Analgesics
Antiandrogens
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Abstract
All vitamin C studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchVitamin CVitamin C (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

Therapeutic potential of megadose vitamin C to reverse organ dysfunction in sepsis and COVID-19

May et al., British Journal of Pharmacology, doi:10.1111/bph.15579
Jun 2021  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Vitamin C for COVID-19
7th treatment shown to reduce risk in September 2020
 
*, now known with p = 0.000000098 from 67 studies, recognized in 10 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments. c19early.org
Review of data supporting the use of megadose vitamin C as a treatment for sepsis and COVID-19.
Reviews covering vitamin C for COVID-19 include Arora, Biancatelli, Feyaerts, Foshati, Hemilä, Hemilä (B), Holford, May, Schloss, Yamasaki.
May et al., 1 Jun 2021, peer-reviewed, 3 authors.
This PaperVitamin CAll
Therapeutic potential of megadose vitamin C to reverse organ dysfunction in sepsis and COVID‐19
Clive N May, Rinaldo Bellomo, Yugeesh R Lankadeva
British Journal of Pharmacology, doi:10.1111/bph.15579
Sepsis induced by bacteria or viruses can result in multiorgan dysfunction, which is a major cause of death in intensive care units. Current treatments are only supportive, and there are no treatments that reverse the pathophysiological effects of sepsis. Vitamin C has antioxidant, anti-inflammatory, anticoagulant and immune modulatory actions, so it is a rational treatment for sepsis. Here, we summarise data that support the use of megadose vitamin C as a treatment for sepsis and COVID-19. Megadose intravenous sodium ascorbate (150 g per 40 kg over 7 h) dramatically improved the clinical state and cardiovascular, pulmonary, hepatic and renal function and decreased body temperature, in a clinically relevant ovine model of Gram-negative bacteriainduced sepsis. In a critically ill COVID-19 patient, intravenous sodium ascorbate (60 g) restored arterial pressure, improved renal function and increased arterial blood oxygen levels. These findings suggest that megadose vitamin C should be trialled as a treatment for sepsis and COVID-19.
CONFLICT OF INTEREST YRL, RB and CNM have a provisional patent on vitamin C use in sepsis (2020901120).
References
Alexander, Fabbro, Kelly, Mathie, Peters et al., The concise guide to PHARMACOLOGY 2019/20: Catalytic receptors, British Journal of Pharmacology, doi:10.1111/bph.14751
Alexander, Fabbro, Kelly, Mathie, Peters et al., The concise guide to PHARMACOLOGY 2019/20: Enzymes, British Journal of Pharmacology, doi:10.1111/bph.14752
Alexander, Kelly, Mathie, Peters, Veale et al., The concise guide to PHARMACOLOGY 2019/20: Transporters, British Journal of Pharmacology, doi:10.1111/bph.14753
Annane, Bellissant, Sebille, Lesieur, Mathieu et al., Impaired pressor sensitivity to noradrenaline in septic shock patients with and without impaired adrenal function reserve, British Journal of Clinical Pharmacology, doi:10.1046/j.1365-2125.1998.00833.x
Bellomo, Baldwin, Ronco, Kellum, ICU-based renal replacement therapy, Critical Care Medicine, doi:10.1097/CCM.0000000000004831
Calzavacca, Evans, Bailey, Bellomo, May, Cortical and medullary tissue perfusion and oxygenation in experimental septic acute kidney injury, Critical Care Medicine, doi:10.1097/CCM.0000000000001198
Chen, Espey, Sun, Pooput, Kirk et al., Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice, Proceedings of the National Academy of Sciences of the United States of America, doi:10.1073/pnas.0804226105
Chertoff, N-Acetylcysteine's role in sepsis and potential benefit in patients with microcirculatory derangements, Journal of Intensive Care Medicine, doi:10.1177/0885066617696850
Chiscano-Camon, Ruiz-Rodriguez, Ruiz-Sanmartin, Roca, Ferrer, Vitamin C levels in patients with SARS-CoV-2-associated acute respiratory distress syndrome, Critical Care, doi:10.1186/s13054-020-03249-y
Fowler, Syed, Knowlson, Sculthorpe, Farthing et al., Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis, Journal of Translational Medicine, doi:10.1186/1479-5876-12-32
Fowler, Truwit, Hite, Morris, Dewilde et al., Effect of vitamin C infusion on organ failure and biomarkers of inflammation and vascular injury in patients with sepsis and severe acute respiratory failure: The CITRIS-ALI randomized clinical trial, JAMA: The Journal of the American Medical Association, doi:10.1001/jama.2019.11825
Fujii, Luethi, Young, Frei, Eastwood et al., Effect of vitamin C, hydrocortisone, and thiamine vs hydrocortisone alone on time alive and free of vasopressor support among patients with septic shock: The VITAMINS randomized clinical trial, JAMA: The Journal of the American Medical Association, doi:10.1001/jama.2019.22176
Holford, Carr, Jovic, Ali, Whitaker et al., Vitamin C-An adjunctive therapy for respiratory infection, sepsis and COVID-19, Nutrients, doi:10.3390/nu12123760
Hwang, Ryoo, Park, Jo, Jang et al., Combination therapy of vitamin C and thiamine for septic shock: A multi-Centre, double-blinded randomized, controlled study, Intensive Care Medicine, doi:10.1007/s00134-020-06191-3
Ivanov, Goc, Ivanova, Niedzwiecki, Rath, Inhibition of ACE2 expression by ascorbic acid alone and its combinations with other natural compounds, Infectious Diseases: Research and Treatment
Jamalimoghadamsiahkali, Zarezade, Koolaji, Seyedalinaghi, Zendehdel et al., Safety and effectiveness of high-dose vitamin C in patients with COVID-19: A randomized open-label clinical trial, European Journal of Medical Research, doi:10.1186/s40001-021-00490-1
Joffre, Hellman, Oxidative stress and endothelial dysfunction in sepsis and acute inflammation, Antioxidants & Redox Signaling, doi:10.1089/ars.2021.0027
Ladurner, Schmitt, Schachner, Atanasov, Werner et al., Ascorbate stimulates endothelial nitric oxide synthase enzyme activity by rapid modulation of its phosphorylation status, Free Radical Biology & Medicine, doi:10.1016/j.freeradbiomed.2012.03.022
Langenberg, Bagshaw, May, Bellomo, The histopathology of septic acute kidney injury: A systematic review, Critical Care, doi:10.1186/cc6823
Lankadeva, Okazaki, Evans, Bellomo, May, Renal medullary hypoxia: A new therapeutic target for septic acute kidney injury?, Seminars in Nephrology, doi:10.1016/j.semnephrol.2019.10.004
Lankadeva, Peiris, Okazaki, Birchall, Trask-Marino et al., Reversal of the pathophysiological responses to gram-negative sepsis by megadose vitamin C, Critical Care Medicine, doi:10.1097/CCM.0000000000004770
Marik, Khangoora, Rivera, Hooper, Catravas, Hydrocortisone, vitamin C, and thiamine for the treatment of severe sepsis and septic shock: A retrospective before-after study, Chest, doi:10.1016/j.chest.2016.11.036
Matejovic, Krouzecky, Martinkova, Rokyta, Radej et al., Effects of tempol, a free radical scavenger, on long-term hyperdynamic porcine bacteremia, Critical Care Medicine, doi:10.1097/01.CCM.0000162927.94753.63
May, Bellomo, Lankadeva, Therapeutic potential of megadose vitamin C to reverse organ dysfunction in sepsis and COVID-19, British Journal of Pharmacology
Moskowitz, Huang, Hou, Gong, Doshi et al., Effect of ascorbic acid, corticosteroids, and thiamine on organ injury in septic shock: The ACTS randomized clinical trial, JAMA: The Journal of the American Medical Association, doi:10.1001/jama.2020.11946
Nourbakhsh, Singh, Role of renal oxygenation and mitochondrial function in the pathophysiology of acute kidney injury. Nephron, Clinical Practice, doi:10.1159/000363545
Padayatty, Sun, Wang, Riordan, Hewitt et al., Vitamin C pharmacokinetics: Implications for oral and intravenous use, Annals of Internal Medicine, doi:10.7326/0003-4819-140-7-200404060-00010
Rhodes, Evans, Alhazzani, Levy, Antonelli et al., Surviving sepsis campaign: International guidelines for management of sepsis and septic shock: 2016, Critical Care Medicine, doi:10.1097/CCM.0000000000002255
Rudd, Johnson, Agesa, Shackelford, Tsoi et al., Global, regional, and national sepsis incidence and mortality, 1990-2017: Analysis for the global burden of disease study, Lancet, doi:10.1016/S0140-6736(19)32989-7
Salama, Han, Yau, Reiss, Kramer et al., Tocilizumab in patients hospitalized with Covid-19 pneumonia, The New England Journal of Medicine, doi:10.1056/NEJMoa2030340
Schorah, Downing, Piripitsi, Gallivan, Al-Hazaa et al., Total vitamin C, ascorbic acid, and dehydroascorbic acid concentrations in plasma of critically ill patients, The American Journal of Clinical Nutrition, doi:10.1093/ajcn/63.5.760
Singer, Deutschman, Seymour, Shankar-Hari, Annane et al., The third international consensus definitions for sepsis and septic shock (Sepsis-3), JAMA: The Journal of the American Medical Association, doi:10.1001/jama.2016.0287
Subramanian, Sabui, Moradi, Marchant, Said, Inhibition of intestinal ascorbic acid uptake by lipopolysaccharide is mediated via transcriptional mechanisms, Biochimica et Biophysica Acta -Biomembranes, doi:10.1016/j.bbamem.2017.10.010
Yanase, Fujii, Naorungroj, Belletti, Luethi et al., Harm of intravenous high dose vitamin C therapy in adult patients: A scoping review, Critical Care Medicine, doi:10.1097/CCM.0000000000004396
Zabet, Mohammadi, Ramezani, Khalili, Effect of high-dose ascorbic acid on vasopressor's requirement in septic shock, Journal of Research in Pharmacy Practice, doi:10.4103/2279-042X.179569
Zhao, Ling, Li, Peng, Huang et al., Beneficial aspects of high dose intravenous vitamin C on patients with COVID-19 pneumonia in severe condition: A retrospective case series study, Annals of Palliative Medicine, doi:10.21037/apm-20-1387
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit