Efficacy of diammonium glycyrrhizinate combined with vitamin C for treating hospitalized COVID-19 patients: a retrospective, observational study

DOI record: { "DOI": "10.1093/qjmed/hcab184", "ISSN": [ "1460-2725", "1460-2393" ], "URL": "http://dx.doi.org/10.1093/qjmed/hcab184", "abstract": "<jats:title>Summary</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>The current global coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has shown limited responses to medical treatments.</jats:p></jats:sec><jats:sec><jats:title>Aims</jats:title><jats:p>To observe the effect of combination treatment of giammonium glycyrrhizinate and vitamin C (DV) on the prognoses of patients with COVID-19.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This retrospective observational study recruited 207 COVID-19 patients from Tongji Hospital, patients were assigned to DV and non-DV groups on the basis of the DV treatment. To make the results more credible, a propensity score matching (PSM) approach was adopted at a 1:3 ratio to determine the participants. Logistic analysis was used to assess the effect of DV therapy in the progress of COVID-19.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>In the DV group, the new-onset incidence rate of acute respiratory distress syndrome (ARDS) after admission was clearly lower than that in the non-DV group (DV vs. non-DV groups, 15.2% vs. 35.7%; P = 0.002). Compared with the non-DV group, the DV group showed fewer new onset of complications (such as ARDS, acute liver injury and acute myocardial injury) (DV vs. non-DV groups, 19.6% vs. 46.1%; P = 0.000). Moreover, DG+VC may help to recover the count of NK cells and decrease the level of sIL-2R.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>DG+VC might be a promising candidate for preventing the deterioration of COVID-19 patients, which is worthy to be studied in large and perspective cohort.</jats:p></jats:sec>", "author": [ { "affiliation": [ { "name": "From the Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China" } ], "family": "Tan", "given": "R", "sequence": "first" }, { "affiliation": [ { "name": "Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China" } ], "family": "Xiang", "given": "X", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China" } ], "family": "Chen", "given": "W", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China" } ], "family": "Yang", "given": "Z", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China" } ], "family": "Hu", "given": "W", "sequence": "additional" }, { "affiliation": [ { "name": "From the Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China" } ], "family": "Qu", "given": "H", "sequence": "additional" }, { "affiliation": [ { "name": "From the Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China" } ], "family": "Liu", "given": "J", "sequence": "additional" } ], "container-title": "QJM: An International Journal of Medicine", 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