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0 0.5 1 1.5 2+ Ventilation 66% Improvement Relative Risk Hospitalization 80% Ordinal scale 43% Time to improve one uni.. 30% no CI Recovery 25% Time to viral- 6% Curcumin  Majeed et al.  EARLY TREATMENT  DB RCT Is early treatment with curcumin + combined treatments beneficial for COVID-19? Double-blind RCT 92 patients in India (September - November 2020) Improved recovery with curcumin + combined treatments (p=0.0043) c19early.org Majeed et al., Evidence-Based Compleme.., Oct 2021 Favors curcumin Favors control

A Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of a Nutritional Supplement (ImmuActive) for COVID-19 Patients

Majeed et al., Evidence-Based Complementary and Alternative Medicine, doi:10.1155/2021/8447545, CTRI/2020/09/027841
Oct 2021  
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Curcumin for COVID-19
14th treatment shown to reduce risk in February 2021
 
*, now known with p = 0.000000046 from 26 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments. c19early.org
RCT 100 patients in India, 50 treated with ImmuActive (curcumin, andrographolides, resveratrol, zinc, selenium, and piperine), showing improved recovery with treatment.
This is the 7th of 20 COVID-19 RCTs for curcumin, which collectively show efficacy with p=0.0000093.
This is the 10th of 26 COVID-19 controlled studies for curcumin, which collectively show efficacy with p=0.000000046 (1 in 22 million).
Study covers selenium, zinc, and curcumin.
risk of mechanical ventilation, 66.2% lower, RR 0.34, p = 1.00, treatment 0 of 45 (0.0%), control 1 of 47 (2.1%), NNT 47, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of hospitalization, 79.7% lower, RR 0.20, p = 0.49, treatment 0 of 45 (0.0%), control 2 of 47 (4.3%), NNT 24, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
relative ordinal scale, 43.0% better, RR 0.57, p = 0.004, treatment 45, control 47, day 28.
relative time to improve one unit on ordinal scale, 30.1% lower, relative time 0.70, treatment 45, control 47.
risk of no recovery, 24.6% lower, RR 0.75, p = 0.08, treatment 26 of 45 (57.8%), control 36 of 47 (76.6%), NNT 5.3, day 28.
time to viral-, 5.8% lower, relative time 0.94, p = 0.47, treatment 45, control 47.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Majeed et al., 11 Oct 2021, Double Blind Randomized Controlled Trial, India, peer-reviewed, 4 authors, study period September 2020 - November 2020, this trial uses multiple treatments in the treatment arm (combined with andrographolides, resveratrol, zinc, selenium, and piperine) - results of individual treatments may vary, trial CTRI/2020/09/027841.
This PaperCurcuminAll
A Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of a Nutritional Supplement (ImmuActiveTM) for COVID-19 Patients
Muhammed Majeed, Kalyanam Nagabhushanam, Kalpesh Shah, Lakshmi Mundkur
Evidence-Based Complementary and Alternative Medicine, doi:10.1155/2021/8447545
Background. SARS-CoV-2 has emerged as a global threat due to its infectivity and rapid transmission. We evaluated the safety and efficacy of herbal and mineral formulation (ImmuActive) as an adjunct therapy in COVID-19 patients. Methods. A randomized, double-blind, placebo-controlled study was conducted in 100 COVID-19 patients in three centers in Southern India, and 92 subjects completed the study. Subjects were followed up until they were discharged from the hospital or for a maximum of 28 days, whichever was earlier. e primary outcome parameters were the mean change and time required to change the ordinal scale of disease severity by one unit. e secondary outcomes were the time required to turn RT-PCR negative or get discharged from the hospital, change in modified Jackson's Symptom Severity score, and COVID-19 quality of life questionnaire. Results. e ordinal scale at the end of the study was significantly lower in COVID-19 patients supplemented with ImmuActive (0.57) than placebo (1.0), with a p value of 0.0043. e ordinal scale decreased by one unit within 2.35 days in ImmuActive-supplemented patients, while it took 3.36 days in placebo-supplemented patients. Days of hospitalization and time required to turn RT-PCR negative were comparatively lower in the ImmuActive arm than the placebo arm. Change in modified Jackson's Symptom Severity Score and COVID-19 QOL were significant from screening to the end of the study in both ImmuActive and placebo arms. ere were no adverse events observed during the study period. Conclusion. e study results suggest that ImmuActive could be a beneficial and safe adjunct treatment for effectively managing COVID-19 infection symptoms.
Conflicts of Interest All the authors are affiliated to Sami-Sabinsa Group Limited or Sabinsa Corporation.
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The secondary outcomes were the time required to turn RT-PCR ' 'negative or get discharged from the hospital, change in modified Jackson’s Symptom Severity ' 'score, and COVID-19 quality of life questionnaire. Results. The ordinal scale at the end of ' 'the study was significantly lower in COVID-19 patients supplemented with ImmuActive (0.57) ' 'than placebo (1.0), with a <jats:inline-formula>\n' ' <math xmlns="http://www.w3.org/1998/Math/MathML" id="M1">\n' ' <mi>p</mi>\n' ' </math>\n' ' </jats:inline-formula> value of 0.0043. The ordinal scale decreased by one ' 'unit within 2.35 days in ImmuActive-supplemented patients, while it took 3.36 days in ' 'placebo-supplemented patients. Days of hospitalization and time required to turn RT-PCR ' 'negative were comparatively lower in the ImmuActive arm than the placebo arm. Change in ' 'modified Jackson’s Symptom Severity Score and COVID-19 QOL were significant from screening to ' 'the end of the study in both ImmuActive and placebo arms. 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