Abstract: Journal of Cellular & Molecular Anesthesia (JCMA) Short Communication Efficacy of High Dose Vitamin C, Melatonin and Zinc in Iranian Patients with Acute Respiratory Syndrome due to Coronavirus Infection: A Pilot Randomized Trial Mahboubeh Darban1 , Farhad Malek1 , Mohammad Memarian1 , Ali Gohari2 Emadi4 , Samaneh Lavvaf 4 , Bahador Bagheri 5,6* Abstract Background: We aimed to investigate the efficacy of high-dose vitamin C, melatonin, and zinc in patients with severe Covid-19. Materials and Methods: Twenty-one adult patients were randomized 1:1 to standard care alone or standard care plus IV vitamin C (2 g, q6hr), oral melatonin (6 mg, q6hr), and oral zinc sulfate (50 mg, q6hr) for 10 days. Patients were monitored for changes in hypoxemia and inflammatory markers. Results: Both treatment modalities were effective to improve PaO2/FiO2 and oxygen saturation. However, there were no significant differences between the 2 study groups (P>0.05). There were reductions in CRP, ESR, and LDH levels in both study groups, although were not significant. No significant difference was noted in the length of ICU stay between the 2 study groups (P=0.3). Conclusion: Our study suggests that the addition of vitamin C, melatonin, and zinc to standard care is not associated with considerable improvement in patients with severe Covid-19. Keywords: Covid-19, Vitamin C, Melatonin, ICU, Hypoxemia , Arda Kiani3 , Alireza 1. Department of Pulmonology, Kowsar Hospital, Semnan University of Medical Sciences, Semnan, Iran 2. Department of Infectious Diseases, Kowsar Hospital, Semnan University of Medical Sciences, Semnan, Iran 3. Department of Pulmonology, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran 4. Deputy of Research and Technology, Semnan University of Medical Sciences, Semnan, Iran 5. Cancer Research Center, Semnan University of Medical Sciences, Semnan, Iran 6. Department of Pharmacology, Semnan University of Medical Sciences, Semnan, Iran. *Corresponding Author: Bahador Bagheri, PhD. Cancer Research Center, Semnan University of Medical Sciences, Semnan, Iran. Email: bagherib@semums.ac.ir Tel: +982333448998 Fax: +98233344899 Please cite this article as: Darban M, Malek F, Memarian M, Gohari A, Kiani A, Emadi A, et al. Efficacy of High Dose Vitamin C, Melatonin and Zinc in Iranian Patients with Acute Respiratory Syndrome due to Coronavirus Infection: A Pilot Randomized Trial. J Cell Mol Anesth. 2021;6(2):164-7.DOI: https://doi.org/10.22037/jcma.v6i2.32182