': 'Quercetin as a possible complementary agent for early-stage COVID-19: '
'Concluding results of a randomized clinical trial',
'volume': '13',
'author': 'Di Pierro',
'year': '2023',
'journal-title': 'Front. Pharmacol.'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib137',
'doi-asserted-by': 'crossref',
'DOI': '10.3389/fnut.2023.1137407',
'article-title': 'NASAFYTOL® supplementation in adults hospitalized with COVID-19 '
'infection: results from an exploratory open-label randomized controlled '
'trial',
'volume': '10',
'author': 'Gérain',
'year': '2023',
'journal-title': 'Front. Nutr.'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib138',
'doi-asserted-by': 'crossref',
'DOI': '10.3389/fphar.2022.898062',
'article-title': 'Oral co-supplementation of curcumin, quercetin, and vitamin D3 as an '
'adjuvant therapy for mild to moderate symptoms of COVID-19-results from '
'a pilot open-label, randomized controlled trial',
'volume': '13',
'author': 'Khan',
'year': '2022',
'journal-title': 'Front. Pharmacol.'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib139',
'doi-asserted-by': 'crossref',
'DOI': '10.3389/fnut.2022.1023997',
'article-title': 'The possible therapeutic role of curcumin and quercetin in the '
'early-stage of COVID-19-Results from a pragmatic randomized clinical '
'trial',
'volume': '9',
'author': 'Ujjan',
'year': '2023',
'journal-title': 'Front. Nutr.'},
{ 'issue': '13',
'key': '10.1016/j.heliyon.2024.e30080_bib140',
'doi-asserted-by': 'crossref',
'first-page': '3900',
'DOI': '10.3390/molecules26133900',
'article-title': 'Flavonoids as promising antiviral agents against SARS-CoV-2 infection: '
'A mechanistic review',
'volume': '26',
'author': 'Khazeei Tabari',
'year': '2021',
'journal-title': 'Molecules'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib141',
'doi-asserted-by': 'crossref',
'first-page': '62',
'DOI': '10.1186/s13020-020-00346-6',
'article-title': 'Mechanism of Dayuanyin in the treatment of coronavirus disease 2019 '
'based on network pharmacology and molecular docking',
'volume': '15',
'author': 'Ruan',
'year': '2020',
'journal-title': 'Chin Med'},
{ 'issue': '20',
'key': '10.1016/j.heliyon.2024.e30080_bib142',
'doi-asserted-by': 'crossref',
'first-page': '5109',
'DOI': '10.1093/bioinformatics/btaa645',
'article-title': 'COVID-19 docking server: A meta server for docking small molecules, '
'peptides and antibodies against potential targets of COVID-19',
'volume': '36',
'author': 'Kong',
'year': '2020',
'journal-title': 'Bioinformatics'},
{ 'issue': '2',
'key': '10.1016/j.heliyon.2024.e30080_bib143',
'doi-asserted-by': 'crossref',
'first-page': '216',
'DOI': '10.3390/biom11020216',
'article-title': 'In silico screening of natural products isolated from Mexican herbal '
'medicines against COVID-19',
'volume': '11',
'author': 'Rivero-Segura',
'year': '2021',
'journal-title': 'Biomolecules'},
{ 'issue': '10',
'key': '10.1016/j.heliyon.2024.e30080_bib144',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.arabjc.2021.103353',
'article-title': 'Exploring the interaction of quercetin-3-O-sophoroside with SARS-CoV-2 '
'main proteins by theoretical studies: A probable prelude to control '
'some variants of coronavirus including Delta',
'volume': '14',
'author': 'Khan',
'year': '2021',
'journal-title': 'Arab. J. Chem.'},
{ 'issue': '2',
'key': '10.1016/j.heliyon.2024.e30080_bib145',
'doi-asserted-by': 'crossref',
'first-page': '67',
'DOI': '10.1007/s13205-020-02630-6',
'article-title': 'Factual insights of the allosteric inhibition mechanism of SARS-CoV-2 '
'main protease by quercetin: An in silico analysis',
'volume': '11',
'author': 'Verma',
'year': '2021',
'journal-title': '3 Biotech.'},
{ 'issue': '10',
'key': '10.1016/j.heliyon.2024.e30080_bib146',
'doi-asserted-by': 'crossref',
'first-page': '639',
'DOI': '10.1038/s41429-021-00437-y',
'article-title': 'Proteomics-based target identification of natural products affecting '
'cancer metabolism',
'volume': '74',
'author': 'Muroi',
'year': '2021',
'journal-title': 'J. Antibiot. (Tokyo)'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib147',
'article-title': 'Network pharmacology, molecular docking integrated surface plasmon '
'resonance technology reveals the mechanism of Toujie Quwen Granules '
'against coronavirus disease 2019 pneumonia',
'volume': '85',
'author': 'Ye',
'year': '2019',
'journal-title': 'Phytomedicine'},
{ 'issue': '15',
'key': '10.1016/j.heliyon.2024.e30080_bib148',
'doi-asserted-by': 'crossref',
'first-page': '7703',
'DOI': '10.1128/JVI.02560-09',
'article-title': 'Upregulation of the chemokine (C-C motif) ligand 2 via a severe acute '
'respiratory syndrome coronavirus spike-ACE2 signaling pathway',
'volume': '84',
'author': 'Chen',
'year': '2010',
'journal-title': 'J. Virol.'},
{ 'issue': '19',
'key': '10.1016/j.heliyon.2024.e30080_bib149',
'doi-asserted-by': 'crossref',
'first-page': '5803',
'DOI': '10.3390/molecules26195803',
'article-title': 'Natural Polyphenols as Immunomodulators to Rescue Immune Response '
'Homeostasis: Quercetin as a Research Model against Severe COVID-19',
'volume': '26',
'author': 'Bernini',
'year': '2021',
'journal-title': 'Molecules'},
{ 'issue': '11',
'key': '10.1016/j.heliyon.2024.e30080_bib150',
'doi-asserted-by': 'crossref',
'first-page': '1105',
'DOI': '10.3390/antiox9111105',
'article-title': 'Cell clearing systems as targets of polyphenols in viral infections: '
'Potential implications for COVID-19 pathogenesis',
'volume': '9',
'author': 'Limanaqi',
'year': '2020',
'journal-title': 'Antioxidants (Basel)'},
{ 'issue': '14',
'key': '10.1016/j.heliyon.2024.e30080_bib151',
'doi-asserted-by': 'crossref',
'first-page': '6463',
'DOI': '10.1080/07391102.2021.1885495',
'article-title': 'Anti-HIV-drug and phyto-flavonoid combination against SARS-CoV-2: a '
'molecular docking-simulation base assessment',
'volume': '40',
'author': 'Swain',
'year': '2022',
'journal-title': 'J. Biomol. Struct. Dyn.'},
{ 'issue': '5',
'key': '10.1016/j.heliyon.2024.e30080_bib152',
'doi-asserted-by': 'crossref',
'first-page': '2042',
'DOI': '10.1002/ptr.7436',
'article-title': 'Therapeutic and prophylactic effect of flavonoids in post-COVID-19 '
'therapy',
'volume': '36',
'author': 'Bardelčíková',
'year': '2022',
'journal-title': 'Phytother. Res.'},
{ 'issue': '2',
'key': '10.1016/j.heliyon.2024.e30080_bib153',
'doi-asserted-by': 'crossref',
'first-page': '232',
'DOI': '10.1002/biof.1726',
'article-title': 'Long-COVID syndrome-associated brain fog and chemofog: Luteolin to the '
'rescue',
'volume': '47',
'author': 'Theoharides',
'year': '2021',
'journal-title': 'Biofactors'},
{ 'issue': '2',
'key': '10.1016/j.heliyon.2024.e30080_bib154',
'first-page': '417',
'article-title': 'Antibodies for COVID-19 - which, when and how long?',
'volume': '35',
'author': 'Theoharides',
'year': '2021',
'journal-title': 'J. Biol. Regul. Homeost. Agents'},
{ 'issue': '3',
'key': '10.1016/j.heliyon.2024.e30080_bib155',
'doi-asserted-by': 'crossref',
'first-page': '1850',
'DOI': '10.1007/s12035-021-02696-0',
'article-title': 'Could SARS-CoV-2 spike protein be responsible for long-COVID syndrome?',
'volume': '59',
'author': 'Theoharides',
'year': '2022',
'journal-title': 'Mol. Neurobiol.'},
{ 'issue': '2',
'key': '10.1016/j.heliyon.2024.e30080_bib156',
'doi-asserted-by': 'crossref',
'first-page': '83',
'DOI': '10.1007/s12519-021-00499-w',
'article-title': 'Clinical practice guidelines in multisystem inflammatory syndrome '
'(MIS-C) related to COVID-19: a critical review and recommendations',
'volume': '18',
'author': 'Algarni',
'year': '2022',
'journal-title': 'World J. Pediatr.'},
{ 'issue': '4',
'key': '10.1016/j.heliyon.2024.e30080_bib157',
'first-page': '531',
'article-title': 'MIS-A after COVID-19: points to ponder',
'volume': '26',
'author': 'Ish',
'year': '2022',
'journal-title': 'Indian J. Crit. Care. Med.'},
{ 'issue': '5',
'key': '10.1016/j.heliyon.2024.e30080_bib158',
'doi-asserted-by': 'crossref',
'first-page': '53',
'DOI': '10.1007/s11882-022-01031-4',
'article-title': 'Multisystem inflammatory syndrome in children (MIS-C)',
'volume': '22',
'author': 'Patel',
'year': '2022',
'journal-title': 'Curr. Allergy Asthma Rep.'},
{ 'issue': '4',
'key': '10.1016/j.heliyon.2024.e30080_bib159',
'doi-asserted-by': 'crossref',
'first-page': '338',
'DOI': '10.1016/j.jped.2021.08.006',
'article-title': 'Multisystem inflammatory syndrome (MIS-C): a systematic review and '
'meta-analysis of clinical characteristics, treatment, and outcomes',
'volume': '98',
'author': 'Santos',
'year': '2022',
'journal-title': 'J. Pediatr. (Rio. J.)'},
{ 'issue': '8',
'key': '10.1016/j.heliyon.2024.e30080_bib160',
'doi-asserted-by': 'crossref',
'first-page': '58',
'DOI': '10.1007/s11926-021-01028-4',
'article-title': 'Current understanding of multisystem inflammatory syndrome (MIS-C) '
'following COVID-19 and its distinction from Kawasaki disease',
'volume': '23',
'author': 'Bukulmez',
'year': '2021',
'journal-title': 'Curr. Rheumatol. Rep.'},
{ 'issue': '1',
'key': '10.1016/j.heliyon.2024.e30080_bib161',
'doi-asserted-by': 'crossref',
'first-page': '50',
'DOI': '10.1186/s12245-021-00373-6',
'article-title': 'Multisystem inflammatory syndrome in children (MIS-C): a mini-review',
'volume': '14',
'author': 'Giacalone',
'year': '2021',
'journal-title': 'Int. J. Emerg. Med.'},
{ 'issue': '10',
'key': '10.1016/j.heliyon.2024.e30080_bib162',
'doi-asserted-by': 'crossref',
'DOI': '10.1172/JCI146614',
'article-title': 'HLA class I-associated expansion of TRBV11-2 T cells in multisystem '
'inflammatory syndrome in children',
'volume': '131',
'author': 'Porritt',
'year': '2021',
'journal-title': 'J. Clin. Invest.'},
{ 'issue': '10',
'key': '10.1016/j.heliyon.2024.e30080_bib163',
'doi-asserted-by': 'crossref',
'first-page': '737',
'DOI': '10.1080/23744235.2021.1924397',
'article-title': 'Long COVID or post-COVID-19 syndrome: Putative pathophysiology, risk '
'factors, and treatments',
'volume': '53',
'author': 'Yong',
'year': '2021',
'journal-title': 'Infect. Dis. (Lond)'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib164',
'doi-asserted-by': 'crossref',
'DOI': '10.12659/MSM.935005',
'article-title': 'Editorial: Multisystem inflammatory syndrome in adults (MIS-A) and the '
'spectrum of COVID-19',
'volume': '27',
'author': 'Parums',
'year': '2021',
'journal-title': 'Med. Sci. Monit.'},
{ 'issue': '8',
'key': '10.1016/j.heliyon.2024.e30080_bib165',
'doi-asserted-by': 'crossref',
'first-page': '1345',
'DOI': '10.1080/03639045.2020.1788070',
'article-title': 'Network pharmacology and molecular docking analysis on molecular '
'targets and mechanisms of Huashi Baidu formula in the treatment of '
'COVID-19',
'volume': '46',
'author': 'Tao',
'year': '2020',
'journal-title': 'Drug Dev. Ind. Pharm.'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib166',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.eujim.2020.101241',
'article-title': 'Analysis of the mechanism of Shufeng Jiedu capsule prevention and '
'treatment for COVID-19 by network pharmacology tools',
'volume': '40',
'author': 'Xiong',
'year': '2020',
'journal-title': 'Eur. J. Integr. Med.'},
{ 'issue': '12',
'key': '10.1016/j.heliyon.2024.e30080_bib167',
'doi-asserted-by': 'crossref',
'first-page': '863',
'DOI': '10.3390/antibiotics9120863',
'article-title': 'Geranii Herba as a potential inhibitor of SARS-CoV-2 main 3CLpro, spike '
'RBD, and regulation of unfolded protein response: An in silico approach',
'volume': '9',
'author': 'Arokiyaraj',
'year': '2020',
'journal-title': 'Antibiotics (Basel)'},
{ 'issue': '1',
'key': '10.1016/j.heliyon.2024.e30080_bib168',
'first-page': '21',
'article-title': 'Perspectives on plant flavonoid quercetin-based drugs for novel '
'SARS-CoV-2, Beni. Suef. Univ. J. Basic',
'volume': '10',
'author': 'Saakre',
'year': '2021',
'journal-title': 'Appl. Sci.'},
{ 'issue': '21',
'key': '10.1016/j.heliyon.2024.e30080_bib169',
'doi-asserted-by': 'crossref',
'first-page': '8095',
'DOI': '10.3390/ijms21218095',
'article-title': 'Inhibition of porcine epidemic diarrhea virus replication and viral '
'3C-like protease by quercetin',
'volume': '21',
'author': 'Li',
'year': '2020',
'journal-title': 'Int. J. Mol. Sci.'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib170',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.micpath.2021.104954',
'article-title': 'Phytochemicals present in Indian ginseng possess potential to inhibit '
'SARS-CoV-2 virulence: A molecular docking and MD simulation study',
'volume': '157',
'author': 'Kushwaha',
'year': '2021',
'journal-title': 'Microb. Pathog.'},
{ 'key': '10.1016/j.heliyon.2024.e30080_bib171',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.molstruc.2021.130380',
'article-title': 'Rational design of flavonoid based potential inhibitors targeting '
'SARS-CoV 3CL protease for the treatment of COVID-19',
'volume': '1237',
'author': 'Bhati',
'year': '2021',
'journal-title': 'J. Mol. Struct.'},
{ 'issue': '1',
'key': '10.1016/j.heliyon.2024.e30080_bib172',
'doi-asserted-by': 'crossref',
'first-page': '10',
'DOI': '10.1007/s40203-020-00073-8',
'article-title': 'Evaluation of certain medicinal plants compounds as new potential '
'inhibitors of novel corona virus (COVID-19) using molecular docking '
'analysis',
'volume': '9',
'author': 'Alrasheid',
'year': '2021',
'journal-title': 'Silico. Pharmacol.'},
{ 'issue': '14',
'key': '10.1016/j.heliyon.2024.e30080_bib173',
'doi-asserted-by': 'crossref',
'first-page': '5129',
'DOI': '10.1080/07391102.2020.1784291',
'article-title': 'Repurposing of FDA-approved antivirals, antibiotics, anthelmintics, '
'antioxidants, and cell protectives against SARS-CoV-2 papain-like '
'protease',
'volume': '39',
'author': 'Kandeel',
'year': '2021',
'journal-title': 'J. Biomol. Struct. Dyn.'},
{ 'issue': '12',
'key': '10.1016/j.heliyon.2024.e30080_bib174',
'doi-asserted-by': 'crossref',
'first-page': '4510',
'DOI': '10.1080/07391102.2020.1778539',
'article-title': 'SARS-CoV-2 host entry and replication inhibitors from Indian ginseng: '
'an in-silico approach',
'volume': '39',
'author': 'Chikhale',
'year': '2021',
'journal-title': 'J. Biomol. Struct. Dyn.'},
{ 'issue': '17',
'key': '10.1016/j.heliyon.2024.e30080_bib175',
'doi-asserted-by': 'crossref',
'first-page': '7656',
'DOI': '10.1080/07391102.2021.1900919',
'article-title': 'Evaluation of the effects of chlorhexidine and several flavonoids as '
'antiviral purposes on SARS-CoV-2 main protease: molecular docking, '
'molecular dynamics simulation studies',
'volume': '40',
'author': 'Tatar',
'year': '2022',
'journal-title': 'J. Biomol. Struct. Dyn.'}],
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