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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 10% Improvement Relative Risk Vitamin C for COVID-19  Salehi et al.  ICU PATIENTS Is very late treatment with vitamin C beneficial for COVID-19? Retrospective 125 patients in Iran (April - September 2021) Lower mortality with vitamin C (not stat. sig., p=0.56) c19early.org Salehi et al., Research Square, March 2022 Favors vitamin C Favors control

Risk factors of death in mechanically ventilated COVID-19 patients: a retrospective multi-center study

Salehi et al., Research Square, doi:10.21203/rs.3.rs-1362678/v1
Mar 2022  
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Vitamin C for COVID-19
7th treatment shown to reduce risk in September 2020
 
*, now known with p = 0.00000011 from 68 studies, recognized in 10 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,900+ studies for 60+ treatments. c19early.org
Retrospective 125 mechanically ventilated ICU patients in Iran, showing no significant difference with vitamin C treatment in unadjusted results.
Although the 10% lower mortality is not statistically significant, it is consistent with the significant 19% lower mortality [9‑28%] from meta analysis of the 40 mortality results to date.
This is the 44th of 68 COVID-19 controlled studies for vitamin C, which collectively show efficacy with p=0.00000011.
19 studies are RCTs, which show efficacy with p=0.0021.
This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details; very late stage, ICU patients.
Study covers remdesivir, HCQ, and vitamin C.
risk of death, 10.1% lower, RR 0.90, p = 0.56, treatment 22 of 40 (55.0%), control 52 of 85 (61.2%), NNT 16.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Salehi et al., 11 Mar 2022, retrospective, Iran, preprint, mean age 62.0, 11 authors, study period April 2021 - September 2021.
This PaperVitamin CAll
Risk factors of death in mechanically ventilated COVID-19 patients: a retrospective multi- center study
Mohammadreza Salehi, Mohammad-Taghi Beig Mohammadi, Seyed Hamidreza Abtahi, Samrand-Fattah Ghazi, Abolfazl Sobati, Rama Bozorgmehr, Seyed Ali Dehghan Manshadi, Saeed Reza Jamali Siahkali, Mostafa Mohammadi, Banafsheh Moradmand Badie, Ensiyeh Rahimi
doi:10.21203/rs.3.rs-1362678/v1
Introduction: Despite the improvement in COVID-19 therapeutic management the mortality of mechanically ventilated COVID-19 patients remains high. In this study, we determined risk factors of mortality in these cases. Methods: This retrospective study examined clinical and paraclinical data of COVID-19 patients mechanically ventilated at the time of hospitalization to ICU admission until death or discharge from hospital between April and September in 2021 in three COVID-19 referral hospitals. Results: One hundred twenty-ve patients (60% male, mean age 62 ± 15.18, range 17 to 97 years old) were recruited to this study. 51(40%) survived and 74 (60%) didn't survive. At the time of hospital admission, the vital signs were not signi cantly different between the survivors and non-survivors groups, also diarrhea was not reported in non-survivors, but reported in 9.5% of survivors (P = 0.02). The mean age of 74 non-survivors was higher than 51 survivors (65.1 ± 14.17 vs 56.9 ± 15.41, P = 0.003). The intubation time since the patients were admitted to hospitals was not signi cantly different between the two groups (3.38 ± 2.88 days vs 4.16 ± 3.42 days, P = 0.34). The mean LDH and D-dimer at the time of ICU admission were signi cantly higher in the non-survivors group (863 ± 449 vs 613 ± 326, P = 0.01; 4081 ± 3342 vs 542 ± 634, P = 0.009; respectively). However, the mean CRP was not signi cantly different between the two groups (76 ± 66.4, 54 ± 84.3; P = 0.1). Mean APACHE-II score was higher in the non-survivors than the survivors (15 vs 13; P = 0.01). Use of remdesivir, interfrone beta-1a, and low dose corticosteroids were signi cantly higher in the survivors group (P = 0.009, P = 0.001, P = 0.000). Conclusion: Success of weaning and hospital discharge among mechanically ventilated COVID-19 patients are probably higher in younger patients with lower D-dimmer and LDH levels that received low dose corticosteroids during treatment.
The study is retrospective. It was not possible to use written consent. According to the Medical Ethics Committee, patients' information remains con dential. Patients agreed to receive routine treatment upon arrival at the hospital. Then they received the treatment they needed. Finally, they were analyzed based on the treatment received in different groups. Consent for publication: We the authors give our consent for the publication of identi able details within the text to be published in the Journal of Critical Care.
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Late treatment
is less effective
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