Conv. Plasma
Nigella Sativa

All quercetin studies
Meta analysis
study COVID-19 treatment researchQuercetinQuercetin (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta PPIs Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

Use of Quercetin for Therapeutic Purposes in COVID-19 Infections: The Opinion of the Geriatrician Doctor

Massimo Magro et al., Journal of Modern Biology and Drug Discovery, doi:10.53964/jmbdd.2023004
May 2023  
  Source   PDF   All Studies   Meta AnalysisMeta
Quercetin for COVID-19
23rd treatment shown to reduce risk in July 2021
*, now with p = 0.0031 from 11 studies.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 81 treatments.
Review of the antiviral properties and potential benefits of quercetin for COVID-19.
Reviews covering quercetin for COVID-19 include1-17.
Massimo Magro et al., 15 May 2023, peer-reviewed, 2 authors. Contact:
This PaperQuercetinAll
Use of Quercetin for Therapeutic Purposes in COVID-19 Infections: The Opinion of the Geriatrician Doctor
PhD, Geriatrician Valerio Massimo Magro
Journal of Modern Biology and Drug Discovery, doi:10.53964/jmbdd.2023004
The COVID-19 epidemic has put health systems around the world in distress, at the same time stimulating global research in an attempt to discover new therapeutic strategies against this virus. In this opinion we analyze the characteristics of a flavonoid, quercetin, trying to better understand its usefulness in the treatment of coronavirus infection.
Conflicts of Interest The author declared no conflict of interest. Author Contribution Magro VM was the primary researcher and wrote the manuscript. Magro VM provided research and editing assistance to the manuscript. Magro VM contributed to overall article design, data collection as well as revising and approving the manuscript. Abbreviation List 3CL pro , 3-chymotrypsin-like protease ACE2, Angiotensin-converting enzyme 2 Nrf2, Nuclear factor erythroid-derived 2-like 2 PL pro , Papain-like protease
Abian, Ortega-Alarcon, Jimenez-Alesanco, Structural stability of SARS-CoV-2 3CL pro and identification of quercetin as an inhibitor by experimental screening, Int J Biol Macromol, doi:10.1016/j.ijbiomac.2020.07.235
Ali, Spinler, COVID-19 and thrombosis: From bench to bedside, Trends Cardiovas Med, doi:10.1016/j.tcm.2020.12.004
Alizadeh, Ebrahimzadeh, O-glycoside quercetin derivatives: Biological activities, mechanisms of action, and structure-activity relationship for drug design, a review, Phytother Res, doi:10.1002/ptr.7352
Babaei, Mirzababaei, Nassiri-Asl, Quercetin in food: Possible mechanisms of its effect on memory, J Food Sci, doi:10.1111/1750-3841.14317
Bhattacharya, Bordoloi, Chanu, In silico discovery of 3 novel quercetin derivatives against papainlike protease, spike protein, and 3C-like protease of SARS-CoV-2, J Genet Eng Biotechnol, doi:10.1186/s43141-022-00314-7
Boccalone, Lanni, Magro, Role of natural drugs in severe acute respiratory syndrome coronavirus 2: Potential beneficial effects in prevention or prior treatment in elderly and cancer patients, Geriatric Care, doi:10.4081/gc.2020.9016
Boots, Veith, Albrecht, The dietary antioxidant quercetin reduces hallmarks of bleomycininduced lung fibrogenesis in mice, BMC Pulm Med, doi:10.1186/s12890-020-1142-x
Brito, Lima, Cordeiro, Effectiveness of supplementation with quercetin-type flavonols for treatment of viral lower respiratory tract infections: Systematic review and meta-analysis of preclinical studies, Phytother Res, doi:10.1002/ptr.7122
Cheema, Sohail, Quercetin for the treatment of COVID-19 patients: A systematic review and meta-analysis, Rev Med Virol, doi:10.1002/rmv.2427
Chen, Jiang, Wu, Therapeutic effects of quercetin on inflammation, obesity, and type 2 diabetes, Mediat Inflamm, doi:10.1155/2016/9340637
Choi, Kim, Kim, Comparative effect of quercetin and quercetin-3-O-β-d-glucoside on fibrin polymers, blood clots, and in rodent models, J Biochem Mol Toxic, doi:10.1002/jbt.21822
Cushnie, Lamb, Antimicrobial activity of flavonoids, Int J Antimicrob Agents, doi:10.1016/j.ijantimicag.2005.09.002
Deng, Li, Fang, Therapeutic potential of quercetin as an antiatherosclerotic agent in atherosclerotic cardiovascular disease: A Review, Evid-based Compl Alt Med, doi:10.1155/2020/5926381
Derosa, Maffioli, Angelo, A role for quercetin in coronavirus disease 2019 (COVID-19), Phytother Res, doi:10.1002/ptr.6887
Ebrahimpour, Zakeri, Esmaeili, Crosstalk between obesity, diabetes, and alzheimer's disease: Introducing quercetin as an effective triple herbal medicine, Ageing Res Rev, doi:10.1016/j.arr.2020.101095
Eltayb, Abdalla, Rabie, Novel investigational anti-SARS-CoV-2 agent ensitrelvir "S-217622": A very promising potential universal broad-spectrum antiviral at the therapeutic frontline of coronavirus species, ACS Omega, doi:10.1021/acsomega.2c03881
Ganesh, Fuehrer, Starzengrüber, Antiplasmodial activity of flavonol quercetin and its analogues in plasmodium falciparum: Evidence from clinical isolates in bangladesh and standardized parasite clones, Parasitol Res, doi:10.1007/s00436-011-2763-z
Gómez-Mesa, Galindo-Coral, Montes, Thrombosis and Coagulopathy in COVID-19, J Mod Biol Drug Discov, doi:10.1016/j.cpcardiol.2020.100742
Hubbard, Wolffram, Lovegrove, Ingestion of quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in humans, J Thromb Haemost, doi:10.1111/j.1538-7836.2004.01067.x
Imran, Thabet, Alaqel, The therapeutic and prophylactic potential of quercetin against COVID-19: An outlook on the clinical studies, inventive compositions, and patent literature, Antioxidants (Basel), doi:10.3390/antiox11050876
Ishizawa, Yoshizumi, Kawai, Pharmacology in health food: Metabolism of quercetin in vivo and its protective effect against arteriosclerosis, J Pharmacol Sci, doi:10.1254/jphs.10R38FM
Jafarinia, Hosseini, Kasiri, Quercetin with the potential effect on allergic diseases, Allergy Asthma Clin Immunol, doi:10.1186/s13223-020-00434-0
Jean-Moreno, Rojas, Goyeneche, Leishmania donovani: Differential activities of classical topoisomerase inhibitors and antileishmanials against parasite and host cells at the level of DNA topoisomerase I and in cytotoxicity assays, Exp Parasitol, doi:10.1016/j.exppara.2005.08.014
Jia, Zhang, Si, Quercetin alleviates oxidative damage by activating nuclear factor erythroid 2-related factor 2 signaling in porcine enterocytes, Nutrients, doi:10.3390/nu13020375
Junior, Tolouei, Lívero, Natural agents modulating ACE-2: A review of compounds with potential against SARS-CoV-2 infections, Curr Pharm Des, doi:10.2174/1381612827666210114150607
Kevill, Lambert-Slosarska, Pellett, Assessment of two types of passive sampler for the efficient recovery of SARS-CoV-2 and other viruses from wastewater, Sci Total Environ, doi:10.1016/j.scitotenv.2022.156580
Khan, Niaz, Maqbool, Molecular targets underlying the anticancer effects of quercetin: An update, Nutrients, doi:10.3390/nu8090529
Lee, Lee, Lee, Nrf2 Expression and apoptosis in quercetin-treated malignant mesothelioma cells, Mol Cells, doi:10.14348/molcells.2015.2268
Li, Yao, Han, None, Inflammation and immunity. Nutrients, doi:10.3390/nu8030167
Magar, Sohng, A review on structure, modifications and structure-activity relation of quercetin and its derivatives, J Microbiol Biotechnol, doi:10.4014/jmb.1907.07003
Magro, The defeat of general medicine as a role and ability to protect itself and its patients in the coronavirus pandemic era, Fam Pract, doi:10.1093/fampra/cmac028
Martínez, Campos, Flavonoids as a therapeutical option for the treatment of thrombotic complications associated with COVID-19, Phytother Res, doi:10.1002/ptr.7700
Marunaka, Marunaka, Sun, Actions of quercetin, a polyphenol, on blood pressure, Molecules, doi:10.3390/molecules22020209
Memariani, Memariani, Ghasemian, An overview on anti-biofilm properties of quercetin against bacterial pathogens, World J Microbiol Biotechnol, doi:10.1007/s11274-019-2719-5
Nappi, Iervolino, Singh, Molecular insights of SARS-CoV-2 antivirals administration: A balance between safety profiles and impact on cardiovascular phenotypes, Biomedicines, doi:10.3390/biomedicines10020437
Nguyen, Grigori, Just, The in vivo anti-Candida albicans activity of flavonoids, J Oral Biosci, doi:10.1016/j.job.2021.03.004
Nishimuro, Ohnishi, Sato, Estimated daily intake and seasonal food sources of quercetin in Japan, Nutrients, doi:10.3390/nu7042345
Oliveira, Carraro, Auler, Quercetin and rutin as potential agents antifungal against cryptococcus spp, Braz J Biol, doi:10.1590/1519-6984.07415
Padula, Malaviya, Reid, Economic value of vaccines to address the COVID-19 pandemic: A U, J Med Econ, doi:10.1080/13696998.2021.1965732
Parums, Editorial: Current status of oral antiviral drug treatments for SARS-CoV-2 infection in non-hospitalized patients, Med Sci Monit, doi:10.12659/MSM.935952
Pasquale, Palma, Effetti indiretti della pandemia COVID-19 sulla mortalità cardiovascolare, G Ital Cardiol (Rome)
Patel, Mistry, Shinde, Therapeutic potential of quercetin as a cardiovascular agent, Eur J Med Chem, doi:10.1016/j.ejmech.2018.06.053
Pawar, Russo, A critical evaluation of risk to reward ratio of quercetin supplementation for COVID-19 and associated comorbid conditions, Phytother Res, doi:10.1002/ptr.7461
Pierro, Iqtadar, Khan, Potential clinical benefits of quercetin in the early stage of COVID-19: Results of a second, pilot, randomized, controlled and open-label clinical trial, Int J Gen Med, doi:10.2147/IJGM.S318949
Pierro, Khan, Iqtadar, Quercetin as a possible complementary agent for early-stage COVID-19: Concluding results of a randomized clinical trial, Front Pharmacol, doi:10.3389/fphar.2022.1096853
Rabie, Abdalla, Forodesine and Riboprine exhibit strong anti-SARS-CoV-2 repurposing potential: In silico and in vitro studies, ACS Bio Med Chem Au, doi:10.1021/acsbiomedchemau.2c00039
Rabie, Efficacious preclinical repurposing of the nucleoside analogue didanosine against COVID-19 polymerase and exonuclease, ACS Omega, doi:10.1021/acsomega.1c07095
Rabie, Eltayb, Potent dual polymerase/exonuclease inhibitory activities of antioxidant aminothiadiazoles against the COVID-19 omicron virus: A promising in silico/in vitro repositioning research study, Mol Biotechnol, doi:10.1007/s12033-022-00551-8
Rabie, Potent toxic effects of Taroxaz-104 on the replication of SARS-CoV-2 particles, Chem Biol Interact, doi:10.1016/j.cbi.2021.109480
Rabie, Successful repurposing against COVID-19 as the first potent multitarget anti-SARS-CoV-2 drugs, New J Chem, doi:10.1039/D0NJ03708G
Rabie, Teriflunomide: A possible effective drug for the comprehensive treatment of COVID-19, Curr Res Pharmacol Drug Discov, doi:10.1016/j.crphar.2021.100055
Rajpal, Rahimi, Ismail-Beigi, high morbidity and mortality of COVID-19 in patients with type 2 diabetes, J Mod Biol Drug Discov, doi:10.1111/1753-0407.13085
Saeedi-Boroujeni, Mr, Antiinflammatory potential of Quercetin in COVID-19 treatment, J Inflamm (Lond), doi:10.1186/s12950-021-00268-6
Scioscia, Pace, Giganti, Real life experience of molnupiravir as a treatment of SARS-CoV-2 infection in vaccinated and unvaccinated patients: A letter on its effectiveness at preventing hospitalization, Ir J Med Sci, doi:10.1007/s11845-022-03241-1
Shahinozzaman, Basak, Emran, Artepillin C: A comprehensive review of its chemistry, bioavailability, and pharmacological properties, J Mod Biol Drug Discov, doi:10.1016/j.fitote.2020.104775
Talirevic, Sehovic, Quercetin in the treatment of dyslipidemia, Med Arh, doi:10.5455/medarh.2012.66.87-88
Vida, Fittler, Somogyi-Végh, Dietary quercetin supplements: Assessment of online product informations and quantitation of quercetin in the products by high-performance liquid chromatography, Phytother Res, doi:10.1002/ptr.6382
Vrolijk, Haenen, Opperhuizen, The supplement-drug interaction of quercetin with tamsulosin on vasorelaxation, Eur J Pharmacol, doi:10.1016/j.ejphar.2014.11.006
Wen, Chen, Tang, Efficacy and safety of three new oral antiviral treatment (molnupiravir, fluvoxamine and Paxlovid) for COVID-19: A meta-analysis, Ann Med, doi:10.1080/07853890.2022.2034936
Wong, Chin, Nirwana, Quercetin as an agent for protecting the bone: A review of the current evidence, Int J Mol Sci, doi:10.3390/ijms21176448
Xiong, Zhu, Wang, Discovery of naturally occurring inhibitors against SARS-CoV-2 3CL pro from Ginkgo biloba leaves via large-scale screening, Fitoterapia, doi:10.1016/j.fitote.2021.104909
Yang, Wang, Long, Quercetin: Its main pharmacological activity and potential application in clinical medicine, Oxid Med Cell Longev, doi:10.1155/2020/8825387
Zhang, Ma, Yang, Neuroprotective effects of quercetin on ischemic stroke: A literature review, Front Pharmacol, doi:10.3389/fphar.2022.854249
Önal, Arslan, Ergun, Treatment of COVID-19 patients with quercetin: A prospective, single center, randomized, controlled trial, Turk J Biol, doi:10.3906/biy-2104-16
{ 'indexed': {'date-parts': [[2023, 5, 17]], 'date-time': '2023-05-17T04:56:20Z', 'timestamp': 1684299380284}, 'reference-count': 0, 'publisher': 'Innovation Forever Publishing Group Limited', 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'abstract': '<jats:p>The COVID-19 epidemic has put health systems around the world in distress, at the ' 'same time stimulating global research in an attempt to discover new therapeutic strategies ' 'against this virus. In this opinion we analyze the characteristics of a flavonoid, quercetin, ' 'trying to better understand its usefulness in the treatment of coronavirus ' 'infection.</jats:p>', 'DOI': '10.53964/jmbdd.2023004', 'type': 'journal-article', 'created': {'date-parts': [[2023, 5, 17]], 'date-time': '2023-05-17T02:26:12Z', 'timestamp': 1684290372000}, 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Use of Quercetin for Therapeutic Purposes in COVID-19 Infections: The Opinion of the ' 'Geriatrician Doctor', 'prefix': '10.53964', 'author': [ { 'ORCID': '', 'authenticated-orcid': False, 'given': 'Valerio', 'family': 'Massimo Magro', 'sequence': 'first', 'affiliation': []}, { 'name': 'Department of Internal Medicine and Geriatry, University of Campania “luigi ' 'Vanvitelli”, Naples, Italy', 'sequence': 'first', 'affiliation': []}], 'member': '32140', 'published-online': {'date-parts': [[2023, 5, 15]]}, 'container-title': 'Journal of Modern Biology and Drug Discovery', 'original-title': [], 'link': [ { 'URL': '', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2023, 5, 17]], 'date-time': '2023-05-17T02:46:49Z', 'timestamp': 1684291609000}, 'score': 1, 'resource': {'primary': {'URL': ''}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2023, 5, 15]]}, 'references-count': 0, 'URL': '', 'relation': {}, 'ISSN': ['2788-8088'], 'container-title-short': 'J Mod Biol Drug Discov', 'published': {'date-parts': [[2023, 5, 15]]}}
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop