Real-world evidence with a retrospective cohort of 15,968 COVID-19 hospitalized patients suggests 21 new effective treatments

DOI record: { "DOI": "10.1186/s12985-023-02195-9", "ISSN": [ "1743-422X" ], "URL": "http://dx.doi.org/10.1186/s12985-023-02195-9", "abstract": "<jats:title>Abstract</jats:title><jats:sec>\n <jats:title>Purpose</jats:title>\n <jats:p>Despite the extensive vaccination campaigns in many countries, COVID-19 is still a major worldwide health problem because of its associated morbidity and mortality. Therefore, finding efficient treatments as fast as possible is a pressing need. Drug repurposing constitutes a convenient alternative when the need for new drugs in an unexpected medical scenario is urgent, as is the case with COVID-19.</jats:p>\n </jats:sec><jats:sec>\n <jats:title>Methods</jats:title>\n <jats:p>Using data from a central registry of electronic health records (the Andalusian Population Health Database), the effect of prior consumption of drugs for other indications previous to the hospitalization with respect to patient outcomes, including survival and lymphocyte progression, was studied on a retrospective cohort of 15,968 individuals, comprising all COVID-19 patients hospitalized in Andalusia between January and November 2020.</jats:p>\n </jats:sec><jats:sec>\n <jats:title>Results</jats:title>\n <jats:p>Covariate-adjusted hazard ratios and analysis of lymphocyte progression curves support a significant association between consumption of 21 different drugs and better patient survival. Contrarily, one drug, furosemide, displayed a significant increase in patient mortality.</jats:p>\n </jats:sec><jats:sec>\n <jats:title>Conclusions</jats:title>\n <jats:p>In this study we have taken advantage of the availability of a regional clinical database to study the effect of drugs, which patients were taking for other indications, on their survival. The large size of the database allowed us to control covariates effectively.</jats:p>\n </jats:sec>", "alternative-id": [ "2195" ], "article-number": "226", "assertion": [ { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Received", "name": "received", "order": 1, "value": "6 December 2022" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Accepted", "name": "accepted", "order": 2, "value": "27 September 2023" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "First Online", "name": "first_online", "order": 3, "value": "6 October 2023" }, { "group": { "label": "Declarations", "name": "EthicsHeading" }, "name": "Ethics", "order": 1 }, { "group": { "label": "Competing interests", "name": "EthicsHeading" }, "name": "Ethics", "order": 2, "value": "The authors declare no competing interests." }, { "group": { "label": "Ethics approval", "name": "EthicsHeading" }, "name": "Ethics", "order": 3, "value": "This project was reviewed and approved by the Ethics Committee for the Coordination of Biomedical Research in Andalusia (29th September, 2020, Acta 09/20)." }, { "group": { "label": "Conflict of interest", "name": "EthicsHeading" }, "name": "Ethics", "order": 4, "value": "The authors have no competing interests to declare that are relevant to the content of this article." } ], "author": [ { "ORCID": "http://orcid.org/0000-0001-9598-6965", "affiliation": [], "authenticated-orcid": false, "family": "Loucera", "given": "Carlos", "sequence": "first" }, { "ORCID": "http://orcid.org/0000-0002-4235-2886", "affiliation": [], "authenticated-orcid": false, "family": "Carmona", "given": "Rosario", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0003-2632-9587", "affiliation": [], "authenticated-orcid": false, "family": "Esteban-Medina", "given": "Marina", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0002-1690-6347", "affiliation": [], "authenticated-orcid": false, 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