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0 0.5 1 1.5 2+ Symptomatic case 93% Improvement Relative Risk Rondanelli et al. NCT05037240 Quercetin RCT Prophylaxis Is prophylaxis with quercetin beneficial for COVID-19? Double-blind RCT 120 patients in Italy Fewer symptomatic cases with quercetin (p=0.042) Rondanelli et al., Life, doi:10.3390/life12010066 Favors quercetin Favors control

Promising Effects of 3-Month Period of Quercetin Phytosome® Supplementation in the Prevention of Symptomatic COVID-19 Disease in Healthcare Workers: A Pilot Study

Rondanelli et al., Promising Effects of 3-Month Period of Quercetin Phytosome® Supplementation in the Prevention of Symptomatic.., Life, doi:10.3390/life12010066, NCT05037240
Jan 2022   Source   PDF  
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RCT 120 healthcare workers, 60 treated with quercetin phytosome, showing lower risk of cases with treatment. Quercetin phytosome 250mg twice a day.
This is the 6th of 9 COVID-19 RCTs for quercetin, which collectively show efficacy with p=0.0075.
This is the 7th of 10 COVID-19 controlled studies for quercetin, which collectively show efficacy with p=0.0043.
risk of symptomatic case, 92.9% lower, HR 0.07, p = 0.04, treatment 1 of 60 (1.7%), control 4 of 60 (6.7%), adjusted per study, inverted to make HR<1 favor treatment, Cox proportional risk.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Rondanelli et al., 4 Jan 2022, Double Blind Randomized Controlled Trial, placebo-controlled, Italy, peer-reviewed, 12 authors, trial NCT05037240 (history).
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Promising Effects of 3-Month Period of Quercetin Phytosome® Supplementation in the Prevention of Symptomatic COVID-19 Disease in Healthcare Workers: A Pilot Study
Mariangela Rondanelli, Simone Perna, Clara Gasparri, Giovanna Petrangolini, Pietro Allegrini, Alessandro Cavioni, Milena Anna Faliva, Francesca Mansueto, Zaira Patelli, Gabriella Peroni, Alice Tartara, Antonella Riva
Life, doi:10.3390/life12010066
Quercetin, for its crucial properties, fulfills the need for a multifactor action that is useful for the potential counterbalance of a COVID-19 infection. Given this background, the aim of the study was to evaluate the potential effect of 3 months' supplementation with Quercetin Phytosome ® (250 mg twice a day) as prevention against symptomatic COVID-19. In total, 120 subjects were enrolled (males, 63; females, 57; age 49 ± 12), with 60 in the supplementation group and 60 in the placebo group. No significant differences were detected between groups in terms of gender, smoking, and chronic disease. Subjects underwent rapid COVID-19 diagnostic tests every 3 weeks. During our study, 5 subjects had COVID-19, 1 out of 60 subjects in the quercetin group and 4 out of 60 in the control group. Complete clinical remission was recorded at 7 and 15 days in the quercetin and placebo groups, respectively. Analysis showed that, at 5 months, the COVID free survival function (risk of infection) was 99.8% in subjects under quercetin supplementation and 96.5% in control group. As shown by the value of EXP(B), those who had taken the supplement had a protection factor of 14% more to not contract the COVID-19 infection than that of those who had taken a placebo. Obtained results are encouraging, but further studies are required to add quercetin as regular prophylaxis.
Institutional Review Board Statement: The study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Ethics Committee of the University (approval number: 1222/01022021). Informed Consent Statement: Informed consent was obtained from all subjects involved in the study.
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