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Home   COVID-19 treatment studies for Vitamin C  COVID-19 treatment studies for Vitamin C  C19 studies: Vitamin C  Vitamin C   Select treatmentSelect treatmentTreatmentsTreatments
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0 0.5 1 1.5 2+ Progression 33% Improvement Relative Risk ICU time 6% c19early.org/c Darban et al. Vitamin C for COVID-19 RCT ICU PATIENTS Is very late treatment with vitamin C+melatonin and zinc beneficial for COVID-19? RCT 20 patients in Iran Trial underpowered to detect differences Darban et al., J. Cellular & Molecular Anesthesia, doi:10.22037/jcma.v6i2.32182 Favors vitamin C Favors control
Efficacy of High Dose Vitamin C, Melatonin and Zinc in Iranian Patients with Acute Respiratory Syndrome due to Coronavirus Infection: A Pilot Randomized Trial
Darban et al., Journal of Cellular & Molecular Anesthesia, doi:10.22037/jcma.v6i2.32182
Darban et al., Efficacy of High Dose Vitamin C, Melatonin and Zinc in Iranian Patients with Acute Respiratory Syndrome due to.., Journal of Cellular & Molecular Anesthesia, doi:10.22037/jcma.v6i2.32182
Dec 2020   Source   PDF  
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Small RCT in Iran with 20 ICU patients, 10 treated with high-dose vitamin C, melatonin, and zinc, not showing significant differences. IRCT20151228025732N52.
risk of progression, 33.3% lower, RR 0.67, p = 1.00, treatment 2 of 10 (20.0%), control 3 of 10 (30.0%), NNT 10.
ICU time, 6.0% lower, relative time 0.94, p = 0.30, treatment 10, control 10.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Darban et al., 15 Dec 2020, Randomized Controlled Trial, Iran, peer-reviewed, 8 authors, this trial uses multiple treatments in the treatment arm (combined with melatonin and zinc) - results of individual treatments may vary.
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Abstract: Journal of Cellular & Molecular Anesthesia (JCMA) Short Communication Efficacy of High Dose Vitamin C, Melatonin and Zinc in Iranian Patients with Acute Respiratory Syndrome due to Coronavirus Infection: A Pilot Randomized Trial Mahboubeh Darban1 , Farhad Malek1 , Mohammad Memarian1 , Ali Gohari2 Emadi4 , Samaneh Lavvaf 4 , Bahador Bagheri 5,6* Abstract Background: We aimed to investigate the efficacy of high-dose vitamin C, melatonin, and zinc in patients with severe Covid-19. Materials and Methods: Twenty-one adult patients were randomized 1:1 to standard care alone or standard care plus IV vitamin C (2 g, q6hr), oral melatonin (6 mg, q6hr), and oral zinc sulfate (50 mg, q6hr) for 10 days. Patients were monitored for changes in hypoxemia and inflammatory markers. Results: Both treatment modalities were effective to improve PaO2/FiO2 and oxygen saturation. However, there were no significant differences between the 2 study groups (P>0.05). There were reductions in CRP, ESR, and LDH levels in both study groups, although were not significant. No significant difference was noted in the length of ICU stay between the 2 study groups (P=0.3). Conclusion: Our study suggests that the addition of vitamin C, melatonin, and zinc to standard care is not associated with considerable improvement in patients with severe Covid-19. Keywords: Covid-19, Vitamin C, Melatonin, ICU, Hypoxemia , Arda Kiani3 , Alireza 1. Department of Pulmonology, Kowsar Hospital, Semnan University of Medical Sciences, Semnan, Iran 2. Department of Infectious Diseases, Kowsar Hospital, Semnan University of Medical Sciences, Semnan, Iran 3. Department of Pulmonology, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran 4. Deputy of Research and Technology, Semnan University of Medical Sciences, Semnan, Iran 5. Cancer Research Center, Semnan University of Medical Sciences, Semnan, Iran 6. Department of Pharmacology, Semnan University of Medical Sciences, Semnan, Iran. *Corresponding Author: Bahador Bagheri, PhD. Cancer Research Center, Semnan University of Medical Sciences, Semnan, Iran. Email: bagherib@semums.ac.ir Tel: +982333448998 Fax: +98233344899 Please cite this article as: Darban M, Malek F, Memarian M, Gohari A, Kiani A, Emadi A, et al. Efficacy of High Dose Vitamin C, Melatonin and Zinc in Iranian Patients with Acute Respiratory Syndrome due to Coronavirus Infection: A Pilot Randomized Trial. J Cell Mol Anesth. 2021;6(2):164-7.DOI: https://doi.org/10.22037/jcma.v6i2.32182
Late treatment
is less effective
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