Role of ivermectin in the prevention of SARS-CoV-2 infection among healthcare workers in India: A matched case-control study
et al., PLoS ONE, doi:10.1371/journal.pone.0247163 (date from earlier preprint)
, Role of ivermectin in the prevention of SARS-CoV-2 infection among healthcare workers in India: A matched.., PLoS ONE, doi:10.1371/journal.pone.0247163 (date from earlier preprint)
Retrospective matched case-control prophylaxis study for HCQ, ivermectin, and vitamin C with 372 healthcare workers, showing lower COVID-19 incidence for all treatments, with statistical significance reached for ivermectin.HCQ OR 0.56, p = 0.29
Ivermectin OR 0.27, p < 0.001
Vitamin C OR 0.82, p = 0.58This is the 5th of 61 COVID-19 controlled studies for vitamin C, which collectively show efficacy with p=0.00000098. 15 studies are RCTs, which show efficacy with p=0.00013.
Ivermectin OR 0.27, p < 0.001
Vitamin C OR 0.82, p = 0.58This is the 5th of 61 COVID-19 controlled studies for vitamin C, which collectively show efficacy with p=0.00000098. 15 studies are RCTs, which show efficacy with p=0.00013.
This study includes vitamin C, ivermectin, and HCQ.
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risk of case, 18.0% lower, OR 0.82, p = 0.58, treatment 29 of 67 (43.3%) cases,
38 of 148 (25.7%) controls, adjusted per study, case control OR, model 2 conditional logistic regression.
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risk of case, 29.0% lower, OR 0.71, p = 0.24, treatment 29 of 67 (43.3%) cases,
38 of 148 (25.7%) controls, adjusted per study, case control OR, matched pair analysis.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Behera et al., 3 Nov 2020, retrospective, India, peer-reviewed, 13 authors.
Role of ivermectin in the prevention of SARS-CoV-2 infection among healthcare workers in India: A matched case-control study
PLOS ONE, doi:10.1371/journal.pone.0247163
Background Ivermectin is one among several potential drugs explored for its therapeutic and preventive role in SARS-CoV-2 infection. The study was aimed to explore the association between ivermectin prophylaxis and the development of SARS-CoV-2 infection among healthcare workers.
Methods A hospital-based matched case-control study was conducted among healthcare workers of AIIMS Bhubaneswar, India, from September to October 2020. Profession, gender, age and date of diagnosis were matched for 186 case-control pairs. Cases and controls were healthcare workers who tested positive and negative, respectively, for COVID-19 by RT-PCR. Exposure was defined as the intake of ivermectin and/or hydroxychloroquine and/or vitamin-C and/or other prophylaxis for COVID-19. Data collection and entry was done in Epicol-lect5, and analysis was performed using STATA version 13. Conditional logistic regression models were used to describe the associated factors for SARS-CoV-2 infection.
Results Ivermectin prophylaxis was taken by 76 controls and 41 cases. Two-dose ivermectin prophylaxis (AOR 0.27, 95% CI, 0.15-0.51) was associated with a 73% reduction of SARS-CoV-2 infection among healthcare workers for the following month. Those involved in physical activity (AOR 3.06 95% CI, 1.18-7.93) for more than an hour/day were more likely to contract SARS-CoV-2 infection. Type of household, COVID duty, single-dose ivermectin
Supporting information S1 Appendix. Questionnaire used in the study (English and Odia language). (PDF)
S1 Protocol. Study protocol. (DOC)
Author Contributions
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