Quercetin: A Potential Polydynamic Drug

{ 'indexed': { 'date-parts': [[2023, 12, 20]], 'date-time': '2023-12-20T00:36:08Z', 'timestamp': 1703032568536}, 'reference-count': 240, 'publisher': 'MDPI AG', 'issue': '24', 'license': [ { 'start': { 'date-parts': [[2023, 12, 17]], 'date-time': '2023-12-17T00:00:00Z', 'timestamp': 1702771200000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0/'}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'abstract': '<jats:p>The study of natural products as potential drug leads has gained tremendous research ' 'interest. Quercetin is one of those natural products. It belongs to the family of flavonoids ' 'and, more specifically, flavonols. This review summarizes the beneficial pharmaceutical ' 'effects of quercetin, such as its anti-cancer, anti-inflammatory, and antimicrobial ' 'properties, which are some of the quercetin effects described in this review. Nevertheless, ' 'quercetin shows poor bioavailability and low solubility. For this reason, its encapsulation ' 'in macromolecules increases its bioavailability and therefore pharmaceutical efficiency. In ' 'this review, a brief description of the different forms of encapsulation of quercetin are ' 'described, and new ones are proposed. The beneficial effects of applying new pharmaceutical ' 'forms of nanotechnology are outlined.</jats:p>', 'DOI': '10.3390/molecules28248141', 'type': 'journal-article', 'created': { 'date-parts': [[2023, 12, 18]], 'date-time': '2023-12-18T16:28:07Z', 'timestamp': 1702916887000}, 'page': '8141', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Quercetin: A Potential Polydynamic Drug', 'prefix': '10.3390', 'volume': '28', 'author': [ { 'given': 'Nikitas', 'family': 'Georgiou', 'sequence': 'first', 'affiliation': [ { 'name': 'Laboratory of Organic Chemistry, Department of Chemistry, ' 'National and Kapodistrian University of Athens, ' 'Panepistimiopolis Zografou, 15771 Athens, Greece'}]}, { 'given': 'Margarita Georgia', 'family': 'Kakava', 'sequence': 'additional', 'affiliation': [ { 'name': 'Laboratory of Organic Chemistry and Biochemistry, Department of ' 'Chemistry, University of Patras, 26504 Patras, Greece'}]}, { 'given': 'Efthymios Alexandros', 'family': 'Routsi', 'sequence': 'additional', 'affiliation': [ { 'name': 'Laboratory of Organic Chemistry, Department of Chemistry, ' 'National and Kapodistrian University of Athens, ' 'Panepistimiopolis Zografou, 15771 Athens, Greece'}, { 'name': 'Center of Excellence for Drug Design and Discovery, National and ' 'Kapodistrian University of Athens, 15771 Athens, Greece'}]}, { 'given': 'Errikos', 'family': 'Petsas', 'sequence': 'additional', 'affiliation': [ { 'name': 'Laboratory of Organic Chemistry, Department of Chemistry, ' 'National and Kapodistrian University of Athens, ' 'Panepistimiopolis Zografou, 15771 Athens, Greece'}]}, { 'given': 'Nikolaos', 'family': 'Stavridis', 'sequence': 'additional', 'affiliation': [ { 'name': 'Laboratory of Organic Chemistry, Department of Chemistry, ' 'National and Kapodistrian University of Athens, ' 'Panepistimiopolis Zografou, 15771 Athens, Greece'}]}, { 'given': 'Christoforos', 'family': 'Freris', 'sequence': 'additional', 'affiliation': [ { 'name': 'Laboratory of Analytical Chemistry, Department of Chemistry, ' 'National and Kapodistrian University of Athens, ' 'Panepistimiopolis Zografou, 15771 Athens, Greece'}]}, { 'given': 'Nikoletta', 'family': 'Zoupanou', 'sequence': 'additional', 'affiliation': [ { 'name': 'Laboratory of Organic Chemistry, Department of Chemistry, ' 'National and Kapodistrian University of Athens, ' 'Panepistimiopolis Zografou, 15771 Athens, Greece'}]}, { 'given': 'Kalliopi', 'family': 'Moschovou', 'sequence': 'additional', 'affiliation': [ { 'name': 'Laboratory of Organic Chemistry, Department of Chemistry, ' 'National and Kapodistrian University of Athens, ' 'Panepistimiopolis Zografou, 15771 Athens, Greece'}]}, { 'ORCID': 'http://orcid.org/0000-0003-2509-3277', 'authenticated-orcid': False, 'given': 'Sofia', 'family': 'Kiriakidi', 'sequence': 'additional', 'affiliation': [ { 'name': 'Laboratory of Organic Chemistry, Department of Chemistry, ' 'National and Kapodistrian University of Athens, ' 'Panepistimiopolis Zografou, 15771 Athens, Greece'}, { 'name': 'Departamento de Quimica Orgánica, Facultade de Quimica, ' 'Universidade de Vigo, 36310 Vigo, Spain'}]}, { 'ORCID': 'http://orcid.org/0000-0001-5309-992X', 'authenticated-orcid': False, 'given': 'Thomas', 'family': 'Mavromoustakos', 'sequence': 'additional', 'affiliation': [ { 'name': 'Laboratory of Organic Chemistry, Department of Chemistry, ' 'National and Kapodistrian University of Athens, ' 'Panepistimiopolis Zografou, 15771 Athens, Greece'}]}], 'member': '1968', 'published-online': {'date-parts': [[2023, 12, 17]]}, 'reference': [ { 'key': 'ref_1', 'first-page': '530', 'article-title': 'Comparative Study of Polyphenols, Flavonoids and Chlorophylls in ' 'Equisetum arvense L. 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