Efficacy of diammonium glycyrrhizinate combined with vitamin C for treating hospitalized COVID-19 patients: a retrospective, observational study

{ 'indexed': {'date-parts': [[2023, 11, 7]], 'date-time': '2023-11-07T00:35:24Z', 'timestamp': 1699317324792}, 'reference-count': 24, 'publisher': 'Oxford University Press (OUP)', 'issue': '2', 'license': [ { 'start': { 'date-parts': [[2021, 7, 27]], 'date-time': '2021-07-27T00:00:00Z', 'timestamp': 1627344000000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model'}], 'funder': [ { 'name': 'Medical-engineering Cross Foundation of Shanghai Jiao Tong University', 'award': ['YG2020YQ30']}, { 'name': 'Three-year Plan For Developing a Public Health System of Shanghai, Talent Training', 'award': ['GWV-10.2-XD03']}, { 'DOI': '10.13039/501100001809', 'name': 'National Natural Science Foundation of China', 'doi-asserted-by': 'publisher', 'award': ['81770005', '81970005']}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'published-print': {'date-parts': [[2022, 2, 21]]}, 'abstract': '<jats:title>Summary</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>The ' 'current global coronavirus disease 2019 (COVID-19) pandemic caused by severe acute ' 'respiratory syndrome coronavirus 2 (SARS-CoV-2) has shown limited responses to medical ' 'treatments.</jats:p></jats:sec><jats:sec><jats:title>Aims</jats:title><jats:p>To observe the ' 'effect of combination treatment of giammonium glycyrrhizinate and vitamin C (DV) on the ' 'prognoses of patients with ' 'COVID-19.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This ' 'retrospective observational study recruited 207 COVID-19 patients from Tongji Hospital, ' 'patients were assigned to DV and non-DV groups on the basis of the DV treatment. To make the ' 'results more credible, a propensity score matching (PSM) approach was adopted at a 1:3 ratio ' 'to determine the participants. Logistic analysis was used to assess the effect of DV therapy ' 'in the progress of ' 'COVID-19.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>In the DV ' 'group, the new-onset incidence rate of acute respiratory distress syndrome (ARDS) after ' 'admission was clearly lower than that in the non-DV group (DV vs. non-DV groups, 15.2% vs. ' '35.7%; P\u2009=\u20090.002). Compared with the non-DV group, the DV group showed fewer new ' 'onset of complications (such as ARDS, acute liver injury and acute myocardial injury) (DV vs. ' 'non-DV groups, 19.6% vs. 46.1%; P\u2009=\u20090.000). Moreover, DG+VC may help to recover the ' 'count of NK cells and decrease the level of ' 'sIL-2R.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>DG+VC might ' 'be a promising candidate for preventing the deterioration of COVID-19 patients, which is ' 'worthy to be studied in large and perspective cohort.</jats:p></jats:sec>', 'DOI': '10.1093/qjmed/hcab184', 'type': 'journal-article', 'created': {'date-parts': [[2021, 7, 23]], 'date-time': '2021-07-23T11:11:31Z', 'timestamp': 1627038691000}, 'page': '77-83', 'source': 'Crossref', 'is-referenced-by-count': 7, 'title': 'Efficacy of diammonium glycyrrhizinate combined with vitamin C for treating hospitalized ' 'COVID-19 patients: a retrospective, observational study', 'prefix': '10.1093', 'volume': '115', 'author': [ { 'given': 'R', 'family': 'Tan', 'sequence': 'first', 'affiliation': [ { 'name': 'From the Department of Critical Care Medicine, Ruijin Hospital, ' 'Shanghai Jiao Tong University School of Medicine, Shanghai ' '200025, China'}]}, { 'given': 'X', 'family': 'Xiang', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Infectious Diseases, Ruijin Hospital, Shanghai ' 'Jiao Tong University School of Medicine, Shanghai 200025, ' 'China'}]}, { 'given': 'W', 'family': 'Chen', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Pulmonary and Critical Care Medicine, Ruijin ' 'Hospital, Shanghai Jiao Tong University School of Medicine, ' 'Shanghai 200025, China'}]}, { 'given': 'Z', 'family': 'Yang', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong ' 'University School of Medicine, Shanghai 200025, China'}]}, { 'given': 'W', 'family': 'Hu', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong ' 'University School of Medicine, Shanghai 200025, China'}]}, { 'given': 'H', 'family': 'Qu', 'sequence': 'additional', 'affiliation': [ { 'name': 'From the Department of Critical Care Medicine, Ruijin Hospital, ' 'Shanghai Jiao Tong University School of Medicine, Shanghai ' '200025, China'}]}, { 'given': 'J', 'family': 'Liu', 'sequence': 'additional', 'affiliation': [ { 'name': 'From the Department of Critical Care Medicine, Ruijin Hospital, ' 'Shanghai Jiao Tong University School of Medicine, Shanghai ' '200025, China'}]}], 'member': '286', 'published-online': {'date-parts': [[2021, 7, 27]]}, 'reference': [ { 'key': '2022022115094689500_hcab184-B1', 'doi-asserted-by': 'crossref', 'first-page': '113', 'DOI': '10.1038/s41586-020-2577-1', 'article-title': 'Discovery of SARS-CoV-2 antiviral drugs through large-scale compound ' 'repurposing', 'volume': '586', 'author': 'Riva', 'year': '2020', 'journal-title': 'Nature'}, { 'key': '2022022115094689500_hcab184-B2', 'doi-asserted-by': 'crossref', 'first-page': '497', 'DOI': '10.1016/S0140-6736(20)30183-5', 'article-title': 'Clinical features of patients infected with 2019 novel coronavirus in ' 'Wuhan, China', 'volume': '395', 'author': 'Huang', 'year': '2020', 'journal-title': 'Lancet'}, { 'key': '2022022115094689500_hcab184-B3', 'doi-asserted-by': 'crossref', 'first-page': '1161', 'DOI': '10.1093/bib/bbaa141', 'article-title': 'Integrative pharmacological mechanism of vitamin C combined with ' 'glycyrrhizic acid against COVID-19: findings of bioinformatics analyses', 'volume': '22', 'author': 'Li', 'year': '2020', 'journal-title': 'Brief Bioinform'}, { 'key': '2022022115094689500_hcab184-B4', 'doi-asserted-by': 'crossref', 'first-page': '105995', 'DOI': '10.1016/j.ijantimicag.2020.105995', 'article-title': 'Pharmacological perspective: glycyrrhizin may be an efficacious ' 'therapeutic agent for COVID-19', 'volume': '55', 'author': 'Luo', 'year': '2020', 'journal-title': 'Int J Antimicrob Agents'}, { 'key': '2022022115094689500_hcab184-B5', 'doi-asserted-by': 'crossref', 'first-page': '107618', 'DOI': '10.1016/j.pharmthera.2020.107618', 'article-title': 'Glycyrrhizin: an alternative drug for the treatment of COVID-19 ' 'infection and the associated respiratory syndrome?', 'volume': '214', 'author': 'Bailly', 'year': '2020', 'journal-title': 'Pharmacol Ther'}, { 'key': '2022022115094689500_hcab184-B6', 'doi-asserted-by': 'crossref', 'first-page': '210', 'DOI': '10.1016/j.phrs.2019.04.025', 'article-title': 'Natural products in licorice for the therapy of liver diseases: ' 'progress and future opportunities', 'volume': '144', 'author': 'Li', 'year': '2019', 'journal-title': 'Pharmacol Res'}, { 'key': '2022022115094689500_hcab184-B7', 'doi-asserted-by': 'crossref', 'first-page': '3760', 'DOI': '10.3390/nu12123760', 'article-title': 'Vitamin C-an adjunctive therapy for respiratory infection, sepsis and ' 'COVID-19', 'volume': '12', 'author': 'Holford', 'year': '2020', 'journal-title': 'Nutrients'}, { 'key': '2022022115094689500_hcab184-B8', 'doi-asserted-by': 'crossref', 'first-page': '99', 'DOI': '10.1080/14787210.2020.1706483', 'article-title': 'The antiviral properties of vitamin C', 'volume': '18', 'author': 'Colunga Biancatelli', 'year': '2020', 'journal-title': 'Expert Rev Anti Infect Ther'}, { 'key': '2022022115094689500_hcab184-B9', 'doi-asserted-by': 'crossref', 'first-page': '5', 'DOI': '10.1186/s13613-020-00792-3', 'article-title': 'Pilot trial of high-dose vitamin C in critically ill COVID-19 patients', 'volume': '11', 'author': 'Zhang', 'year': '2021', 'journal-title': 'Ann Intensive Care'}, { 'key': '2022022115094689500_hcab184-B10', 'doi-asserted-by': 'crossref', 'first-page': 'e620', 'DOI': '10.1097/CCM.0000000000004396', 'article-title': 'Harm of IV high-dose vitamin C therapy in adult patients: a scoping ' 'review', 'volume': '48', 'author': 'Yanase', 'year': '2020', 'journal-title': 'Crit Care Med'}, { 'key': '2022022115094689500_hcab184-B11', 'first-page': '2526', 'article-title': 'Acute respiratory distress syndrome: the Berlin Definition', 'volume': '307', 'author': 'Force', 'year': '2012', 'journal-title': 'JAMA'}, { 'key': '2022022115094689500_hcab184-B12', 'doi-asserted-by': 'crossref', 'first-page': '18', 'DOI': '10.1038/ajg.2016.517', 'article-title': 'ACG clinical guideline: evaluation of abnormal liver chemistries', 'volume': '112', 'author': 'Kwo', 'year': '2017', 'journal-title': 'Am J Gastroenterol'}, { 'key': '2022022115094689500_hcab184-B13', 'doi-asserted-by': 'crossref', 'first-page': '801', 'DOI': '10.1001/jama.2016.0287', 'article-title': 'The Third International Consensus Definitions for Sepsis and Septic ' 'Shock (Sepsis-3)', 'volume': '315', 'author': 'Singer', 'year': '2016', 'journal-title': 'JAMA'}, { 'key': '2022022115094689500_hcab184-B14', 'doi-asserted-by': 'crossref', 'first-page': '1339', 'DOI': '10.1007/s00134-020-06153-9', 'article-title': 'Acute kidney injury in critically ill patients with COVID-19', 'volume': '46', 'author': 'Gabarre', 'year': '2020', 'journal-title': 'Intensive Care Med'}, { 'key': '2022022115094689500_hcab184-B15', 'doi-asserted-by': 'crossref', 'first-page': '934', 'DOI': '10.1001/jamainternmed.2020.0994', 'article-title': 'risk factors associated with acute respiratory distress syndrome and ' 'death in patients with coronavirus disease 2019 pneumonia in Wuhan, ' 'China', 'volume': '180', 'author': 'Wu', 'year': '2020', 'journal-title': 'JAMA Intern Med'}, { 'key': '2022022115094689500_hcab184-B16', 'doi-asserted-by': 'crossref', 'first-page': '1054', 'DOI': '10.1016/S0140-6736(20)30566-3', 'article-title': 'Clinical course and risk factors for mortality of adult inpatients with ' 'COVID-19 in Wuhan, China: a retrospective cohort study', 'volume': '395', 'author': 'Zhou', 'year': '2020', 'journal-title': 'Lancet'}, { 'key': '2022022115094689500_hcab184-B17', 'doi-asserted-by': 'crossref', 'first-page': '2000524', 'DOI': '10.1183/13993003.00524-2020', 'article-title': 'Predictors of mortality for patients with COVID-19 pneumonia caused by ' 'SARS-CoV-2: a prospective cohort study', 'volume': '55', 'author': 'Du', 'year': '2020', 'journal-title': 'Eur Respir J'}, { 'key': '2022022115094689500_hcab184-B18', 'doi-asserted-by': 'crossref', 'first-page': '57', 'DOI': '10.1038/s41392-020-0158-2', 'article-title': 'A retrospective cohort study of methylprednisolone therapy in severe ' 'patients with COVID-19 pneumonia', 'volume': '5', 'author': 'Wang', 'year': '2020', 'journal-title': 'Signal Transduct Target Ther'}, { 'key': '2022022115094689500_hcab184-B19', 'doi-asserted-by': 'crossref', 'first-page': '102559', 'DOI': '10.1016/j.autrev.2020.102559', 'article-title': 'SARS-CoV-2 infection complicated by inflammatory syndrome. Could ' 'high-dose human immunoglobulin for intravenous use (IVIG) be ' 'beneficial?', 'volume': '19', 'author': 'Prete', 'year': '2020', 'journal-title': 'Autoimmun Rev'}, { 'key': '2022022115094689500_hcab184-B20', 'doi-asserted-by': 'crossref', 'first-page': '507', 'DOI': '10.1016/S0140-6736(20)30211-7', 'article-title': 'Epidemiological and clinical characteristics of 99 cases of 2019 novel ' 'coronavirus pneumonia in Wuhan, China: a descriptive study', 'volume': '395', 'author': 'Chen', 'year': '2020', 'journal-title': 'Lancet'}, { 'key': '2022022115094689500_hcab184-B21', 'doi-asserted-by': 'crossref', 'first-page': '522', 'DOI': '10.1186/s13054-020-03249-y', 'article-title': 'Vitamin C levels in patients with SARS-CoV-2-associated acute ' 'respiratory distress syndrome', 'volume': '24', 'author': 'Chiscano-Camón', 'year': '2020', 'journal-title': 'Crit Care'}, { 'key': '2022022115094689500_hcab184-B22', 'doi-asserted-by': 'crossref', 'first-page': '1259', 'DOI': '10.1080/14787210.2020.1794819', 'article-title': 'The use of IV vitamin C for patients with COVID-19: a case series', 'volume': '18', 'author': 'Hiedra', 'year': '2020', 'journal-title': 'Expert Rev Anti Infect Ther'}, { 'key': '2022022115094689500_hcab184-B23', 'doi-asserted-by': 'crossref', 'first-page': '2200', 'DOI': '10.1002/jmv.26064', 'article-title': 'Glycyrrhetinic acid and its derivatives as potential alternative ' 'medicine to relieve symptoms in nonhospitalized COVID-19 patients', 'volume': '92', 'author': 'Ding', 'year': '2020', 'journal-title': 'J Med Virol'}, { 'key': '2022022115094689500_hcab184-B24', 'doi-asserted-by': 'crossref', 'first-page': '1193', 'DOI': '10.3390/nu12041193', 'article-title': 'A novel combination of vitamin C, curcumin and glycyrrhizic acid ' 'potentially regulates immune and inflammatory response associated with ' 'coronavirus infections: a perspective from system biology analysis', 'volume': '12', 'author': 'Chen', 'year': '2020', 'journal-title': 'Nutrients'}], 'container-title': 'QJM: An International Journal of Medicine', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'http://academic.oup.com/qjmed/advance-article-pdf/doi/10.1093/qjmed/hcab184/40664592/hcab184.pdf', 'content-type': 'application/pdf', 'content-version': 'am', 'intended-application': 'syndication'}, { 'URL': 'https://academic.oup.com/qjmed/article-pdf/115/2/77/42568425/hcab184.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'syndication'}, { 'URL': 'https://academic.oup.com/qjmed/article-pdf/115/2/77/42568425/hcab184.pdf', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2023, 11, 6]], 'date-time': '2023-11-06T11:18:07Z', 'timestamp': 1699269487000}, 'score': 1, 'resource': {'primary': {'URL': 'https://academic.oup.com/qjmed/article/115/2/77/6329274'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2021, 7, 27]]}, 'references-count': 24, 'journal-issue': { 'issue': '2', 'published-online': {'date-parts': [[2021, 7, 27]]}, 'published-print': {'date-parts': [[2022, 2, 21]]}}, 'URL': 'http://dx.doi.org/10.1093/qjmed/hcab184', 'relation': {}, 'ISSN': ['1460-2725', '1460-2393'], 'subject': ['General Medicine'], 'published-other': {'date-parts': [[2022, 2, 1]]}, 'published': {'date-parts': [[2021, 7, 27]]}}