Vitamin C and COVID-19
et al., Frontiers in Medicine, doi:10.3389/fmed.2020.559811 (Review)
, Vitamin C and COVID-19, Frontiers in Medicine, doi:10.3389/fmed.2020.559811 (Review)
Review of the use of vitamin C for infections and the potential benefit for COVID-19.
Hemilä et al., 18 Jan 2021, peer-reviewed, 2 authors.
Vitamin C and COVID-19
Frontiers in Medicine, doi:10.3389/fmed.2020.559811
In numerous animal studies, vitamin C has prevented and alleviated viral and bacterial infections. In a few dozen placebo-controlled trials with humans, vitamin C has shortened infections caused by respiratory viruses, which indicates that the vitamin can also influence viral infections in humans. In critically ill patients, plasma vitamin C levels are commonly very low. Gram doses of vitamin C are needed to increase the plasma vitamin C levels of critically ill patients to the levels of ordinary healthy people. A meta-analysis of 12 trials with 1,766 patients calculated that vitamin C reduced the length of ICU stay on average by 8%. Another meta-analysis found that vitamin C shortened the duration of mechanical ventilation in ICU patients. Two randomized placebo-controlled trials found statistically significant reduction in the mortality of sepsis patients. The effects of vitamin C on acute respiratory distress syndrome (ARDS) frequently complicating COVID-19 pneumonia should be considered. Vitamin C is a safe and inexpensive essential nutrient.
AUTHOR CONTRIBUTIONS HH and AM participated in the revision of the manuscript.
Conflict of Interest: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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