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Quercetin: A Potential Polydynamic Drug

Georgiou et al., Molecules, doi:10.3390/molecules28248141
Dec 2023  
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Quercetin for COVID-19
24th treatment shown to reduce risk in July 2021
*, now known with p = 0.0031 from 11 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments.
Review of the biological and medicinal properties of quercetin, particularly its anti-inflammatory, antioxidant, anti-tumor, and antiviral effects. Quercetin demonstrates promise against SARS-CoV-2 as evidenced by its binding interactions with key viral targets like the spike protein, though its poor bioavailability requires advanced formulations. Researchers have successfully complexed quercetin with cyclodextrins, polymers, liposomes, and nanomaterials to form stable compounds with enhanced solubility and bioavailability. Combination therapy synergizing quercetin with other drugs also shows promising results, with multiple studies showing augmented inhibition of viruses, cancers, cardiovascular diseases, and more. Overall, authors find that complexed and synergized formulations of quercetin have significant potential as inexpensive, safe therapeutics, especially as adjunct treatments for viral infections like COVID-19 where oxidative damage contributes to pathogenesis.
Reviews covering quercetin for COVID-19 include Agrawal, Biancatelli, Derosa, Dinda, Gasmi, Georgiou, Imran, Massimo Magro, Matías-Pérez, Mirza, Rizky, Shorobi.
Georgiou et al., 17 Dec 2023, peer-reviewed, 10 authors. Contact: (corresponding author),,,,,,,,,
This PaperQuercetinAll
Quercetin: A Potential Polydynamic Drug
Nikitas Georgiou, Margarita Georgia Kakava, Efthymios Alexandros Routsi, Errikos Petsas, Nikolaos Stavridis, Christoforos Freris, Nikoletta Zoupanou, Kalliopi Moschovou, Sofia Kiriakidi, Thomas Mavromoustakos
Molecules, doi:10.3390/molecules28248141
The study of natural products as potential drug leads has gained tremendous research interest. Quercetin is one of those natural products. It belongs to the family of flavonoids and, more specifically, flavonols. This review summarizes the beneficial pharmaceutical effects of quercetin, such as its anti-cancer, anti-inflammatory, and antimicrobial properties, which are some of the quercetin effects described in this review. Nevertheless, quercetin shows poor bioavailability and low solubility. For this reason, its encapsulation in macromolecules increases its bioavailability and therefore pharmaceutical efficiency. In this review, a brief description of the different forms of encapsulation of quercetin are described, and new ones are proposed. The beneficial effects of applying new pharmaceutical forms of nanotechnology are outlined.
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