Analgesics
Antiandrogens
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Results
Abstract
All vitamin C studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchVitamin CVitamin C (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Recovery time, SD, S 33% Improvement Relative Risk Recovery time, SD, NS 45% Recovery time, SD, S, vs... 24% Recovery time, SD, NS, vs... 28% Recovery time, DR, S 27% Recovery time, DR, NS 23% Recovery time, DR, S, vs... 15% Recovery time, DR, NS, vs.. 15% Time to viral-, S 36% Time to viral-, NS 32% Time to viral-, S, vs. low d.. 14% Time to viral-, NS, vs. low.. 19% Vitamin C  Yang et al.  LATE TREATMENT  RCT Is late treatment with vitamin C + TCM beneficial for COVID-19? RCT 20 patients in China (February - February 2020) Faster recovery (p<0.0001) and viral clearance (p<0.0001) c19early.org Yang et al., Am. J. Transl. Res., January 2022 Favors vitamin C Favors control

Traditional Chinese medicine together with high-dose vitamin C improves the therapeutic effect of western medicine against COVID-19

Yang et al., Am. J. Transl. Res., 14:1, ChiCTR2000032717
Jan 2022  
  Post
  Facebook
Share
  Source   PDF   All   Meta
Vitamin C for COVID-19
7th treatment shown to reduce risk in September 2020
 
*, now known with p = 0.000000098 from 67 studies, recognized in 10 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments. c19early.org
Prospective study of 60 patients in China with three arms: SOC, SOC+TCM, and SOC+TCM+high dose vitamin C, showing successively faster recovery with the addition of TCM and the addition of high dose vitamin C. TCM included inhaled vitamin C 10g, 3-7 times per day. IV vitamin C 10g/60kg twice a day, and oral vitamin C 3g three times a day. Group C vs. group A includes combined treatment with TCM, while group C vs. group B both include vitamin C (high vs. low dose).
This is the 11th of 18 COVID-19 RCTs for vitamin C, which collectively show efficacy with p=0.00088.
This is the 40th of 67 COVID-19 controlled studies for vitamin C, which collectively show efficacy with p=0.000000098 (1 in 10 million).
This study is excluded in the after exclusion results of meta analysis: combined treatments may contribute significantly to the effect seen.
recovery time, 32.9% lower, relative time 0.67, p < 0.001, treatment mean 10.2 (±1.75) n=10, control mean 15.2 (±2.49) n=10, symptom disappearance, severe patients, group C vs. group A.
recovery time, 44.6% lower, relative time 0.55, p < 0.001, treatment mean 4.1 (±0.88) n=10, control mean 7.4 (±1.26) n=10, symptom disappearance, non-severe patients, group C vs. group A.
recovery time, 23.9% lower, relative time 0.76, p = 0.006, treatment mean 10.2 (±1.75) n=10, control mean 13.4 (±2.76) n=10, symptom disappearance, severe patients, group C vs. group B (high vs. low dose).
recovery time, 28.1% lower, relative time 0.72, p = 0.003, treatment mean 4.1 (±0.88) n=10, control mean 5.7 (±1.16) n=10, symptom disappearance, non-severe patients, group C vs. group B (high vs. low dose).
recovery time, 27.1% lower, relative time 0.73, p = 0.002, treatment mean 13.45 (±3.11) n=10, control mean 18.45 (±3.12) n=10, disease recovery, severe patients, group C vs. group A.
recovery time, 23.2% lower, relative time 0.77, p < 0.001, treatment mean 7.0 (±0.94) n=10, control mean 9.11 (±1.25) n=10, disease recovery, non-severe patients, group C vs. group A.
recovery time, 15.4% lower, relative time 0.85, p = 0.15, treatment mean 13.45 (±3.11) n=10, control mean 15.89 (±4.06) n=10, disease recovery, severe patients, group C vs. group B (high vs. low dose).
recovery time, 14.6% lower, relative time 0.85, p = 0.02, treatment mean 7.0 (±0.94) n=10, control mean 8.2 (±1.14) n=10, disease recovery, non-severe patients, group C vs. group B (high vs. low dose).
time to viral-, 35.8% lower, relative time 0.64, p < 0.001, treatment mean 9.7 (±1.49) n=10, control mean 15.1 (±2.38) n=10, severe patients, group C vs. group A.
time to viral-, 32.0% lower, relative time 0.68, p < 0.001, treatment mean 5.1 (±0.95) n=10, control mean 7.5 (±0.97) n=10, non-severe patients, group C vs. group A.
time to viral-, 14.2% lower, relative time 0.86, p = 0.25, treatment mean 9.7 (±1.49) n=10, control mean 11.3 (±4.03) n=10, severe patients, group C vs. group B (high vs. low dose).
time to viral-, 19.0% lower, relative time 0.81, p = 0.02, treatment mean 5.1 (±0.95) n=10, control mean 6.3 (±1.06) n=10, non-severe patients, group C vs. group B (high vs. low dose).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Yang et al., 15 Jan 2022, Randomized Controlled Trial, China, peer-reviewed, 11 authors, study period 1 February, 2020 - 29 February, 2020, this trial uses multiple treatments in the treatment arm (combined with TCM) - results of individual treatments may vary, trial ChiCTR2000032717.
This PaperVitamin CAll
Traditional Chinese medicine together with high-dose vitamin C improves the therapeutic effect of western medicine against COVID-19
Xudong Yang, Yali Wang, Yongping Liu, Lei Shang, Zhijian Cheng, Liping Fang, Jian Zhang, Yifan Feng, Kuiwei Zhang, Shanjiao Jiang, Xijing He
Objectives: Traditional Chinese medicine has been reported to be effective in the treatment of epidemic diseases. Here, we aimed to investigate the effects of combined therapy of Chinese and western medicine on coronavirus disease 2019 (COVID-19). Methods: A total of 60 patients diagnosed with COVID-19 were enrolled. Both the ordinary and severely affected patients were randomly divided into Groups A-C each with 10 cases each. The patients in Group A-C received Western medicine, Western medicine + traditional Chinese medicine, and Western medicine + traditional Chinese medicine + high dose of vitamin C, respectively. The time of disease recovery, symptoms disappearance, chest CT improvement, and tongue amelioration was recorded. Leukocyte, neutrophil and lymphocyte were monitored, as well as C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), procalitonin (PCT), inflammatory factors, partial pressure of oxygen and carbon dioxide (PaCO 2 ) and oxygenation index (PaO 2 ). Urinary tract stones, liver function, and other side-effects such as gastrointestinal dysfunction were also investigated. Results: Traditional Chinese medicine enhanced the effect of Western medicine, including the reduction of CRP, ESR, PCT, and inflammatory factors, and the increase of leukocyte, neutrophil, and lymphocyte counts, and the improvement of respiratory rate, PaO 2 , PaCO 2 , and oxygenation index. Traditional Chinese medicine combined with high-dose Vitamin C therapy more effectively shortened the time of disease recovery, symptom disappearance, chest CT improvement, and tongue amelioration. Conclusions: a combined therapy of Western medicine, traditional Chinese medicine, and high dose of Vitamin C results in a most effective outcome in the treatment of COVID-19.
References
Ai, Wu, Qi, Zhang, Hu et al., Study on the mechanisms of active compounds in traditional Chinese medicine for the treatment of influenza virus by virtual screening, Interdiscip Sci
Biancatelli, Berrill, Marik, The antiviral properties of vitamin C, Expert Rev Anti Infect Ther
Chen, Wu, Li, Liu, Jia et al., Aster tataricus attenuates asthma efficiently by simultaneously inhibiting tracheal ring contraction and inflammation, Biomed Pharmacother
Chen, Zhao, Zhang, Jia, Wu et al., Clinical effect of intravenous vitamin C on viral myocarditis in children: a systematic review and meta-analysis, Evid Based Complement Alternat Med
Chiow, Phoon, Putti, Bk, Chow, Evaluation of antiviral activities of Houttuynia cordata Thunb. extract, quercetin, quercetrin and cinanserin on murine coronavirus and dengue virus infection, Asian Pac J Trop Med
Chu, Wei, Yang, Cao, Xie et al., Effects of an anthraquinone derivative from rheum officinale baill, emodin, on airway responses in a murine model of asthma, Food Chem Toxicol
Farjana, Moni, Sohag, Hasan, Hannan et al., Repositioning vitamin C as a promising option to alleviate complications associated with COVID-19, Infect Chemother
Fu, Gao, Fu, Meng, Lu, Scutellaria baicalensis inhibits coxsackievirus B3-induced myocarditis via AKT and p38 pathways, J Microbiol Biotechnol
Gong, Xu, Jin, Deng, Wang et al., Treatment of advanced non-small-cell lung cancer with Qinourishing essence-replenishing Chinese herbal medicine combined with chemotherapy, Biol Proced Online
Halaji, Farahani, Ranjbar, Heiat, Dehkordi, Emerging coronaviruses: first SARS, second MERS and third SARS-CoV-2: epidemiological updates of COVID-19, Infez Med
Hoang, Shaw, Han, Possible application of high-dose vitamin C in the prevention and therapy of coronavirus infection, J Glob Antimicrob Resist
Holford, Carr, Jovic, Ali, Whitaker et al., Vitamin C-an adjunctive therapy for respiratory infection, sepsis and COVID-19, Nutrients
Jia, Guan, Wu, Yu, Lin et al., Taraxacum mongolicum extract exhibits a protective effect on hepatocytes and an antiviral effect against hepatitis B virus in animal and human cells, Mol Med Rep
Jin, Yang, Wu, Chen, Zhang et al., Virology, epidemiology, pathogenesis, and control of COVID-19, Viruses
Junior, Santos, Quintans-Junior, Walker, Borges et al., SARS, MERS and SARS-CoV-2 (COVID-19) treatment: a patent review, Expert Opin Ther Pat
Kim, Kim, A network-based pharmacology study of active compounds and targets of Fritillaria thunbergii against influenza, Comput Biol Chem
Kim, Kim, Hong, Kwon, Song et al., Anti-inflammatory effects of fritillaria thunbergii miquel extracts in LPS-stimulated murine macrophage RAW 264.7 cells, Exp Ther Med
Kim, Kim, Park, Kim, Chung et al., Baicalin from scutellaria baicalensis impairs Th1 polarization through inhibition of dendritic cell maturation, J Pharmacol Sci
Kim, Nguyen, Heo, Park, Paik et al., Antiviral activity of fritillaria thunbergii extract against human influenza virus H1N1 (PR8) in vitro, in ovo and in vivo, J Microbiol Biotechnol
Lee, Ha, Cho, An, Kim et al., Antiviral activity of furanocoumarins isolated from angelica dahurica against influenza a viruses H1N1 and H9N2, J Ethnopharmacol
Lee, Lee, Kim, Choi, Ahn et al., Angelica dahurica ameliorates the inflammation of gingival tissue via regulation of pro-inflammatory mediators in experimental model for periodontitis, J Ethnopharmacol
Li, Zhang, Wu, Zhao, The mechanism and clinical outcome of patients with corona virus disease 2019 whose nucleic acid test has changed from negative to positive, and the therapeutic efficacy of favipiravir: a structured summary of a study protocol for a randomised controlled trial, Trials
Liao, Ye, Gao, Liu, The main bioactive compounds of Scutellaria baicalensis Georgi. for alleviation of inflammatory cytokines: a comprehensive review, Biomed Pharmacother
Liu, Zhu, Zhang, Peng, Intravenous high-dose vitamin C for the treatment of severe COVID-19: study protocol for a multicentre randomised controlled trial, BMJ Open
Pan, Wang, Leu, Wu, Wu, Inhibitory effects of Scutellaria baicalensis extract on hepatic stellate cells through inducing G2/M cell cycle arrest and activating ERK-dependent apoptosis via Bax and caspase pathway, J Ethnopharmacol
Rabaan, Sh, Haque, Sah, Tiwari et al., SARS-CoV-2, SARS-CoV, and MERS-COV: a comparative overview, Infez Med
Yang, Islam, Wang, Traditional Chinese medicine in the treatment of patients infected with 2019-new coronavirus (SARS-CoV-2): a review and perspective, Int J Biol Sci
Zhang, Shao, Song, Xia, Yang et al., Protective effects of Forsythia suspense extract with antioxidant and anti-inflammatory properties in a model of rotenone induced neurotoxicity, Neurotoxicology
Zhang, Xu, Liu, Yuan, Mitochondrion-permeable antioxidants to treat ROSburst-mediated acute diseases, Oxid Med Cell Longev
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit