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The Therapeutic and Prophylactic Potential of Quercetin against COVID-19: An Outlook on the Clinical Studies, Inventive Compositions, and Patent Literature

Imran et al., Antioxidants, doi:10.3390/antiox11050876
Apr 2022  
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Quercetin for COVID-19
22nd treatment shown to reduce risk in July 2021
 
*, now known with p = 0.0031 from 11 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,200+ studies for 70+ treatments. c19early.org
Review of the evidence supporting the use of quercetin for COVID-19 from clinical studies and patents.
Reviews covering quercetin for COVID-19 include Agrawal, Biancatelli, Chen, Derosa, Dinda, Gasmi, Georgiou, Ho, Imran, Massimo Magro, Matías-Pérez, Mirza, Rizky, Shorobi, Vajdi, Yong.
Imran et al., 29 Apr 2022, peer-reviewed, 10 authors. Contact: mohammad.baks@nbu.edu.sa (corresponding author), saleh.alaqel@nbu.edu.sa, abeda.mohammed@nbu.edu.sa, hamdykhamees@gmail.com, aralzahrani@uqu.edu.sa, mokaalshammari@moh.gov.sa, m.uddin@psau.edu.sa, anupama.diwan@asu.apeejay.edu, salshehri1@ksu.edu.sa, sasdag@mcst.edu.sa.
This PaperQuercetinAll
The Therapeutic and Prophylactic Potential of Quercetin against COVID-19: An Outlook on the Clinical Studies, Inventive Compositions, and Patent Literature
Mohd Imran, Hamdy Khamees Thabet, Saleh I Alaqel, Abdullah R Alzahrani, Abida Abida, Mohammed Kanan Alshammari, Mehnaz Kamal, Anupama Diwan, Syed Mohammed Basheeruddin Asdaq, Sultan Alshehri
Antioxidants, doi:10.3390/antiox11050876
Quercetin is a phenolic flavonol compound with established antioxidant, anti-inflammatory, and immuno-stimulant properties. Recent studies demonstrate the potential of quercetin against COVID-19. This article highlighted the prophylactic/therapeutic potential of quercetin against COVID-19 in view of its clinical studies, inventions, and patents. The literature for the subject matter was collected utilizing different databases, including PubMed, Sci-Finder, Espacenet, Patentscope, and USPTO. Clinical studies expose the potential of quercetin monotherapy, and also its combination therapy with other compounds, including zinc, vitamin C, curcumin, vitamin D3, masitinib, hydroxychloroquine, azithromycin, and ivermectin. The patent literature also examines claims that quercetin containing nutraceuticals, pharmaceuticals, and dietary supplements, alone or in combination with other drugs/compounds, including favipiravir, remdesivir, molnupiravir, navitoclax, dasatinib, disulfiram, rucaparib, tamarixin, iota-carrageenan, and various herbal extracts (aloe, poria, rosemary, and sphagnum) has potential for use against COVID-19. The literature reveals that quercetin exhibits anti-COVID-19 activity because of its inhibitory effect on the expression of the human ACE2 receptors and the enzymes of SARS-CoV-2 (MPro, PLPro, and RdRp). The USFDA designated quercetin as a "Generally Recognized as Safe" substance for use in the food and beverage industries. It is also an inexpensive and readily available compound. These facts increase the possibility and foreseeability of making novel and economical drug combinations containing quercetin to prevent/treat COVID-19. Quercetin is an acidic compound and shows metabolic interaction with some antivirals, antibiotics, and anti-inflammatory agents. Therefore, the physicochemical and metabolic drug interactions between quercetin and the combined drugs/compounds must be better understood before developing new compositions.
Conflicts of Interest: The authors declare no conflict of interest.
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Quercetin is an acidic compound and shows ' 'metabolic interaction with some antivirals, antibiotics, and anti-inflammatory agents. 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