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Antiviral Significance of Isoquercetin (Quercetin-3-O-Glucoside) With Special Reference to its Anti-Coronaviral Potential

Agrawal et al., Natural Product Communications, doi:10.1177/1934578X231219560
Jan 2024  
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Quercetin for COVID-19
24th treatment shown to reduce risk in July 2021
*, now known with p = 0.0031 from 11 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments.
Review of the broad-spectrum antiviral significance of isoquercetin (quercetin-3-O-glucoside), focusing on SARS-CoV-2. Authors describe evidence from many studies showing inhibitory effects of isoquercetin on several stages of the viral life cycle, including blocking virus entry, interfering with replication, and preventing virus release. Through molecular docking studies, isoquercetin is predicted to bind viral proteins like the main protease (Mpro) and spike protein. Authors recommend further investigation of isoquercetin for SARS-CoV-2 due its multi-targeted binding and inhibitory effects on viral processes combined with ancillary antioxidant, anti-inflammatory, and anticoagulant properties.
Reviews covering quercetin for COVID-19 include Agrawal, Biancatelli, Derosa, Dinda, Gasmi, Georgiou, Imran, Massimo Magro, Matías-Pérez, Mirza, Rizky, Shorobi.
Agrawal et al., 9 Jan 2024, peer-reviewed, 3 authors. Contact:
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Antiviral Significance of Isoquercetin (Quercetin-3-O-Glucoside) With Special Reference to its Anti-Coronaviral Potential
Pawan K Agrawal, Gerald Blunden, Claus Jacob
Natural Product Communications, doi:10.1177/1934578x231219560
Isoquercetin, a naturally occurring dietary flavonoid glycoside, has shown many promising biological activities, such as antioxidant, anti-inflammatory, and anticancer. It also exhibits broad-spectrum antiviral activity, significantly reducing cell infection by influenza, Zika, Ebola, and dengue viruses, among others. Its beneficial effect for mitigating the disease of COVID-19 can be explained due to its inhibitory effects on several stages of the viral life cycle, from entry to replication and virus infectivity, and thus isoquercetin can be a promising anticoronaviral flavonoid to manage severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection and warrants further investigation into its potential use in clinical settings.
Declaration of Conflicting Interests The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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