Retrospective 176 hospitalized patients, 96 treated with oral vitamin C (from 500mg to 1500mg daily), showing lower mortality with treatment.
Although the 29% lower mortality is not statistically significant, it is consistent with the significant 20% lower mortality
[10‑28%] from meta analysis of the
46 mortality results to date.
, which show efficacy with
p=0.0012.
Standard of Care (SOC) for COVID-19 in the study country,
the USA, is
very poor with
very low average efficacy for approved treatments
1.
Only expensive, high-profit treatments were approved. Low-cost treatments were excluded, reducing the probability of treatment—especially early—due to access and cost barriers, and eliminating complementary and synergistic benefits seen with many low-cost treatments.
This may explain in part the very high mortality seen in this study.
Results may differ in countries with improved SOC.
|
risk of death, 29.5% lower, RR 0.71, p = 0.18, treatment 22 of 96 (22.9%), control 26 of 80 (32.5%), NNT 10.
|
|
risk of death, 15.6% lower, RR 0.84, p = 0.60, treatment 15 of 30 (50.0%), control 16 of 27 (59.3%), NNT 11, ICU patients.
|
|
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
|
Patel et al., 1 Oct 2020, retrospective, USA, peer-reviewed, 8 authors, dosage 1000mg days 1-4, 500mg to 1500mg daily.
THE SIGNIFICANCE OF ORAL ASCORBIC ACID IN PATIENTS WITH COVID-19
Manishkumar Patel, Gloria Hong, Bernadette Schmidt, Laith Al-Janabi, Radha Kishan Adusumilli, Jurgena Tusha, Padmini Giri, Sarwan Kumar
Chest, doi:10.1016/j.chest.2020.08.322
Our observational study showed even when ascorbic acid is administered in oral form as an adjunct to COVID-19 therapy, it is associated with a mortality benefit and improved extubation rate. DISCLOSURES: No relevant relationships by Radha Kishan Adusumilli, source¼Web Response No relevant relationships by Laith Al-janabi, source¼Web Response No relevant relationships by Padmini Giri, source¼Web Response No relevant relationships by Gloria Hong, source¼Web Response No relevant relationships by Sarwan Kumar, source¼Web Response No relevant relationships by Manishkumar Patel, source¼Web Response No relevant relationships by Bernadette Schmidt, source¼Web Response No relevant relationships by Jurgena Tusha, source¼Web Response
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