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Role of intravenous vitamin C on outcomes in hospitalized patients with moderate or severe COVID-19: a real life data of Turkish patients

Uz et al., Inflammopharmacology, doi:10.1007/s10787-024-01597-7
Nov 2024  
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Mortality, high dose 84% Improvement Relative Risk Mortality, low dose 90% Vitamin C for COVID-19  Uz et al.  LATE TREATMENT Is late treatment with vitamin C beneficial for COVID-19? Retrospective 270 patients in Turkey Lower mortality with vitamin C (p=0.05) c19early.org Uz et al., Inflammopharmacology, November 2024 Favorsvitamin C Favorscontrol 0 0.5 1 1.5 2+
Vitamin C for COVID-19
6th treatment shown to reduce risk in September 2020, now with p = 0.00000002 from 73 studies, recognized in 12 countries.
Lower risk for mortality, ICU, hospitalization, and recovery.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 112 treatments. c19early.org
Retrospective 270 moderate/severe hospitalized COVID-19 patients, showing lower mortality with high (25 g/day) or low-dose (2 g/day) intraveneous vitamin C.
This is the 73rd COVID-19 controlled study for vitamin C, which collectively show efficacy with p=0.00000002 (1 in 50 million).
21 studies are RCTs, which show efficacy with p=0.0012.
risk of death, 84.2% lower, OR 0.16, p = 0.04998, treatment 41, control 46, adjusted per study, high dose, multivariable, RR approximated with OR.
risk of death, 90.2% lower, OR 0.10, p = 0.004, treatment 183, control 46, adjusted per study, low dose, multivariable, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Uz et al., 13 Nov 2024, retrospective, Turkey, peer-reviewed, 6 authors.
This PaperVitamin CAll
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' 'https://doi.org/10.3390/antiox10122022', 'journal-title': 'Antioxidants (Basel)'}, { 'issue': '6', 'key': '1597_CR38', 'doi-asserted-by': 'publisher', 'first-page': '907', 'DOI': '10.1080/10715760100301401', 'volume': '35', 'author': 'VM Victor', 'year': '2001', 'unstructured': 'Victor VM, Guayerbas N, Puerto M, De la Fuente M (2001) Changes in the ' 'ascorbic acid levels of peritoneal lymphocytes and macrophages of mice ' 'with endotoxin-induced oxidative stress. Free Radic Res 35(6):907–916. ' 'https://doi.org/10.1080/10715760100301401', 'journal-title': 'Free Radic Res'}, { 'key': '1597_CR39', 'doi-asserted-by': 'publisher', 'first-page': '106504', 'DOI': '10.1016/j.intimp.2020.106504', 'volume': '84', 'author': 'AP Yang', 'year': '2020', 'unstructured': 'Yang AP, Liu JP, Tao WQ, Li HM (2020) The diagnostic and predictive role ' 'of NLR, d-NLR and PLR in COVID-19 patients. Int Immunopharmacol ' '84:106504. https://doi.org/10.1016/j.intimp.2020.106504', 'journal-title': 'Int Immunopharmacol'}, { 'issue': '1', 'key': '1597_CR40', 'doi-asserted-by': 'publisher', 'first-page': '5', 'DOI': '10.1186/s13613-020-00792-3', 'volume': '11', 'author': 'J Zhang', 'year': '2021', 'unstructured': 'Zhang J, Rao X, Li Y, Zhu Y, Liu F, Guo G, Luo G, Meng Z, De Backer D, ' 'Xiang H, Peng Z (2021) Pilot trial of high-dose vitamin C in critically ' 'ill COVID-19 patients. Ann Intensive Care 11(1):5. ' 'https://doi.org/10.1186/s13613-020-00792-3', 'journal-title': 'Ann Intensive Care'}], 'container-title': 'Inflammopharmacology', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://link.springer.com/content/pdf/10.1007/s10787-024-01597-7.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/article/10.1007/s10787-024-01597-7/fulltext.html', 'content-type': 'text/html', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/content/pdf/10.1007/s10787-024-01597-7.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2024, 11, 13]], 'date-time': '2024-11-13T12:32:22Z', 'timestamp': 1731501142000}, 'score': 1, 'resource': {'primary': {'URL': 'https://link.springer.com/10.1007/s10787-024-01597-7'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2024, 11, 13]]}, 'references-count': 40, 'alternative-id': ['1597'], 'URL': 'http://dx.doi.org/10.1007/s10787-024-01597-7', 'relation': {}, 'ISSN': ['0925-4692', '1568-5608'], 'subject': [], 'container-title-short': 'Inflammopharmacol', 'published': {'date-parts': [[2024, 11, 13]]}, 'assertion': [ { 'value': '17 October 2024', 'order': 1, 'name': 'received', 'label': 'Received', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '1 November 2024', 'order': 2, 'name': 'accepted', 'label': 'Accepted', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '13 November 2024', 'order': 3, 'name': 'first_online', 'label': 'First Online', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, {'order': 1, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Declarations'}}, { 'value': 'The authors have no relevant financial or non-financial interests to disclose.', 'order': 2, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Competing Interests'}}, { 'value': 'This study was performed in line with the principles of the Declaration of ' 'Helsinki. Approval was granted by the Ethics Committee of Ondokuz Mayıs ' 'University (13.04.2022/OMÜ KAEK 2022-167). In addition, this trial was approved ' 'by the Academic and Ethichs Committee of Medicana International Samsun Hospital ' '(03.03.2022/2) and the General Directorate of Health Services at the Republic ' 'of Turkey Ministry of Health (16.03.2022).', 'order': 3, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Ethical approval'}}, { 'value': 'Informed consent was obtained from all individual participants included in the ' 'study.', 'order': 4, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Consent to participate'}}, { 'value': 'Our manuscript does not contain any individual person’s data.', 'order': 5, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Consent to publish'}}]}
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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