Therapeutic potential of megadose vitamin C to reverse organ dysfunction in sepsis and COVID‐19
Clive N May, Rinaldo Bellomo, Yugeesh R Lankadeva
British Journal of Pharmacology, doi:10.1111/bph.15579
Sepsis induced by bacteria or viruses can result in multiorgan dysfunction, which is a major cause of death in intensive care units. Current treatments are only supportive, and there are no treatments that reverse the pathophysiological effects of sepsis. Vitamin C has antioxidant, anti-inflammatory, anticoagulant and immune modulatory actions, so it is a rational treatment for sepsis. Here, we summarise data that support the use of megadose vitamin C as a treatment for sepsis and COVID-19. Megadose intravenous sodium ascorbate (150 g per 40 kg over 7 h) dramatically improved the clinical state and cardiovascular, pulmonary, hepatic and renal function and decreased body temperature, in a clinically relevant ovine model of Gram-negative bacteriainduced sepsis. In a critically ill COVID-19 patient, intravenous sodium ascorbate (60 g) restored arterial pressure, improved renal function and increased arterial blood oxygen levels. These findings suggest that megadose vitamin C should be trialled as a treatment for sepsis and COVID-19.
CONFLICT OF INTEREST YRL, RB and CNM have a provisional patent on vitamin C use in sepsis (2020901120).
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doi:10.21037/apm-20-1387DOI record:
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