The impact of vitamin and mineral supplements usage prior to COVID-19 infection on disease severity and hospitalization
Nimer et al.
, The impact of vitamin and mineral supplements usage prior to COVID-19 infection on disease severity and..
, Bosnian Journal of Basic Medical Sciences, doi:10.17305/bjbms.2021.7009
Retrospective survey based analysis of 2,148 COVID-19 recovered patients in Jordan, showing no significant differences in the risk of severity and hospitalization with zinc prophylaxis.
risk of hospitalization, 25.4% higher, RR 1.25, p = 0.21, treatment 41 of 326 (12.6%), control 178 of 1,822 (9.8%), adjusted per study, odds ratio converted to relative risk, multivariable.
risk of severe case, 13.0% higher, RR 1.13, p = 0.46, treatment 46 of 326 (14.1%), control 214 of 1,822 (11.7%), adjusted per study, odds ratio converted to relative risk, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Nimer et al., 28 Feb 2022, retrospective, Jordan, peer-reviewed, survey, 4 authors, study period March 2021 - July 2021.
Abstract: Bosnian Journal of Basic Medical Sciences
ISSN: 1512-8601 (Print) | ISSN: 1840-4812 (Online) | OPEN ACCESS
Journal Impact Factor® (2020): 3.36
CiteScore® (2020): 4.0
www.bjbms.org | blog.bjbms.org
The BJBMS publishes an “Advanced online” manuscript format as a free service to authors in order to expedite the dissemination
of scientific findings to the research community as soon as possible after acceptance following peer review and corresponding
modification (where appropriate). An “Advanced online” manuscript is published online prior to copyediting, formatting
for publication and author proofing, but is nonetheless fully citable through its Digital Object Identifier (doi®).
Nevertheless, this “Advanced online” version is NOT the final version of the manuscript. When the final version of this
paper is published within a definitive issue of the journal with copyediting, full pagination, etc. the new final version will be
accessible through the same doi and this "Advanced online" version of the paper will disappear.
NEW AND EMERGING
Nimer, et al.: Dietary supplements and COVID-19
The impact of vitamin and mineral
supplements usage prior to COVID-19
infection on disease severity and
Refat Nimer1*, Omar Khabour1, Samer Swedan1, Hassan Kofahi1
1Department of Medical Laboratory Sciences, Jordan University of Science and Technology,
*Corresponding author: Refat Nimer, PhD, Department of Medical Laboratory Sciences,
Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan
Submitted: 31 January 2022/Accepted: 19 February 2022/ Published online: 28 February 2022
Conflict of interests: Authors declare no conflict of interests.
Funding: This study is supported by the deanship of research at Jordan University of Science
and Technology (grant number 20210173).
License: © The Author(s) (2022). This work is licensed under a Creative Commons Attribution
4.0 Intenational License.
The COVID-19 pandemic has caused a global public health emergency. Nutritional status
is suggested to be related to the severity of COVID-19 infection. Herein, we aimed to explore the
impact of using vitamin and mineral supplements prior to COVID-19 infection on disease severity
and hospitalization. In addition, the prior use of aspirin as an anticoagulant on the disease severity
was investigated. A cross-sectional, self-administered survey was conducted between March and
July 2021. Recovered COVID-19 individuals (age ≥ 18 years, n = 2148) were recruited in the
study. A multivariate logistic regression was used to evaluate the associations of supplements and
aspirin use with COVID-19 disease severity and hospitalization status. Among the participants,
12.1% reported symptoms consistent with severe COVID-19, and 10.2% were hospitalized due to
COVID-19. After adjustment for confounding variables (age, gender, BMI, cigarette smoking
status, and the number of comorbidities), the multivariate logistic regression model showed that
the consumption of vitamin D supplements prior to COVID-19 infection was associated with a
significant decrease in disease severity (OR = 0.68, 95% CI 0.50 - 0.92; P = 0.01), and a lower risk
of hospitalization (OR = 0.64, 95% CI 0.45 - 0.89; P = 0.01). On the other hand, there were no
significant differences in the frequencies of severe illness and hospitalizations with the
Please send us corrections, updates, or comments. Vaccines and
treatments are complementary. All practical, effective, and safe means should
be used based on risk/benefit analysis. No treatment, vaccine, or intervention
is 100% available and effective for all current and future variants. We do not
provide medical advice. Before taking any medication, consult a qualified
physician who can provide personalized advice and details of risks and
benefits based on your medical history and situation. FLCCC
provide treatment protocols.