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Traditional Chinese medicine together with high-dose vitamin C improves the therapeutic effect of western medicine against COVID-19

Yang et al., American Journal of Translational Research, 14:1, ChiCTR2000032717

Jan 2022

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Vitamin C for COVID-19

6th treatment shown to reduce risk in September 2020, now with p = 0.00000002 from 73 studies, recognized in 12 countries.

Lower risk for mortality, ICU admission, hospitalization, and recovery.

No treatment is 100% effective. Protocols combine treatments.

5,100+ studies for 109 treatments. c19early.org

Prospective study of 60 patients in China with three arms: SOC, SOC+TCM, and SOC+TCM+high dose vitamin C, showing successively faster recovery with the addition of TCM and the addition of high dose vitamin C. TCM included inhaled vitamin C 10g, 3-7 times per day. IV vitamin C 10g/60kg twice a day, and oral vitamin C 3g three times a day. Group C vs. group A includes combined treatment with TCM, while group C vs. group B both include vitamin C (high vs. low dose).

This is the 11th of 21 COVID-19 RCTs for vitamin C, which collectively show efficacy with p=0.0012.

This is the 40th of 73 COVID-19 controlled studies for vitamin C, which collectively show efficacy with p=0.00000002 (1 in 50 million).

This study is excluded in the after exclusion results of meta analysis: combined treatments may contribute significantly to the effect seen.

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recovery time, 32.9% lower, relative time 0.67, p < 0.001, treatment mean 10.2 (±1.75) n=10, control mean 15.2 (±2.49) n=10, symptom disappearance, severe patients, group C vs. group A.

recovery time, 44.6% lower, relative time 0.55, p < 0.001, treatment mean 4.1 (±0.88) n=10, control mean 7.4 (±1.26) n=10, symptom disappearance, non-severe patients, group C vs. group A.

recovery time, 23.9% lower, relative time 0.76, p = 0.006, treatment mean 10.2 (±1.75) n=10, control mean 13.4 (±2.76) n=10, symptom disappearance, severe patients, group C vs. group B (high vs. low dose).

recovery time, 28.1% lower, relative time 0.72, p = 0.003, treatment mean 4.1 (±0.88) n=10, control mean 5.7 (±1.16) n=10, symptom disappearance, non-severe patients, group C vs. group B (high vs. low dose).

recovery time, 27.1% lower, relative time 0.73, p = 0.002, treatment mean 13.45 (±3.11) n=10, control mean 18.45 (±3.12) n=10, disease recovery, severe patients, group C vs. group A.

recovery time, 23.2% lower, relative time 0.77, p < 0.001, treatment mean 7.0 (±0.94) n=10, control mean 9.11 (±1.25) n=10, disease recovery, non-severe patients, group C vs. group A.

recovery time, 15.4% lower, relative time 0.85, p = 0.15, treatment mean 13.45 (±3.11) n=10, control mean 15.89 (±4.06) n=10, disease recovery, severe patients, group C vs. group B (high vs. low dose).

recovery time, 14.6% lower, relative time 0.85, p = 0.02, treatment mean 7.0 (±0.94) n=10, control mean 8.2 (±1.14) n=10, disease recovery, non-severe patients, group C vs. group B (high vs. low dose).

time to viral-, 35.8% lower, relative time 0.64, p < 0.001, treatment mean 9.7 (±1.49) n=10, control mean 15.1 (±2.38) n=10, severe patients, group C vs. group A.

time to viral-, 32.0% lower, relative time 0.68, p < 0.001, treatment mean 5.1 (±0.95) n=10, control mean 7.5 (±0.97) n=10, non-severe patients, group C vs. group A.

time to viral-, 14.2% lower, relative time 0.86, p = 0.25, treatment mean 9.7 (±1.49) n=10, control mean 11.3 (±4.03) n=10, severe patients, group C vs. group B (high vs. low dose).

time to viral-, 19.0% lower, relative time 0.81, p = 0.02, treatment mean 5.1 (±0.95) n=10, control mean 6.3 (±1.06) n=10, non-severe patients, group C vs. group B (high vs. low dose).

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Yang et al., 15 Jan 2022, Randomized Controlled Trial, China, peer-reviewed, 11 authors, study period 1 February, 2020 - 29 February, 2020, this trial uses multiple treatments in the treatment arm (combined with TCM) - results of individual treatments may vary, trial ChiCTR2000032717.

This Paper Vitamin C All

Traditional Chinese medicine together with high-dose vitamin C improves the therapeutic effect of western medicine against COVID-19

Xudong Yang, Yali Wang, Yongping Liu, Lei Shang, Zhijian Cheng, Liping Fang, Jian Zhang, Yifan Feng, Kuiwei Zhang, Shanjiao Jiang, Xijing He

Objectives: Traditional Chinese medicine has been reported to be effective in the treatment of epidemic diseases. Here, we aimed to investigate the effects of combined therapy of Chinese and western medicine on coronavirus disease 2019 (COVID-19). Methods: A total of 60 patients diagnosed with COVID-19 were enrolled. Both the ordinary and severely affected patients were randomly divided into Groups A-C each with 10 cases each. The patients in Group A-C received Western medicine, Western medicine + traditional Chinese medicine, and Western medicine + traditional Chinese medicine + high dose of vitamin C, respectively. The time of disease recovery, symptoms disappearance, chest CT improvement, and tongue amelioration was recorded. Leukocyte, neutrophil and lymphocyte were monitored, as well as C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), procalitonin (PCT), inflammatory factors, partial pressure of oxygen and carbon dioxide (PaCO 2 ) and oxygenation index (PaO 2 ). Urinary tract stones, liver function, and other side-effects such as gastrointestinal dysfunction were also investigated. Results: Traditional Chinese medicine enhanced the effect of Western medicine, including the reduction of CRP, ESR, PCT, and inflammatory factors, and the increase of leukocyte, neutrophil, and lymphocyte counts, and the improvement of respiratory rate, PaO 2 , PaCO 2 , and oxygenation index. Traditional Chinese medicine combined with high-dose Vitamin C therapy more effectively shortened the time of disease recovery, symptom disappearance, chest CT improvement, and tongue amelioration. Conclusions: a combined therapy of Western medicine, traditional Chinese medicine, and high dose of Vitamin C results in a most effective outcome in the treatment of COVID-19.

References

Ai, Wu, Qi, Zhang, Hu et al., Study on the mechanisms of active compounds in traditional Chinese medicine for the treatment of influenza virus by virtual screening, Interdiscip Sci

Biancatelli, Berrill, Marik, The antiviral properties of vitamin C, Expert Rev Anti Infect Ther

Chen, Wu, Li, Liu, Jia et al., Aster tataricus attenuates asthma efficiently by simultaneously inhibiting tracheal ring contraction and inflammation, Biomed Pharmacother

Chen, Zhao, Zhang, Jia, Wu et al., Clinical effect of intravenous vitamin C on viral myocarditis in children: a systematic review and meta-analysis, Evid Based Complement Alternat Med

Chiow, Phoon, Putti, Bk, Chow, Evaluation of antiviral activities of Houttuynia cordata Thunb. extract, quercetin, quercetrin and cinanserin on murine coronavirus and dengue virus infection, Asian Pac J Trop Med

Chu, Wei, Yang, Cao, Xie et al., Effects of an anthraquinone derivative from rheum officinale baill, emodin, on airway responses in a murine model of asthma, Food Chem Toxicol

Farjana, Moni, Sohag, Hasan, Hannan et al., Repositioning vitamin C as a promising option to alleviate complications associated with COVID-19, Infect Chemother

Fu, Gao, Fu, Meng, Lu, Scutellaria baicalensis inhibits coxsackievirus B3-induced myocarditis via AKT and p38 pathways, J Microbiol Biotechnol

Gong, Xu, Jin, Deng, Wang et al., Treatment of advanced non-small-cell lung cancer with Qinourishing essence-replenishing Chinese herbal medicine combined with chemotherapy, Biol Proced Online

Halaji, Farahani, Ranjbar, Heiat, Dehkordi, Emerging coronaviruses: first SARS, second MERS and third SARS-CoV-2: epidemiological updates of COVID-19, Infez Med

Hoang, Shaw, Han, Possible application of high-dose vitamin C in the prevention and therapy of coronavirus infection, J Glob Antimicrob Resist

Holford, Carr, Jovic, Ali, Whitaker et al., Vitamin C-an adjunctive therapy for respiratory infection, sepsis and COVID-19, Nutrients

Jia, Guan, Wu, Yu, Lin et al., Taraxacum mongolicum extract exhibits a protective effect on hepatocytes and an antiviral effect against hepatitis B virus in animal and human cells, Mol Med Rep

Jin, Yang, Wu, Chen, Zhang et al., Virology, epidemiology, pathogenesis, and control of COVID-19, Viruses

Junior, Santos, Quintans-Junior, Walker, Borges et al., SARS, MERS and SARS-CoV-2 (COVID-19) treatment: a patent review, Expert Opin Ther Pat

Kim, Kim, A network-based pharmacology study of active compounds and targets of Fritillaria thunbergii against influenza, Comput Biol Chem

Kim, Kim, Hong, Kwon, Song et al., Anti-inflammatory effects of fritillaria thunbergii miquel extracts in LPS-stimulated murine macrophage RAW 264.7 cells, Exp Ther Med

Kim, Kim, Park, Kim, Chung et al., Baicalin from scutellaria baicalensis impairs Th1 polarization through inhibition of dendritic cell maturation, J Pharmacol Sci

Kim, Nguyen, Heo, Park, Paik et al., Antiviral activity of fritillaria thunbergii extract against human influenza virus H1N1 (PR8) in vitro, in ovo and in vivo, J Microbiol Biotechnol

Lee, Ha, Cho, An, Kim et al., Antiviral activity of furanocoumarins isolated from angelica dahurica against influenza a viruses H1N1 and H9N2, J Ethnopharmacol

Lee, Lee, Kim, Choi, Ahn et al., Angelica dahurica ameliorates the inflammation of gingival tissue via regulation of pro-inflammatory mediators in experimental model for periodontitis, J Ethnopharmacol

Li, Zhang, Wu, Zhao, The mechanism and clinical outcome of patients with corona virus disease 2019 whose nucleic acid test has changed from negative to positive, and the therapeutic efficacy of favipiravir: a structured summary of a study protocol for a randomised controlled trial, Trials

Liao, Ye, Gao, Liu, The main bioactive compounds of Scutellaria baicalensis Georgi. for alleviation of inflammatory cytokines: a comprehensive review, Biomed Pharmacother

Liu, Zhu, Zhang, Peng, Intravenous high-dose vitamin C for the treatment of severe COVID-19: study protocol for a multicentre randomised controlled trial, BMJ Open

Pan, Wang, Leu, Wu, Wu, Inhibitory effects of Scutellaria baicalensis extract on hepatic stellate cells through inducing G2/M cell cycle arrest and activating ERK-dependent apoptosis via Bax and caspase pathway, J Ethnopharmacol

Rabaan, Sh, Haque, Sah, Tiwari et al., SARS-CoV-2, SARS-CoV, and MERS-COV: a comparative overview, Infez Med

Yang, Islam, Wang, Traditional Chinese medicine in the treatment of patients infected with 2019-new coronavirus (SARS-CoV-2): a review and perspective, Int J Biol Sci

Zhang, Shao, Song, Xia, Yang et al., Protective effects of Forsythia suspense extract with antioxidant and anti-inflammatory properties in a model of rotenone induced neurotoxicity, Neurotoxicology

Zhang, Xu, Liu, Yuan, Mitochondrion-permeable antioxidants to treat ROSburst-mediated acute diseases, Oxid Med Cell Longev

Late treatment
is less effective

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