Vitamin C and COVID-19

DOI record: { "DOI": "10.3389/fmed.2020.559811", "ISSN": [ "2296-858X" ], "URL": "http://dx.doi.org/10.3389/fmed.2020.559811", "abstract": "<jats:p>In numerous animal studies, vitamin C has prevented and alleviated viral and bacterial infections. In a few dozen placebo-controlled trials with humans, vitamin C has shortened infections caused by respiratory viruses, which indicates that the vitamin can also influence viral infections in humans. In critically ill patients, plasma vitamin C levels are commonly very low. Gram doses of vitamin C are needed to increase the plasma vitamin C levels of critically ill patients to the levels of ordinary healthy people. A meta-analysis of 12 trials with 1,766 patients calculated that vitamin C reduced the length of ICU stay on average by 8%. Another meta-analysis found that vitamin C shortened the duration of mechanical ventilation in ICU patients. Two randomized placebo-controlled trials found statistically significant reduction in the mortality of sepsis patients. The effects of vitamin C on acute respiratory distress syndrome (ARDS) frequently complicating COVID-19 pneumonia should be considered. Vitamin C is a safe and inexpensive essential nutrient.</jats:p>", "alternative-id": [ "10.3389/fmed.2020.559811" ], "author": [ { "affiliation": [], "family": "Hemilä", "given": "Harri", "sequence": "first" }, { "affiliation": [], "family": "de Man", "given": "Angelique M. E.", "sequence": "additional" } ], "container-title": [ "Frontiers in Medicine" ], "content-domain": { "crossmark-restriction": true, "domain": [ "frontiersin.org" ] }, "created": { "date-parts": [ [ 2021, 1, 18 ] ], "date-time": "2021-01-18T05:01:36Z", "timestamp": 1610946096000 }, "deposited": { "date-parts": [ [ 2021, 1, 18 ] ], "date-time": "2021-01-18T05:01:39Z", "timestamp": 1610946099000 }, "indexed": { "date-parts": [ [ 2021, 11, 11 ] ], "date-time": "2021-11-11T15:48:34Z", "timestamp": 1636645714107 }, "is-referenced-by-count": 5, "issn-type": [ { "type": "electronic", "value": "2296-858X" } ], "issued": { "date-parts": [ [ 2021, 1, 18 ] ] }, "license": [ { "URL": "https://creativecommons.org/licenses/by/4.0/", "content-version": "vor", "delay-in-days": 0, "start": { "date-parts": [ [ 2021, 1, 18 ] ], "date-time": "2021-01-18T00:00:00Z", "timestamp": 1610928000000 } } ], "link": [ { "URL": "https://www.frontiersin.org/articles/10.3389/fmed.2020.559811/full", "content-type": "unspecified", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "1965", "original-title": [], "prefix": "10.3389", "published": { "date-parts": [ [ 2021, 1, 18 ] ] }, "published-online": { "date-parts": [ [ 2021, 1, 18 ] ] }, "publisher": "Frontiers Media SA", "reference": [ { "DOI": "10.3390/nu9040339", "article-title": "Vitamin C and infections", "author": "Hemilä", "doi-asserted-by": "publisher", "first-page": "339", "journal-title": "Nutrients", "key": "B1", "volume": "9", "year": "2017" }, { "key": "B2", "unstructured": "10518\n HemiläH\n HelsinkiUniversity of HelsinkiDo Vitamins C and E Affect Respiratory Infections2006" }, { "DOI": "10.1177/014107680710001109", "article-title": "Vitamin C may affect lung infections", "author": "Hemilä", "doi-asserted-by": "publisher", "first-page": "495", "journal-title": "J R Soc Med", "key": "B3", "volume": "100", "year": "2007" }, { "DOI": "10.1002/14651858.CD005532.pub3", "article-title": "Vitamin C for preventing and treating pneumonia", "author": "Hemilä", "doi-asserted-by": "publisher", "first-page": "CD005532", "journal-title": "Cochrane Database Syst Rev", "key": "B4", "volume": "8", "year": "2013" }, { "DOI": "10.1089/ars.2012.4988", "article-title": "Vitamin C promotes maturation of T-cells", "author": "Manning", "doi-asserted-by": "publisher", "first-page": "2054", "journal-title": "Antioxid. 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