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Clinical & Demographical Status of Hospitalized and Non-Hospitalized Covid-19 Cases: A Multicenter Hospital Based Study in Bangladesh

Rahman et al., Molecular Mechanism Research, 1:1
Nov 2023  
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Hospitalization -23% Improvement Relative Risk Acetaminophen  Rahman et al.  EARLY TREATMENT Is early treatment with acetaminophen beneficial for COVID-19? Retrospective 600 patients in Bangladesh Higher hospitalization with acetaminophen (not stat. sig., p=0.11) c19early.org Rahman et al., Molecular Mechanism Res.., Nov 2023 Favorsacetaminophen Favorscontrol 0 0.5 1 1.5 2+
2nd treatment shown to increase risk in November 2020, now with p = 0.00000029 from 27 studies, but still recommended in 64 countries.
5,100+ studies for 112 treatments. c19early.org
Retrospective 416 non-hospitalized and 184 hospitalized COVID-19 patients in Bangladesh, showing higher acetaminophen and lower vitamin C usage for hospitalized patients. Confounding may be significant and baseline details per treatment group are not provided, however fever and symptomatic patients were more common in the non-hospitalized group. Note there is an alignment mismatch in Table 1.
Acetaminophen is also known as paracetamol, Tylenol, Panadol, Calpol, Tempra, Calprofen, Doliprane, Efferalgan, Grippostad C, Dolo, Acamol, Fevadol, Crocin, and Perfalgan.
This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details; significant unadjusted confounding possible.
Study covers vitamin C and acetaminophen.
risk of hospitalization, 22.6% higher, RR 1.23, p = 0.11, treatment 84 of 244 (34.4%), control 100 of 356 (28.1%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Rahman et al., 8 Nov 2023, retrospective, Bangladesh, peer-reviewed, 5 authors.
This PaperAcetaminophenAll
Clinical & Demographical Status of Hospitalized and Non-Hospitalized Covid-19 Cases: A Multicenter Hospital Based Study in Bangladesh
Md Ashiqur Rahman, Sadia Islam, Shohanur Rahaman, Md Raihanul Islam, Md. Sujon Ali, Senior Sujon Ali
Background: The COVID-19 pandemic has had a profound impact on global health, with millions of individuals affected by the viral infection. Among the vulnerable populations, diabetic patients face a higher risk of severe illness and complications when exposed to the SARS-CoV-2 virus. Bangladesh, like many other countries, has witnessed a significant number of COVID-19 cases, raising concerns about the management and outcomes of diabetic patients during this pandemic. This study highlights clinical and demographical experiences in hospitalized and non-hospitalized covid-19 patients in Bangladesh. Methodology: This descriptive crosssectional study was from May 2021 to August 2022. Five selected government hospitals and six private hospitals located in the Dhaka Division were included in this study. The diagnosis of SARS-CoV-2 infection was confirmed by real-time reverse transcriptase polymerase chain reaction (RT-PCR) test. Results: Data of 416 nonhospitalized patients with COVID-19 were recorded and analyzed. The mean age of the patients was 44.42 ± 14.20 year with 336 males and 80 females. Comorbidities were present of which hypertension 38.5%, diabetes 32.7%. A significant proportion of patients had symptomatic such as fever 92.3%, dry cough 88.5%, loss of taste 48.07%, loss of smell 50.96% was the most common. Majority of the patients were managed with supportive treatment with paracetamol 38.46%, antihistamine 76.9%, oral vitamin-c 83.65%, and antibiotics 67.30%. It took an average of 12-14 days for them to become negative. And hospitalized patients, of whom 131 were males and 53 were female. Overall mean age was 45.12±13.80 years. They have some kind of comorbidities present like diabetes mellitus 45.65%, hypertension 56.52%, hyperlipidemia 17.39%, coronary heart disease 21.73% etc. In addition, they have taken some medicine as per the doctors advise such as paracetamol 45.65%, antihistamine 63.04, oral vitamin c 69.56%, antibiotics 58.69%, antifungal 45.6% and oxygen therapy 28 (15.21%). Some changed laboratory parameters were observed. Conclusion: We concluded that laboratory results from nonhospitalized patients did not show any major alterations or abnormalities, but laboratory results from hospitalized patients did show substantial changes. There is a post-COVID-19 tiredness warning for them.
Informed Consent Informed consent was obtained from all individuals included in this study.
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