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0 0.5 1 1.5 2+ Mortality 18% Improvement Relative Risk c19early.org/fm Loucera et al. Famotidine for COVID-19 Prophylaxis Favors famotidine Favors control
Real-world evidence with a retrospective cohort of 15,968 Andalusian COVID-19 hospitalized patients suggests 21 new effective treatments and one drug that increases death risk
Loucera et al., medRxiv, doi:10.1101/2022.08.14.22278751 (Preprint)
16 Aug 2022    Source   PDF   Share   Tweet
Retrospective 15,968 COVID-19 hospitalized patients in Spain, showing lower mortality with existing use of several medications including metformin, HCQ, aspirin, vitamin D, vitamin C, and budesonide.
Although the 18% lower mortality is not statistically significant, it is consistent with the significant 17% lower mortality [5‑28%] from meta analysis of the 18 mortality results to date.
risk of death, 17.5% lower, HR 0.82, p = 0.25, treatment 207, control 15,761, Cox proportional hazards, day 30.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Loucera et al., 16 Aug 2022, retrospective, Spain, preprint, 8 authors, study period January 2020 - November 2020.
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