Efficacy of High Dose Vitamin C, Melatonin and Zinc in Iranian Patients with Acute Respiratory Syndrome due to Coronavirus Infection: A Pilot Randomized Trial
Mahboubeh Darban, Farhad Mal, Mohammad Memari, Ali Goha, Arda Kiani, Alireza Emadi, Samaneh Lavvaf, Bahador Bagheri
doi:10.22037/jcma.v6i2.32182
Background: We aimed to investigate the efficacy of high-dose vitamin C, melatonin, and zinc in patients with severe Covid-19. Materials and Methods: Twenty-one adult patients were randomized 1:1 to standard care alone or standard care plus IV vitamin C (2 g, q6hr), oral melatonin (6 mg, q6hr), and oral zinc sulfate (50 mg, q6hr) for 10 days. Patients were monitored for changes in hypoxemia and inflammatory markers. Results: Both treatment modalities were effective to improve PaO2/FiO2 and oxygen saturation. However, there were no significant differences between the 2 study groups (P>0.05). There were reductions in CRP, ESR, and LDH levels in both study groups, although were not significant. No significant difference was noted in the length of ICU stay between the 2 study groups (P=0.3).
Conclusion: Our study suggests that the addition of vitamin C, melatonin, and zinc to standard care is not associated with considerable improvement in patients with severe Covid-19.
Conflicts of Interest The authors declare that they have no conflict of interest.
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DOI record:
{
"DOI": "10.22037/jcma.v6i2.32182",
"ISSN": "24765120, 25382462",
"URL": "https://doi.org/10.22037/jcma.v6i2.32182",
"abstract": "INTRODUCTION: Our aim was to investigate the efficacy of vitamin C, melatonin, and zinc in patients with severe Covid-19. METHODS: Twenty-one adult patients were randomized 1:1 to standard care alone or standard care plus IV vitamin C (2 g, q6hr), oral melatonin (6 mg, q6hr), and oral zinc sulfate (50 mg, q6hr) for 10 days. Patients were monitored for changes in hypoxemia and inflammatory markers. RESULTS: Both treatment modalities were effective to improve PaO2/FiO2 and oxygen saturation. However, there were no significant differences between 2 groups (P > 0.05). There were reductions in CRP, ESR, and LDH levels in both study groups, although not significant. No significant difference was noted in length of ICU stay between 2 groups (P = 0.3). CONCLUSION: Our study suggests that addition of vitamin C, melatonin, and zinc to standard care is not associated with considerable improvement in patients with severe Covid-19. ",
"author": [
{
"family": "Darban",
"given": "Mahboubeh"
},
{
"family": "Malek",
"given": "Farhad"
},
{
"family": "Memarian",
"given": "Mohammad"
},
{
"family": "Gohari",
"given": "Ali"
},
{
"family": "Kiani",
"given": "Arda"
},
{
"family": "Emadi",
"given": "Alireza"
},
{
"family": "Lavvaf",
"given": "Samaneh"
},
{
"family": "Bagheri",
"given": "Bahador"
}
],
"container-title": "Journal of Cellular & Molecular Anesthesia",
"issue": "2",
"issued": {
"date-parts": [
[
2020,
12,
15
]
]
},
"language": "eng",
"medium": "JB",
"page": "164-167",
"page-first": "164",
"publisher": "Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences",
"publisher-place": "IR",
"title": "Efficacy of High Dose Vitamin C, Melatonin and Zinc in Iranian Patients with Acute Respiratory Syndrome due to Coronavirus Infection: A Pilot Randomized Trial",
"type": "article-journal",
"volume": "6"
}
