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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Recovery time, SD, S 33% Improvement Relative Risk Recovery time, SD, NS 45% Recovery time, SD, S, vs... 24% Recovery time, SD, NS, vs... 28% Recovery time, DR, S 27% Recovery time, DR, NS 23% Recovery time, DR, S, vs... 15% Recovery time, DR, NS, vs.. 15% Time to viral-, S 36% Time to viral-, NS 32% Time to viral-, S, vs. low d.. 14% Time to viral-, NS, vs. low.. 19% Vitamin C  Yang et al.  LATE TREATMENT  RCT Is late treatment with vitamin C + TCM beneficial for COVID-19? RCT 20 patients in China (February - February 2020) Faster recovery (p<0.0001) and viral clearance (p<0.0001) c19early.org Yang et al., Am. J. Transl. Res., January 2022 Favors vitamin C Favors control

Traditional Chinese medicine together with high-dose vitamin C improves the therapeutic effect of western medicine against COVID-19

Yang et al., Am. J. Transl. Res., 14:1, ChiCTR2000032717
Jan 2022  
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Vitamin C for COVID-19
7th treatment shown to reduce risk in September 2020
 
*, now known with p = 0.00000011 from 68 studies, recognized in 10 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,900+ studies for 60+ treatments. c19early.org
Prospective study of 60 patients in China with three arms: SOC, SOC+TCM, and SOC+TCM+high dose vitamin C, showing successively faster recovery with the addition of TCM and the addition of high dose vitamin C. TCM included inhaled vitamin C 10g, 3-7 times per day. IV vitamin C 10g/60kg twice a day, and oral vitamin C 3g three times a day. Group C vs. group A includes combined treatment with TCM, while group C vs. group B both include vitamin C (high vs. low dose).
This is the 11th of 19 COVID-19 RCTs for vitamin C, which collectively show efficacy with p=0.0021.
This is the 40th of 68 COVID-19 controlled studies for vitamin C, which collectively show efficacy with p=0.00000011.
This study is excluded in the after exclusion results of meta analysis: combined treatments may contribute significantly to the effect seen.
recovery time, 32.9% lower, relative time 0.67, p < 0.001, treatment mean 10.2 (±1.75) n=10, control mean 15.2 (±2.49) n=10, symptom disappearance, severe patients, group C vs. group A.
recovery time, 44.6% lower, relative time 0.55, p < 0.001, treatment mean 4.1 (±0.88) n=10, control mean 7.4 (±1.26) n=10, symptom disappearance, non-severe patients, group C vs. group A.
recovery time, 23.9% lower, relative time 0.76, p = 0.006, treatment mean 10.2 (±1.75) n=10, control mean 13.4 (±2.76) n=10, symptom disappearance, severe patients, group C vs. group B (high vs. low dose).
recovery time, 28.1% lower, relative time 0.72, p = 0.003, treatment mean 4.1 (±0.88) n=10, control mean 5.7 (±1.16) n=10, symptom disappearance, non-severe patients, group C vs. group B (high vs. low dose).
recovery time, 27.1% lower, relative time 0.73, p = 0.002, treatment mean 13.45 (±3.11) n=10, control mean 18.45 (±3.12) n=10, disease recovery, severe patients, group C vs. group A.
recovery time, 23.2% lower, relative time 0.77, p < 0.001, treatment mean 7.0 (±0.94) n=10, control mean 9.11 (±1.25) n=10, disease recovery, non-severe patients, group C vs. group A.
recovery time, 15.4% lower, relative time 0.85, p = 0.15, treatment mean 13.45 (±3.11) n=10, control mean 15.89 (±4.06) n=10, disease recovery, severe patients, group C vs. group B (high vs. low dose).
recovery time, 14.6% lower, relative time 0.85, p = 0.02, treatment mean 7.0 (±0.94) n=10, control mean 8.2 (±1.14) n=10, disease recovery, non-severe patients, group C vs. group B (high vs. low dose).
time to viral-, 35.8% lower, relative time 0.64, p < 0.001, treatment mean 9.7 (±1.49) n=10, control mean 15.1 (±2.38) n=10, severe patients, group C vs. group A.
time to viral-, 32.0% lower, relative time 0.68, p < 0.001, treatment mean 5.1 (±0.95) n=10, control mean 7.5 (±0.97) n=10, non-severe patients, group C vs. group A.
time to viral-, 14.2% lower, relative time 0.86, p = 0.25, treatment mean 9.7 (±1.49) n=10, control mean 11.3 (±4.03) n=10, severe patients, group C vs. group B (high vs. low dose).
time to viral-, 19.0% lower, relative time 0.81, p = 0.02, treatment mean 5.1 (±0.95) n=10, control mean 6.3 (±1.06) n=10, non-severe patients, group C vs. group B (high vs. low dose).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Yang et al., 15 Jan 2022, Randomized Controlled Trial, China, peer-reviewed, 11 authors, study period 1 February, 2020 - 29 February, 2020, this trial uses multiple treatments in the treatment arm (combined with TCM) - results of individual treatments may vary, trial ChiCTR2000032717.
This PaperVitamin CAll
Traditional Chinese medicine together with high-dose vitamin C improves the therapeutic effect of western medicine against COVID-19
Xudong Yang, Yali Wang, Yongping Liu, Lei Shang, Zhijian Cheng, Liping Fang, Jian Zhang, Yifan Feng, Kuiwei Zhang, Shanjiao Jiang, Xijing He
Objectives: Traditional Chinese medicine has been reported to be effective in the treatment of epidemic diseases. Here, we aimed to investigate the effects of combined therapy of Chinese and western medicine on coronavirus disease 2019 (COVID-19). Methods: A total of 60 patients diagnosed with COVID-19 were enrolled. Both the ordinary and severely affected patients were randomly divided into Groups A-C each with 10 cases each. The patients in Group A-C received Western medicine, Western medicine + traditional Chinese medicine, and Western medicine + traditional Chinese medicine + high dose of vitamin C, respectively. The time of disease recovery, symptoms disappearance, chest CT improvement, and tongue amelioration was recorded. Leukocyte, neutrophil and lymphocyte were monitored, as well as C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), procalitonin (PCT), inflammatory factors, partial pressure of oxygen and carbon dioxide (PaCO 2 ) and oxygenation index (PaO 2 ). Urinary tract stones, liver function, and other side-effects such as gastrointestinal dysfunction were also investigated. Results: Traditional Chinese medicine enhanced the effect of Western medicine, including the reduction of CRP, ESR, PCT, and inflammatory factors, and the increase of leukocyte, neutrophil, and lymphocyte counts, and the improvement of respiratory rate, PaO 2 , PaCO 2 , and oxygenation index. Traditional Chinese medicine combined with high-dose Vitamin C therapy more effectively shortened the time of disease recovery, symptom disappearance, chest CT improvement, and tongue amelioration. Conclusions: a combined therapy of Western medicine, traditional Chinese medicine, and high dose of Vitamin C results in a most effective outcome in the treatment of COVID-19.
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Late treatment
is less effective
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