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Rebound effect explains the divergence in survival after 5 days in a controlled trial on vitamin C for COVID-19 patients

Hemilä et al., Frontiers in Medicine, doi:10.3389/fmed.2024.1391346
May 2024  
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Vitamin C for COVID-19
6th treatment shown to reduce risk in September 2020
*, now known with p = 0.000000038 from 71 studies, recognized in 12 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,200+ studies for 70+ treatments.
Reanalysis of the REMAP-CAP and LOVIT-COVID vitamin C RCTs1 showing that the poor results may be explained by a rebound effect due to the abrupt termination of vitamin C treatment after 4 days.
Authors describe a rebound effect where a sudden stop in high-dose vitamin C administration can lead to a rapid drop in vitamin C levels, potentially below the levels before treatment began, and this may have adverse health effects. The authors cite previous research on sepsis patients where a similar pattern of increased mortality was observed after the cessation of vitamin C treatment.
Reviews covering vitamin C for COVID-19 include2-12.
Hemilä et al., 21 May 2024, peer-reviewed, 2 authors.
This PaperVitamin CAll
Abstract: TYPE Opinion PUBLISHED 21 May 2024 DOI 10.3389/fmed.2024.1391346 OPEN ACCESS EDITED BY Sebastien Gibot, Centre Hospitalier Universitaire de Nancy, France REVIEWED BY Margreet C. M. Vissers, University of Otago, New Zealand *CORRESPONDENCE Harri Hemilä Rebound effect explains the divergence in survival after 5 days in a controlled trial on vitamin C for COVID-19 patients Harri Hemilä1* and Elizabeth Chalker2 Department of Public Health, University of Helsinki, Helsinki, Finland, 2 National Centre for Epidemiology and Population Health, Australian National University, Canberra, ACT, Australia 1 RECEIVED 25 February 2024 ACCEPTED 06 May 2024 PUBLISHED 21 May 2024 KEYWORDS CITATION ascorbic acid, intensive care, mortality, SARS-CoV-2, scurvy, sepsis, time factors, vitamins Hemilä H and Chalker E (2024) Rebound effect explains the divergence in survival after 5 days in a controlled trial on vitamin C for COVID-19 patients. Front. Med. 11:1391346. doi: 10.3389/fmed.2024.1391346
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