Conv. Plasma
Nigella Sativa

All vitamin C studies
Meta analysis
study COVID-19 treatment researchVitamin CVitamin C (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

Serum Levels of Vitamin C and Vitamin D in a Cohort of Critically Ill COVID-19 Patients of a North American Community Hospital Intensive Care Unit in May 2020: A Pilot Study

Arvinte et al., Med. Drug Discov, doi:10.1016/j.medidd.2020.100064
Sep 2020  
  Source   PDF   All Studies   Meta AnalysisMeta
Vitamin C for COVID-19
7th treatment shown to reduce risk in September 2020
*, now known with p = 0.000000098 from 67 studies, recognized in 10 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments.
Pilot study with 21 ICU patients finding low serum levels of vitamin C and vitamin D in most patients. Older age and low vitamin C level appeared to be co-dependent risk factors for mortality.
This study is excluded in the after exclusion results of meta analysis: very late stage, ICU patients.
Arvinte et al., 8 Sep 2020, peer-reviewed, 3 authors.
This PaperVitamin CAll
Serum Levels of Vitamin C and Vitamin D in a Cohort of Critically Ill COVID-19 Patients of a North American Community Hospital Intensive Care Unit in May 2020: A Pilot Study
MD a, ⁎ Cristian Arvinte, PhD Maharaj Singh, MD, FCCP Paul E Marik
Medicine in Drug Discovery, doi:10.1016/j.medidd.2020.100064
Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre -including this research content -immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
Conflict of Interest The authors of this paper have had no conflicts of interest in conducting and publishing this research. Ethical Approval and Informed Consent The work involved in conducting our research has followed standard medical ethical rules and regulations.
Biancatelli, Berrill, Marik, The antiviral properties of vitamin C, Expert Rev Anti-Infect Ther, doi:10.1080/14787210.2020.1706483
Carr, Maggini, Vitamin C and immune function, Nutrients
Carr, Rosengrave, Bayer, Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes, Crit Care, doi:10.1186/s13054-017-1891-y
Chiscano-Camón, Vitamin C levels in patients with SARS-CoV-2-associated acute respiratory distress Syndrome, Crit Care, doi:10.1186/s13054-020-03249-y
Dwivedi, Parenteral vitamin D supplementation is superior to oral in vitamin D insufficient patients with type 2 diabetes mellitus, Diabetes Metab Syndr Clin Res Rev. November, doi:10.1016/j.dsx.2017.03.019
Einarsdóttir, Effect of a single 'megadose' intramuscular vitamin D (600,000 IU) injection on vitamin D concentrations and bone mineral density following biliopancreatic diversion surgery, Obes Surg, doi:10.1007/s11695-009-0024-3
Grant, Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths, Nutrients
Long, Dosing matters! Vitamin C in critical illness, Crit Care Med
Marik, Vitamin C: an essential "stress hormone" during sepsis, J Thorac Dis
Martin, Avoidance of vitamin D deficiency to slow the COVID-19 pandemic, BMJ Nutrition, Prevention & Health, doi:10.1136/bmjnph-2020-000096
Mccartney, Byrne, Optimization of Vitamin D Status for Enhanced Immuno-protection Against Covid-19, Ir Med J
Oudemans-Van Straaten, Man, De Waard, Vitamin C revisited, Crit Care, doi:10.1186/s13054-014-0460-x
Paul, Vitamin C for the treatment of sepsis: The scientific rationale, Pharmacol Ther, doi:10.1016/j.pharmthera.2018.04.007
Schleicher, Serum vitamin C and the prevalence of vitamin C deficiency in the United States: 2003-2004 National Health and Nutrition Examination Survey (NHANES), Am J Clin Nutr, doi:10.3945/ajcn.2008.27016
Scurvy, None, Lancet, doi:10.1016/S0140-6736(01)52008-5
Silberstein, Vitamin D: A simpler alternative to tocilizumab for trial in COVID-19?, Med Hypotheses
The, Heart, Lung, and Blood Institute PETAL Clinical Trials Network: early high-dose vitamin D3 for critically ill, vitamin D-deficient patients, N Engl J Med, doi:10.1056/NEJMoa1911124
Wu, An update on current therapeutic drugs treating COVID-19, Cur Pharmacol Rep
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop