Targeting SIRT1: A Potential Strategy for Combating Severe COVID‐19
et al., BioMed Research International, doi:10.1155/bmri/9507417, Jan 2025
Quercetin for COVID-19
27th treatment shown to reduce risk in
July 2021, now with p = 0.002 from 12 studies.
No treatment is 100% effective. Protocols
combine treatments.
6,300+ studies for
210+ treatments. c19early.org
|
Review showing that SIRT1 activation may benefit COVID-19 treatment through multiple anti-inflammatory and antiviral mechanisms.
Bioavailability. Quercetin has low bioavailability and studies typically use advanced formulations to improve bioavailability which may be required to reach therapeutic concentrations.
Review covers quercetin, curcumin, and resveratrol.
1.
Sanduzzi Zamparelli et al., Immune-Boosting and Antiviral Effects of Antioxidants in COVID-19 Pneumonia: A Therapeutic Perspective, Life, doi:10.3390/life15010113.
2.
Duan et al., Bioactive compounds,quercetin, curcumin and β-glucan,regulate innate immunity via the gut-liver-brain axis, Trends in Food Science & Technology, doi:10.1016/j.tifs.2024.104864.
3.
Beşler et al., Investigation of potential effects of quercetin on COVID-19 treatment: a systematic review of randomized controlled trials, Clinical Science of Nutrition, doi:10.62210/ClinSciNutr.2024.86.
4.
Ho et al., Therapeutic Implications of Quercetin and its Derived-products in COVID-19 Protection and Prophylactic, Heliyon, doi:10.1016/j.heliyon.2024.e30080.
5.
Vajdi et al., Effect of polyphenols against complications of COVID-19: current evidence and potential efficacy, Pharmacological Reports, doi:10.1007/s43440-024-00585-6.
6.
Chen et al., Effect and mechanism of quercetin or quercetin‐containing formulas against COVID‐19: From bench to bedside, Phytotherapy Research, doi:10.1002/ptr.8175.
7.
Yong et al., Natural Products-Based Inhaled Formulations for Treating Pulmonary Diseases, International Journal of Nanomedicine, doi:10.2147/ijn.s451206.
8.
Agrawal et al., Antiviral Significance of Isoquercetin (Quercetin-3-O-Glucoside) With Special Reference to its Anti-Coronaviral Potential, Natural Product Communications, doi:10.1177/1934578X231219560.
9.
Matías-Pérez et al., Relationship of quercetin intake and oxidative stress in persistent Covid, Frontiers in Nutrition, doi:10.3389/fnut.2023.1278039.
10.
Georgiou et al., Quercetin: A Potential Polydynamic Drug, Molecules, doi:10.3390/molecules28248141.
11.
Donzelli, A., Neglected Effective Early Therapies against COVID-19: Focus on Functional Foods and Related Active Substances. A Review, MDPI AG, doi:10.20944/preprints202312.1178.v1.
12.
Dinda et al., Anti-SARS-CoV-2, antioxidant and immunomodulatory potential of dietary flavonol quercetin: Focus on molecular targets and clinical efficacy, European Journal of Medicinal Chemistry Reports, doi:10.1016/j.ejmcr.2023.100125.
13.
Mirza et al., Quercetin as a Therapeutic Product: Evaluation of Its Pharmacological Action and Clinical Applications—A Review, Pharmaceuticals, doi:10.3390/ph16111631.
14.
Massimo Magro et al., Use of Quercetin for Therapeutic Purposes in COVID-19 Infections: The Opinion of the Geriatrician Doctor, Journal of Modern Biology and Drug Discovery, doi:10.53964/jmbdd.2023004.
15.
Shorobi et al., Quercetin: A Functional Food-Flavonoid Incredibly Attenuates Emerging and Re-Emerging Viral Infections through Immunomodulatory Actions, Molecules, doi:10.3390/molecules28030938.
16.
Gasmi et al., Quercetin in the Prevention and Treatment of Coronavirus Infections: A Focus on SARS-CoV-2, Pharmaceuticals, doi:10.3390/ph15091049.
17.
Rizky et al., The pharmacological mechanism of quercetin as adjuvant therapy of COVID-19, Life Research, doi:10.53388/life2022-0205-302.
18.
Imran et al., The Therapeutic and Prophylactic Potential of Quercetin against COVID-19: An Outlook on the Clinical Studies, Inventive Compositions, and Patent Literature, Antioxidants, doi:10.3390/antiox11050876.
Shokri-Afra et al., 31 Jan 2025, peer-reviewed, 8 authors.
Contact: msc.musavi66@gmail.com, malekzadeganyalda@gmail.com.
Targeting SIRT1: A Potential Strategy for Combating Severe COVID‐19
BioMed Research International, doi:10.1155/bmri/9507417
Sirtuin 1 (SIRT1) is a crucial regulator of cellular processes, including inflammation, metabolism, and stress responses, playing a significant role in the body's defense mechanisms. During SARS-CoV-2 infection, SIRT1 plays a crucial role in modulating the immune response. This protein helps to enhance the antiviral response through deacetylating key transcription factors and regulating proinflammatory cytokines, thereby reducing the cytokine storm (an overwhelming immune response) associated with severe COVID-19 cases. SIRT1 influences the expression of angiotensin-converting enzyme 2 (ACE2), the primary receptor for SARS-CoV-2, thereby potentially mitigating viral entry and replication. Natural activators of SIRT1, such as resveratrol, have been shown to enhance its activity, offering promising avenues for therapeutic interventions aimed at bolstering the immune response during COVID-19. Understanding the multifaceted role of SIRT1 in human defense mechanisms against SARS-CoV-2 could pave the way for innovative strategies to manage COVID-19 and similar viral infections, emphasizing the importance of SIRT1 as a potential target for future therapeutic approaches.
Disclosure All authors reviewed the manuscript. All authors agree to be accountable for the research presented.
Conflicts of Interest The authors declare no conflicts of interest.
Author Contributions H.S-A., H.M., P.K., F.S.J., Z.B., E.Y.A., D.I., and Y.M. wrote the main manuscript text. H.S-A. prepared Figures 1 and 2 .
References
Abu-Eid, Ward, Targeting the PI3K/Akt/mTOR Pathway: A Therapeutic Strategy in COVID-19 Patients, Immunology Letters, doi:10.1016/j.imlet.2021.09.005
Aleebrahim-Dehkordi, Soveyzi, Deravi, Rabbani, Saghazadeh et al., Human Coronaviruses SARS-CoV, MERS-CoV, and SARS-CoV-2 in Children, Journal of Pediatric Nursing, doi:10.1016/j.pedn.2020.10.020
Alefishat, Jelinek, Mousa, Tay, Alsafar, Immune Response to SARS-CoV-2 Variants: A Focus on Severity, Susceptibility, and Preexisting Immunity, Journal of Infection and Public Health, doi:10.1016/j.jiph.2022.01.007
Andreakos, Tsiodras, COVID-19: Lambda Interferon Against Viral Load and Hyperinflammation, EMBO Molecular Medicine, doi:10.15252/emmm.202012465
Ateyya, Atif, Abd El-Fadeal, Hesperetin Protects Against Rotenone-Induced Motor Disability and Neurotoxicity via the Regulation of SIRT1/NLRP3 Signaling, Toxicology Mechanisms and Methods, doi:10.1080/15376516.2024.2390646
Azizidoost, Adelipour, Haybar, Shabaninejad, Rashidi, Implications of Quercetin in Mitigating Myocardial Ischemia-Reperfusion Injury: A Review Study, Advanced Biomedical Research
Banu, Panikar, Leal, Leal, Protective Role of ACE2 and Its Downregulation in SARS-CoV-2 Infection Leading to Macrophage Activation Syndrome: Therapeutic Implications, Life Sciences, doi:10.1016/j.lfs.2020.117905
Barbagallo, Vanella, Cambria, Silibinin Regulates Lipid Metabolism and Differentiation in Functional Human Adipocytes, Frontiers in Pharmacology
Bastin, Netticadan, Abbasi, Effects of Resveratrol on Inflammatory Cytokines in COVID-19 Patients: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial, Molecular and Cellular Biochemistry, doi:10.1007/s11010-025-05290-3
Battagello, Dragunas, Klein, Ayub, Velloso et al., Unpuzzling COVID-19: Tissue-Related Signaling Pathways Associated With SARS-CoV-2 Infection and Transmission, Clinical Science, doi:10.1042/CS20200904
Baur, Biochemical Effects of SIRT1 Activators, Biochimica et Biophysica Acta (Bba)-Proteins and Proteomics, doi:10.1016/j.bbapap.2009.10.025
Bhutta, Gallo, Borenstein, Multifaceted Role of AMPK in Viral Infections, Cells, doi:10.3390/cells10051118
Birra, Benucci, Landolfi, COVID 19: A Clue From Innate Immunity, Immunologic Research, doi:10.1007/s12026-020-09137-5
Bordoni, Tartaglia, Sacchi, The Unbalanced p53/SIRT1 Axis May Impact Lymphocyte Homeostasis in COVID-19 Patients, International Journal of Infectious Diseases, doi:10.1016/j.ijid.2021.02.019
Bosch-Barrera, Martin-Castillo, Buxó, Brunet, Encinar et al., Silibinin and SARS-CoV-2: Dual Targeting of Host Cytokine Storm and Virus Replication Machinery for Clinical Management of COVID-19 Patients, Journal of Clinical Medicine, doi:10.3390/jcm9061770
Carboni, Carta, Carboni, Can Pioglitazone Be Potentially Useful Therapeutically in Treating Patients With COVID-19?, Medical Hypotheses, doi:10.1016/j.mehy.2020.109776
Chauhan, Comprehensive Review of Coronavirus Disease 2019 (COVID-19), Biomedical Journal, doi:10.1016/j.bj.2020.05.023
Chawla, Subramanian, Rahman, Autophagy in Virus Infection: A Race Between Host Immune Response and Viral Antagonism, Immuno, doi:10.3390/immuno2010012
Chen, Guo, Qiu, Zhang, Deng et al., Immunomodulatory and Antiviral Activity of Metformin and Its Potential Implications in Treating Coronavirus Disease 2019 and Lung Injury, Frontiers in Immunology, doi:10.3389/fimmu.2020.02056
Chen, Ho, Wu, Cytoprotective Effects of Fisetin Against Hypoxia-Induced Cell Death in PC12 Cells, Food & Function, doi:10.1039/C4FO00948G
Chen, Shentu, Wen, Johnson, Shyy, Regulation of SIRT1 by Oxidative Stress-Responsive miRNAs and a Systematic Approach to Identify Its Role in the Endothelium, Antioxidants & Redox Signaling, doi:10.1089/ars.2012.4803
Chen, Ye, Wan, The Roles of c-Jun N-Terminal Kinase (JNK) in Infectious Diseases, International Journal of Molecular Sciences, doi:10.3390/ijms22179640
Chong, Shang, Wang, Maiese, SIRT1: New Avenues of Discovery for Disorders of Oxidative Stress, Expert Opinion on Therapeutic Targets, doi:10.1517/14728222.2012.648926
Cicero, Baggioni, Berberine and Its Role in Chronic Disease, Anti-Inflammatory Nutraceuticals and Chronic Diseases, doi:10.1007/978-3-319-41334-1_2
Clark, Jit, Warren-Gash, Global, Regional, and National Estimates of the Population at Increased Risk of Severe COVID-19 due to Underlying Health Conditions in 2020: A Modelling Study, Lancet Global Health, doi:10.1016/S2214-109X(20)30264-3
Clarke, Belyaev, Lambert, Turner, Epigenetic Regulation of Angiotensin-Converting Enzyme 2 (ACE2) by SIRT1 Under Conditions of Cell Energy Stress, Clinical Science, doi:10.1042/CS20130291
Costela-Ruiz, Illescas-Montes, Puerta-Puerta, Ruiz, Melguizo-Rodríguez, SARS-CoV-2 Infection: The Role of Cytokines in COVID-19 Disease, Cytokine & Growth Factor Reviews, doi:10.1016/j.cytogfr.2020.06.001
D'acquisto, May, Ghosh, Inhibition of Nuclear Factor Kappa B (NF-B):: An Emerging Theme in Anti-Inflammatory Therapies, Molecular Interventions, doi:10.1124/mi.2.1.22
Da Silva, Manica, Da Silva, High Levels of Extracellular ATP Lead to Different Inflammatory Responses in COVID-19 Patients According to the Severity, Journal of Molecular Medicine, doi:10.1007/s00109-022-02185-4
Darif, Hammi, Kihel, Saik, Guessous et al., The Pro-Inflammatory Cytokines in COVID-19 Pathogenesis: What Goes Wrong?, Microbial Pathogenesis, doi:10.1016/j.micpath.2021.104799
Dean, Bozza, Twomey, Luo, Nalli et al., The Fight Against COVID-19: Striking a Balance in the Renin-Angiotensin System, Drug Discovery Today, doi:10.1016/j.drudis.2021.04.006
Desai, Prickril, Rasooly, Mechanisms of Phytonutrient Modulation of Cyclooxygenase-2 (COX-2) and Inflammation Related to Cancer, Nutrition and Cancer, doi:10.1080/01635581.2018.1446091
Di Pierro, Derosa, Maffioli, Possible Therapeutic Effects of Adjuvant Quercetin Supplementation Against Early-Stage COVID-19 Infection: A Prospective, Randomized, Controlled, and Open-Label Study, International Journal of General Medicine, doi:10.2147/IJGM.S318720
Di Pierro, Khan, Iqtadar, Quercetin as a Possible Complementary Agent for Early-Stage COVID-19: Concluding Results of a Randomized Clinical Trial, Frontiers in Pharmacology, doi:10.3389/fphar.2022.1096853
Ding, Zhu, Wang, Li, Ma et al., SIRT1 Is a Regulator of Autophagy: Implications for the Progression and Treatment of Myocardial Ischemia-Reperfusion, Pharmacological Research, doi:10.1016/j.phrs.2023.106957
Dinicolantonio, Mccarty, O'keefe, Nutraceutical Activation of Sirt 1: A Review, Open Heart, doi:10.1136/openhrt-2022-002171
Dmytriw, Chibbar, Chen, Outcomes of Acute Respiratory Distress Syndrome in COVID-19 Patients Compared to the General Population: A Systematic Review and Meta-Analysis, Expert Review of Respiratory Medicine, doi:10.1080/17476348.2021.1920927
Domi, Hoxha, Kolovani, Tricarico, Zappacosta, The Importance of Nutraceuticals in COVID-19: What's the Role of Resveratrol?, Molecules, doi:10.3390/molecules27082376
Dominguez-Andres, Netea, Long-Term Reprogramming of the Innate Immune System, Journal of Leukocyte Biology, doi:10.1002/JLB.MR0318-104R
Dupuis, Laurin, Tardif, Fourteen-Day Evolution of COVID-19 Symptoms During the Third Wave in Nonvaccinated Subjects and Effects of Hesperidin Therapy: A Randomized, Double-Blinded, Placebo-Controlled Study, Evidence-based Complementary and Alternative Medicine, doi:10.1155/2022/3125662
Erickson, Fenno, Barzilai, Metformin for Treatment of Acute COVID-19: Systematic Review of Clinical Trial Data Against SARS-CoV-2, Diabetes Care, doi:10.2337/dc22-2539
Farahani, Niknam, Amirabad, Molecular Pathways Involved in COVID-19 and Potential Pathway-Based Therapeutic Targets, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2021.112420
Fontani, Domazetovic, Marcucci, Vincenzini, Iantomasi, MMPs, ADAMs and Their Natural Inhibitors in Inflammatory Bowel Disease: Involvement of Oxidative Stress, J Clin Gastroenterol Treat
Fu, Ho, Kang, Pharmaceutical Prospects of Curcuminoids for the Remedy of COVID-19: Truth or Myth, Frontiers in Pharmacology, doi:10.3389/fphar.2022.863082
Gao, Xu, Wang, Liu, Cytokine Storm Syndrome in Coronavirus Disease 2019: A Narrative Review, Journal of Internal Medicine, doi:10.1111/joim.13144
Gassen, Papies, Bajaj, SARS-CoV-2-Mediated Dysregulation of Metabolism and Autophagy Uncovers Host-Targeting Antivirals, Nature Communications, doi:10.1038/s41467-021-24007-w
Giordo, Zinellu, Eid, Pintus, Therapeutic Potential of Resveratrol in COVID-19-Associated Hemostatic Disorders, Molecules, doi:10.3390/molecules26040856
Grimes, Grimes, p38 MAPK Inhibition: A Promising Therapeutic Approach for COVID-19, Journal of Molecular and Cellular Cardiology, doi:10.1016/j.yjmcc.2020.05.007
Guedj, Million, Dudouet, 18F-FDG Brain PET Hypometabolism in Post-SARS-CoV-2 Infection: Substrate for Persistent/Delayed Disorders?, European Journal of Nuclear Medicine and Molecular Imaging, doi:10.1007/s00259-020-04973-x
Guo, Jin, Chen, NF-κB in Biology and Targeted Therapy: New Insights and Translational Implications, Signal Transduction and Targeted Therapy, doi:10.1038/s41392-024-01757-9
Gupta, Patchva, Koh, Aggarwal, Discovery of Curcumin, a Component of Golden Spice, and Its Miraculous Biological Activities, Clinical and Experimental Pharmacology and Physiology, doi:10.1111/j.1440-1681.2011.05648.x
Hammad, Raftari, Cesário, Roles of Oxidative Stress and Nrf2 Signaling in Pathogenic and Non-Pathogenic Cells: A Possible General Mechanism of Resistance to Therapy, Antioxidants, doi:10.3390/antiox12071371
Hassan, Choudhury, Dayhoff, The Importance of Accessory Protein Variants in the Pathogenicity of SARS-CoV-2, Archives of Biochemistry and Biophysics, doi:10.1016/j.abb.2022.109124
Hirano, Murakami, COVID-19: A New Virus, but a Familiar Receptor and Cytokine Release Syndrome, Immunity, doi:10.1016/j.immuni.2020.04.003
Holczer, Hajdú, Lőrincz, Szarka, Bánhegyi et al., Fine-Tuning of AMPK-ULK1-mTORC1 Regulatory Triangle Is Crucial for Autophagy Oscillation, Scientific Reports, doi:10.1038/s41598-020-75030-8
Hu, Huang, Yin, The Cytokine Storm and COVID-19, Journal of Medical Virology, doi:10.1002/jmv.26232
Huang, Qiu, Cheng, Berberine Protects Secondary Injury in Mice With Traumatic Brain Injury Through Anti-Oxidative and Anti-Inflammatory Modulation, Neurochemical Research, doi:10.1007/s11064-018-2597-5
Idrees, Kumar, Khan, Hesperetin Activated SIRT1 Neutralizes Cadmium Effects on the Early Bovine Embryo Development, Theriogenology, doi:10.1016/j.theriogenology.2022.06.008
Iside, Scafuro, Nebbioso, Altucci, SIRT1 Activation by Natural Phytochemicals: An Overview, Frontiers in Pharmacology
Iskender, Dokumacioglu, Sen, Ince, Kanbay et al., The Effect of Hesperidin and Quercetin on Oxidative Stress, NF-κB and SIRT1 Levels in a STZ-Induced Experimental Diabetes Model, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2017.03.102
Jahangirifard, Mirtajani, Karimzadeh, The Effect of Hesperidin on Laboratory Parameters of Patients With COVID 19: A Preliminary Report of a Clinical Trial Study, Journal of Iranian Medical Council, doi:10.18502/jimc.v5i1.9575
Jia, Shen, Liu, The Deacetylation of Akt by SIRT1 Inhibits Inflammation in Macrophages and Protects Against Sepsis, Experimental Biology and Medicine, doi:10.1177/15353702231165707
Kauppinen, Suuronen, Ojala, Kaarniranta, Salminen, Antagonistic Crosstalk Between NF-κB and SIRT1 in the Regulation of Inflammation and Metabolic Disorders, Cellular Signalling, doi:10.1016/j.cellsig.2013.06.007
Khan, Patel, Majumdar, Role of NRF2 and Sirtuin Activators in COVID-19, Clinical Immunology, doi:10.1016/j.clim.2021.108879
Kim, Kim, Son, Moon, Pyo et al., Fisetin Induces Sirt1 Expression While Inhibiting Early Adipogenesis in 3T3-L1 Cells, Biochemical and Biophysical Research Communications, doi:10.1016/j.bbrc.2015.10.094
Kim, Silwal, Jo, Sirtuin 1 in Host Defense During Infection, Cells, doi:10.3390/cells11182921
Kitada, Ogura, Koya, The Protective Role of Sirt1 in Vascular Tissue: Its Relationship to Vascular Aging and Atherosclerosis, Aging, doi:10.18632/aging.101068
Kosgei, Coelho, Guéant-Rodriguez, Guéant, Sirt1-PPARS Cross-Talk in Complex Metabolic Diseases and Inherited Disorders of the One Carbon Metabolism, Cells, doi:10.3390/cells9081882
Lekshmi, Asha, Sanicas, Asi, Arya et al., PI3K/Akt/Nrf2 Mediated Cellular Signaling and Virus-Host Interactions: Latest Updates on the Potential Therapeutic Management of SARS-CoV-2 Infection, Frontiers in Molecular Biosciences, doi:10.3389/fmolb.2023.1158133
Li, Wang, Sharvan, Gao, Qu, Berberine Could Inhibit Thyroid Carcinoma Cells by Inducing Mitochondrial Apoptosis, G0/G1 Cell Cycle Arrest and Suppressing Migration via PI3K-AKT and MAPK Signaling Pathways, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2017.09.010
Li, Yao, Han, Quercetin, Inflammation and Immunity, Nutrients, doi:10.3390/nu8030167
Liao, Wu, Wu, Resveratrol as an Adjunctive Therapy for Excessive Oxidative Stress in Aging COVID-19 Patients, Antioxidants, doi:10.3390/antiox10091440
Liu, Zhang, Joo, Sun, NF-κB Signaling in Inflammation, Signal Transduction and Targeted Therapy, doi:10.1038/sigtrans.2017.23
Man, Li, Xia, The Role of Sirtuin1 in Regulating Endothelial Function, Arterial Remodeling and Vascular Aging, Frontiers in Physiology, doi:10.3389/fphys.2019.01173
Marinella, Indomethacin and Resveratrol as Potential Treatment Adjuncts for SARS-CoV-2/COVID-19, International Journal of Clinical Practice, doi:10.1111/ijcp.13535
Mccreary, Schnell, Rhoda, Randomized Double-Blind Placebo-Controlled Proof-of-Concept Trial of Resveratrol for Outpatient Treatment of Mild Coronavirus Disease (COVID-19), Scientific Reports, doi:10.1038/s41598-022-13920-9
Mendes, De Farias, Santos, Nuclear Sirtuins and Inflammatory Signaling Pathways, Cytokine & Growth Factor Reviews, doi:10.1016/j.cytogfr.2017.11.001
Michalak, Michalak, Brenk-Krakowska, Acute COVID-19 and LongCOVID Syndrome-Molecular Implications for Therapeutic Strategies-Review, Frontiers in Immunology, doi:10.3389/fimmu.2025.1582783
Miller, Wentzel, Richards, COVID-19: NAD(+) Deficiency May Predispose the Aged, Obese and Type2 Diabetics to Mortality Through Its Effect on SIRT1 Activity, Medical Hypotheses, doi:10.1016/j.mehy.2020.110044
Miyazaki, Ichiki, Hashimoto, SIRT1, a Longevity Gene, Downregulates Angiotensin II Type 1 Receptor Expression in Vascular Smooth Muscle Cells, Arteriosclerosis, Thrombosis, and Vascular Biology, doi:10.1161/ATVBAHA.108.166991
Naqvi, Fatima, Mohammad, Insights Into SARS-CoV-2 Genome, Structure, Evolution, Pathogenesis and Therapies: Structural Genomics Approach, Biochimica et Biophysica Acta -Molecular Basis of Disease, doi:10.1016/j.bbadis.2020.165878
Nazerian, Ghasemi, Yassaghi, Nazerian, Hashemi, Role of SARS-CoV-2-Induced Cytokine Storm in Multi-Organ Failure: Molecular Pathways and Potential Therapeutic Options, International Immunopharmacology, doi:10.1016/j.intimp.2022.109428
Ni, Yang, Yang, Role of Angiotensin-Converting Enzyme 2 (ACE2) in COVID-19, Critical Care, doi:10.1186/s13054-020-03120-0
Park, Fischer, Dechend, p38 Mitogen-Activated Protein Kinase Inhibition Ameliorates Angiotensin II-Induced Target Organ Damage, Hypertension, doi:10.1161/01.HYP.0000256831.33459.ea
Pillai, Sundaresan, Gupta, Regulation of Akt Signaling by Sirtuins: Its Implication in Cardiac Hypertrophy and Aging, Circulation Research, doi:10.1161/CIRCRESAHA.113.300536
Rafacho, Stice, Liu, Greenberg, Ausman et al., Inhibition of Diethylnitrosamine-Initiated Alcohol-Promoted Hepatic Inflammation and Precancerous Lesions by Flavonoid Luteolin Is Associated With Increased Sirtuin 1 Activity in Mice, Hepatobiliary Surgery and Nutrition, doi:10.3978/j.issn.2304-3881.2014.08.06
Razak, Jelas, Muhammad, In Vitro Anti-SARS-CoV-2 Activities of Curcumin and Selected Phenolic Compounds, Natural Product Communications, doi:10.1177/1934578X231188861
Redondo, Zaldívar-López, Garrido, Montoya, SARS-CoV-2 Accessory Proteins in Viral Pathogenesis: Knowns and Unknowns, Frontiers in Immunology, doi:10.3389/fimmu.2021.708264
Ren, Wen, Fan, COVID-19 Immune Features Revealed by a Large-Scale Single-Cell Transcriptome Atlas, Cell, doi:10.1016/j.cell.2021.01.053
Resnik, Lopez Mingorance, Rivera, Mitchell, Gonzalez et al., Autophagy in Inflammatory Response Against SARS-CoV-2, International Journal of Molecular Sciences, doi:10.3390/ijms24054928
Ricordi, Zanuso, Menichelli, Role of Exercise and Natural Protective Substances on Sirtuin Activation, Journal of Physical Medicine and Rehabilitation, doi:10.33696/rehabilitation.3.019
Rossi, Sacco, Capizzi, Mastromarino, Can Resveratrol-Inhaled Formulations Be Considered Potential Adjunct Treatments for COVID-19?, Frontiers in Immunology, doi:10.3389/fimmu.2021.670955
Saccani, Pantano, Natoli, p38-Dependent Marking of Inflammatory Genes for Increased NF-κB Recruitment, Nature Immunology, doi:10.1038/ni748
Salminen, Kaarniranta, Kauppinen, Crosstalk Between Oxidative Stress and SIRT1: Impact on the Aging Process, International Journal of Molecular Sciences, doi:10.3390/ijms14023834
Salomone, Barbagallo, Godos, Silibinin Restores NAD+ Levels and Induces the SIRT1/AMPK Pathway in Non-Alcoholic Fatty Liver, Nutrients
Santamaria, Targeting the PI3K/AKT Pathway: A Potential New Weapon in the Global Fight Against SARS-CoV-2?, International Journal of Biological Sciences, doi:10.7150/ijbs.63969
Satarker, Tom, Shaji, Alosious, Luvis et al., JAK-STAT Pathway Inhibition and Their Implications in COVID-19 Therapy, Postgraduate Medicine, doi:10.1080/00325481.2020.1855921
Sayed, Hassanein, Salem, Hussein, Mahmoud, Flavonoids-Mediated SIRT1 Signaling Activation in Hepatic Disorders, Life Sciences, doi:10.1016/j.lfs.2020.118173
Scortegagna, Cataisson, Martin, HIF-1alpha Regulates Epithelial Inflammation by Cell Autonomous NFkappaB Activation and Paracrine Stromal Remodeling, Blood, doi:10.1182/blood-2007-10-115758
Sechi, Lall, Afolabi, Fisetin Targets YB-1/ RSK Axis Independent of Its Effect on ERK Signaling: Insights From In Vitro and In Vivo Melanoma Models, Scientific Reports, doi:10.1038/s41598-018-33879-w
Shokri Afra, Zangooei, Meshkani, Hesperetin Is a Potent Bioactivator That Activates SIRT1-AMPK Signaling Pathway in HepG2 Cells, Journal of Physiology and Biochemistry, doi:10.1007/s13105-019-00678-4
Singh, Garg, Singh, Tripathi, Rizvi, Fisetin, a Potential Caloric Restriction Mimetic, Modulates Ionic Homeostasis in Senescence Induced and Naturally Aged Rats, Archives of Physiology and Biochemistry, doi:10.1080/13813455.2019.1662452
Singh, Gupta, Satija, Pabreja, Chellappan et al., COVID-19 Transmission Through Host Cell Directed Network of GPCR, Drug Development Research, doi:10.1002/ddr.21674
Song, Hao, Fan, Biological Properties and Clinical Applications of Berberine, Frontiers of Medicine, doi:10.1007/s11684-019-0724-6
Su, Yu, Zhou, SARS-CoV-2 ORF3a Induces Incomplete Autophagy via the Unfolded Protein Response, Viruses, doi:10.3390/v13122467
Supriya, Gao, Gu, Baker, Role of Exercise Intensity on Th1/Th2 Immune Modulations During the COVID-19 Pandemic, Frontiers in Immunology, doi:10.3389/fimmu.2021.761382
Tarique, Suhail, Naz, Where Do T Cell Subsets Stand in SARS-CoV-2 Infection: An Update, Frontiers in Cellular and Infection Microbiology, doi:10.3389/fcimb.2022.964265
Tehrani, Rahbardar, Shoorgashti, Nayeri, Mohammadpour et al., Evaluation of Berberine Pellet Effect on Clinical Recovery Time in COVID-19 Outpatients: A Pilot Clinical Trial, Avicenna Journal of Phytomedicine
Verdecchia, Cavallini, Spanevello, Angeli, The Pivotal Link Between ACE2 Deficiency and SARS-CoV-2 Infection, European Journal of Internal Medicine, doi:10.1016/j.ejim.2020.04.037
Verdoorn, Evans, Hanson, Fisetin for COVID-19 in Skilled Nursing Facilities: Senolytic Trials in the COVID Era, Journal of the American Geriatrics Society, doi:10.1111/jgs.17416
Villalba, Alcaín, Sirtuin Activators and Inhibitors, BioFactors, doi:10.1002/biof.1032
Wafi, Hong, Rudebush, Curcumin Improves Exercise Performance of Mice With Coronary Artery Ligation-Induced HFrEF: Nrf2 And Antioxidant Mechanisms in Skeletal Muscle, Journal of Applied Physiology, doi:10.1152/japplphysiol.00654.2018
Wang, Song, Xu, Lei, Zhang et al., Stand Up to Stand Out: Natural Dietary Polyphenols Curcumin, Resveratrol, and Gossypol as Potential Therapeutic Candidates Against Severe Acute Respiratory Syndrome Coronavirus 2 Infection, Nutrients, doi:10.3390/nu15183885
Wang, Wang, Sheng, Hesperetin, a SIRT1 Activator, Inhibits Hepatic Inflammation via AMPK/CREB Pathway, International Immunopharmacology, doi:10.1016/j.intimp.2020.107036
Wang, Wu, Li, Yuen, He, The Effects of SARS-CoV-2 Infection on Modulating Innate Immunity and Strategies of Combating Inflammatory Response for COVID-19 Therapy, Journal of Biomedical Science, doi:10.1186/s12929-022-00811-4
Wiernsperger, Al-Salameh, Cariou, Lalau, Protection by Metformin Against Severe Covid-19: An In-Depth Mechanistic Analysis, Diabetes & Metabolism, doi:10.1016/j.diabet.2022.101359
Williams, PKR; a Sentinel Kinase for Cellular Stress, Oncogene, doi:10.1038/sj.onc.1203127
Wu, Xiang, Jing, Wang, Novakovic et al., Damage to Endothelial Barriers and Its Contribution to Long COVID, Angiogenesis, doi:10.1007/s10456-023-09878-5
Wu, Zhang, Chen, The Sirtuin Family in Health and Disease, Signal Transduction and Targeted Therapy, doi:10.1038/s41392-022-01257-8
Xiong, Liu, Cao, Transcriptomic Characteristics of Bronchoalveolar Lavage Fluid and Peripheral Blood Mononuclear Cells in COVID-19 Patients, Emerging Microbes & Infections, doi:10.1080/22221751.2020.1747363
Yang, Dong, SIRT1-Related Signaling Pathways and Their Association With Bronchopulmonary Dysplasia, Frontiers in Medicine, doi:10.3389/fmed.2021.595634
Yang, Liu, Wang, Regulation of SIRT1 and Its Roles in Inflammation, Frontiers in Immunology, doi:10.3389/fimmu.2022.831168
Yang, Tan, Lv, Regulation of Sirt1/Nrf2/TNFα Signaling Pathway by Luteolin Is Critical to Attenuate Acute Mercuric Chloride Exposure Induced Hepatotoxicity, Scientific Reports, doi:10.1038/srep37157
Yi, Luo, SIRT1 and p53, Effect on Cancer, Senescence and Beyond, Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, doi:10.1016/j.bbapap.2010.05.002
Yim, Mizushima, Autophagosome Maturation Stymied by SARS-CoV-2, Developmental Cell, doi:10.1016/j.devcel.2021.02.002
Yu, Dong, Li, Liu, SIRT1 and HIF1α Signaling in Metabolism and Immune Responses, Cancer Letters
Yu, Sun, Wang, Liu, Wang et al., Curcumin Management of Myocardial Fibrosis and Its Mechanisms of Action: A Review, American Journal of Chinese Medicine, doi:10.1142/S0192415X19500861
Zandi, Shafaati, Kalantar-Neyestanaki, The Role of SARS-CoV-2 Accessory Proteins in Immune Evasion, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113889
Zendedel, Butler, Atkin, Sahebkar, Impact of Curcumin on Sirtuins: A Review, Journal of Cellular Biochemistry, doi:10.1002/jcb.27371
Zhang, Sun, Pei, The SARS-CoV-2 Protein ORF3a Inhibits Fusion of Autophagosomes With Lysosomes, Cell Discovery, doi:10.1038/s41421-021-00268-z
Zhang, Wang, Ni, COVID-19: Melatonin as a Potential Adjuvant Treatment, Life Sciences, doi:10.1016/j.lfs.2020.117583
Zhang, Zhao, Zhao, Virus Caused Imbalance of Type I IFN Responses and Inflammation in COVID-19, Frontiers in Immunology, doi:10.3389/fimmu.2021.633769
Zhong, Farag, Chen, He, Xiao, Recent Advances in the Biosynthesis, Structure-Activity Relationships, Formulations, Pharmacology, and Clinical Trials of Fisetin, eFood, doi:10.1002/efd2.3
Zhou, Zhang, Ding, As a Modulator, Multitasking Roles of SIRT1 in Respiratory Diseases, Immune Network, doi:10.4110/in.2022.22.e21
Zipeto, Palmeira, Argañaraz, Argañaraz, ACE2/ADAM17/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19, Frontiers in Immunology, doi:10.3389/fimmu.2020.576745
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