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Efficacy of physiological seawater nasal irrigation for the treatment of children with SARS-CoV-2 Omicron BA.2 variant infection: a randomized controlled trial

Lin et al., World Journal of Pediatrics, doi:10.1007/s12519-023-00749-z, Sep 2023
https://c19early.org/lin8.html
Viral clearance 25% Improvement Relative Risk Viral clearance (b) 21% NaCl  Lin et al.  EARLY TREATMENT  RCT Is early treatment with NaCl beneficial for COVID-19? RCT 403 patients in China Improved viral clearance with NaCl (not stat. sig., p=0.11) c19early.org Lin et al., World J. Pediatrics, September 2023 FavorsNaCl Favorscontrol 0 0.5 1 1.5 2+
RCT 403 children in China with mild/asymptomatic COVID-19, showing significantly faster viral clearance with physiological seawater nasal irrigation.
Standard of Care (SOC) for COVID-19 in the study country, China, is poor with low average efficacy for approved treatments1.
risk of no viral clearance, 24.8% lower, HR 0.75, p = 0.11, treatment 204, control 199, inverted to make HR<1 favor treatment, viral clearance, day 5.
risk of no viral clearance, 21.3% lower, HR 0.79, p = 0.02, treatment 204, control 199, inverted to make HR<1 favor treatment, shorter viral shedding duration, day 5.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Lin et al., 10 Sep 2023, Randomized Controlled Trial, China, peer-reviewed, 10 authors.
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