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Vitamin C as prophylaxis and adjunctive medical treatment for COVID-19?

Feyaerts et al., Nutrition, doi:10.1016/j.nut.2020.110948
Jul 2020  
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Vitamin C for COVID-19
6th treatment shown to reduce risk in September 2020
*, now known with p = 0.000000087 from 70 studies, recognized in 11 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments.
Review concluding that there is clear evidence that vitamin C in high doses can reduce interleukin-6 and endothelin-1 mediators. Authors suggest a relatively low dose as prophylaxis, and in cases of severe COVID-19, an (intravenous) high-dose regimen may be beneficial.
Reviews covering vitamin C for COVID-19 include Arora, Biancatelli, Feyaerts, Foshati, Hemilä, Hemilä (B), Holford, May, Schloss, Yamasaki.
Feyaerts et al., 25 Jul 2020, peer-reviewed, 2 authors.
This PaperVitamin CAll
Vitamin C as prophylaxis and adjunctive medical treatment for COVID-19?
Ph.D Adam F Feyaerts, Ph.D Walter Luyten
Nutrition, doi:10.1016/j.nut.2020.110948
Severe acute respiratory syndrome coronavirus 2 causes the potentially fatal coronavirus disease 2019 . Already during the outbreak of the severe acute respiratory syndrome coronavirus 1, the use of vitamin C was suggested. Many patients with severe COVID-19 have elevated levels of the mediators interleukin-6 and endothelin-1. These mediators may explain the age dependence of COVID-19 pneumonia, the preponderance of male and obese or hypertensive patients, as well as of persons of color and smokers. There is clear evidence that vitamin C in high doses can reduce these mediators. Vitamin C is cheap and safe. Hence, using a relatively low dose of vitamin C as prophylaxis, and in cases of severe COVID-19, an (intravenous) high-dose regimen may be beneficial. Ongoing clinical trials are expected to provide more definitive evidence.
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