Analgesics
Antiandrogens
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Abstract
All vitamin C studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchVitamin CVitamin C (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

Antioxidants and clinical outcomes of patients with coronavirus disease 2019: A systematic review of observational and interventional studies

Foshati et al., Food Science & Nutrition, doi:10.1002/fsn3.3034
Sep 2022  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Vitamin C for COVID-19
6th treatment shown to reduce risk in September 2020
 
*, now known with p = 0.000000087 from 70 studies, recognized in 11 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments. c19early.org
Systematic review showing that vitamin C, vitamin D, selenium, and zinc can improve COVID-19 clinical outcomes.
Reviews covering vitamin C for COVID-19 include Arora, Biancatelli, Feyaerts, Foshati, Hemilä, Hemilä (B), Holford, May, Schloss, Yamasaki.
Review covers vitamin C, vitamin D, selenium, and zinc.
Foshati et al., 2 Sep 2022, peer-reviewed, 5 authors. Contact: r_amani@nutr.mui.ac.ir.
This PaperVitamin CAll
Antioxidants and clinical outcomes of patients with coronavirus disease 2019: A systematic review of observational and interventional studies
Sahar Foshati, Fatemeh Mirjalili, Mahsa Rezazadegan, Farnoosh Fakoorziba, Reza Amani
Food Science & Nutrition, doi:10.1002/fsn3.3034
Coronavirus disease 2019 (COVID-19) is a viral infection caused by a highly contagious pathogen named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This disease usually results in mild to moderate influenza-like symptoms, including fever, dry cough, and fatigue but can also lead to serious outcomes, such as hypoxemia, dyspnea, chest pain, and death. In early 2020, COVID-19 infection speedily spread throughout the world and was announced as a global pandemic by the World Health
References
Abrishami, Dalili, Mohammadi Torbati, Asgari, Arab-Ahmadi et al., Possible association of vitamin D status with lung involvement and outcome in patients with COVID-19: A retrospective study, European Journal of Nutrition
Akhtar, Das, Ismail, Wahid, Saeed et al., Nutritional perspectives for the prevention and mitigation of COVID-19, Nutrition Reviews
Annweiler, Corvaisier, Gautier, Dubée, Legrand et al., Vitamin D supplementation associated to better survival in hospitalized frail elderly COVID-19 patients: The GERIA-COVID quasi-experimental study, Biological Trace Element Research
Annweiler, Hanotte, Del'eprevier, Sabatier, Lafaie et al., Vitamin D and survival in COVID-19 patients: A quasi-experimental study, The Journal of Steroid Biochemistry and Molecular Biology
Arvinte, Singh, Marik, Serum levels of vitamin C and vitamin D in a cohort of critically ill COVID-19 patients of a north American community hospital intensive care unit in May 2020: A pilot study, Medicine in Drug Discovery
Bagheri, Haghollahi, Shariat, Jafarabadi, Aryamloo et al., Supplement usage pattern in a group of COVID-19 patients in Tehran, Journal of Family & Reproductive Health
Baktash, Hosack, Patel, Shah, Kandiah et al., Vitamin D status and outcomes for hospitalised older patients with COVID-19, Postgraduate Medical Journal
Budholiya, Ali, Gunwan, Sahil, Tyagi et al., COVID-19: A global pandemic of 21st century, Journal of Drug Delivery and Therapeutics
Cannalire, Cerchia, Beccari, Di Leva, Summa, Targeting SARS-CoV-2 proteases and polymerase for COVID-19 treatment: State of the art and future opportunities, Journal of Medicinal Chemistry
Carlucci, Ahuja, Petrilli, Rajagopalan, Jones et al., Zinc sulfate in combination with a zinc ionophore may improve outcomes in hospitalized COVID-19 patients, Journal of Medical Microbiology
Carocho, Ferreira, A review on antioxidants, prooxidants and related controversy: Natural and synthetic compounds, screening and analysis methodologies and future perspectives, Food and Chemical Toxicology
Carpagnano, Di Lecce, Quaranta, Zito, Buonamico et al., Vitamin D deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19, Journal of Endocrinological Investigation
Castillo, Costa, Barrios, Díaz, Miranda et al., Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study, The Journal of Steroid Biochemistry and Molecular Biology
Cecchini, Cecchini, SARS-CoV-2 infection pathogenesis is related to oxidative stress as a response to aggression, Medical Hypotheses
Cerullo, Negro, Parimbelli, Pecoraro, Perna et al., The long history of vitamin C: From prevention of the common cold to potential aid in the treatment of COVID-19, Frontiers in Immunology
Chernyak, Popova, Prikhodko, Grebenchikov, Zinovkina et al., COVID-19 and oxidative stress, Biochemistry
Cure, Cure, Alpha-lipoic acid may protect patients with diabetes against COVID-19 infection, Medical Hypotheses
Daneshkhah, Agrawal, Eshein, Subramanian, Roy et al., Evidence for possible association of vitamin D status with cytokine storm and unregulated inflammation in COVID-19 patients, Aging Clinical and Experimental Research
Darma, Ranuh, Merbawani, Setyoningrum, Hidajat et al., Zinc supplementation effect on the bronchial cilia length, the number of cilia, and the number of intact bronchial cell in zinc deficiency rats, The Indonesian Biomedical Journal
De Smet, De Smet, Herroelen, Gryspeerdt, Martens, Serum 25 (OH) D level on hospital admission associated with COVID-19 stage and mortality, American Journal of Clinical Pathology
Delgado-Roche, Mesta, Oxidative stress as key player in severe acute respiratory syndrome coronavirus (SARS-CoV) infection, Archives of Medical Research
Derwand, Scholz, Zelenko, COVID-19 outpatients: Early risk-stratified treatment with zinc plus low-dose hydroxychloroquine and azithromycin: A retrospective case series study, International Journal of Antimicrobial Agents
Earar, Arbune, Dorobat, Rusu-Negraia, Stefanescu et al., Biochemical effects and therapeutic application of vitamin C (C6H8O6) on COVID-19 infection, Revista de Chimie
Eijkelkamp, Morey, Neville, Tan, Pederick et al., Dietary zinc and the control of Streptococcus pneumoniae infection, PLoS Pathogens
Farjana, Moni, Sohag, Hasan, Hannan et al., Repositioning vitamin C as a promising option to alleviate complications associated with COVID-19
Ghodratizadeh, Kanbak, Beyramzadeh, Dikmen, Memarzadeh et al., Effect of carotenoid βcryptoxanthin on cellular and humoral immune response in rabbit, Veterinary Research Communications
Guillin, Vindry, Ohlmann, Chavatte, Selenium, selenoproteins and viral infection, Nutrients
Hajhashemy, Foshati, Saneei, Relationship between abdominal obesity (based on waist circumference) and serum vitamin D levels: A systematic review and meta-analysis of epidemiologic studies, Nutrition Reviews
Halliwell, Biochemistry of oxidative stress, Biochemical Society Transactions
Hars, Mendes, Serratrice, Herrmann, Gold et al., Sex-specific association between vitamin D deficiency and COVID-19 mortality in older patients, Osteoporosis International
Heller, Sun, Hackler, Seelig, Seibert et al., Prediction of survival odds in COVID-19 by zinc, age and selenoprotein P as composite biomarker, Redox Biology
Hernández, Nan, Fernandez-Ayala, García-Unzueta, Hernández-Hernández et al., Vitamin D status in hospitalized patients with SARS-CoV-2 infection, The Journal of Clinical Endocrinology and Metabolism
Hiedra, Lo, Elbashabsheh, Gul, Wright et al., The use of IV vitamin C for patients with COVID-19: A case series, Expert Review of Anti-Infective Therapy
Huang, Liu, Qi, Brand, Zheng, Role of vitamin A in the immune system, Journal of Clinical Medicine
Imai, Kuba, Rao, Huan, Guo et al., Angiotensin-converting enzyme 2 protects from severe acute lung failure, Nature
Jayawardena, Sooriyaarachchi, Chourdakis, Jeewandara, Ranasinghe, Enhancing immunity in viral infections, with special emphasis on COVID-19: A review, Diabetes & Metabolic Syndrome: Clinical Research & Reviews
Jothimani, Kailasam, Danielraj, Nallathambi, Ramachandran et al., COVID-19: Poor outcomes in patients with zinc deficiency, International Journal of Infectious Diseases
Karahan, Katkat, Impact of serum 25 (OH) vitamin D level on mortality in patients with COVID-19 in Turkey, The Journal of Nutrition, Health & Aging
Kim, Zhang, Cha, Kolitz, Funt et al., Advanced bioinformatics rapidly identifies existing therapeutics for patients with coronavirus disease-2019 (COVID-19), Journal of Translational Medicine
Konrad, Vicini, Kusterer, Höflich, Assadkhani et al., Alpha-lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with type 2 diabetes, Diabetes Care
Koparal, Kurt, Altuntas, Dogan, Assessment of mucociliary clearance as an indicator of nasal function in patients with COVID-19: A cross-sectional study, European Archives of Oto-Rhino-Laryngology
Kudlay, Svistunov, COVID-19 vaccines: An overview of different platforms, Bioengineering
Kumar, Gupta, Banerjee, Does vitamin D have a potential role against COVID-19?, Alimentary Pharmacology & Therapeutics
Laird, Rhodes, Kenny, Vitamin D and inflammation: Potential implications for severity of COVID-19, Irish Medical Journal
Lewis, Meydani, Wu, Regulatory role of vitamin E in the immune system and inflammation, IUBMB Life
Li, Wu, Li, Liang, Tse et al., Revealing the targets and mechanisms of vitamin A in the treatment of COVID-19, Aging
Lottes, Newton, Spyropoulos, Baatz, Lactate as substrate for mitochondrial respiration in alveolar epithelial type II cells, American Journal of Physiology-Lung Cellular and Molecular Physiology
Luo, Liao, Shen, Li, Cheng, Vitamin D deficiency is inversely associated with COVID-19 incidence and disease severity in Chinese people, The Journal of Nutrition
Maghbooli, Sahraian, Ebrahimi, Pazoki, Kafan et al., Vitamin D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng/mL reduced risk for adverse clinical outcomes in patients with COVID-19 infection, PLoS One
Malek Mahdavi, A brief review of interplay between vitamin D and angiotensin-converting enzyme 2: Implications for a potential treatment for COVID-19, Reviews in Medical Virology
Mccarty, Sunlight exposure assessment: Can we accurately assess vitamin D exposure from sunlight questionnaires?, The American Journal of Clinical Nutrition
Mccullough, Northrop-Clewes, Thurnham, The effect of vitamin A on epithelial integrity, Proceedings of the Nutrition Society
Mehta, Gowder, Members of antioxidant machinery and their functions
Merzon, Tworowski, Gorohovski, Vinker, Golan Cohen et al., Low plasma 25 (OH) vitamin D level is associated with increased risk of COVID-19 infection: An Israeli population-based study, The FEBS Journal
Moghaddam, Heller, Sun, Seelig, Cherkezov et al., Selenium deficiency is associated with mortality risk from COVID-19, Nutrients
Morgan, Whaley, Thayer, Schünemann, Identifying the PECO: A framework for formulating good questions to explore the association of environmental and other exposures with health outcomes, Environment International
Musavi, Abazari, Barartabar, Kalaki-Jouybari, Hemmati-Dinarvand et al., The benefits of vitamin D in the COVID-19 pandemic: Biochemical and immunological mechanisms, Archives of Physiology and Biochemistry, doi:10.1080/13813455.2020.1826530
Nimse, Pal, Free radicals, natural antioxidants, and their reaction mechanisms, RSC Advances
Padhi, Suvankar, Panda, Pati, Panda, Lower levels of vitamin D are associated with SARS-CoV-2 infection and mortality in the Indian population: An observational study, International Immunopharmacology
Page, Mckenzie, Bossuyt, Boutron, Hoffmann et al., The PRISMA 2020 statement: An updated guideline for reporting systematic reviews, BMJ
Panagiotou, Tee, Ihsan, Athar, Marchitelli et al., Low serum 25-hydroxyvitamin D (25 [OH] D) levels in patients hospitalized with COVID-19 are associated with greater disease severity, Clinical Endocrinology
Paraiso, Revel, Stevens, Potential use of polyphenols in the battle against COVID-19, Current Opinion in Food Science
Peron, Nakaya, Susceptibility of the elderly to SARS-CoV-2 infection: ACE-2 overexpression, shedding, and antibodydependent enhancement, Clinics
Petersen, Gerasimenko, Gerasimenko, Endocytic uptake of SARS-CoV-2: The critical roles of pH, Ca2+, and NAADP, Function
Pizzini, Aichner, Sahanic, Böhm, Egger et al., Impact of vitamin D deficiency on COVID-19-a prospective analysis from the CovILD Registry, Nutrients
Radujkovic, Hippchen, Tiwari-Heckler, Dreher, Boxberger et al., Vitamin D deficiency and outcome of COVID-19 patients, Nutrients
Rajendran, Nandakumar, Rengarajan, Palaniswami, Gnanadhas et al., Antioxidants and human diseases, Clinica Chimica Acta
Rastogi, Bhansali, Khare, Suri, Yaddanapudi et al., Short term, high-dose vitamin D supplementation for COVID-19 disease: A randomised, placebocontrolled, study (SHADE study), Postgraduate Medical Journal
Ratnam, Ankola, Bhardwaj, Sahana, Kumar, Role of antioxidants in prophylaxis and therapy: A pharmaceutical perspective, Journal of Controlled Release
Read, Obeid, Ahlenstiel, Ahlenstiel, The role of zinc in antiviral immunity, Advances in Nutrition
Sajjadi, Foshati, Haddadian-Khouzani, Rouhani, The role of selenium in depression: A systematic review and meta-analysis of human observational and interventional studies, Scientific Reports
Santos, Pimenta, Nobre, The PICO strategy for the research question construction and evidence search, Revista Latino-Americana de Enfermagem
Sayıner, Serakıncı, Alpha lipoic acid as a potential treatment for COVID-19 -A hypothesis, Current Topics in Nutraceutical Research
Seale, Torres, Berry, Pitts, A role for selenium-dependent GPX1 in SARS-CoV-2 virulence, The American Journal of Clinical Nutrition
Sharma, Gupta, Sharma, A comprehensive review of free radicals, antioxidants, and their relationship with human ailments, Critical Reviews™ in Eukaryotic Gene Expression
Silvagno, Vernone, Pescarmona, The role of glutathione in protecting against the severe inflammatory response triggered by COVID-19, Antioxidants
Singh, Kaur, Singh, Revisiting the role of vitamin D levels in the prevention of COVID-19 infection and mortality in European countries post infections peak, Aging Clinical and Experimental Research
Skalny, Rink, Ajsuvakova, Aschner, Gritsenko et al., Zinc and respiratory tract infections: perspectives for COVID-19, International Journal of Molecular Medicine
Stroup, Berlin, Morton, Olkin, Williamson et al., Meta-analysis of observational studies in epidemiology: A proposal for reporting, The Journal of the American Medical Association
Takashita, Kinoshita, Yamayoshi, Sakai-Tagawa, Fujisaki et al., Efficacy of antibodies and antiviral drugs against COVID-19 omicron variant, New England Journal of Medicine
Tibullo, Li Volti, Giallongo, Grasso, Tomassoni et al., Biochemical and clinical relevance of alpha lipoic acid: Antioxidant and anti-inflammatory activity, molecular pathways and therapeutic potential, Inflammation Research
Xu, Yang, Chen, Luo, Zhang et al., Vitamin D alleviates lipopolysaccharideinduced acute lung injury via regulation of the reninangiotensin system, Molecular Medicine Reports
Yao, Paguio, Dee, Tan, Moulick et al., The minimal effect of zinc on the survival of hospitalized patients with COVID-19: An observational study, Chest
Yasui, Yasui, Suzuki, Saitou, Yamamoto et al., Analysis of the predictive factors for a critical illness of COVID-19 during treatment-relationship between serum zinc level and critical illness of COVID-19, International Journal of Infectious Diseases
Ye, Tang, Liao, Shaw, Deng et al., Does serum vitamin D level affect COVID-19 infection and its severity?-A case-control study, Journal of the American College of Nutrition
Yılmaz, Şen, Is vitamin D deficiency a risk factor for COVID-19 in children?, Pediatric Pulmonology
Zhang, Rao, Li, Zhu, Liu et al., Pilot trial of high-dose vitamin C in critically ill COVID-19 patients, Annals of Intensive Care
Zhang, Tang, Huang, Zhou, Cui et al., Metabolic regulation of gene expression by histone lactylation, Nature
Zhang, Taylor, Bennett, Saad, Rayman, Association between regional selenium status and reported outcome of COVID-19 cases in China, The American Journal of Clinical Nutrition
Zhang, Tsao, Dietary polyphenols, oxidative stress and antioxidant and anti-inflammatory effects, Current Opinion in Food Science
Zhou, Yu, Du, Fan, Liu et al., Clinical course and risk factors for mortality of adult in patients with COVID-19 in Wuhan, China: A retrospective cohort study, The Lancet
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit