Analgesics
Antiandrogens
Antihistamines
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
PPIs
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Results
Abstract
All curcumin studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchCurcuminCurcumin (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta PPIs Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis       

Effect of nanocurcumin supplementation on the severity of symptoms and length of hospital stay in patients with COVID-19: A randomized double-blind placebo-controlled trial

Honarkar Shafie et al., Phytotherapy Research, doi:10.1002/ptr.7374
Jan 2022  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Hospitalization time 29% Improvement Relative Risk Pulmonary involvement.. 9% no CI Curcumin  Honarkar Shafie et al.  LATE TREATMENT  DB RCT Is late treatment with curcumin beneficial for COVID-19? Double-blind RCT 44 patients in Iran Shorter hospitalization with curcumin (not stat. sig., p=0.22) c19early.org Honarkar Shafie et al., Phytotherapy R.., Jan 2022 Favorscurcumin Favorscontrol 0 0.5 1 1.5 2+
Curcumin for COVID-19
15th treatment shown to reduce risk in February 2021, now with p = 0.0000000096 from 27 studies.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 109 treatments. c19early.org
RCT 48 hospitalized patients in Iran, 24 treated with nanocurcumin, showing lower hospitalization time with treatment. The number of patients shown in Table 3 (31 and 27 for each arm) is inconsistent with the number reported as randomized to each arm (24). 160 mg/day nanocurcumin for 6 days. IRCT20131125015536N13.
This study is excluded in meta analysis: unresolved data inconsistency.
hospitalization time, 28.9% lower, relative time 0.71, p = 0.22, treatment mean 6.31 (±5.26) n=23, control mean 8.87 (±8.12) n=21.
relative pulmonary involvement score, 9.1% better, RR 0.91, treatment 23, control 21.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Honarkar Shafie et al., 12 Jan 2022, Double Blind Randomized Controlled Trial, placebo-controlled, Iran, peer-reviewed, 10 authors.
This PaperCurcuminAll
Effect of nanocurcumin supplementation on the severity of symptoms and length of hospital stay in patients with COVID‐19: A randomized double‐blind placebo‐controlled trial
Elaheh Honarkar Shafie, Fateme Taheri, Neda Alijani, Ahmad Reza Okhovvat, Razieh Goudarzi, Nasrin Borumandnia, Leila Aghaghazvini, Seyed Mahdi Rezayat, Saeidreza Jamalimoghadamsiahkali, Mohammad Javad Hosseinzadeh‐attar
Phytotherapy Research, doi:10.1002/ptr.7374
It has been more than a year since the outbreak of COVID-19, and it is still the most critical issue of the healthcare system. Discovering effective strategies to treat infected patients is necessary to decrease the mortality rate. This study aimed to
CONFLICT OF INTEREST The authors declared no conflicts of interest.
References
Adibian, Hodaei, Nikpayam, Sohrab, Hekmatdoost et al., The effects of curcumin supplementation on high-sensitivity C-reactive protein, serum adiponectin, and lipid profile in patients with type 2 diabetes: A randomized, double-blind, placebocontrolled trial, Phytotherapy Research
Aggarwal, Harikumar, Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases, The International Journal of Biochemistry & Cell Biology
Anand, Kunnumakkara, Newman, Aggarwal, Bioavailability of curcumin: Problems and promises, Molecular Pharmaceutics
Bahrs, Kimmig, Weis, Ankert, Hagel et al., 2 point seroprevalence among hospital staff, doi:10.1111/tbed.14041
Barrett, Brown, Mundt, Safdar, Dye et al., The Wisconsin upper respiratory symptom survey is responsive, reliable, and valid, Journal of Clinical Epidemiology
Cavezzi, Troiani, Corrao, COVID-19: Hemoglobin, iron, and hypoxia beyond inflammation. A Narrative Review, Clinics and Practice
Chen, Zheng, Liu, Yan, Xu et al., Plasma CRP level is positively associated with the severity of COVID-19, Annals of Clinical Microbiology and Antimicrobials
Conti, Ronconi, Caraffa, Gallenga, Ross et al., Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): Anti-inflammatory strategies, Journal of Biological Regulators and Homeostatic Agents
Festa, D'agostino, Jr, Howard, Mykkänen et al., Chronic subclinical inflammation as part of the insulin resistance syndrome: The insulin resistance atherosclerosis study (IRAS), Circulation
Gold, Sehayek, Gabrielli, Zhang, Mccusker et al., COVID-19 and comorbidities: A systematic review and meta-analysis, Postgraduate Medicine
Guay, Champagne, Guibord, Gruenwald, The Efficacy and Safety of a Patent Pending Combination of Ginger and Goldenrod Extracts on the Management of Cold Symptoms: A Randomized, Double-Blind Controlled Trial, The Efficacy and Safety of a Patent Pending Combination of Ginger and Goldenrod Extracts on the Management of Cold Symptoms: A Randomized, Double-Blind Controlled Trial
Gupta, Patchva, Aggarwal, Therapeutic roles of curcumin: Lessons learned from clinical trials, The AAPS Journal
Hewlings, Kalman, Curcumin: A review of its' effects on human health, Food
Holmes, Macfarlane, Macfarlane, Hubbard, Symptoms, signs, and prescribing for acute lower respiratory tract illness, British Journal of General Practice
Khaerunnisa, Kurniawan, Awaluddin, Suhartati, Soetjipto, Potential inhibitor of COVID-19 main protease (Mpro) from several medicinal plant compounds by molecular docking study
Kocher, Bohnert, Schiborr, Frank, Highly bioavailable micellar curcuminoids accumulate in blood, are safe and do not reduce blood lipids and inflammation markers in moderately hyperlipidemic individuals, Molecular Nutrition & Food Research
Mahase, China coronavirus: mild but infectious cases may make it hard to control outbreak, report warns, BMJ, doi:10.1136/bmj.m325
Moballegh Nasery, Abadi, Poormoghadam, Zarrabi, Keyhanvar et al., Curcumin delivery mediated by biobased nanoparticles: A review, Molecules, doi:10.3390/molecules25030689
Moghadamtousi, Abdul Kadir, Hassandarvish, Tajik, Abubakar et al., Effect of nanocurcumin supplementation on the severity of symptoms and length of hospital stay in patients with COVID-19: A randomized double-blind placebo-controlled trial, Phytotherapy Research
Palmeira, Barbuto, Silva, Carneiro-Sampaio, Why is SARS-CoV-2 infection milder among children?, Clinics, doi:10.6061/clinics/2020/e1947
Pan, Ye, Sun, Gui, Liang et al., Time course of lung changes at chest CT during recovery from coronavirus disease 2019 (COVID-19), Radiology, doi:10.1148/radiol.2020200370
Panahi, Hosseini, Khalili, Naimi, Majeed et al., Antioxidant and anti-inflammatory effects of curcuminoidpiperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis, Clinical Nutrition
Pepys, Hirschfield, C-reactive protein: a critical update, The Journal of Clinical Investigation
Raut, Schein, Mody, Grant, Benson et al., Estimating the economic impact of a half-day reduction in length of hospital stay among patients with community-acquired pneumonia in the US, Current Medical Research and Opinion
Saadati, Sadeghi, Mansour, Yari, Poustchi et al., Curcumin and inflammation in non-alcoholic fatty liver disease: a randomized, placebo controlled clinical trial, BMC Gastroenterology, doi:10.1186/s12876-019-1055-4
Sahebkar, Are curcuminoids effective C-reactive proteinlowering agents in clinical practice? Evidence from a meta-analysis, Phytotherapy Research
Salehi, Abedi, Balakrishnan, Gholamrezanezhad, Coronavirus disease 2019 (COVID-19): A systematic review of imaging findings in 919 patients, American Journal of Roentgenology
Shelke, Pawar, Tripathi, Maurya, Srivasthav et al., An open label, randomized, multicenter, comparative, three arm phase II clinical study to evaluate the safety and efficacy of mixture of five species of Ocimum in subjects with acute common cold, Annals of Phytomedicine
Shiri, Sorouri, Geramifar, Nazari, Abdollahi et al., Machine learning-based prognostic modeling using clinical data and quantitative radiomic features from chest CT images in COVID-19 patients, Computers in Biology and Medicine
Stohs, Chen, Ray, Ji, Bucci et al., Highly bioavailable forms of curcumin and promising avenues for curcumin-based research and application: A review, Molecules
Xie, Covassin, Fan, Singh, Gao et al., Association between hypoxemia and mortality in patients with COVID-19, Mayo Clinic Proceedings, doi:10.1016/j.mayocp.2020.04.006
Ye, Wang, Mao, Cytokine storm in COVID-19 and treatment, The Journal of Infection
Zhou, Wang, Zhu, Xia, CT features of coronavirus disease 2019 (COVID-19) pneumonia in 62 patients in Wuhan, China, American Journal of Roentgenology
{ 'indexed': {'date-parts': [[2022, 1, 14]], 'date-time': '2022-01-14T06:42:44Z', 'timestamp': 1642142564531}, 'reference-count': 33, 'publisher': 'Wiley', 'license': [ { 'start': { 'date-parts': [[2022, 1, 12]], 'date-time': '2022-01-12T00:00:00Z', 'timestamp': 1641945600000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'http://onlinelibrary.wiley.com/termsAndConditions#vor'}, { 'start': { 'date-parts': [[2022, 1, 12]], 'date-time': '2022-01-12T00:00:00Z', 'timestamp': 1641945600000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'http://doi.wiley.com/10.1002/tdm_license_1.1'}], 'funder': [ { 'DOI': '10.13039/501100004484', 'name': 'Tehran University of Medical Sciences and Health Services', 'doi-asserted-by': 'publisher', 'award': ['47473']}], 'content-domain': {'domain': ['onlinelibrary.wiley.com'], 'crossmark-restriction': True}, 'short-container-title': ['Phytotherapy Research'], 'DOI': '10.1002/ptr.7374', 'type': 'journal-article', 'created': {'date-parts': [[2022, 1, 13]], 'date-time': '2022-01-13T05:38:27Z', 'timestamp': 1642052307000}, 'update-policy': 'http://dx.doi.org/10.1002/crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': [ 'Effect of nanocurcumin supplementation on the severity of symptoms and length of hospital stay ' 'in patients with COVID‐19: A randomized double‐blind placebo‐controlled trial'], 'prefix': '10.1002', 'author': [ { 'given': 'Elaheh', 'family': 'Honarkar Shafie', 'sequence': 'first', 'affiliation': [ { 'name': 'Department of Clinical Nutrition, School of Nutritional Sciences ' 'and Dietetics Tehran University of Medical Sciences Tehran ' 'Iran'}]}, { 'ORCID': 'http://orcid.org/0000-0002-8993-7945', 'authenticated-orcid': False, 'given': 'Fateme', 'family': 'Taheri', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Clinical Nutrition, School of Nutritional Sciences ' 'and Dietetics Tehran University of Medical Sciences Tehran ' 'Iran'}]}, { 'given': 'Neda', 'family': 'Alijani', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Infectious Disease, Shariati Hospital Tehran ' 'university of medical sciences Tehran Iran'}]}, { 'given': 'Ahmad Reza', 'family': 'Okhovvat', 'sequence': 'additional', 'affiliation': [{'name': 'Central Herbarium Tehran University Tehran Iran'}]}, { 'given': 'Razieh', 'family': 'Goudarzi', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Clinical Nutrition, School of Nutritional Sciences ' 'and Dietetics Tehran University of Medical Sciences Tehran ' 'Iran'}]}, { 'given': 'Nasrin', 'family': 'Borumandnia', 'sequence': 'additional', 'affiliation': [ { 'name': 'Urology and Nephrology Research Center Shahid Beheshti ' 'University of Medical Sciences Tehran Iran'}]}, { 'given': 'Leila', 'family': 'Aghaghazvini', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Radiology, Shariati hospital Tehran University of ' 'Medical Sciences Tehran Iran'}]}, { 'given': 'Seyed Mahdi', 'family': 'Rezayat', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Pharmacology, School of Medicine Tehran University ' 'of Medical Sciences Tehran Iran'}]}, { 'given': 'Saeidreza', 'family': 'Jamalimoghadamsiahkali', 'sequence': 'additional', 'affiliation': [ { 'name': 'Ziaeian Hospital Tehran University of Medical Sciences Tehran ' 'Iran'}]}, { 'given': 'Mohammad Javad', 'family': 'Hosseinzadeh‐Attar', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Clinical Nutrition, School of Nutritional Sciences ' 'and Dietetics Tehran University of Medical Sciences Tehran ' 'Iran'}]}], 'member': '311', 'published-online': {'date-parts': [[2022, 1, 12]]}, 'reference': [ { 'issue': '5', 'key': 'e_1_2_9_2_1', 'doi-asserted-by': 'crossref', 'first-page': '1374', 'DOI': '10.1002/ptr.6328', 'article-title': 'The effects of curcumin supplementation on high‐sensitivity C‐reactive ' 'protein, serum adiponectin, and lipid profile in patients with type 2 ' 'diabetes: A randomized, double‐blind, placebo‐controlled trial', 'volume': '33', 'author': 'Adibian M.', 'year': '2019', 'journal-title': 'Phytotherapy Research'}, { 'issue': '1', 'key': 'e_1_2_9_3_1', 'doi-asserted-by': 'crossref', 'first-page': '40', 'DOI': '10.1016/j.biocel.2008.06.010', 'article-title': 'Potential therapeutic effects of curcumin, the anti‐inflammatory agent, ' 'against neurodegenerative, cardiovascular, pulmonary, metabolic, ' 'autoimmune and neoplastic diseases', 'volume': '41', 'author': 'Aggarwal B. B.', 'year': '2009', 'journal-title': 'The International Journal of Biochemistry & Cell Biology'}, { 'issue': '6', 'key': 'e_1_2_9_4_1', 'doi-asserted-by': 'crossref', 'first-page': '807', 'DOI': '10.1021/mp700113r', 'article-title': 'Bioavailability of curcumin: Problems and promises', 'volume': '4', 'author': 'Anand P.', 'year': '2007', 'journal-title': 'Molecular Pharmaceutics'}, { 'key': 'e_1_2_9_5_1', 'article-title': 'Prospective surveillance study in a 1,400‐bed university hospital: ' 'COVID‐19 exposure at home was the main risk factor for SARS‐CoV‐2 point ' 'seroprevalence among hospital staff', 'author': 'Bahrs C.', 'year': '2021', 'journal-title': 'Transboundary and Emerging Diseases'}, { 'issue': '6', 'key': 'e_1_2_9_6_1', 'doi-asserted-by': 'crossref', 'first-page': '609', 'DOI': '10.1016/j.jclinepi.2004.11.019', 'article-title': 'The Wisconsin upper respiratory symptom survey is responsive, reliable, ' 'and valid', 'volume': '58', 'author': 'Barrett B.', 'year': '2005', 'journal-title': 'Journal of Clinical Epidemiology'}, { 'issue': '2', 'key': 'e_1_2_9_7_1', 'doi-asserted-by': 'crossref', 'first-page': '24', 'DOI': '10.4081/cp.2020.1271', 'article-title': 'COVID‐19: Hemoglobin, iron, and hypoxia beyond inflammation. A ' 'Narrative Review', 'volume': '10', 'author': 'Cavezzi A.', 'year': '2020', 'journal-title': 'Clinics and Practice'}, { 'key': 'e_1_2_9_8_1', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.1186/s12941-020-00362-2', 'article-title': 'Plasma CRP level is positively associated with the severity of COVID‐19', 'volume': '19', 'author': 'Chen W.', 'year': '2020', 'journal-title': 'Annals of Clinical Microbiology and Antimicrobials'}, { 'issue': '2', 'key': 'e_1_2_9_9_1', 'first-page': '1', 'article-title': 'Induction of pro‐inflammatory cytokines (IL‐1 and IL‐6) and lung ' 'inflammation by Coronavirus‐19 (COVI‐19 or SARS‐CoV‐2): ' 'Anti‐inflammatory strategies', 'volume': '34', 'author': 'Conti P.', 'year': '2020', 'journal-title': 'Journal of Biological Regulators and Homeostatic Agents'}, { 'issue': '1', 'key': 'e_1_2_9_10_1', 'doi-asserted-by': 'crossref', 'first-page': '42', 'DOI': '10.1161/01.CIR.102.1.42', 'article-title': 'Chronic subclinical inflammation as part of the insulin resistance ' 'syndrome: The insulin resistance atherosclerosis study (IRAS)', 'volume': '102', 'author': 'Festa A.', 'year': '2000', 'journal-title': 'Circulation'}, { 'issue': '8', 'key': 'e_1_2_9_11_1', 'doi-asserted-by': 'crossref', 'first-page': '749', 'DOI': '10.1080/00325481.2020.1786964', 'article-title': 'COVID‐19 and comorbidities: A systematic review and meta‐analysis', 'volume': '132', 'author': 'Gold M. S.', 'year': '2020', 'journal-title': 'Postgraduate Medicine'}, { 'key': 'e_1_2_9_12_1', 'doi-asserted-by': 'crossref', 'unstructured': 'Guay J. Champagne P. Guibord P. &Gruenwald J.(2012).The Efficacy and ' 'Safety of a Patent Pending Combination of Ginger and Goldenrod Extracts ' 'on the Management of Cold Symptoms: A Randomized Double‐Blind Controlled ' 'Trial The Efficacy and Safety of a Patent Pending Combination of Ginger ' 'and Goldenrod Extracts on the Management of Cold Symptoms: A Randomized ' 'Double‐Blind Controlled Trial.', 'DOI': '10.4236/fns.2012.312216'}, { 'issue': '1', 'key': 'e_1_2_9_13_1', 'doi-asserted-by': 'crossref', 'first-page': '195', 'DOI': '10.1208/s12248-012-9432-8', 'article-title': 'Therapeutic roles of curcumin: Lessons learned from clinical trials', 'volume': '15', 'author': 'Gupta S. C.', 'year': '2013', 'journal-title': 'The AAPS Journal'}, { 'issue': '10', 'key': 'e_1_2_9_14_1', 'doi-asserted-by': 'crossref', 'first-page': '92', 'DOI': '10.3390/foods6100092', 'article-title': "Curcumin: A review of its' effects on human health", 'volume': '6', 'author': 'Hewlings S. J.', 'year': '2017', 'journal-title': 'Food'}, { 'issue': '464', 'key': 'e_1_2_9_15_1', 'first-page': '177', 'article-title': 'Symptoms, signs, and prescribing for acute lower respiratory tract ' 'illness', 'volume': '51', 'author': 'Holmes W. F.', 'year': '2001', 'journal-title': 'British Journal of General Practice'}, { 'key': 'e_1_2_9_16_1', 'doi-asserted-by': 'crossref', 'unstructured': 'Khaerunnisa S. Kurniawan H. Awaluddin R. Suhartati S. &Soetjipto ' 'S.(2020).Potential inhibitor of COVID‐19 main protease (Mpro) from ' 'several medicinal plant compounds by molecular docking study.', 'DOI': '10.20944/preprints202003.0226.v1'}, { 'issue': '7', 'key': 'e_1_2_9_17_1', 'doi-asserted-by': 'crossref', 'first-page': '1555', 'DOI': '10.1002/mnfr.201501034', 'article-title': 'Highly bioavailable micellar curcuminoids accumulate in blood, are safe ' 'and do not reduce blood lipids and inflammation markers in moderately ' 'hyperlipidemic individuals', 'volume': '60', 'author': 'Kocher A.', 'year': '2016', 'journal-title': 'Molecular Nutrition & Food Research'}, { 'key': 'e_1_2_9_18_1', 'doi-asserted-by': 'crossref', 'first-page': 'm325', 'DOI': '10.1136/bmj.m325', 'article-title': 'China coronavirus: mild but infectious cases may make it hard to ' 'control outbreak, report warns', 'volume': '368', 'author': 'Mahase E.', 'year': '2020', 'journal-title': 'BMJ'}, { 'issue': '3', 'key': 'e_1_2_9_19_1', 'doi-asserted-by': 'crossref', 'first-page': '689', 'DOI': '10.3390/molecules25030689', 'article-title': 'Curcumin delivery mediated by bio‐based nanoparticles: A review', 'volume': '25', 'author': 'Moballegh Nasery M.', 'year': '2020', 'journal-title': 'Molecules'}, { 'key': 'e_1_2_9_20_1', 'doi-asserted-by': 'crossref', 'first-page': 'e1947', 'DOI': '10.6061/clinics/2020/e1947', 'article-title': 'Why is SARS‐CoV‐2 infection milder among children?', 'volume': '75', 'author': 'Palmeira P.', 'year': '2020', 'journal-title': 'Clinics'}, { 'issue': '3', 'key': 'e_1_2_9_21_1', 'doi-asserted-by': 'crossref', 'first-page': '715', 'DOI': '10.1148/radiol.2020200370', 'article-title': 'Time course of lung changes at chest CT during recovery from ' 'coronavirus disease 2019 (COVID‐19)', 'volume': '295', 'author': 'Pan F.', 'year': '2020', 'journal-title': 'Radiology'}, { 'issue': '6', 'key': 'e_1_2_9_22_1', 'doi-asserted-by': 'crossref', 'first-page': '1101', 'DOI': '10.1016/j.clnu.2014.12.019', 'article-title': 'Antioxidant and anti‐inflammatory effects of curcuminoid‐piperine ' 'combination in subjects with metabolic syndrome: A randomized ' 'controlled trial and an updated meta‐analysis', 'volume': '34', 'author': 'Panahi Y.', 'year': '2015', 'journal-title': 'Clinical Nutrition'}, { 'issue': '12', 'key': 'e_1_2_9_23_1', 'doi-asserted-by': 'crossref', 'first-page': '1805', 'DOI': '10.1172/JCI200318921', 'article-title': 'C‐reactive protein: a critical update', 'volume': '111', 'author': 'Pepys M. B.', 'year': '2003', 'journal-title': 'The Journal of Clinical Investigation'}, { 'issue': '9', 'key': 'e_1_2_9_24_1', 'doi-asserted-by': 'crossref', 'first-page': '2151', 'DOI': '10.1185/03007990903102743', 'article-title': 'Estimating the economic impact of a half‐day reduction in length of ' 'hospital stay among patients with community‐acquired pneumonia in the ' 'US', 'volume': '25', 'author': 'Raut M.', 'year': '2009', 'journal-title': 'Current Medical Research and Opinion'}, { 'issue': '1', 'key': 'e_1_2_9_25_1', 'doi-asserted-by': 'crossref', 'first-page': '133', 'DOI': '10.1186/s12876-019-1055-4', 'article-title': 'Curcumin and inflammation in non‐alcoholic fatty liver disease: a ' 'randomized, placebo controlled clinical trial', 'volume': '19', 'author': 'Saadati S.', 'year': '2019', 'journal-title': 'BMC Gastroenterology'}, { 'issue': '5', 'key': 'e_1_2_9_26_1', 'doi-asserted-by': 'crossref', 'first-page': '633', 'DOI': '10.1002/ptr.5045', 'article-title': 'Are curcuminoids effective C‐reactive protein‐lowering agents in ' 'clinical practice? Evidence from a meta‐analysis', 'volume': '28', 'author': 'Sahebkar A.', 'year': '2014', 'journal-title': 'Phytotherapy Research'}, { 'issue': '1', 'key': 'e_1_2_9_27_1', 'doi-asserted-by': 'crossref', 'first-page': '87', 'DOI': '10.2214/AJR.20.23034', 'article-title': 'Coronavirus disease 2019 (COVID‐19): A systematic review of imaging ' 'findings in 919 patients', 'volume': '215', 'author': 'Salehi S.', 'year': '2020', 'journal-title': 'American Journal of Roentgenology'}, { 'issue': '2', 'key': 'e_1_2_9_28_1', 'doi-asserted-by': 'crossref', 'first-page': '38', 'DOI': '10.21276/ap.2016.5.2.4', 'article-title': 'An open label, randomized, multicenter, comparative, three arm phase II ' 'clinical study to evaluate the safety and efficacy of mixture of five ' 'species of Ocimum in subjects with acute common cold', 'volume': '5', 'author': 'Shelke P.', 'year': '2016', 'journal-title': 'Annals of Phytomedicine'}, { 'key': 'e_1_2_9_29_1', 'doi-asserted-by': 'crossref', 'first-page': '104304', 'DOI': '10.1016/j.compbiomed.2021.104304', 'article-title': 'Machine learning‐based prognostic modeling using clinical data and ' 'quantitative radiomic features from chest CT images in COVID‐19 ' 'patients', 'volume': '132', 'author': 'Shiri I.', 'year': '2021', 'journal-title': 'Computers in Biology and Medicine'}, { 'issue': '6', 'key': 'e_1_2_9_30_1', 'doi-asserted-by': 'crossref', 'first-page': '1397', 'DOI': '10.3390/molecules25061397', 'article-title': 'Highly bioavailable forms of curcumin and promising avenues for ' 'curcumin‐based research and application: A review', 'volume': '25', 'author': 'Stohs S. J.', 'year': '2020', 'journal-title': 'Molecules'}, { 'issue': '6', 'key': 'e_1_2_9_31_1', 'doi-asserted-by': 'crossref', 'first-page': '1138', 'DOI': '10.1016/j.mayocp.2020.04.006', 'article-title': 'Association between hypoxemia and mortality in patients with COVID‐19', 'volume': '95', 'author': 'Xie J.', 'year': '2020', 'journal-title': 'Mayo Clinic Proceedings'}, { 'key': 'e_1_2_9_32_1', 'doi-asserted-by': 'crossref', 'first-page': '607', 'DOI': '10.1016/j.jinf.2020.03.037', 'article-title': 'Cytokine storm in COVID‐19 and treatment', 'volume': '80', 'author': 'Ye Q.', 'year': '2020', 'journal-title': 'The Journal of Infection'}, { 'issue': '6', 'key': 'e_1_2_9_33_1', 'doi-asserted-by': 'crossref', 'first-page': '1287', 'DOI': '10.2214/AJR.20.22975', 'article-title': 'CT features of coronavirus disease 2019 (COVID‐19) pneumonia in 62 ' 'patients in Wuhan, China', 'volume': '214', 'author': 'Zhou S.', 'year': '2020', 'journal-title': 'American Journal of Roentgenology'}, { 'key': 'e_1_2_9_34_1', 'doi-asserted-by': 'crossref', 'first-page': '186864', 'DOI': '10.1155/2014/186864', 'article-title': 'A review on antibacterial, antiviral, and antifungal activity of ' 'curcumin', 'volume': '2014', 'author': 'Zorofchian Moghadamtousi S.', 'year': '2014', 'journal-title': 'BioMed Research International'}], 'container-title': ['Phytotherapy Research'], 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://onlinelibrary.wiley.com/doi/pdf/10.1002/ptr.7374', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ptr.7374', 'content-type': 'application/xml', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://onlinelibrary.wiley.com/doi/pdf/10.1002/ptr.7374', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2022, 1, 13]], 'date-time': '2022-01-13T05:38:53Z', 'timestamp': 1642052333000}, 'score': 1, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2022, 1, 12]]}, 'references-count': 33, 'alternative-id': ['10.1002/ptr.7374'], 'URL': 'http://dx.doi.org/10.1002/ptr.7374', 'archive': ['Portico'], 'relation': {}, 'ISSN': ['0951-418X', '1099-1573'], 'issn-type': [{'value': '0951-418X', 'type': 'print'}, {'value': '1099-1573', 'type': 'electronic'}], 'subject': ['Pharmacology'], 'published': {'date-parts': [[2022, 1, 12]]}, 'assertion': [ { 'value': '2021-04-22', 'order': 0, 'name': 'received', 'label': 'Received', 'group': {'name': 'publication_history', 'label': 'Publication History'}}, { 'value': '2021-12-27', 'order': 1, 'name': 'accepted', 'label': 'Accepted', 'group': {'name': 'publication_history', 'label': 'Publication History'}}, { 'value': '2022-01-12', 'order': 2, 'name': 'published', 'label': 'Published', 'group': {'name': 'publication_history', 'label': 'Publication History'}}]}
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit