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Quercetin in the Prevention and Treatment of Coronavirus Infections: A Focus on SARS-CoV-2

Gasmi et al., Pharmaceuticals, doi:10.3390/ph15091049
Aug 2022  
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Quercetin for COVID-19
23rd treatment shown to reduce risk in July 2021
*, now with p = 0.0031 from 11 studies.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 79 treatments.
Review of the potential benefits of quercetin for COVID-19, including inhibitory effects on several stages of the viral life cycle, antioxidant, anti-inflammatory, and immunomodulatory effects, and synergistic effects with other treatments.
Reviews covering quercetin for COVID-19 include1-17.
Gasmi et al., 25 Aug 2022, peer-reviewed, 9 authors. Contact: (corresponding author).
This PaperQuercetinAll
Quercetin in the Prevention and Treatment of Coronavirus Infections: A Focus on SARS-CoV-2
Amin Gasmi, Pavan Kumar Mujawdiya, Roman Lysiuk, Mariia Shanaida, Massimiliano Peana, Asma Gasmi Benahmed, Nataliya Beley, Nadiia Kovalska, Geir Bjørklund
Pharmaceuticals, doi:10.3390/ph15091049
The COVID-19 outbreak seems to be the most dangerous challenge of the third millennium due to its highly contagious nature. Amongst natural molecules for COVID-19 treatment, the flavonoid molecule quercetin (QR) is currently considered one of the most promising. QR is an active agent against SARS and MERS due to its antimicrobial, antiviral, anti-inflammatory, antioxidant, and some other beneficial effects. QR may hold therapeutic potential against SARS-CoV-2 due to its inhibitory effects on several stages of the viral life cycle. In fact, QR inhibits viral entry, absorption, and penetration in the SARS-CoV virus, which might be at least partly explained by the ability of QR and its derivatives to inhibit 3-chymotrypsin-like protease (3CLpro) and papain-like protease (PLpro). QR is a potent immunomodulatory molecule due to its direct modulatory effects on several immune cells, cytokines, and other immune molecules. QR-based nanopreparations possess enhanced bioavailability and solubility in water. In this review, we discuss the prospects for the application of QR as a preventive and treatment agent for COVID-19. Given the multifactorial beneficial action of QR, it can be considered a very valid drug as a preventative, mitigating, and therapeutic agent of COVID-19 infection, especially in synergism with zinc, vitamins C, D, and E, and other polyphenols.
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In fact, QR inhibits viral entry, absorption, and penetration in the SARS-CoV ' 'virus, which might be at least partly explained by the ability of QR and its derivatives to ' 'inhibit 3-chymotrypsin-like protease (3CLpro) and papain-like protease (PLpro). QR is a ' 'potent immunomodulatory molecule due to its direct modulatory effects on several immune ' 'cells, cytokines, and other immune molecules. QR-based nanopreparations possess enhanced ' 'bioavailability and solubility in water. In this review, we discuss the prospects for the ' 'application of QR as a preventive and treatment agent for COVID-19. Given the multifactorial ' 'beneficial action of QR, it can be considered a very valid drug as a preventative, ' 'mitigating, and therapeutic agent of COVID-19 infection, especially in synergism with zinc, ' 'vitamins C, D, and E, and other polyphenols.</jats:p>', 'DOI': '10.3390/ph15091049', 'type': 'journal-article', 'created': {'date-parts': [[2022, 8, 26]], 'date-time': '2022-08-26T06:04:32Z', 'timestamp': 1661493872000}, 'page': '1049', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Quercetin in the Prevention and Treatment of Coronavirus Infections: A Focus on SARS-CoV-2', 'prefix': '10.3390', 'volume': '15', 'author': [ { 'ORCID': '', 'authenticated-orcid': False, 'given': 'Amin', 'family': 'Gasmi', 'sequence': 'first', 'affiliation': []}, {'given': 'Pavan Kumar', 'family': 'Mujawdiya', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': '', 'authenticated-orcid': False, 'given': 'Roman', 'family': 'Lysiuk', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': '', 'authenticated-orcid': False, 'given': 'Mariia', 'family': 'Shanaida', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': '', 'authenticated-orcid': False, 'given': 'Massimiliano', 'family': 'Peana', 'sequence': 'additional', 'affiliation': []}, {'given': 'Asma', 'family': 'Gasmi Benahmed', 'sequence': 'additional', 'affiliation': []}, {'given': 'Nataliya', 'family': 'Beley', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': '', 'authenticated-orcid': False, 'given': 'Nadiia', 'family': 'Kovalska', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': '', 'authenticated-orcid': False, 'given': 'Geir', 'family': 'Bjørklund', 'sequence': 'additional', 'affiliation': []}], 'member': '1968', 'published-online': {'date-parts': [[2022, 8, 25]]}, 'reference': [ {'key': 'ref1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S0140-6736(20)30183-5'}, {'key': 'ref2', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/s41421-020-0153-3'}, { 'key': 'ref3', 'unstructured': 'COVID-19 Coronavirus Pandemic\n' ''}, {'key': 'ref4', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S1473-3099(21)00167-5'}, {'key': 'ref5', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.ijantimicag.2020.105948'}, {'key': 'ref6', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.joim.2020.02.005'}, {'key': 'ref7', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.fct.2017.10.039'}, {'key': 'ref8', 'doi-asserted-by': 'publisher', 'DOI': '10.3390/ijms19113568'}, {'key': 'ref9', 'doi-asserted-by': 'publisher', 'DOI': '10.1249/JSR.0b013e3181ae8959'}, {'key': 'ref10', 'doi-asserted-by': 'publisher', 'DOI': '10.4103/0973-7847.194044'}, {'key': 'ref11', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/s41598-017-08024-8'}, {'key': 'ref12', 'doi-asserted-by': 'publisher', 'DOI': '10.3390/nu8030167'}, {'key': 'ref13', 'doi-asserted-by': 'publisher', 'DOI': '10.1155/2009/830616'}, {'key': 'ref14', 'doi-asserted-by': 'publisher', 'DOI': '10.2174/1381612826666200526150113'}, {'key': 'ref15', 'doi-asserted-by': 'publisher', 'DOI': '10.3390/nu7042345'}, {'key': 'ref16', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.chroma.2019.04.052'}, {'key': 'ref17', 'doi-asserted-by': 'publisher', 'DOI': '10.1111/1541-4337.12342'}, {'key': 'ref18', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S0014-5793(00)01211-4'}, {'key': 'ref19', 'doi-asserted-by': 'publisher', 'DOI': '10.1007/978-1-4419-7756-4_38'}, {'key': 'ref20', 'doi-asserted-by': 'publisher', 'DOI': '10.3390/molecules24061123'}, {'key': 'ref21', 'doi-asserted-by': 'publisher', 'DOI': '10.1155/2016/5698931'}, {'key': 'ref22', 'doi-asserted-by': 'publisher', 'DOI': '10.1371/journal.pone.0022934'}, {'key': 'ref23', 'doi-asserted-by': 'publisher', 'DOI': '10.3945/jn.108.096271'}, {'key': 'ref24', 'doi-asserted-by': 'publisher', 'DOI': '10.3390/nu10111618'}, {'key': 'ref25', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.ejphar.2006.11.014'}, {'key': 'ref26', 'doi-asserted-by': 'publisher', 'DOI': '10.3892/or.2017.5766'}, {'key': 'ref27', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.biopha.2019.109604'}, { 'key': 'ref28', 'first-page': '33', 'article-title': 'Photobiomodulation of quercetin antiproliferative effects seen in human ' 'acute T leukemic Jurkat cells', 'volume': '17', 'author': 'Seremet', 'year': '2007', 'journal-title': 'Rom. 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