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Home   COVID-19 treatment studies for Vitamin C  COVID-19 treatment studies for Vitamin C  C19 studies: Vitamin C  Vitamin C   Select treatmentSelect treatmentTreatmentsTreatments
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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Progression 5% Improvement Relative Risk Improvement 50% Discharge 22% c19early.org/c Coppock et al. Vitamin C for COVID-19 RCT LATE TREATMENT Favors vitamin C Favors control
Pharmacologic Ascorbic Acid as Early Therapy for Hospitalized Patients with COVID-19: A Randomized Clinical Trial
Coppock et al., Life, doi:10.3390/life12030453
19 Mar 2022    Source   PDF   Share   Tweet
RCT with 66 very late stage (8 days from symptom onset) hospitalized patients, 44 treated with vitamin C and 22 control patients, showing no significant differences with treatment.
risk of progression, 5.0% lower, HR 0.95, p = 0.64, treatment 4 of 44 (9.1%), control 2 of 22 (9.1%), adjusted per study, within 36 hours.
risk of no improvement, 49.7% better, RR 0.50, p = 0.16, treatment 6 of 44 (13.6%), control 6 of 22 (27.3%), NNT 7.3, adjusted per study, inverted to make RR<1 favor treatment, odds ratio converted to relative risk, within 36 hours.
risk of no hospital discharge, 22.5% lower, RR 0.78, p = 0.07, treatment 31 of 44 (70.5%), control 20 of 22 (90.9%), NNT 4.9, within 36 hours.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Coppock et al., 19 Mar 2022, Randomized Controlled Trial, USA, peer-reviewed, 14 authors, average treatment delay 8.1 days.
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This PaperVitamin CAll
Late treatment
is less effective
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