Efficacy of diammonium glycyrrhizinate combined with vitamin C for treating hospitalized 2 COVID-19 patients: a retrospective, observational study 3 4
Ruoming Tan, Xiaogang Xiang, Wei Chen, Zhitao Yang, Weiguo Hu, Hongping Qu, Liu
doi:10.1093/qjmed/hcab184/6329274
Aims: To observe the effect of combination treatment of giammonium glycyrrhizinate and vitamin 36 C (DV)on the prognoses of patients with COVID-19. 37 Methods: This retrospective observational study recruited 207 COVID-19 patients from Tongji 38 Hospital，patients were assigned to DV and non-DV groups on the basis of the DV treatment. To 39 make the results more credible, a propensity-score matching (PSM) approach was adopted at a 1:3 40 ratio to determine the participants. Logistic analysis was used to assess the effect of DV therapy in 41 the progress of COVID-19. 42 Results: In the DV group, the new onset incidence rate of acute respiratory distress syndrome 43 (ARDS) after admission was clearly lower than that in the non-DV group (DV vs non-DV groups, 44 15.2% vs 35.7%; P=0.002). Compared with the non-DV group, the DV group showed fewer new 45 onset of complications (such as ARDS, acute liver injury and acute myocardial injury) (DV vs non-46 DV groups,19.6% vs 46.1%; P=0.000). Moreover, DG+VC may help to recover the count of NK 47 cells and decrease the level of sIL-2R. 48 Conclusions: DG+VC might be a promising candidate for preventing the deterioration of COVID-49 19 patients, which is worthy to be studied in large and perspective cohort. 50
Authors' contributions
300 LJL and HPQ contributed to study concept and design. RMT and XGX contributed to the literature
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'abstract': '<jats:title>Summary</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>The '
'current global coronavirus disease 2019 (COVID-19) pandemic caused by severe acute '
'respiratory syndrome coronavirus 2 (SARS-CoV-2) has shown limited responses to medical '
'treatments.</jats:p></jats:sec><jats:sec><jats:title>Aims</jats:title><jats:p>To observe the '
'effect of combination treatment of giammonium glycyrrhizinate and vitamin C (DV) on the '
'prognoses of patients with '
'COVID-19.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This '
'retrospective observational study recruited 207 COVID-19 patients from Tongji Hospital, '
'patients were assigned to DV and non-DV groups on the basis of the DV treatment. To make the '
'results more credible, a propensity score matching (PSM) approach was adopted at a 1:3 ratio '
'to determine the participants. Logistic analysis was used to assess the effect of DV therapy '
'in the progress of '
'COVID-19.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>In the DV '
'group, the new-onset incidence rate of acute respiratory distress syndrome (ARDS) after '
'admission was clearly lower than that in the non-DV group (DV vs. non-DV groups, 15.2% vs. '
'35.7%; P\u2009=\u20090.002). Compared with the non-DV group, the DV group showed fewer new '
'onset of complications (such as ARDS, acute liver injury and acute myocardial injury) (DV vs. '
'non-DV groups, 19.6% vs. 46.1%; P\u2009=\u20090.000). Moreover, DG+VC may help to recover the '
'count of NK cells and decrease the level of '
'sIL-2R.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>DG+VC might '
'be a promising candidate for preventing the deterioration of COVID-19 patients, which is '
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