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0 0.5 1 1.5 2+ Mortality 86% Improvement Relative Risk ICU admission 94% Hospitalization 68% c19early.org/q Di Pierro et al. NCT04578158 Quercetin RCT EARLY TREATMENT Favors quercetin Favors control
Possible Therapeutic Effects of Adjuvant Quercetin Supplementation Against Early-Stage COVID-19 Infection: A Prospective, Randomized, Controlled, and Open-Label Study
Di Pierro et al., International Journal of General Medicine, doi:10.2147/IJGM.S318720, NCT04578158 (history)
8 Jun 2021    Source   PDF   Share   Tweet
RCT 152 outpatients in Pakistan, 76 treated with quercetin phytosome, showing lower mortality, ICU admission, and hospitalization with treatment.
risk of death, 85.7% lower, RR 0.14, p = 0.25, treatment 0 of 76 (0.0%), control 3 of 76 (3.9%), NNT 25, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of ICU admission, 94.1% lower, RR 0.06, p = 0.006, treatment 0 of 76 (0.0%), control 8 of 76 (10.5%), NNT 9.5, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of hospitalization, 68.2% lower, RR 0.32, p = 0.003, treatment 7 of 76 (9.2%), control 22 of 76 (28.9%), NNT 5.1.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Di Pierro et al., 8 Jun 2021, Randomized Controlled Trial, Pakistan, peer-reviewed, 19 authors, trial NCT04578158 (history).
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