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All Studies   All Outcomes    Recent:   
0 0.5 1 1.5 2+ Mortality 68% Improvement Relative Risk Ventilation 87% ICU admission 59% Hospitalization time 52% Nitazoxanide  Calderón et al.  LATE TREATMENT Is late treatment with nitazoxanide beneficial for COVID-19? Retrospective 44 patients in Mexico Study compares with HCQ, results vs. placebo may differ Lower ICU admission (p<0.0001) and shorter hospitalization (p=0.0065) c19early.org Calderón et al., PAMJ - Clinical Medic.., Nov 2021 Favors nitazoxanide Favors HCQ

Treatment with hydroxychloroquine vs nitazoxanide in patients with COVID-19: brief report

Calderón et al., PAMJ - Clinical Medicine, doi:10.11604/pamj-cm.2021.7.15.30981
Nov 2021  
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Planned RCT of HCQ vs. HCQ+nitazoxanide which was aborted due to the retracted Surgisphere paper. Authors retrospectively analyze a small set of HCQ vs. nitazoxanide patients (which were protocol deviations in the planned RCT), showing reduced hospitalization time and ICU admission with nitazoxanide.
Study covers HCQ and nitazoxanide.
risk of death, 68.2% lower, RR 0.32, p = 0.38, treatment 1 of 17 (5.9%), control 5 of 27 (18.5%), NNT 7.9.
risk of mechanical ventilation, 86.7% lower, RR 0.13, p = 0.15, treatment 0 of 17 (0.0%), control 4 of 27 (14.8%), NNT 6.8, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of ICU admission, 59.3% lower, RR 0.41, p < 0.001, treatment 0 of 17 (0.0%), control 16 of 27 (59.3%), NNT 1.7, adjusted per study.
hospitalization time, 51.8% lower, relative time 0.48, p = 0.006, treatment 17, control 27.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Calderón et al., 23 Nov 2021, retrospective, Mexico, peer-reviewed, 7 authors, this trial compares with another treatment - results may be better when compared to placebo.
This PaperNitazoxanideAll
Late treatment
is less effective
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