The significance of oral ascorbic acid in patients with COVID-19

Patel et al., Chest Infections, doi:10.1016/j.chest.2020.08.322

Patel et al., The significance of oral ascorbic acid in patients with COVID-19, Chest Infections, doi:10.1016/j.chest.2020.08.322

Oct 2020 Source PDF

Twitter
Facebook

All Studies Meta

Retrospective 176 hospitalized patients, 96 treated with oral vitamin C (from 500mg to 1500mg daily), showing lower mortality with treatment.

Although the 29% lower mortality is not statistically significant, it is consistent with the significant 20% lower mortality [10‑29%] from meta analysis of the 36 mortality results to date.

This is the 4th of 61 COVID-19 controlled studies for vitamin C, which collectively show efficacy with p=0.00000098. 15 studies are RCTs, which show efficacy with p=0.00013.

Important missing comments or errors? Let us know.

risk of death, 29.5% lower, RR 0.71, p = 0.18, treatment 22 of 96 (22.9%), control 26 of 80 (32.5%), NNT 10.

risk of death, 15.6% lower, RR 0.84, p = 0.60, treatment 15 of 30 (50.0%), control 16 of 27 (59.3%), NNT 11, ICU patients.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Patel et al., 1 Oct 2020, retrospective, USA, peer-reviewed, 8 authors.

All Studies Meta Analysis Submit Updates or Corrections

This Paper Vitamin C All

THE SIGNIFICANCE OF ORAL ASCORBIC ACID IN PATIENTS WITH COVID-19

Manishkumar Patel, Gloria Hong, Bernadette Schmidt, Laith Al-Janabi, Radha Kishan Adusumilli, Jurgena Tusha, Padmini Giri, Sarwan Kumar

Chest, doi:10.1016/j.chest.2020.08.322

Our observational study showed even when ascorbic acid is administered in oral form as an adjunct to COVID-19 therapy, it is associated with a mortality benefit and improved extubation rate. DISCLOSURES: No relevant relationships by Radha Kishan Adusumilli, source¼Web Response No relevant relationships by Laith Al-janabi, source¼Web Response No relevant relationships by Padmini Giri, source¼Web Response No relevant relationships by Gloria Hong, source¼Web Response No relevant relationships by Sarwan Kumar, source¼Web Response No relevant relationships by Manishkumar Patel, source¼Web Response No relevant relationships by Bernadette Schmidt, source¼Web Response No relevant relationships by Jurgena Tusha, source¼Web Response

Late treatment
is less effective

Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.

Submit