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0 0.5 1 1.5 2+ Mortality 1% Improvement Relative Risk Vitamin B9 for COVID-19  Loucera et al.  Prophylaxis Is prophylaxis with vitamin B9 beneficial for COVID-19? Retrospective 15,968 patients in Spain (January - November 2020) No significant difference in mortality c19early.org Loucera et al., Virology J., August 2022 Favors vitamin B9 Favors control

Real-world evidence with a retrospective cohort of 15,968 COVID-19 hospitalized patients suggests 21 new effective treatments

Loucera et al., Virology Journal, doi:10.1186/s12985-023-02195-9 (date from preprint)
Aug 2022  
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Retrospective 15,968 COVID-19 hospitalized patients in Spain, showing no significant difference in mortality with existing use of folic acid. Since only hospitalized patients are included, results do not reflect different probabilities of hospitalization across treatments.
Study covers vitamin B9, HCQ, aspirin, ibuprofen, vitamin C, budesonide, famotidine, and metformin.
risk of death, 1.5% lower, HR 0.99, p = 0.88, treatment 624, control 15,344, Cox proportional hazards, day 30.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Loucera et al., 16 Aug 2022, retrospective, Spain, peer-reviewed, 8 authors, study period January 2020 - November 2020.
This PaperVitamin B9All
Real-world evidence with a retrospective cohort of 15,968 Andalusian COVID-19 hospitalized patients suggests 21 new effective treatments and one drug that increases death risk
Carlos Loucera, Rosario Carmona, Marina Esteban-Medina, Gerrit Bostelmann, Dolores Muñoyerro-Muñiz, Román Villegas, María Peña-Chilet, Joaquin Dopazo
doi:10.1101/2022.08.14.22278751
Despite the extensive vaccination campaigns in many countries, COVID-19 is still a major worldwide health problem because of its associated morbidity and mortality. Therefore, finding efficient treatments as fast as possible is a pressing need. Drug repurposing constitutes a convenient alternative when the need for new drugs in an unexpected medical scenario is urgent, as is the case with COVID-19. Using data from a central registry of electronic health records (the Andalusian Population Health Database, BPS), the effect of prior consumption of drugs for other indications previous to the hospitalization with respect to patient survival was studied on a retrospective cohort of 15,968 individuals, comprising all COVID-19 patients hospitalized in Andalusia between January and November 2020. Covariate-adjusted hazard ratios and analysis of lymphocyte progression curves support a significant association between consumption of 21 different drugs and better patient survival. Contrarily, one drug, furosemide, displayed a significant increase in patient mortality.
Supplementary Material Supplementary Table 1 . Data imported from BPS for each patient: code and definition of the variable. 2 . Log Hazard ratios obtained for the drugs tested, along with standard deviations (SDs), upper and lower coefficient intervals (CI), nominal and FDR-adjusted p-values. Also, Lymphocyte proliferation values (see Methods) along with standard deviations (SDs), upper and lower coefficient intervals (CI), nominal and FDR-adjusted p-values. The two last columns indicate the drugs used in the machine learning drug repurposing prediction study 10 and the significance of the prediction. Supplementary Table
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' 'Drug repurposing constitutes a convenient alternative when the need for new drugs in an ' 'unexpected medical scenario is urgent, as is the case with COVID-19.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Methods</jats:title>\n' ' <jats:p>Using data from a central registry of electronic health records (the ' 'Andalusian Population Health Database), the effect of prior consumption of drugs for other ' 'indications previous to the hospitalization with respect to patient outcomes, including ' 'survival and lymphocyte progression, was studied on a retrospective cohort of 15,968 ' 'individuals, comprising all COVID-19 patients hospitalized in Andalusia between January and ' 'November 2020.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Results</jats:title>\n' ' <jats:p>Covariate-adjusted hazard ratios and analysis of lymphocyte ' 'progression curves support a significant association between consumption of 21 different ' 'drugs and better patient survival. Contrarily, one drug, furosemide, displayed a significant ' 'increase in patient mortality.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Conclusions</jats:title>\n' ' <jats:p>In this study we have taken advantage of the availability of a ' 'regional clinical database to study the effect of drugs, which patients were taking for other ' 'indications, on their survival. 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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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