The impact of vitamin and mineral supplements usage prior to COVID-19 infection on disease severity and hospitalization
Nimer et al.
, The impact of vitamin and mineral supplements usage prior to COVID-19 infection on disease severity and..
, Bosnian Journal of Basic Medical Sciences, doi:10.17305/bjbms.2021.7009
Retrospective 2,148 COVID-19 recovered patients in Jordan, showing lower risk of severity and hospitalization with vitamin C prophylaxis, without statistical significance.
Although the 25% lower hospitalization is not statistically significant, it is consistent with the significant 17% lower hospitalization [3‑28%]
from meta analysis of the 11 hospitalization results to date
risk of hospitalization, 24.7% lower, RR 0.75, p = 0.08, treatment 52 of 651 (8.0%), control 167 of 1,497 (11.2%), NNT 32, adjusted per study, odds ratio converted to relative risk, multivariable.
risk of severe case, 17.0% lower, RR 0.83, p = 0.18, treatment 66 of 651 (10.1%), control 194 of 1,497 (13.0%), NNT 35, adjusted per study, odds ratio converted to relative risk, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Nimer et al., 28 Feb 2022, retrospective, Jordan, peer-reviewed, survey, 4 authors, study period March 2021 - July 2021.
Abstract: Bosnian Journal of Basic Medical Sciences
ISSN: 1512-8601 (Print) | ISSN: 1840-4812 (Online) | OPEN ACCESS
Journal Impact Factor® (2020): 3.36
CiteScore® (2020): 4.0
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NEW AND EMERGING
Nimer, et al.: Dietary supplements and COVID-19
The impact of vitamin and mineral
supplements usage prior to COVID-19
infection on disease severity and
Refat Nimer1*, Omar Khabour1, Samer Swedan1, Hassan Kofahi1
1Department of Medical Laboratory Sciences, Jordan University of Science and Technology,
*Corresponding author: Refat Nimer, PhD, Department of Medical Laboratory Sciences,
Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan
Submitted: 31 January 2022/Accepted: 19 February 2022/ Published online: 28 February 2022
Conflict of interests: Authors declare no conflict of interests.
Funding: This study is supported by the deanship of research at Jordan University of Science
and Technology (grant number 20210173).
License: © The Author(s) (2022). This work is licensed under a Creative Commons Attribution
4.0 Intenational License.
The COVID-19 pandemic has caused a global public health emergency. Nutritional status
is suggested to be related to the severity of COVID-19 infection. Herein, we aimed to explore the
impact of using vitamin and mineral supplements prior to COVID-19 infection on disease severity
and hospitalization. In addition, the prior use of aspirin as an anticoagulant on the disease severity
was investigated. A cross-sectional, self-administered survey was conducted between March and
July 2021. Recovered COVID-19 individuals (age ≥ 18 years, n = 2148) were recruited in the
study. A multivariate logistic regression was used to evaluate the associations of supplements and
aspirin use with COVID-19 disease severity and hospitalization status. Among the participants,
12.1% reported symptoms consistent with severe COVID-19, and 10.2% were hospitalized due to
COVID-19. After adjustment for confounding variables (age, gender, BMI, cigarette smoking
status, and the number of comorbidities), the multivariate logistic regression model showed that
the consumption of vitamin D supplements prior to COVID-19 infection was associated with a
significant decrease in disease severity (OR = 0.68, 95% CI 0.50 - 0.92; P = 0.01), and a lower risk
of hospitalization (OR = 0.64, 95% CI 0.45 - 0.89; P = 0.01). On the other hand, there were no
significant differences in the frequencies of severe illness and hospitalizations with the
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