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All Studies   Meta Analysis    Recent:   

Possible Therapeutic Effects of Adjuvant Quercetin Supplementation Against Early-Stage COVID-19 Infection: A Prospective, Randomized, Controlled, and Open-Label Study

Di Pierro et al., International Journal of General Medicine, doi:10.2147/IJGM.S318720, NCT04578158
Jun 2021  
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Mortality 86% Improvement Relative Risk ICU admission 94% Hospitalization 68% Quercetin  Di Pierro et al.  EARLY TREATMENT  RCT Is early treatment with quercetin beneficial for COVID-19? RCT 152 patients in Pakistan (September 2020 - March 2021) Lower ICU admission (p=0.0064) and hospitalization (p=0.0033) c19early.org Di Pierro et al., Int. J. General Medi.., Jun 2021 Favorsquercetin Favorscontrol 0 0.5 1 1.5 2+
Quercetin for COVID-19
23rd treatment shown to reduce risk in July 2021
 
*, now with p = 0.0031 from 11 studies.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,500+ studies for 81 treatments. c19early.org
RCT 152 outpatients in Pakistan, 76 treated with quercetin phytosome, showing lower mortality, ICU admission, and hospitalization with treatment.
Bioavailability. Quercetin has low bioavailability and studies typically use advanced formulations to improve bioavailability which may be required to reach therapeutic concentrations.
This is the 3rd of 10 COVID-19 RCTs for quercetin, which collectively show efficacy with p=0.0049.
This is the 3rd of 11 COVID-19 controlled studies for quercetin, which collectively show efficacy with p=0.0031.
risk of death, 85.7% lower, RR 0.14, p = 0.25, treatment 0 of 76 (0.0%), control 3 of 76 (3.9%), NNT 25, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of ICU admission, 94.1% lower, RR 0.06, p = 0.006, treatment 0 of 76 (0.0%), control 8 of 76 (10.5%), NNT 9.5, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of hospitalization, 68.2% lower, RR 0.32, p = 0.003, treatment 7 of 76 (9.2%), control 22 of 76 (28.9%), NNT 5.1.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Di Pierro et al., 8 Jun 2021, Randomized Controlled Trial, Pakistan, peer-reviewed, 19 authors, study period September 2020 - March 2021, trial NCT04578158 (history).
This PaperQuercetinAll
Possible Therapeutic Effects of Adjuvant Quercetin Supplementation Against Early-Stage COVID-19 Infection: A Prospective, Randomized, Controlled, and Open-Label Study
Francesco Di Pierro, Giuseppe Derosa, Pamela Maffioli, Alexander Bertuccioli, Stefano Togni, Antonella Riva, Pietro Allegrini, Amjad Khan, Saeed Khan, Bilal Ahmad Khan, Naireen Altaf, Maria Zahid, Ikram Din Ujjan, Roohi Nigar, Mehwish Imam Khushk, Maryam Phulpoto, Amanullah Lail, Bikha Ram Devrajani, Sagheer Ahmed
International Journal of General Medicine, doi:10.2147/ijgm.s318720
Background: Quercetin, a well-known naturally occurring polyphenol, has recently been shown by molecular docking, in vitro and in vivo studies to be a possible anti-COVID-19 candidate. Quercetin has strong antioxidant, anti-inflammatory, immunomodulatory, and antiviral properties, and it is characterized by a very high safety profile, exerted in animals and in humans. Like most other polyphenols, quercetin shows a very low rate of oral absorption and its clinical use is considered by most of modest utility. Quercetin in a delivery-food grade system with sunflower phospholipids (Quercetin Phytosome ® , QP) increases its oral absorption up to 20-fold. Methods: In the present prospective, randomized, controlled, and open-label study, a daily dose of 1000 mg of QP was investigated for 30 days in 152 COVID-19 outpatients to disclose its adjuvant effect in treating the early symptoms and in preventing the severe outcomes of the disease. Results: The results revealed a reduction in frequency and length of hospitalization, in need of non-invasive oxygen therapy, in progression to intensive care units and in number of deaths. The results also confirmed the very high safety profile of quercetin and suggested possible anti-fatigue and pro-appetite properties. Conclusion: QP is a safe agent and in combination with standard care, when used in early stage of viral infection, could aid in improving the early symptoms and help in preventing the severity of COVID-19 disease. It is suggested that a double-blind, placebo-controlled study should be urgently carried out to confirm the results of our study.
International Journal of General Medicine Dovepress DovePress International Journal of General Medicine 2021:14
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