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All Studies   All Outcomes    Recent:   

ANTICOV Trial Finds Nitazoxanide/Ciclesonide Drug Combination Does Not Reduce Hospitalisation Risk in Patients With Mild COVID-19

ANTICOV, News, ANTICOV, NCT04920838
Feb 2022  
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Progression -188% Improvement Relative Risk Nitazoxanide  ANTICOV  EARLY TREATMENT  RCT Is early treatment with nitazoxanide + ciclesonide beneficial for COVID-19? RCT 905 patients in multiple countries Trial compares with paracetamol, results vs. placebo may differ Higher progression with nitazoxanide + ciclesonide (p=0.04) c19early.org ANTICOV, News, February 2022 Favorsnitazoxanide Favorsparacetamol 0 0.5 1 1.5 2+
RCT with 462 nitazoxanide/ciclesonide and 443 paracetamol patients, up to 7 days from onset, showing no significant difference in progression. Minimal details, with the primary mortality outcome and treatment delay not being reported.
This study is excluded in the after exclusion results of meta analysis: minimal details provided.
risk of progression, 187.7% higher, RR 2.88, p = 0.04, treatment 15 of 462 (3.2%), control 5 of 443 (1.1%), SpO2 ≤ 93% within 14 days.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
ANTICOV et al., 28 Feb 2022, Randomized Controlled Trial, multiple countries, preprint, 1 author, this trial compares with another treatment - results may be better when compared to placebo, this trial uses multiple treatments in the treatment arm (combined with ciclesonide) - results of individual treatments may vary, trial NCT04920838 (history) (ANTICOV).
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