Efficacy of High Dose Vitamin C, Melatonin and Zinc in Iranian Patients with Acute Respiratory Syndrome due to Coronavirus Infection: A Pilot Randomized Trial
Darban et al.,
Efficacy of High Dose Vitamin C, Melatonin and Zinc in Iranian Patients with Acute Respiratory Syndrome due to..,
Journal of Cellular & Molecular Anesthesia, doi:10.22037/jcma.v6i2.32182
Small RCT in Iran with 20 ICU patients, 10 treated with high-dose vitamin C, melatonin, and zinc, not showing significant differences. IRCT20151228025732N52.
risk of progression, 33.3% lower, RR 0.67, p = 1.00, treatment 2 of 10 (20.0%), control 3 of 10 (30.0%), NNT 10.
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ICU time, 6.0% lower, relative time 0.94, p = 0.30, treatment 10, control 10.
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Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
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Darban et al., 15 Dec 2020, Randomized Controlled Trial, Iran, peer-reviewed, 8 authors, this trial uses multiple treatments in the treatment arm (combined with melatonin and zinc) - results of individual treatments may vary.
Abstract: Journal of Cellular & Molecular Anesthesia (JCMA)
Short Communication
Efficacy of High Dose Vitamin C, Melatonin and Zinc in Iranian
Patients with Acute Respiratory Syndrome due to Coronavirus
Infection: A Pilot Randomized Trial
Mahboubeh Darban1
, Farhad Malek1 , Mohammad Memarian1 , Ali Gohari2
Emadi4 , Samaneh Lavvaf 4 , Bahador Bagheri 5,6*
Abstract
Background: We aimed to investigate the efficacy of high-dose vitamin C,
melatonin, and zinc in patients with severe Covid-19.
Materials and Methods: Twenty-one adult patients were randomized 1:1 to
standard care alone or standard care plus IV vitamin C (2 g, q6hr), oral
melatonin (6 mg, q6hr), and oral zinc sulfate (50 mg, q6hr) for 10 days.
Patients were monitored for changes in hypoxemia and inflammatory markers.
Results: Both treatment modalities were effective to improve PaO2/FiO2
and oxygen saturation. However, there were no significant differences
between the 2 study groups (P>0.05). There were reductions in CRP, ESR,
and LDH levels in both study groups, although were not significant. No
significant difference was noted in the length of ICU stay between the 2 study
groups (P=0.3).
Conclusion: Our study suggests that the addition of vitamin C, melatonin,
and zinc to standard care is not associated with considerable improvement in
patients with severe Covid-19.
Keywords: Covid-19, Vitamin C, Melatonin, ICU, Hypoxemia
, Arda Kiani3
, Alireza
1. Department of Pulmonology,
Kowsar Hospital, Semnan University
of Medical Sciences, Semnan, Iran
2. Department of Infectious Diseases,
Kowsar Hospital, Semnan University
of Medical Sciences, Semnan, Iran
3. Department of Pulmonology, Masih
Daneshvari Hospital, Shahid Beheshti
University of Medical Sciences,
Tehran, Iran
4. Deputy of Research and Technology,
Semnan University of Medical
Sciences, Semnan, Iran
5. Cancer Research Center, Semnan
University of Medical Sciences,
Semnan, Iran
6. Department of Pharmacology,
Semnan University of Medical
Sciences, Semnan, Iran.
*Corresponding Author: Bahador
Bagheri, PhD. Cancer Research Center,
Semnan University of Medical
Sciences, Semnan, Iran.
Email: bagherib@semums.ac.ir
Tel: +982333448998
Fax: +98233344899
Please cite this article as: Darban M, Malek F, Memarian M, Gohari A, Kiani A, Emadi A, et al. Efficacy of High Dose Vitamin C,
Melatonin and Zinc in Iranian Patients with Acute Respiratory Syndrome due to Coronavirus Infection: A Pilot Randomized Trial. J Cell Mol
Anesth. 2021;6(2):164-7.DOI: https://doi.org/10.22037/jcma.v6i2.32182
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