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Home   COVID-19 treatment studies for Bromhexine  COVID-19 treatment studies for Bromhexine  C19 studies: Bromhexine  Bromhexine   Select treatmentSelect treatmentTreatmentsTreatments
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All Studies   Meta Analysis   Recent: 
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibito
Hoffman et al., Cell, doi:10.1016/j.cell.2020.02.052 (In Vitro)
5 Mar 2020    Source   PDF   Share   Tweet
In Vitro study showing that SARS-CoV-2 uses ACE2 for entry and TMPRSS2 for S protein priming, and that TMPRSS2 inhibitor camostat blocked entry and may be an effective treaetment.
Bromhexine may be less effective for omicron due to the entry process moving towards TMPRSS2-independent fusion.
2 In Vitro studies support the efficacy of bromhexine [Carpinteiro, Hoffman].
Hoffman et al., 5 Mar 2020, peer-reviewed, 13 authors.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
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