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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Hospitalization 40% Improvement Relative Risk Vitamin C for COVID-19  Rahman et al.  EARLY TREATMENT Is early treatment with vitamin C beneficial for COVID-19? Retrospective 600 patients in Bangladesh Lower hospitalization with vitamin C (p=0.00012) Rahman et al., Molecular Mechanism Res.., Nov 2023 Favors vitamin C Favors control

Clinical & Demographical Status of Hospitalized and Non-Hospitalized Covid-19 Cases: A Multicenter Hospital Based Study in Bangladesh

Rahman et al., Molecular Mechanism Research, 1:1
Nov 2023  
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Vitamin C for COVID-19
6th treatment shown to reduce risk in September 2020
*, now known with p = 0.000000087 from 70 studies, recognized in 11 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments.
Retrospective 416 non-hospitalized and 184 hospitalized COVID-19 patients in Bangladesh, showing higher acetaminophen and lower vitamin C usage for hospitalized patients. Confounding may be significant and baseline details per treatment group are not provided, however fever and symptomatic patients were more common in the non-hospitalized group. Note there is an alignment mismatch in Table 1.
This is the 69th of 70 COVID-19 controlled studies for vitamin C, which collectively show efficacy with p=0.000000087 (1 in 11 million).
21 studies are RCTs, which show efficacy with p=0.0012.
This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details; significant unadjusted confounding possible.
Study covers vitamin C and acetaminophen.
risk of hospitalization, 40.5% lower, RR 0.60, p < 0.001, treatment 128 of 476 (26.9%), control 56 of 124 (45.2%), NNT 5.5.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Rahman et al., 8 Nov 2023, retrospective, Bangladesh, peer-reviewed, 5 authors.
This PaperVitamin CAll
Clinical & Demographical Status of Hospitalized and Non-Hospitalized Covid-19 Cases: A Multicenter Hospital Based Study in Bangladesh
Md Ashiqur Rahman, Sadia Islam, Shohanur Rahaman, Md Raihanul Islam, Md. Sujon Ali, Senior Sujon Ali
Background: The COVID-19 pandemic has had a profound impact on global health, with millions of individuals affected by the viral infection. Among the vulnerable populations, diabetic patients face a higher risk of severe illness and complications when exposed to the SARS-CoV-2 virus. Bangladesh, like many other countries, has witnessed a significant number of COVID-19 cases, raising concerns about the management and outcomes of diabetic patients during this pandemic. This study highlights clinical and demographical experiences in hospitalized and non-hospitalized covid-19 patients in Bangladesh. Methodology: This descriptive crosssectional study was from May 2021 to August 2022. Five selected government hospitals and six private hospitals located in the Dhaka Division were included in this study. The diagnosis of SARS-CoV-2 infection was confirmed by real-time reverse transcriptase polymerase chain reaction (RT-PCR) test. Results: Data of 416 nonhospitalized patients with COVID-19 were recorded and analyzed. The mean age of the patients was 44.42 ± 14.20 year with 336 males and 80 females. Comorbidities were present of which hypertension 38.5%, diabetes 32.7%. A significant proportion of patients had symptomatic such as fever 92.3%, dry cough 88.5%, loss of taste 48.07%, loss of smell 50.96% was the most common. Majority of the patients were managed with supportive treatment with paracetamol 38.46%, antihistamine 76.9%, oral vitamin-c 83.65%, and antibiotics 67.30%. It took an average of 12-14 days for them to become negative. And hospitalized patients, of whom 131 were males and 53 were female. Overall mean age was 45.12±13.80 years. They have some kind of comorbidities present like diabetes mellitus 45.65%, hypertension 56.52%, hyperlipidemia 17.39%, coronary heart disease 21.73% etc. In addition, they have taken some medicine as per the doctors advise such as paracetamol 45.65%, antihistamine 63.04, oral vitamin c 69.56%, antibiotics 58.69%, antifungal 45.6% and oxygen therapy 28 (15.21%). Some changed laboratory parameters were observed. Conclusion: We concluded that laboratory results from nonhospitalized patients did not show any major alterations or abnormalities, but laboratory results from hospitalized patients did show substantial changes. There is a post-COVID-19 tiredness warning for them.
Informed Consent Informed consent was obtained from all individuals included in this study.
Akram, Islam, Rahman, Islam, Ali et al., The prevalence of asymptomatic COVID-19 cases in a single center and duration of viral clearance, Bangladesh Journal of Medical Microbiology
Akram, Khan, Rahman, Islam, Ali et al., Anosmia with or without Ageusia as a Presenting Symptom in COVID-19 Positive Patients: A Single Center Study at Dhaka in Bangladesh, Bangladesh Journal of Infectious Diseases
Asghar, Kazmi, Khan, Akram, Khan et al., Clinical profiles, characteristics, and outcomes of the first 100 admitted COVID-19 patients in Pakistan: a singlecenter retrospective study in a tertiary care hospital of Karachi, Cureus
Chen, Zhou, Dong, Qu, Gong et al., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study, Lancet
Fang, Karakiulakis, Roth, Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?, Lancet Respir Med, doi:10.1016/S2213-2600(20)30116-8
Guan, Ni, Hu, Liang, Ou et al., Clinical characteristics of coronavirus disease 2019 in China, N Engl J Med
Guo, Cao, Hong, Tan, Chen et al., The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak-an update on the status, Military medical research
Hamming, Timens, Bulthuis, Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis, J Pathol
Hu, Song, Xu, Chen, Xu, Clinical characteristics of 24 asymptomatic infections with COVID-19 screened among close contacts in Nanjing, China, Sci China Life Sci
Huang, Wang, Li, Ren, Zhao et al., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, Lancet
Huang, Wang, Li, Ren, Zhao et al., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, The lancet
Islam, Akram, Rahman, Ali, Islam et al., Molecular identification, clinical assessment, characterization of SARS-CoV-2 RT-PCR results: Insights into twenty-one months of COVID-19 pandemic in a single center in Bangladesh
Li, Guan, Wu, Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia, N Engl J Med, doi:10.1056/NEJMoa2001316
Lippi, Plebani, The critical role of laboratory medicine during coronavirus disease 2019 (COVID19) and other viral outbreaks, Clin Chem Lab Med
Liu, Fang, Deng, Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei province, Chin Med J (Engl), doi:10.1097/CM9.0000000000000744
Mohan, Tiwari, Bhatnagar, Patel, Maurya et al., Clinico-demographic profile & hospital outcomes of COVID-19 patients admitted at a tertiary care centre in north India, The Indian journal of medical research
Renu, Prasanna, Valsala Gopalakrishnan, Coronaviruses pathogenesis, comorbidities and multiorgan damage -a review, Life Sci
Shanbehzadeh, Tavahomi, Zanjari, Ebrahimi-Takamjani, Amiri-Arimi, Physical and mental health complications post-COVID-19: Scoping review, Journal of psychosomatic research
Shi, Han, Jiang, Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study, Lancet Infect Dis, doi:10.1016/S1473-3099(20)30086-4
Soni, Kajal, Yaddanapudi, Malhotra, Puri et al., Demographic & clinical profile of patients with COVID-19 at a tertiary care hospital in north India, The Indian journal of medical research
Wang, Hu, Hu, Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China, JAMA, doi:10.1001/jama.2020.1585
Wu, Mcgoogan, Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention, JAMA
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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